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Variable High-Order Multiblock Overlapping Grid Methods for Mixed Steady and Unsteady Multiscale Viscous Flows,Part II:Hypersonic Nonequilibrium Flows

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communications in computational Physics 2013年第2期13卷 583-602页

作者： Andrea Lani Björn Sjögreen H.c.Yee william D.Henshaw NASA Ames/Stanford centre for Turbulence Research Palo AltoCAUSA Lawrence Livermore National Laboratory LivermoreCAUSA MS 258-5 NASA Ames Research CenterMoffett FieldCAUSA

The variable high-order multiblock overlapping(overset)grids method of Sj¨ogreen&Yee[cicP,Vol.5,2009]for a perfect gas has been extended to nonequilibrium *** work makes use of the recently developed high-order well-balanced shock-capturing schemes and their filter counterparts[Wang et al.,***.,2009,2010]that exactly preserve certain non-trivial steady state solutions of the chemical nonequilibrium governing *** turbulence with strong shocks and flows containing both steady and unsteady components is best treated by mixing of numerical methods and switching on the appropriate scheme in the appropriate subdomains of the flow fields,even under the multiblock grid or adaptive grid refinement *** low dissipative sixth-or higher-order shock-capturing filter methods are appropriate for unsteady turbulence with shocklets,second-and thirdorder shock-capturing methods are more effective for strong steady or nearly steady shocks in terms of *** is anticipated that our variable high-order overset grid framework capability with its highly modular design will allow for an optimum synthesis of these new algorithms in such a way that the most appropriate spatial discretizations can be tailored for each particular region of the *** this paper some of the latest developments in single block high-order filter schemes for chemical nonequilibrium flows are applied to overset grid *** numerical approach is validated on a number of test cases characterized by hypersonic conditions with strong shocks,including the reentry flow surrounding a 3D Apollo-like NASA crew Exploration Vehicle that might contain mixed steady and unsteady components,depending on the flow conditions.

关键词： Unstructured mesh hypersonic flows thermo-chemical nonequilibrium residual distribution schemes double cone

Microstructural Evolution of Nb–V–Mo and V containing TRIP-assisted Steels during Thermomechanical Processing

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Journal of Materials Science & Technology 2017年第4期33卷 311-320页

作者： Erfan Abbasi william Mark Rainforth Department of Materials Science and Engineering The University of Sheffield

The microstructural evolution and precipitation behaviour of Nb–V–Mo and single V containing transformation induced plasticity assisted steels were investigated during thermomechanical processing. A plane strain compression testing machine was used to simulate the thermomechanical processing. Microstructures were characterised by optical microscopy, scanning-transmission electron microscopy and microanalysis, and X-ray diffraction analysis, and Vickers hardness was obtained from the deformed specimens. The resulting microstructure of both Nb–V–Mo and V steels at room temperature primarily consisted of an acicular/bainitic ferrite, retained austenite and martensite surrounded by allotriomorphic *** TEM analysis showed that a significant number of Nb（V,Mo）（c,N） precipitates were formed in the microstructure down to the finishing stage in Nb–V–Mo steel（i.e. 830℃）. It was also found that the V（c,N）precipitation primarily occurred in both ferrite and deformed austenite below the finishing stage. The results suggested that Nb–Mo additions considerably increased the temperature stability of microalloy precipitates and controlled the microstructural evolution of austenite. However, the microalloy precipitation did not cause a significant precipitation strengthening in both Nb–V–Mo and V steels at room temperature.

关键词： Microalloyed TRiP-assisted steel Thermomechanical processing Precipitation behaviour Microstructural evolution

Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： william chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren Wong Danny con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BAcKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(Hcc).Hcc-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve Hcc-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against Hcc,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for Hcc from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of Hcc-recurrence and all-cause mortality,Hcc-recurrence and Hcc-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis c,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed Hcc-recurrence,48(15.74%)died,17(5.57%)from Hcc-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of Hcc-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%cI:0.58-2.30;HR:1.21,95%cI:0.28-5.27;HR:0.61,95%cI:0.27-1.36],Hcc-recurrence(HR:0.52,95%cI:0.20-1.35;HR:0.51,95%cI:0.14-1.93;HR 1.00,95%cI:0.37-2.72),or Hcc-related mortality(HR:0.32,95%cI:0.033-3.09;HR:0.71,95%cI:0.14-3.73;HR:1.57,95%cI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in Hcc-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-co-A reductase Aspirin Metformin Mammalian target of rapamycin

The changing pattern of renal osteodystrophy

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肾脏病与透析肾移植杂志 1996年第2期 1-9+95页

作者： Allen c.Alfrey william E.Huffer Department of Medicine and Pathology Denver V.A.Medical center and University of colorado Health Sciences center USA Department of Medicine and Pathology Denver V.A.Medical center and University of colorado Health Sciences center USA

Aluminum intoxication has been a ma-jor cause of morbidity and mortality in dia-lyzed uremic *** the last 7-years means to markedly reduce aluminumexposure in this population have been *** study was carried out to de-termine how effective restriction of alu-minum exposure has been in preventing alu-minum loading and toxicity in uremic *** All bone histology processed onpatients with end-stage renal disease(452patients)between January 1984 and Decem-ber 1991 were *** were performed and bones dividedinto four major grouping:①high turnover,osteitis firosa;②low turnover,osteomala-cia;③low turnover,adynamic and ④mixedtype bone *** Between 1985 and 1991 a signifi-cant decrease in aluminum loading wasfound in patients with end-stage renal dis-ease as determined by a fall in plasma alu-minum from 74±30 μg/L to 12±7 μg/L and decrease in aluminum positive bonespecimens from 87.2% to 35.8%(Pction in aluminumloading low turnover osteomalacic bone dis-ease decreased from 11.6% to less than 5%(Pcimensstudied and the fraction of mixed bone dis-ease with osteomalacic features decreasedfrom 33% to 19%(Pchange in the other types of bone *** The present methods of limit-ing aluminum exposure in dialysis patientsappears to be fairly effective in preventingaluminum loading and skeletal toxicity,manifested as a mineralization ***-ever,aluminum restriction had no influenceon high turnover bone disease or the ady-namic type of low turnover disease support-ing a different etiology for these two typesof bone disease.

关键词： aluminum uremia osteomalacia hyperparathyroid bone

Targeting DNA topoisomerases: past & future

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cancer Drug Resistance 2021年第4期4卷 758-761页

作者： william H.Gmeiner Robert c.A.Mvan Waardenburg Department of cancer Biology Wake Forest School of Medicine Medical Center BlvdWinston-SalemNC 27157USA Department of Pharmacology and Toxicology University of Alabama at BirminghamBirminghamAL 35294-0019USA

Aggressive malignancies are characterized by relatively uncontrolled cell proliferation making them especially reliant on topoisomerase enzymes to enable high rates of DNA replication and *** topoisomerases resolve topological problems associated with DNA replication and other essential cellular processes involving DNA,such as transcription and recombination^([1]).As such,they are important targets for anti-cancer ***,understanding of topoisomerase biology is important for unraveling the mechanistic basis for resistance to many widely used anti-cancer drugs,such as doxorubicin,etoposide,and topotecan,for which DNA topoisomerases are established ***,several drugs that are not considered to directly target topoisomerase enzymes,such as the nucleoside analogs 5-FU and Arac,and those in development such as the polymeric fluoropyrimidine cF10^([2]),also affect the function of topoisomerases.

关键词： analogs topological enable

A new perspective on quiet Sun magnetism

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Science china(Physics,Mechanics & Astronomy) 2009年第11期52卷 1660-1664页

作者： LITES Bruce william High Altitude Observatory National Center for Atmospheric ResearchP.O. Box 3000 Boulder CO 80307 USA

The Hinode mission has provided us with a new, quantitative view of the magnetism of the quiet Sun. It has revealed that the quiet internetwork areas are blanketed by horizontal fields that appear at first sight to have more flux than the vertical fields resolved on the same 0.3 size scale. These measurements point to the possibility that the horizontal fields might be the primary source of the "hidden turbulent flux" of the quiet Sun anticipated from Hanle effect depolarization. In this paper, evidence is presented suggesting that the "seething" horizontal fields observed by Harvey in 2007 and the horizontal fields revealed by Hinode are the same phenomenon. Because the seething fields appear to be of uniform fluctuation over the whole disk, the phenomenon is most likely not associated with the dynamo source of solar activity. Thus, the small-scale "hidden turbulent flux" lends support to the notion of a local solar dynamo acting on granular sizes and time scales.

关键词： Sun magnetism fields granulation

MicroRNAs: Mechanisms, Functions and Progress

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 237-238页

作者： Tongbin Li william c.S.cho *** Research Group LC SciencesHoustonTX 77054USA Department of clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

In 1993 when Ambros and co-workers [1] discovered that a mysterious caenorhabditis elegans gene, lin-4, does not encode a protein, but acts in the form of a small RNA and represses the expression of its target gene, lin-14, through base-pairing with its 3＇ untranslated region （3tUTR）, nobody would imagine that 20 years later, this category of small RNAs - now widely known as microR- NAs （or miRNAs）, has ～2000 known members in the human genome （and counting）, and that miRNA-mediated gene regulation is deeply involved in virtually all important biological processes in animals and plants.

关键词： caenorhabditis elegans biological processes gene regulation human genome target gene small RNA form of

Photonic crystal Fibers

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光学学报 2003年第S1期23卷 11-12页

作者： william J. Wadsworth Jonathan c. Knight william H. Reeves Philip St.J. Russell Department of Physics University of Bath Bath BA2 7AY UK.Department of Physics University of Bath Bath BA2 7AY UK.Department of Physics University of Bath Bath BA2 7AY UK.Department of Physics University of Bath Bath BA2 7AY UK.

By offering greatly enhanced control of light compared to conventional step-index structures, photonic crystal fibres are radically improving the performance of linear and nonlinear fibre devices, including gas-Raman ... 详细信息

关键词： PcF of or Photonic crystal Fibers in

Machine-learning-facilitated earthquake and anthropogenic source detections near the Weiyuan Shale Gas Blocks,Sichuan,china

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Earth and Planetary Physics 2021年第6期5卷 501-519页

作者： Pengcheng Zhou william L.Ellsworth HongFeng Yang Yen Joe Tan Gregory c.Beroza MinHan Sheng RiSheng chu Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510301China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongSha TinHong Kong 999077China Department of Geophysics Stanford UniversityStanfordCA 94305USA State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China

Seismic hazard assessment and risk mitigation depend critically on rapid analysis and characterization of earthquake *** seismicity in shale gas blocks of the Sichuan Basin,china,has presented a serious challenge to monitoring and managing the seismicity *** this study,to detect events we apply a machine-learning-based phase picker(PhaseNet)to continuous seismic data collected between November 2015 and November 2016 from a temporary network covering the Weiyuan Shale Gas Blocks(SGB).Both P-and S-phases are picked and associated for *** refine the velocity model by using detected explosions and earthquakes and then relocate the detected events using our new velocity *** detections and absolute relocations provide the basis for building a high-precision earthquake *** primary catalog contains about 60 times as many earthquakes as those in the catalog of the chinese Earthquake Network center(cENc),which used only the sparsely distributed permanent *** also measure the local magnitude and achieve magnitude completeness of *** relocate clusters of events,showing sequential migration patterns overlapping with horizontal well branches around several well pads in the Wei202 and Wei204 *** results demonstrate the applicability of a machine-learning phase picker to a dense seismic *** algorithms can facilitate rapid characterization of earthquake sequences.

关键词： induced seismicity machine learning Weiyuan Shale Gas Block