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Optimization of Lip Contour Estimation

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Chinese Journal of Electronics 2014年第2期23卷 341-347页

作者： wu wenchao WANG Shilin KURUOGLU Ercan Engin MA Xiaoli LI Shenghong LI Jianhua Lionel M.Ni Department of Computer Science and Engineering Hong Kong University of Science and Technology Fok Ying Tung Research Institute Hong Kong University of Science and Technology School of Information Security Engineering Shanghai Jiao Tong University Georgia Institute of Technology School of Electrical and Computer Engineering Georgia Institute of Technology Institute of Science and Technology of Information (ISTI) Italian National Council of Research (CNR)

Developing algorithms based on lip contour estimation is a distinctive trend in lip segmentation which is the first step of visual speech recognition. In order to establish an optimized estimation of lip contour that is complex enough to describe the principal features of the lip but at the same time simple enough to be implemented,the selection of lip model, estimator as well as parameters for features of lips, including the horizontal length of snake of feature points and horizontal distance between these feature points will be optimized. Experimental result demonstrates that the optimized estimation method of lip contour provides more accurate and more stable results of lip segmentation.

关键词： Lip contour estimation Lip segmentation Weighted least squares estimator Snake

A combined experimental and computational study of NHC-catalyzed allylation of allenoate with MBH esters:new regiospecific and stereoselective access to 1,5-enyne

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Organic Chemistry Frontiers 2022年第1期9卷 51-57页

作者： Fang Sun Fangfang Lu Xue Song wenchao wu Kai Zhang Chenxia Yu Tuanjie Li Donghui Wei Changsheng Yao Jiangsu Key Lab of Green Synthetic Chemistry for Functional Materials School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhouJiangsu 221116P R China. The College of Chemistry and Molecular Engineering Zhengzhou University100 Science AvenueZhengzhouHenan 450001P R China

An NHC-catalyzed regiospecific allylation ofα-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes bearing a quaternary carbon *** with DFT calculations,the reaction mechanism of this conversion was *** method has the advantages of high regioselectivity,good yields and mild reaction *** transformation not only provided a new access to 1,5-enyne,but also enriched the chemistry of allenoates and NHC catalysis.

关键词： conditions catalysis allyl

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刘蕺山对王阳明“无善无恶”思想的发展

中国哲学史 2019年第3期 101-107页

作者：武文超上海理工大学马克思主义学院

心学发展到明代晚期已产生诸多流弊,致良知的实践工夫不能落实到实处。刘蕺山批评王阳明"四句教"与王畿"四无说",并提出自己的"四句教",强调心体只是个"有善而无恶"。然而在其晚年重要著作《人谱》中却明确地提出并详细地阐发了心体"无... 详细信息

心学发展到明代晚期已产生诸多流弊,致良知的实践工夫不能落实到实处。刘蕺山批评王阳明"四句教"与王畿"四无说",并提出自己的"四句教",强调心体只是个"有善而无恶"。然而在其晚年重要著作《人谱》中却明确地提出并详细地阐发了心体"无善无恶"的思想,作为其心性理论的基础,此与阳明"四句教"之首句"无善无恶心之体"之提法无异。故本文从"无善无恶"之本体、工夫与境界的层面来解析蕺山对于阳明"无善无恶"思想的发展。蕺山学说在思想史上做出了承先启后的重大贡献,对明清实学的产生有重要的影响。

关键词：刘蕺山王阳明心体无善无恶

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Forced expression of double FYVE domain containing protein 1 attenuates activation of cardiac fibroblasts via promoting autophagic flux

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Forced expression of double FYVE domain containing protein 1...

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Junli Li wenchao wu Yanguo Xin Mingyue Zhao Laboratory of Cardiovascular Diseases Regenerative Medicine Research CenterWest China HospitalSichuan University Department of Cardiology West China HospitalSichuan University

Objective Double FYVE domain-containing protein (1DFCP1) is a key mediator of omegasome-derived isolation membrane, the platform of autophagosomes formation. However, its role in cardiac hypertrophy is poorly understood. Recently, autophagy and endoplasmic reticulum stress (ER stress) signaling have been increasingly reported to be associated with cardiac hypertrophy. Therefore, we aimed to test the hypothesis that DFCP1 regulates activation of cardiac fibroblasts via affecting autophagic flux and ER stress signaling. Double

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Calnexin overexpression prevents cardiac fibroblasts activation and endoplasmic reticulum stress induced by TGFβ1

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Calnexin overexpression prevents cardiac fibroblasts activat...

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Mingyue Zhao wenchao wu Xiaojiao Wang Junli Li Xiaojing Liu Laboratory of Cardiovascular Diseases Regenerative Medicine Research CenterWest China HospitalSichuan University

Objective Calnexin, an endoplasmic reticulum (ER) quality control chaperone, plays vital roles in cardiovascular diseases. Although calnexin has been implicated in cardiomyocyte hypertrophy, whether calnexin is involved in cardiac fibroblasts activation is still unknown. Methods In the present study, transverse aortic constriction (TAC) rat model was established to observe the cardiac fibroblasts activation in vivo. TGFβ1 treatment for24 hours was used to induce cardiac fibroblasts activation in vitro. We then used adenovirus to mediate gene si-

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Fracture Failure Analysis of Aluminium Alloy Control Arms for Automobile Applications

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Fracture Failure Analysis of Aluminium Alloy Control Arms fo...

2019中国汽车工程学会年会

作者： Yuan Chengyi Xu Wenlei Wang Tangwei Wang Haipei wu wenchao Geely Automobile Research Institute（Ningbo） Co. Ltd

The fracture failure occurred in the aluminium alloy control arms of the automobile in the dynamic test at the proving *** defects distribution of the failed control arm and its fracture characteristics were investigated by means of a variety of methods including macroscopic inspection,fracture surface morphology analysis,micro-area composition analysis,chemical analysis,microstructure observation and hardness *** numerical simulation was also performed to analyse the cause of defect formation and the defects were re-shown at the production *** results show that the control arm billet was not placed in the right position of the bending die during the bending process,resulting in the folding defects and ultimately leading to the premature fracture failure of the control *** is suggested to improve the positioning of the bending die to avoid the formation of folding defects so as to ensure the sufficient strength of the control arm products.

关键词： aluminium alloy control arms failure analysis folding defects strength

基于道路载荷的汽车结构件可靠性试验方法研究

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中国机械工程 2016年第1期27卷 135-141页

作者：王铁武文超王海沛吴伟泛亚汽车技术中心有限公司上海201201

基于疲劳伪损伤相关性分析,建立了与道路载荷等效的程序载荷谱;对构件疲劳寿命进行了威布尔分析,建立了在一定置信度、可靠度条件下最少样件的可靠性试验方案。通过变速箱支架台架可靠性试验,复现了与道路试验相同的失效模式、疲劳失效... 详细信息

基于疲劳伪损伤相关性分析,建立了与道路载荷等效的程序载荷谱;对构件疲劳寿命进行了威布尔分析,建立了在一定置信度、可靠度条件下最少样件的可靠性试验方案。通过变速箱支架台架可靠性试验,复现了与道路试验相同的失效模式、疲劳失效寿命,分析了影响变速箱支架疲劳寿命的因素,并验证了试验方法的有效性。

关键词：疲劳寿命程序载荷道路载荷威布尔分析

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CTGF基因沉默对肺成纤维细胞增殖及表型转化的影响

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生物医学工程学杂志 2008年第2期25卷 407-412页

作者：刘小菁吴文超陈槐卿四川大学华西医学中心生物医学工程研究室成都610041 四川大学华西医院心血管疾病研究室成都610041

近期研究表明,结缔组织生长因子(Connective tissue growth factor,CTGF)参与了肺成纤维细胞表型转化,与肺纤维化的形成关系密切。因此,本研究应用siRNA表达载体介导的RNA干扰(RNA interference,RNAi)技术,将CTGF-siRNA表达质粒稳定转... 详细信息

近期研究表明,结缔组织生长因子(Connective tissue growth factor,CTGF)参与了肺成纤维细胞表型转化,与肺纤维化的形成关系密切。因此,本研究应用siRNA表达载体介导的RNA干扰(RNA interference,RNAi)技术,将CTGF-siRNA表达质粒稳定转染人肺成纤维细胞MRC-5,并通过定量PCR、Western-blot、细胞生长曲线及群体倍增时间、免疫细胞化学测定等方法检测基因表达、细胞增殖及表型转化等变化。结果显示,与非特异对照Scrambled-siRNA质粒稳定转染的MRC-5细胞或未转染MRC-5细胞相比,CTGF-siRNA表达质粒稳定转染的MRC-5细胞的CTGF表达明显降低;细胞增殖能力明显降低,群体倍增时间延长,由24.63或25.05 h延长至31.14 h(P<0.05);TGFβ1刺激24 h后,细胞内α-平滑肌肌动蛋白-αsmooth muscle actin,-αSMA)、I型胶原及纤维连接蛋白(fibronectin,FN)的表达均明显下降。本研究提示,通过RNA干扰使CTGF基因沉默后,在体外可明显抑制MRC-5肺成纤维细胞的增殖、表型转化及细胞外基质的合成,可为基因治疗肺纤维化提供实验依据。

关键词：结缔组织生长因子 RNA干扰肺成纤维细胞表型转化

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Circulating Nogo-B are correlated with liver cirrhosis

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Circulating Nogo-B are correlated with liver cirrhosis

第十七届西南地区消化病学术会议暨2014贵州省消化病及消化内镜学术年会

作者： Maoyao Wen Ruoting Men Yongjun Zhu Xuelian Dan wenchao wu Xiaojing Liu Li Yang Division of Digestive Diseases West China HospitalSichuan University Laboratory of Cardiovascular Diseases Regenerative Medicine Research CenterWest China HospitalSichuan University

Aim:To evaluate the significance of plasma Nogo-B levels in patients with liver ***:Plasma Nogo-B levels were determined by enzyme linked immunosorbent assay(ELISA)in 301patients with liver cirrhosis and 130 healthy *** parameters were analyzed for the possible relationship with plasma ***:Plasma Nogo-B levels were significantly higher in liver cirrhotic patients(429.84±226.66 pg/mL)than in healthy controls(218.08±77.02 pg/mL,P0.05).Nogo-B levels were the highest in Child-Pugh class C patients among all the Child-Pugh class.(Child-Pugh class A:328.44±141.17 pg/mL,Child-Pugh class B:402.51±179.33 pg/mL,Child-Pugh class C:625.79±273.36 pg/mL,P<0.05).Plasma Nogo-B levels were positively correlated with INR(r=0.523,P=0.000)and negatively with albumin(r=-0.530,P=0.000).Plasma Nogo-B levels were significantly increased in patients with grade 3 ascites(533.25±236.58 pg/mL)than those with grade 1 ascites(351.53±198.88pg/mL)and without ascites(342.73±158.10 pg/mL)(P<0.05).Receiver operating characteristic analysis revealed that a plasma NogoB reading of 291.78 pg/mL provided a sensitivity of 61.8%and a specificity of89.6%).The area under the ROC curve of NogoB in discriminating patients with hepatic cirrhosis from healthy people was 0.815(95%confidence interval:0.771-0.858,P<0.,001).Conclusions:Plasma Nogo-B levels are increased in patients with hepatic cirrhosis while there is no significant difference among patients with different etiologies of ***,the concentrations of Nogo-B are correlated with some clinical parameters of hepatic cirrhosis.

关键词： Plasma Nogo-B hepatic cirrhosis the severity of liver diseases