Mutational analysis of KCNJll in Chinese elderly essential hypertensive patients

作     者：Jia-Yue Li Zong-Bin Li Mei Zhu Yu-Qi Liu Yang Li Shi-Wen Wang Qing-Lei Zhu 

作者机构：Institute of Geriatric CardiologyChinese PLA General Hospital28 Fuxing RoadBeijing 100853China 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2012年第9卷第2期

页      面：153-157页

核心收录：

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 07[理学] 08[工学] 071007[理学-遗传学] 

基　　金：Acknowledgements The authors declare no conflict of interest. This work was supported by the grant from the National Natural Science Foundation of China (81170249  30700305 and 30400549)  the Key Project of National Natural Science Foundation of China (81030002)  the 10th Five-Year Plan for Scientific and Technological Progress of the military (01MA104)  Chinese Postdoctoral Science Foundation (20080431356)  and Beijing Nova Program (2008A064) 

主　　题：Essential hypertension Phenotype Genotype Mutation The elderly 

摘      要：Objective To compare the distribution ofKCNJll polymorphisms between elderly Chinese population with and without hypertension. Methods We examined the mutation of KCNJll gene by directly sequencing. Data for the present study were obtained from 250 hypertensive subjects （60 to 83 years old） as well as 250 normotensive subjects （60 to 86 years old）. Results We found nine different mutations in KCNJ11, including six novel mutations （1131M, L1471, L147V, L147L, Q235H, G245C）. None of the novel mutations were found in the normotensive subjects, and all the residues were conserved in other species. These sequence variants in Chinese population indicate the diversity of the human library and the complexity of hypertension. Conclusions The consistent finding of our present study provided a basis for the development of new strategies to diagnosis and treat hypertension in the elderly.