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Dynamic observation of bone marrow suppression and chromosomal aberrations in patients with acute colchicine poisoning

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World Journal of Emergency Medicine 2022年第2期13卷 130-134页

作者： Yan-qing Liu xiao-xia Lu Kai-xun Hu xiao-bo peng Yun Jiang Li-mei Han Zhi-qiang Ma Ming-fei peng Kun Wan Xi-gang Zhang Ze-wu Qiu Poisoning Treatment Department Department of Hematologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Academy of Military Medical Sciences Academy of Military SciencesBeijing 100850China

Colchicine is a neutral lipophilic tricyclic alkaloid toxic to human cells containing tubulin,[1-2]and primarily stops the proliferation of active cells in the mitotic metaphase,such as intestinal mucosal cells and hematopoietic *** is widely used in treating gout and familial Mediterranean fever,while it is also used in establishing animal and plant experimental model.[3]In the recent study,treatment of patients affected by coronavirus disease 2019(COVID-19)with colchicine may prove a viable path.[4]The course of colchicine poisoning can be divided into three stages,[5]and most of the patients died in the second stage(2-7 d,the multiple organ injury stage).The cause of death was heart failure[6]and bone marrow hematopoietic failure in the terminal phase.[7]Hematopoiesis is a classic sign of colchicine *** cases of colchicine poisoning have been comprehensively reported,and the target organs included heart,digestive tract,muscle,lung,kidney,hematopoietic system,etc.[8-11]This study aimed to investigate the injury of bone marrow hematopoietic system after colchicine poisoning and evaluate the therapeutic effect of bone marrow hematopoietic stimulation drugs.

关键词： establishing neutral alkaloid

Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research International 2024年第6期31卷 1344-1354页

作者： peng-bo Liu Shu-sen Cheng Yu-qing Xue xiao-man Cheng Zhao Liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine

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Chinese Journal of Chemistry 2024年第8期42卷 873-878页

作者： Jian Long Zhiwu Lu xiao-Lin Li peng Xue Wen-bo Liu Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)and College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving intermolecular regioselective arylation and intramolecular nitrile addition, enabling the synthesis of enantioenriched azepine derivatives. This reaction simultaneously installs an all-carbon quaternary stereocenter and introduces an unprotected imine functionality, showing great promise for subsequent transformations. The reaction exhibits good tolerance toward various functional groups, resulting in high yields and enantioselectivities. The synthetic utility of this methodology is further demonstrated through gram-scale synthesis and product derivatization. This research offers an efficient approach to the synthesis of seven-membered nitrogen heterocycles.

关键词： Nickel Asymmetric catalysis N-Heterocycles Alkyne functionalization Quaternary centers

Twelve family members with tetramine poisoning after consumption of vegetables grown in polluted soils

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World Journal of Emergency Medicine 2023年第3期14卷 250-252页

作者： Yan-qing Liu xiao-xia Lu Chun-yan Wang Ming-fei peng xiao-bo peng Yun Jiang Le-xin Zheng Dan-dan Yuan Xi-gang Zhang Ze-wu Qiu Poisoning Treatment Department Senior Department of Hepatologythe Fifth Medical Center of PLA General HospitalBeijing 100071China

The main toxic component of tetramine is tetramethylenedisulfotetramine(TETS).It is a sulfonamide derivative without special antidote,tasteless and tasteless,with high toxicity and high mortality.[1]It was first discovered by a German scientist Hagen in *** its use has been banned worldwide due to its high toxicity and mortality rate,it is still available in certain countries and has led to cases of intentional and unintentional *** blocksγ-neurons,leading to dizziness,fatigue,nausea,vomiting,convulsions,and other symptoms.[2-4]Due to the lack of recognized effective antidotes,many poisoned people suff ocate and die as a result of continuous spasms of the respiratory muscles.[5-7]Tetramine poisoning sometimes occurs,but it is rare for vegetables grown in tetraminecontaminated soil to cause group poisoning after being eaten.

关键词： mortality poisoning vegetables

Chlorine poisoning caused by improper mixing of household disinfectants during the COVID-19 pandemic:Case series

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World Journal of Clinical Cases 2022年第25期10卷 8872-8879页

作者： Guo-Dong Lin Jie-Yi Wu xiao-bo peng xiao-Xia Lu Zhong-Ying Liu Zhi-Guo Pan Ze-Wu Qiu Jian-Guang Dong Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhou 510010Guangdong ProvinceChina Senior Department of Hematology The Fifth Medical Center of PLA General HospitalBeijing 100071China

BACKGROUND Misuse of disinfectants during the coronavirus disease 2019 pandemic has led to several poisoning ***,there are few clinical case reports on poisoning caused by improper mixing of household *** To summarize the clinical characteristics and treatment effects of chlorine poisoning caused by improper mixing of hypochlorite bleach with acidic cleaning *** We retrospectively analyzed baseline and clinical data,clinical symptoms,and treatment methods of seven patients with chlorine poisoning who were admitted to the National Army Poisoning Treatment *** Among the seven patients,the average poisoning time(exposure to admission)was 57 h(4-240 h).All patients were involved in cleaning *** computed tomography scans revealed bilateral lung effusions or inflammatory changes in five *** partial pressure of oxygen decreased in six patients,and respiratory failure occurred in *** patients had different degrees of increase in white blood cell *** oxygen therapy,non-invasive mechanical ventilation,anti-inflammatory corticosteroids,antioxidants,and antibiotics were administered for *** average length of hospital stay was 7 d(4-9 d).All seven patients recovered and were *** Improper mixing of household disinfectants may cause damage to the respiratory system due to chlorine *** may improve lung exudation in severe cases,and symptomatic supportive treatment should be performed early.

关键词： Hypochlorite bleach Acidic cleaning agents Chlorine poisoning Toxic lung injury Household disinfectant

Working condition recognition of sucker rod pumping system based on 4-segment time-frequency signature matrix and deep learning

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Petroleum Science 2024年第1期21卷 641-653页

作者： Yun-peng He Hai-bo Cheng peng Zeng Chuan-Zhi Zang Qing-Wei Dong Guang-Xi Wan xiao-Ting Dong State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016LiaoningChina Key Laboratory of Networked Control Systems Chinese Academy of SciencesShenyang 110016LiaoningChina Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169LiaoningChina University of Chinese Academy of Sciences Beijing100049China School of Artifcial Intelligence Shenyang University of TechnologyShenyang 110870LiaoningChina

High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well *** learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis ***,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational ***,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different ***,there is heterogeneity in field data,which can dramatically impair the diagnostic *** solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this ***,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC ***,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data ***,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the *** on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational *** the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS.

关键词： Sucker-rod pumping system Dynamometer card Working condition recognition Deep learning Time-frequency signature Time-frequency signature matrix

Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： bo Liang Jin-Hui Liu xiao-peng Zhang Gang Liu Wen-Dan Tan Xin-Dan Zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

Simple preparation of C(CS)/g-C_(3)N_(4)/Co carbon aerogel and its catalytic performance for ammonium perchlorate

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Defence Technology（防务技术） 2024年第3期33卷 186-196页

作者： Yujie Yan bo Jin Rufang peng State Key Laboratory of Environment-friendly Energy Materials School of Materials Science and EngineeringSouthwest University of Science and TechnologyMianyang621010China

Biomass chitosan(CS)was used as a template,graphitic phase carbon nitride(g-C_(3)N_(4))with high nitrogen content and certain catalytic activity was used as a dopant,and nano-transition metal cobalt(Co)was used as a catalytic center *** carbon aerogel(C(CS)/g-C_(3)N_(4)/Co)with a three-dimensional network-like structure was prepared by assembling the three materials through experimental operations such as freeze-drying and high-temperature *** was demonstrated by scanning and transmission characterization that the CS in the carbon aerogel could provide more active sites for the cobalt nanoparticles,and the doping of graphite-phase carbon nitride as a template dispersed the cobalt nanoparticles and changed the conductivity of the *** investigate the catalytic effect of carbon aerogel on ammonium perchlorate(AP),it was investigated by differential thermal analyzer and TG thermal *** carbon aerogel was very effective in catalyzing AP,and the 10 wt% content of the catalyst reduced the AP pyrolysis peak from 703.9 to 595.5 *** to further investigate the synergistic effect of the three materials,further carbon aerogels such as C(CS)/Co,g-C_(3)N_(4)/Co were prepared and applied to catalyze AP,and the same ratio reduced the AP pyrolysis peak by 98.1℃ and 97.7℃.This result indicates a synergistic effect of the assembly of the three materials.

关键词： g-C_(3)N_(4) Chitosan Co Ammonium perchlorate Pyrolysis kinetics

Electronic and Thermoelectric Properties in SnS-Nanoribbon-Based Heterojunctions

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Chinese Physics Letters 2024年第9期41卷 63-68页

作者： Kai-bo Zhang Shi-Hua Tan xiao-Fang peng Meng-Qiu Long Hunan Province Key Laboratory of Materials Surface or Interface Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Physics and Electronics Central South UniversityChangsha 410083China

As an earth-abundant and environmentally friendly material,tin sulfide(SnS)is not only a high-performance photovoltaic material,but also a new promising thermoelectric *** extensive research on the thermoelectric properties of this material in recent years,the room-temperature thermoelectric figure of merit(ZT)of SnS has not been broke through 2[2022 *** Mater.651143].In this work,based on a combination of density functional theory and non-equilibrium Green’s function method,the electronic and thermoelectric properties in SnS-nanoribbon-based heterojunctions are *** results show that although SnS nanoribbons(SNSNRs)with zigzag edges(ZSNSNRs)and armchair edges(ASNSNRs)both have semiconductor properties,the bandgaps of ASNSNRs are much wider than those of ZSNSNRs,which induces much wider conductance gaps of𝑁-ASNSNR(N𝑁is the number of tin-sulfide lines across the ribbon width)).In the positive energy region,the ZT peaks of𝐿L-SNS-Au are much larger than those of𝐿L-SNS-GNR(L𝐿represents the number of longitudinal repeating units of SNSNR in the scattering region).While in the positive energy region,the ZT peaks of𝐿-SNSGNR are larger than those of𝐿-*** calculations reveal that the figure of merit will be over 3.7 in L-SNS-Au and 2.2 in𝐿L-SNS-GNR at room temperature,and over 4 in𝐿L-SNS-Au and 2.6 in𝐿L-SNS-GNR at 500 K.

关键词： material. sulfide ribbon