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Vasculature-on-a-chip with stretchable sensor for recapitulating hemodynamics and electrochemical monitoring of endothelium

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Science China Chemistry 2023年第11期66卷 3314-3322页

作者： wen-ting fan Yi Zhao Feng Hong Yan-Ling Liu Wei-Hua Huang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

Vascular endothelium can perceive fluid shear stress(FSS)and cyclic circumferential stretch(CCS)caused by the pulsatile blood flow,and translate the hemodynamics into biochemical signals to regulate vascular ***,existing methods provide little information about the real-time biochemical responses of endothelium when exposed to dynamic FSS and ***,a vasculature-on-a-chip integrated with stretchable sensing is engineered for recapitulating the hemodynamic milieus and in-situ monitoring biochemical responses of endothelial *** integrated device is developed by sandwiching a robust stretchable electrode between an upper fluidic channel and a lower pneumatic *** fluidic and pneumatic channels enable the simultaneous recapitulation of both FSS and CCS,and the integrated sensor exhibits excellent cell-adhesive capacity and electrochemical sensing stability even after long-term hemodynamic *** allow real-time monitoring of hemodynamic form-and duration-dependent endothelium responses,and further efficacy investigation about a recommended drug for COVID-19,demonstrating the great potential in vascular disease and drug screening.

关键词： vasculature-on-a-chip stretchable sensor hemodynamic forces electrochemical monitoring endothelium responses

Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

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Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： Kai-Kai Sheng Yi-Fei Lu wen-ting fan Yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals Bioelectrical signals

Tumorigenesis and spontaneous metastasis by luciferase-labeled human xenograft osteosarcoma cells in nude mice

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Chinese Medical Journal 2012年第22期125卷 4022-4030页

作者： DU Lin XU wen-ting fan Qi-ming TU Bing SHEN Yang YAN Wei TANG ting-ting WANG You Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Shanghai Key Lab Orthoped Implant Shanghai 200011 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Orthoped Surg Shanghai 200011 Peoples R China

Background Osteosarcoma （OS） is the most common primary malignant tumor of bone. Mouse models of human OS can invariably provide greater insight into the complex mechanisms that underlie the development and pathogenesis of this aggressive tumor. Bioluminescence technology favored tracing cancer cells in vivo. In this study, an OS model was described and evaluated using human OS cell line, Saos2, labeled with luciferase （Saos2-1uc）. Methods Saos2 cells were infected by lentivirus loading a firefly luciferase gene. Luciferase expression of Saos2-1uc cells was characterized both in vitro and in vivo. Specific biologic and oncologic features of Saos2-1uc cells were analyzed. The OS was established as orthotopic xenografts in nude mice. Both orthotopic tumors and spontaneous lung metastasis were analyzed. Results Tumorigenesis and spontaneous lung metastasis in nude mice could be monitored in vivo through in vivo imaging system. The enhancement in proliferation, migration and invasion abilities and the attenuation in adhesion ability were observed in Saos2-1uc cells compared with Saos2 cells. Furthermore, there were the up-regulation of Osteocalcin, CCRIO, CXCR1 and ID1 and the down-regulation of ALP, collagen I, CCR1, CCR3, CXCR3, NID and N-cadherin in Saos2-1uc cells compare to Saos2 cells. The rate of spontaneous lung metastasis in Saos2-1uc cells was higher than that in Saos2 cells, although without significant difference. Conclusions Lentivirus transfection may cause alteration of gene expression profiles and further biological functions. This model can be used in the elucidation of molecular mechanisms of tumorigenesis and the screening of new therapeutic agents.

关键词： osteosarcoma lung metastasis luciferase in vivo imaging Saos2 cells

虫草素调控胞内谷胱甘肽稳态实现抗衰老的纳米电化学

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科学通报 2023年第30期68卷 4063-4072页

作者：吴文涛范文婷王宜珂黄卫华武汉大学化学与分子科学学院武汉430072

衰老是所有生命体面临的一种自然现象,伴随着健康水平的下降和疾病发病率的增加.为延缓衰老过程的发生,研制新型抗衰老药物来恢复机体的抗氧化防御系统成为了研究热点.近年来,天然产物虫草素已被报道具有多种生物活性,但其抗衰老功能及... 详细信息

衰老是所有生命体面临的一种自然现象,伴随着健康水平的下降和疾病发病率的增加.为延缓衰老过程的发生,研制新型抗衰老药物来恢复机体的抗氧化防御系统成为了研究热点.近年来,天然产物虫草素已被报道具有多种生物活性,但其抗衰老功能及相关作用机制还鲜有研究.基于此,本工作采用高时空分辨率的纳米电化学技术,原位定量监测了虫草素对单个衰老细胞内谷胱甘肽稳态的调控作用.进一步的机理研究表明,虫草素能够通过激活PI3K/Akt信号通路上调细胞内抗氧化水平,进而抑制氧化损伤,实现抗细胞衰老.本工作提出了一种新型分析策略,揭示了虫草素对于衰老过程的潜在治疗功效,为在亚细胞水平研究各种疾病的发病机制及药理学提供了新的思路.

关键词：虫草素抗衰老纳米电化学谷胱甘肽稳态单细胞

考虑多重异质性的区域环境合作治理小世界网络演化博弈研究

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管理工程学报 2025年第1期39卷 140-154页

作者：范如国吴婷武汉大学经济与管理学院

由于环境污染具有负外部性,跨区域的环境问题不断涌现,因此,地方政府之间的合作治理是化解区域环境问题的重要路径,也是未来中国区域环境治理的发展方向。本文基于复杂网络理论、演化博弈理论,考虑地方政府间的偏好异质性和收入异质性,... 详细信息

由于环境污染具有负外部性,跨区域的环境问题不断涌现,因此,地方政府之间的合作治理是化解区域环境问题的重要路径,也是未来中国区域环境治理的发展方向。本文基于复杂网络理论、演化博弈理论,考虑地方政府间的偏好异质性和收入异质性,引入权重来刻画不同地区在合作中的贡献度的差异,并纳入收益分配机制、违约金机制,构建了加权NW小世界网络上地方政府间合作治理的演化博弈模型;通过数值仿真,分析了合作收益和成本、违约金、异质性三方面对网络合作水平的影响。研究结果表明:合作收益增加与合作成本降低均能促进地方政府合作治理网络向着帕累托最优方向演化,且当合作收益和合作成本到达一定水平时,经济发展水平低的地区对合作收益和合作成本的变化更为敏感。适当的违约金可以促进地方政府合作行为的演化,但违约金只是起到保障和制约的作用,仅提高违约金难以促进合作策略全扩散。节点异质性对于提高地方政府区域合作治理水平是一把双刃剑。

关键词：复杂网络演化博弈区域环境合作治理异质性

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Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai ting Luo Bin Feng Min Liu fan Zheng Shuang Huang Yanpeng fang Dan Ding wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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Effect of a Carbon Fibre-steel Fibre-graphite Conductive Filler on the Electrothermal Properties of Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 141-151页

作者： fan Yanan WEI Hong ZHENG Hongyong DU Hongxiu Department of Architecture and Environmental Engineering Taiyuan UniversityTaiyuan 030032China College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030032China

Carbon fibre,steel fibre and graphite were used as conductive fillers to prepare cementitious materials with excellent electrothermal *** electrically conductive cementitious materials with different volume dosages were analysed through compressive and flexural strength,electrochemical impedance spectroscopy and temperature rise *** equivalent circuit model was established to study the electrically conductive heat generation mechanism in the electrically conductive cementitious *** results indicate that the mechanical properties of cementitious composite materials with a ternary conductive phase are better than those of pristine cementitious materials because the fibrous filler improves their mechanical ***,the incorporation of graphite in the material reduces its *** fibrous and point-like conductive phase materials into the cementitious material enhances the overall conductive pathway and considerably reduces the electrical resistance of the cementitious material,enhancing its conductive *** volume ratios of carbon fibre,steel fibre and graphite that achieve an optimal complex doping in the cementitious material were 0.35%,0.6%and 6%,*** was determined using the mutation point of each circuit element parameter as the percolation *** addition,at a certain safety voltage,there is a uniform change between the internal and surface temperatures of the conductive cementitious material,and the heating effect in this materialis is considerably better than that in the pristine cementitious material.

关键词： cementitious composites conductive fillers electrothermal properties electrochemical impedance spectroscopy