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Joint imaging of ^(99m)TcO_4^- and ^(99m)Tc-MIBI for thyroid carcinoma recurrence and cervical metastases

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Nuclear Science and Techniques 2010年第2期21卷 89-93页

作者： MAQingjie JI Tiefeng GAO shi wen Qiang wang Fan SUN Hui China-Japan Union Hospital Jilin University Changchun 130033 China

In this paper, the joint imaging of 99mTcO4- and 99mTc-methoxy isobutyl isonitrile was compared with neck Color Doppler Ultrasonography (CDU) to identify its value in thyroid carcinoma, postoperative recurrence or cervical metastases. Thyroid carcinoma patients (150 operated and 21 re-operated with suspected postoperative recurrence or cervical metastases) were retrospectively analyzed. Taking the pathological result as the gold standard, the thyroid foci (437 cases), the thyroid foci of ≥1-cm diameter (215 cases) and the suspected postoperative recurrence or cervical metastases (87 cases) were compared by diagnostic results of the joint imaging and the neck CDU. The sensitivity, specificity and accuracy of the joint imaging were 64.18%, 80.00% and 67.82%, and 44.78%, 40.00% and 43.68%, respectively, for the cases with suspected postoperative recurrence or cervical metastases. For thyroid carcinoma of ≥1-cm diameter, the sensitivity of the joint imaging was 97.75%, and the neck CDU was 89.89%, but both specificity and accuracy was similar for thyroid carcinoma independence on their diameter. For thyroid carcinoma, the sensitivity of the joint imaging was 81.99%, and the neck CDU was 89.10%. The results show that the joint imaging is sensitive for large diameter thyroid carcinoma.

关键词：甲状腺癌联合成像宫颈癌复发 MIBI 像对多普勒超声敏感性

Secular trends in the etiology and comorbidity of hospitalized patients with congestive heart failure: A single-center retrospective study

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Journal of Geriatric Cardiology 2012年第4期9卷 361-365页

作者： Zhi-Yong Pei Yu-Sheng Zhao Jia-Yue Li Qiao Xue Lei Gao shi-wen wang Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Geriatric Cardiology Beijing Military General Hospital Beijing 100700 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To assess the secular trends in the etiology and comorbidity ofpatients hospitalized with congestive heart failure (CHF).Methods Data of 7,319 patients (mean age 59.6 years, 62.1% male) with a primary discharge diagnosis of CHF, hospitalized from January 1, 1993 to December 31, 2007 at the Chinese People’s Liberation Army (PLA) General Hospital were extracted and analyzed. These patients were divided into three groups according to hospitalization period: 1993–1997 (n = 1623), 1998–2002 (n = 2444), and 2003–2007 (n = 3252). The etiological characteristics and comorbidities were assessed. Results Over the study period, the proportion of patients with ischemic heart disease (IHD) increased from 37.2% during the period 1993–1997 to 46.8% during the period 2003–2007, while that with valvular heart disease (VHD) decreased from 35.2%during the period 1993–1997 to 16.6% during the period 2003–2007 (both P < 0.05). Atrial fibrillation (AF) was the most common comorbidity of heart failure (23.2%, 23.0% and 20.6%, respectively, in the three periods). Compared to that of the period of 1993–1997 with that of, the proportion of patients with myocardial infarction, pneumonia, renal function impairment and hepatic cirrhosis of the period of 2003–2007 increased significantly (P < 0.05) and the proportion of patients with chronic obstructive pulmonary disease and atrial fibrillation decreased significantly (P < 0.05). Conclusions This study implies that IHD has became a more common etiology of CHF, while VHD has deceased as an etiology of CHF in Chinese patients during the last two decades.

关键词： Atrial fibrillation Comorbidity Congestive heart failure Etiology Hospitalization

Mutational analysis of KCNJll in Chinese elderly essential hypertensive patients

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Journal of Geriatric Cardiology 2012年第2期9卷 153-157页

作者： Jia-Yue Li Zong-Bin Li Mei Zhu Yu-Qi Liu Yang Li shi-wen wang Qing-Lei Zhu Institute of Geriatric Cardiology Chinese PLA General Hospital28 Fuxing RoadBeijing 100853China

Objective To compare the distribution ofKCNJll polymorphisms between elderly Chinese population with and without hypertension. Methods We examined the mutation of KCNJll gene by directly sequencing. Data for the present study were obtained from 250 hypertensive subjects （60 to 83 years old） as well as 250 normotensive subjects （60 to 86 years old）. Results We found nine different mutations in KCNJ11, including six novel mutations （1131M, L1471, L147V, L147L, Q235H, G245C）. None of the novel mutations were found in the normotensive subjects, and all the residues were conserved in other species. These sequence variants in Chinese population indicate the diversity of the human library and the complexity of hypertension. Conclusions The consistent finding of our present study provided a basis for the development of new strategies to diagnosis and treat hypertension in the elderly.

关键词： Essential hypertension Phenotype Genotype Mutation The elderly

Predicting the Activity of Oral Lichen Planus with Glycolysis-related Molecules:A Scikit-learn-based Function

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Current Medical Science 2023年第3期43卷 602-608页

作者： Yan YANG Pei HU Su-rong CHEN Wei-wei WU Pan CHEN shi-wen wang Jing-zhi MA Jing-yu HU Department of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T *** metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic *** present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring *** Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was *** The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy ***,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)*** glycolysis-related molecules were positively correlated to the RAE *** these,LAC had a strong *** univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more *** It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present *** intervention of the glycolytic pathway may provide a potential therapeutic strategy.

关键词： oral lichen planus glycolysis lactic acid linear regression machine learning

In situ observation of surface structures of cardiovascular endothelial cells with atomic force microscope

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Journal of Geriatric Cardiology 2009年第3期6卷 178-181页

作者： Tong Yin Jin Luo Ya-Min Ma Xiao-Long Ji Yu-Sheng Zhao shi-wen wang Institute of Geriatric Cardiology Department of Cardiovascular Surgery General Hospital of PLA Beijing 100853 China Institute of Nanomedicine General Hospital o fArmed Police Forces Beo＇ing 100039 China

Objective To observe the surface structures of cardiovascular endothelial cells in situ with atomic force microscope （AFM）. Methods Fresh aorta and aortic valve were dissected from 10 healthy male New Zealand white rabbits. Before fixed in 1% formaldehyde, the fresh tissues were washed in the buffer phosphate solution. Under general microscope, the fixed aorta or valve was spread on the double side stick tape which had already been stuck on the glass slide. The intima of aorta or the aorta side of valve was towards upside, Then the specimen was dried under 37 degrees centigrade in an attemperator and was washed with pure water. After dried again, the specimen was loaded on the platform ofNanoScope Ⅲa AFM and was scanned in tapping mode with the scanning speed of 0.5 HZ. Results The surface structures of endothelial cell on the fixed and dried tissue could be observed clearly in situ with AFM. aortic endothelial cells were large, branched and arranged sparsely and parallel to the direction of blood flow, whereas endothelial cells on aorta valve surface were small, less branched and arranged intensively and vertical to the direction of blood flow. When the scanning range was dwindled, granular ultra-structures could be observed on the surface of endothelial cells, and, as the scanning range was dwindled further, fissure and convolution could be seen on the surface of granules from aortic endothelial cells. Centre cavity and surrounding swelling volcano-like structure could be seen on the surface of granules from endothelial cells of aortic valve. Conclusions It＇s feasible to observe the surface ultra-structures of cardiovascular endothelial cells in situ with AFM and morphological information provided by AFM might be of clinical value in future histopathological diagnosis（JGeriatr Cardiol2009; 6：178-181）.

关键词： atomic force microscope endothelial cell

Effects of IGF-1 and oxLDL on expression of phosphatase PHLPP1 in vascular smooth muscular cells

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Journal of Geriatric Cardiology 2009年第4期6卷 237-240页

作者： Xing-Li Wu Ding-You Yang Zhong-Su Yang De-Yin Li Hui-Bin Xu shi-wen wang Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To investigate the effects of insulin-like growth factor-1 （IGF-1） and oxidized low density lipoprotein （oxLDL） on expression ofphosphatase PHLPP 1 in vascular smooth muscle cells （VSMCs）. Methods Rabbit aortic VSMCs were cultured. VSMCs proliferation ability was determined by measuring cell number and mitochondrial dehydrogenase （MD） activity with MTT assay. Western blot was used to detect the protein expression ofphosphatase PHLPP1. Results IGF-1 （100ug/L） increased cell number and MD activity to 3.02 and 3.59 times of that in control group, oxLDL（501xg/ml） elevated the above two parameters to 2.03 and 2.91 times respectively. Western blot showed that IGF-1 and oxLDL inhibited the expression of PHLPPI to 39.27% and 40.26% of the control group （P〈0.01 ）. Conclusion IGF- 1 and oxLDL may enhance the proliferation of VSMCs by decreasing the expression ofphosphatase PHLPP 1.

关键词： PH domain leucine-rich repeat protein phosphatasel (PHLPP1) insulin-like growth factor-l oxidized low density lipoprotein(oxLDL) vascular smooth muscle cells

Progress of Deep Geological Survey Project under the China Geological Survey

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China Geology 2020年第1期3卷 153-172页

作者： Qing-tian Lü Jia-yong Yan Xuan-hua Chen He-sheng Hou wen-shi wang Yu-le Hu Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural ResourcesBeijing 100037China SinoProbe Center Chinese Academy of Geological SciencesChina Geological SurveyMinistry of Natural ResourcesBeijing 100037China Institute of Exploration Technique Chinese Academy of Geological SciencesNanchang 330013China China University of Geosciences Wuhan 430074China

Serving as a way to understand the material composition,structure,and dynamic process of the Earth's interior,deep earth exploration is driven by not only mankind's pursuit of natural mysteries but also mankind's basic need to obtain resources and guarantee economic and social *** first phase of deep earth exploration of China(SinoProbe)was carried out from 2008 to 2016 and tremendous results were *** 2016,the China Geological Survey launched a Deep Geological Survey Project(also referred to as the Project)to continuously explore the deep *** on the national energy resources strategy,the Belt and Road Initiative,and major basic issues of the geological survey,the Project was carried out in Songliao Basin(an important energy base in China)and major geological boundaries and tectonic units including Qilian Mountains-Tianshan Mountains and Qinzhou-Hangzhou juncture *** purpose of it is to reveal the process,structure,and forming patterns of the deep ore deposits and petroleum reservoirs,clarify the evolutionary pattern and controlling factors of Mesozoic environmental climate,and discover deep fine structures of key orogens,basins,and mountains by comprehensive geophysical exploration and scientific *** achievements have been obtained after more than three years of efforts,including a cumulative 1552 km of deep seismic reflection profiles and magnetotelluric profiles,an ultra-deep continental scientific crilling well,a scientific drilling pilot hole,and a magnetotelluric array and a portable broadband seismic array,both of which cover South ***,significant progress has been made in ultra-deep drilling technology,deep oil and gas discovery in Songliao Basin,and basic geological issues of Qilian Orogen and Qinzhou-Hangzhou juncture belt in South China,greatly accelerating the deep earth exploration in China and further consolidating China's position as a power in deep earth exploration.

关键词： Deep geological survey Deep oil and gas discovery Ultra-deep scientific drilling technology Songke No.2 well Qilian Mountains-Tianshan Mountains Qinzhou-Hangzhou juncture belt Songliao Basin China

Study on Phospholipid Composition of Erythrocyte Membrane in Hypophosphatemic Cows

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Agricultural Sciences in China 2002年第3期1卷 328-332页

作者： shi Fa-qing, XUAN Da-wei, XU shi-wen and wang Zhen-yong(The College of Animal Medicine , Northeast Agricultural University, Harbin 150030) The College of Animal Medicine Northeast Agricultural University Harbin 150030

The phospholipid constituents of the erythrocyte membrane of cows in hypophosophorus were detected with the field cases and the group comparison. The cows were divided into three groups: the hemoglobinuria group (HN), the hypophosphatemia group (HP) and the control group (CK). The content of the phospholipid constituent in HN and HP obviously changed: phosphatidylethaanolamine (PE) content in HN was significantly lower than that in HP and CK; but sphingomyline (SM) and phosphatidycholine (PC) + phosphatidylserine (PS) content in HN were significantly higher than that in the two other groups; in comparison between HP and CK, PC + PS content was lower and SM content was higher in HP; significant positive correlation and negative correlation were observed between serum phosphorus and PE content, serum phosphorus and SM content respectively.

关键词： Cows Phosphorus Phospholipid composition Erythrocyte membrane

Effectiveness of Hemorrhagic Fever with Renal Syndrome Bivalent Vaccine in China:A Metaanalysis

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国际感染病学（电子版） 2012年第1期1卷 46-50页

作者： Xiao-xia Huang Lei Yan shi-wen wang National Institute for Viral Disease Control and Prevention China CDC

Objective To evaluate the effectiveness of Hemorrhagic Fever with Renal Syndrome(HFRS) bivalent vaccine in *** The articles on effectiveness of HFRS bivalent vaccine were retrieved from Vip Database,China Journal Full-text Database,Wanfang database,China Hospital Knowledge Database,Chinese Biomedical Literature Database,MEDLINE and *** persons extracted data and evaluated the quality of data together for *** Seven articles were included into the analysis,and two articles were random clinical trials,five were ***-analysis showed that the overall effectiveness of HFRS bivalent vaccine was 85%(95%confidence interval:53%-95%) within one year after vaccination,and the effectiveness in two-dose recipients and three-dose recipients was 87%(95%confidence interval:54%-96%) and 60%,respectively;it was 96%(95%confidence interval:78%-99%) within 2-5 years after vaccination,and the effectiveness in two-dose recipients and three-dose recipients was 95%(95%confidence interval:19%-100%) and 96%(95%confidence interval:70%-99%),respectively;it was 100%(only one article included) within 6-9.6 years after *** effectiveness in two-dose recipients was 88%(95%confidence interval:62%-96%) during 1-2.5 years after vaccination,and that in three-dose recipients was 94%(95%confidence interval:70%-99%) during 1-5 years after *** HFRS bivalent vaccine is effective in field,and there is no difference between two-dose recipients and three-dose *** should do some further studies on the long-term effectiveness of HFRS bivalent vaccine and on the age of vaccine reception.

关键词： HFRS HFRS Bivalent Vaccine Effectiveness Meta-analysis