Vasculature-on-a-chip with stretchable sensor for recapitulating hemodynamics and electrochemical monitoring of endothelium

作     者：Wen-Ting Fan Yi Zhao Feng Hong Yan-Ling Liu Wei-Hua Huang 

作者机构：College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第11期

页      面：3314-3322页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080202[工学-机械电子工程] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 

基　　金：supported by the National Key Research and Development Program of China(2022YFA1104802) the National Natural Science Foundation of China(22122408,21721005,22090051) 

主　　题：vasculature-on-a-chip stretchable sensor hemodynamic forces electrochemical monitoring endothelium responses 

摘      要：Vascular endothelium can perceive fluid shear stress(FSS)and cyclic circumferential stretch(CCS)caused by the pulsatile blood flow,and translate the hemodynamics into biochemical signals to regulate vascular ***,existing methods provide little information about the real-time biochemical responses of endothelium when exposed to dynamic FSS and ***,a vasculature-on-a-chip integrated with stretchable sensing is engineered for recapitulating the hemodynamic milieus and in-situ monitoring biochemical responses of endothelial *** integrated device is developed by sandwiching a robust stretchable electrode between an upper fluidic channel and a lower pneumatic *** fluidic and pneumatic channels enable the simultaneous recapitulation of both FSS and CCS,and the integrated sensor exhibits excellent cell-adhesive capacity and electrochemical sensing stability even after long-term hemodynamic *** allow real-time monitoring of hemodynamic form-and duration-dependent endothelium responses,and further efficacy investigation about a recommended drug for COVID-19,demonstrating the great potential in vascular disease and drug screening.