Dynamic observation of bone marrow suppression and chromosomal aberrations in patients with acute colchicine poisoning

作     者：Yan-qing Liu Xiao-xia Lu Kai-xun Hu Xiao-bo Peng Yun Jiang Li-mei Han Zhi-qiang Ma Ming-fei Peng Kun Wan Xi-gang Zhang Ze-wu Qiu Yan-qing Liu;Xiao-xia Lu;Kai-xun Hu;Xiao-bo Peng;Yun Jiang;Li-mei Han;Zhi-qiang Ma;Ming-fei Peng;Kun Wan;Xi-gang Zhang;Ze-wu Qiu

作者机构：Poisoning Treatment DepartmentDepartment of Hematologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Academy of Military Medical SciencesAcademy of Military SciencesBeijing 100850China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2022年第13卷第2期

页      面：130-134页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Key R&D Program of China(No.2019YFC16063000) 

主　　题：establishing neutral alkaloid 

摘      要：Colchicine is a neutral lipophilic tricyclic alkaloid toxic to human cells containing tubulin,[1-2]and primarily stops the proliferation of active cells in the mitotic metaphase,such as intestinal mucosal cells and hematopoietic *** is widely used in treating gout and familial Mediterranean fever,while it is also used in establishing animal and plant experimental model.[3]In the recent study,treatment of patients affected by coronavirus disease 2019(COVID-19)with colchicine may prove a viable path.[4]The course of colchicine poisoning can be divided into three stages,[5]and most of the patients died in the second stage(2-7 d,the multiple organ injury stage).The cause of death was heart failure[6]and bone marrow hematopoietic failure in the terminal phase.[7]Hematopoiesis is a classic sign of colchicine *** cases of colchicine poisoning have been comprehensively reported,and the target organs included heart,digestive tract,muscle,lung,kidney,hematopoietic system,etc.[8-11]This study aimed to investigate the injury of bone marrow hematopoietic system after colchicine poisoning and evaluate the therapeutic effect of bone marrow hematopoietic stimulation drugs.