Targeting DNA topoisomerases: past & future
作者机构：Department of Cancer Biology Wake Forest School of MedicineMedical Center BlvdWinston-SalemNC 27157USA Department of Pharmacology and ToxicologyUniversity of Alabama at BirminghamBirminghamAL 35294-0019USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2021年第4卷第4期
页 面：758-761页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：van Waardenburg RCAM in part funded by American Cancer Society UAB ACS-IRG Junior Faculty Development Grant(ACS-IRG-60-001-53) Department of Defense OCRP pilot award W81XWH-15-1-0198 the National Institutes of Health Cancer Center Core Support Grant(P30CA013148) National Institutes of Health-National Institute of Disorders and Stroke(1R21NS116312-01A1) Gmeiner WH in part supported by the National Cancer Institute Cancer Center Support Grant(P30CA012197)issued to the Wake Forest Baptist Comprehensive Cancer Center and National Institutes of Health-National Cancer Institute R21 CA218933
主 题：analogs topological enable
摘 要：Aggressive malignancies are characterized by relatively uncontrolled cell proliferation making them especially reliant on topoisomerase enzymes to enable high rates of DNA replication and *** topoisomerases resolve topological problems associated with DNA replication and other essential cellular processes involving DNA,such as transcription and recombination^([1]).As such,they are important targets for anti-cancer ***,understanding of topoisomerase biology is important for unraveling the mechanistic basis for resistance to many widely used anti-cancer drugs,such as doxorubicin,etoposide,and topotecan,for which DNA topoisomerases are established ***,several drugs that are not considered to directly target topoisomerase enzymes,such as the nucleoside analogs 5-FU and AraC,and those in development such as the polymeric fluoropyrimidine CF10^([2]),also affect the function of topoisomerases.
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