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Stretchable Electrochemical Sensors: From Electrode Fabrication to Cell Mechanotransduction Monitoring

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Chinese Journal of Chemistry 2023年第4期41卷 443-457页

作者： wen-ting fan Wei-Hua Huang Yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Electrochemical sensing faces huge challenges in characterizing the transient release of biochemical molecules from deformed cells,due to the severely mechanical mismatch between rigid electrodes and soft *** recent years,the emergence of stretchable electrochemical sensors has made a breakthrough by complying with the deformation of living cells and simultaneous monitoring of mechanically evoked biochemical *** review first summarizes two fundamental strategies for the fabrication of stretchable electrodes from the points of structure and ***,recent progresses in construction of functionalized interface to improve the performance of stretchable electrochemical sensors are ***,the application of stretchable electrochemical sensors in real-time monitoring of biomolecules released by mechanically sensitive cells is ***,some perspectives and challenges of stretchable electrochemical sensors regarding cell detection are discussed.

关键词： Stretchable electrode Electrochemical sensing Fabrication Functionalization Cell mechanotransduction

Vasculature-on-a-chip with stretchable sensor for recapitulating hemodynamics and electrochemical monitoring of endothelium

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Science China Chemistry 2023年第11期66卷 3314-3322页

作者： wen-ting fan Yi Zhao Feng Hong Yan-Ling Liu Wei-Hua Huang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

Vascular endothelium can perceive fluid shear stress(FSS)and cyclic circumferential stretch(CCS)caused by the pulsatile blood flow,and translate the hemodynamics into biochemical signals to regulate vascular ***,existing methods provide little information about the real-time biochemical responses of endothelium when exposed to dynamic FSS and ***,a vasculature-on-a-chip integrated with stretchable sensing is engineered for recapitulating the hemodynamic milieus and in-situ monitoring biochemical responses of endothelial *** integrated device is developed by sandwiching a robust stretchable electrode between an upper fluidic channel and a lower pneumatic *** fluidic and pneumatic channels enable the simultaneous recapitulation of both FSS and CCS,and the integrated sensor exhibits excellent cell-adhesive capacity and electrochemical sensing stability even after long-term hemodynamic *** allow real-time monitoring of hemodynamic form-and duration-dependent endothelium responses,and further efficacy investigation about a recommended drug for COVID-19,demonstrating the great potential in vascular disease and drug screening.

关键词： vasculature-on-a-chip stretchable sensor hemodynamic forces electrochemical monitoring endothelium responses

Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,Junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： wen-Long Dang Gang Gao Xin-Cai You Ke-ting fan Jun Wu De-wen Lei wen-Jun He Yong Tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

Z-scheme Bi4O5Br2/NH2-MIL-125（Ti） heterojunctions enable exceptional visible photocatalytic degradation of organic pollutant

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Rare Metals 2024年第7期43卷 3161-3172页

作者： Feng Huang Muhammad Humayun Gang Li ting-ting fan wen-Lin Wang Yu-Lin Cao Anton Nikiforov Chun-Dong Wang Jing Wang Key Laboratory of Analytical Science and Technology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei University Energy Water and Environment LabCollege of Humanities and SciencesPrince Sultan University Baoding Green Yijia Environmental Protection Technology Ltd Physics Laboratory Industrial Training CenterShenzhen Polytechnic University Department of Applied Physics Ghent University School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology

One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized ***,novel Bi4O5Br2/NH2-MIL-125（Ti）Z-scheme heterojunctions are fabricated and used as photocatalysts for organic pollutant *** NH2-MIL-125（Ti） nanosheets are exfoliated via a self-developed alkali solution stripping approach and then uniformly decorated on *** as-prepared Bi4O5Br2/NH2-MIL-125（Ti） presents more than 90% degradation of various pollutants,outperforming the counterpart individual *** various characterization results suggest that the enhanced degradation rate is due to the more intimate face-to-face interfacial contact of the lamellar Z-scheme heterojunction materials,in which the migration path of carriers from the material's interior to the surface can be reduced,in turn enhancing migration efficiency and separation capability significantly.A possible photocatalytic reaction mechanism is proposed based on the photoelectric behaviors,radical trapping experiments and liquid chromatography mass spectrometry *** work promotes the development of new photocatalytic materials for heterojunctions with face-to-face interfacial contacts,as well as the effective purification of wastewater in environmental remediation.

关键词： Z-scheme heterojunctions Photocatalysis Alkaline solution stripping Bi 4 O 5 Br 2 NH 2 -MIL-125(Ti)

Bioinspired designs in active metal-based batteries

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Nano Research 2024年第2期17卷 587-601页

作者： fan Zhang ting Liao Cheng Yan Ziqi Sun School of Chemistry and Physics Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia School of Mechanical Medical and Process Engineering Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia QUT Centre for Materials Science Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia

Active metal-based batteries are drawing increased attention because of their inherent high energy density and specific *** grand challenges,such as dendrite growth,electrode degradation,rapid performance fading,etc.,have limited their practical ***,which involves taking cues from the structures and functions of the natural world,can lead to a wealth of conceptually fresh approaches to regulator the metal ion transportation to achieve a dendrite-free metal plating,thwart the side-reaction reactions,and retard the structural distortions,for a more reliable and secure operation of active metal-based *** this review,we concentrate on the fabrication and application of bioinspired designs in active metal-based batteries with enhanced performance,along with discussion on the challenges and opportunities associated with this promising *** anticipate that this review can offer some insights into the development of functional materials by learning from nature and provide some approaches for the innovations of either the battery structures or the energy materials for metal-based batteries.

关键词： bioinspired materials energy storage devices metal-based batteries

Clinical practice guidelines for neoadjuvant therapy in patients with early-stage breast cancer:Chinese Society of Breast Surgery practice guidelines 2022

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Chinese Medical Journal 2024年第12期137卷 1387-1388页

作者： Juliang Zhang ting Wang Zhe Wang Jing fan Xiaolong Xu Jing Kong Xinxin wen Rui Ling Yinhua Liu Department of Thyroid Breast and Vascular SurgeryXijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Breast Disease Center Peking University First HospitalBeijing 100034China.

Neoadjuvant therapy can yield clinical benefits in earlystage breast cancer with *** indications,treatment regimens,and efficacy of neoadjuvant therapy have been investigated,which have contributed valuable clinical evidence.[1,2]The Chinese Society of Breast Surgery convened a panel of breast disease experts to review and discuss the literature on neoadjuvant therapy for breast cancer and evaluate relevant evidence by referring to the Grading of Recommendations,Assessment,Development,and Evaluations(GRADE)*** into account China’s specific circumstances,the society and participating experts developed the Clinical Practice Guidelines for Neoadjuvant Therapy for Early-stage Breast Cancer(Version 2022)to serve as a reference for breast surgeons in China.

关键词： Surgery Breast breast

Tumorigenesis and spontaneous metastasis by luciferase-labeled human xenograft osteosarcoma cells in nude mice

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Chinese Medical Journal 2012年第22期125卷 4022-4030页

作者： DU Lin XU wen-ting fan Qi-ming TU Bing SHEN Yang YAN Wei TANG ting-ting WANG You Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Shanghai Key Lab Orthoped Implant Shanghai 200011 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Orthoped Surg Shanghai 200011 Peoples R China

Background Osteosarcoma （OS） is the most common primary malignant tumor of bone. Mouse models of human OS can invariably provide greater insight into the complex mechanisms that underlie the development and pathogenesis of this aggressive tumor. Bioluminescence technology favored tracing cancer cells in vivo. In this study, an OS model was described and evaluated using human OS cell line, Saos2, labeled with luciferase （Saos2-1uc）. Methods Saos2 cells were infected by lentivirus loading a firefly luciferase gene. Luciferase expression of Saos2-1uc cells was characterized both in vitro and in vivo. Specific biologic and oncologic features of Saos2-1uc cells were analyzed. The OS was established as orthotopic xenografts in nude mice. Both orthotopic tumors and spontaneous lung metastasis were analyzed. Results Tumorigenesis and spontaneous lung metastasis in nude mice could be monitored in vivo through in vivo imaging system. The enhancement in proliferation, migration and invasion abilities and the attenuation in adhesion ability were observed in Saos2-1uc cells compared with Saos2 cells. Furthermore, there were the up-regulation of Osteocalcin, CCRIO, CXCR1 and ID1 and the down-regulation of ALP, collagen I, CCR1, CCR3, CXCR3, NID and N-cadherin in Saos2-1uc cells compare to Saos2 cells. The rate of spontaneous lung metastasis in Saos2-1uc cells was higher than that in Saos2 cells, although without significant difference. Conclusions Lentivirus transfection may cause alteration of gene expression profiles and further biological functions. This model can be used in the elucidation of molecular mechanisms of tumorigenesis and the screening of new therapeutic agents.

关键词： osteosarcoma lung metastasis luciferase in vivo imaging Saos2 cells

Solvent-free carbon sphere nanofluids towards intelligent lubrication regulation

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Friction 2024年第1期12卷 95-109页

作者： Sheng ZHANG wen LI Xiaoliang MA Xiaoqiang fan Minhao ZHU Tribology Research Institute School of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

By simply switching the electrical circuit installed on steel/steel contact,the tribological behaviors of nanofluids(NFs)can be regulated in real time,thereby achieving the desired performance of friction reduction and wear ***,solvent-free carbon spherical nanofluids(C-NFs)were successfully prepared for intelligent lubrication regulation.C-NFs with excellent lubrication performance can immediately reduce the coefficient of friction(COF)despite applying a weak electric potential(1.5 V).Moreover,polyethylene glycol 400(PEG400)containing 5.0 wt%C-NFs remained responsive to electrical stimulation under the intermittent voltage application with an average coefficient of friction(ACOF)reduction of 20.8%over *** intelligent lubrication regulation of C-NFs under an external electric field(EEF)mainly depends on the orderly arranged double-electric adsorption film of ion canopy-adsorbed carbon spheres(CSs).The intermittent electrical application can continuously reinforce the adsorption film and its durability for real-time controlling the sliding ***-stimulation-responsive intelligent lubricants provide a new technical support for realizing intelligent stepless control of devices.

关键词： solvent-free carbon spherical nanofluids(C-NFs) intelligent lubrication regulation lubrication performance adsorption film

Catalytic effect in lithium metal batteries: From heterogeneous catalyst to homogenous catalyst

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Journal of Energy Chemistry 2024年第3期90卷 305-326,I0008页

作者： Haining fan Xuan-wen Gao Hailong Xu Yichun Ding Shi-Xue Dou wen-Bin Luo School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong 100872China Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghai 200000China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710000ShaanxiChina

Lithium metal batteries are regarded as prominent contenders to address the pressing needs owing to the high theoretical *** the broader implementation,the primary obstacle lies in the intricate multi-electron,multi-step redox reaction associated with sluggish conversion kinetics,subsequently giving rise to a cascade of parasitic *** order to smooth reaction kinetics,catalysts are widely introduced to accelerate reaction rate via modulating the energy *** past decades,a large amount of research has been devoted to the catalyst design and catalytic mechanism exploration,and thus the great progress in electrochemical performance has been ***,it is necessary to make a comprehensive review toward key progress in catalyst design and future development *** this review,the basic mechanism of lithium metal batteries is provided along with corresponding advantages and existing challenges detailly *** main catalysts employed to accelerate cathode reaction with emphasis on their catalytic mechanism are summarized as ***,the rational design and innovative direction toward efficient catalysts are suggested for future application in metal-sulfur/gas battery and *** review is expected to drive and benefit future research on rational catalyst design with multi-parameter synergistic impacts on the activity and stability of next-generation metal battery,thus opening new avenue for sustainable solution to climate change,energy and environmental issues,and the potential industrial economy.

关键词： Energy storage and conversion Metal battery Sulfur battery Air battery Catalytic effect Heterogeneous catalyst Homogeneous catalyst