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Cellular journey of nanomaterials:Theories,trafficking,and kinetics Cellular journey of nanomaterials:Theories,trafficking,andkinetics

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Aggregate 2023年第6期4卷 11-26页

作者： xiangrui wang Wen-Xiong wang School of Energy and Environment and State Key Laboratory of Marine Pollution City University of Hong KongHong KongChina Research Centre for the Oceans and Human Health City University of Hong Kong Shenzhen Research InstituteShenzhenChina

Engineered nanomaterials(NMs)are increasingly fabricated in various fields involv-ing consumer goods,waste management,and biomedical applications such as drug delivery,diagnosis,and treatment of pathological *** these NMs are intentionally or unexpectedly in contact with the human body,there are growing concerns about their intracellular journey,especially considering the therapeu-tic or deleterious effects after they cross the cell *** this review,the cellular journey of NMs including internalization,intracellular trafficking,and depo-sition/exocytosis is systematically *** work highlights the accumulation of NMs in cells not only depends on the moment of NMs crossing the cell membrane but also at the following trafficking and exocytosis process.A deeper understanding of the cellular journey of NMs implies that an alternative strategy to fabricate spe-cific targeting NMs is to bypass a few pathways of intracellular trafficking to achieve potent therapeutic effects with minimal *** comprehensively reviewing the cellular journey of NMs,current progress and application scenarios of kinetic models are ***,this review focuses on the bottleneck problems and the corresponding solution technologies for studying the cellular journey of *** progresses on the cellular journey of NMs provide new insights into the fab-rication of biomedical NMs and facilitate technology development for probing the nano-cell interaction with high temporal-spatial resolution.

关键词： cellular journey exocytosis intracellulartrafficking kineticmodel

Research on an active and continuous monitoring system for human respiratory system

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High Technology Letters 2006年第1期12卷 68-71页

作者：于莲芝 Yan Guozheng Zhang Wenqiang wang xiangrui School of Electronics ＆ Information Shanghai Jiaotong University Shanghai 200030 P.R. China Department of Anesthesiology Renji Hospital Shanghai Second Medical University Shanghai 200001 P.R. China

Continuous and dynamic measurements of human respiratory parameters are very important for vital diseases of respiratory system during mechanical ventilation. This paper analyzed the structure and mechanical properties of the human respiratory system, and designed an active intervening monitoring micro system for it. The mobile mechanism of the micro system is soft and earthworm-like movement actuated by pneumatic rubber actuator, the measurement and therapy unit of the system is an extensible mechanism with sensors in the front. The micro monitoring system can move in respiratory tract and measure the respiratory parameters in bronchium continuously. Experiments had been done in swine＇s respiratory tract, the results proved that the micro robot system could measure the respiratory parameters in real-time successfully and its movement was smith in swine＇s respiratory tract.

关键词： respiratory system monitoring system mechanical ventilation measurement

Enriching Farmers through Sharing: Improving People’s Livelihood and Well-Being in the Modernization of Agriculture and Rural Areas in China

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China Economic Transition 2022年第1期5卷 62-82页

作者： ZHONG Zhen FENG Qifan wang xiangrui School of Agricultural Economics and Rural Development Renmin University of ChinaBeijing 100872China

Shared development is an important means by which to improve people’s livelihood and well-being in the new era. During the 13th Five-Year Plan period (2016–2020), China has made great achievements in the three major aspects of targeted poverty alleviation through industrial development, development of special rural areas, and equalization of urban and rural infrastructure and basic public services. In addition, the important experience of multi-agent participation, multi-mode guidance, and multi-line promotion has been accumulated in the individual, regional and urbanrural dimensions. However, there remain some deficiencies, such as low policy efficiency, poor matching ability, and prominent structural problems. At the beginning of the 14th Five-Year Plan (2021–2025), the task of enriching farmers through sharing has been faced with many challenges, such as major changes in the focus of poverty governance, greater numbers of restraints on the development of special rural areas, and heavy responsibilities of equalizing urban and rural infrastructure and basic public services. Therefore, it is necessary to acquire a profound understanding of the new development concept, and to continuously enrich farmers through sharing in terms of accelerating the improvement of the institutionalized poverty reduction system in the new era, actively building a green development system of agriculture and animal husbandry in special rural areas, and striving to create a fair and complementary urban and rural infrastructure and basic public service system.

关键词： enriching farmers through sharing targeted poverty alleviation through industrial development development of special rural areas equalization of urban and rural infrastructure and basic public services people’s livelihood and well-being

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu xiangrui Xu Fuqiang Hu Jiao Dai Baigen Cai Wei wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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吸入麻醉药物的药理特性及应用

上海医学 2009年第1期32卷 7-8页

作者：王祥瑞上海交通大学医学院附属仁济医院麻醉科

1540年Valerings合成乙醚,Cordus和Paracelsus在有关著作中提到乙醚具有消除疼痛的作用。1818年Faraday发现乙醚具有麻醉作用。1842年美国佐治亚州的乡村医师Crawford Long在乙醚吸入麻醉下切除患者的颈部肿物,但直到1849年才在《南方... 详细信息

1540年Valerings合成乙醚,Cordus和Paracelsus在有关著作中提到乙醚具有消除疼痛的作用。1818年Faraday发现乙醚具有麻醉作用。1842年美国佐治亚州的乡村医师Crawford Long在乙醚吸入麻醉下切除患者的颈部肿物,但直到1849年才在《南方医学外科》杂志进行报道,因而Long被认为是将乙醚用于临床麻醉的开创者。1846年美国康涅狄格州牙科医师Morton在医学家兼化学家Jackson的指导下,验证了牙科手术时吸入乙醚蒸气的麻醉作用。[第一段]

关键词：吸入麻醉药低氧 HIF 异氟烷异氟醚吸入麻醉剂地氟烷药理特性

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急性疼痛的机制和治疗进展

上海医学 2007年第6期30卷 393-395页

作者：王祥瑞上海交通大学医学院附属仁济医院麻醉科 200001

急性疼痛定义为最近产生并可能持续较短时间的疼痛，通常与手术创伤、组织损伤或某些疾病状态有关。不仅给患者带来痛苦，还给其带来严重的心理及生理损伤，增加并发症的发生率。随着疼痛机制的研究和镇痛技术的发展，急性疼痛的治疗已... 详细信息

急性疼痛定义为最近产生并可能持续较短时间的疼痛，通常与手术创伤、组织损伤或某些疾病状态有关。不仅给患者带来痛苦，还给其带来严重的心理及生理损伤，增加并发症的发生率。随着疼痛机制的研究和镇痛技术的发展，急性疼痛的治疗已经从既往的保守治疗改为积极主动的治疗。保守治疗的方法往往是在患者已不能忍受疼痛时，根据需要肌内或静脉注射镇痛药；积极主动的治疗包括患者自控镇痛、硬膜外镇痛和连续神经阻滞镇痛等。

关键词：急性疼痛机制治疗定义

直接气道压力测定在腹腔镜下胆囊切除术中的临床应用

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上海医学 2011年第8期34卷 573-576页

作者：王震虹王祥瑞上海交通大学医学院附属仁济医院麻醉科 200127

目的比较在腹腔镜下胆囊切除术中光纤压力传感器(FOPT)直接气道内测压与麻醉机所测气道压力的区别,评估气道内直接测压的敏感性和有效性,为临床提供更可靠的气道压检测方法。方法腹腔镜下行胆囊切除术的患者60例,比较FOPT插入与否及插... 详细信息

目的比较在腹腔镜下胆囊切除术中光纤压力传感器(FOPT)直接气道内测压与麻醉机所测气道压力的区别,评估气道内直接测压的敏感性和有效性,为临床提供更可靠的气道压检测方法。方法腹腔镜下行胆囊切除术的患者60例,比较FOPT插入与否及插入深度对气道压力的影响,比较二氧化碳(CO2)气腹前后、体位改变及不同气腹时间时将FOPT置入气管导管(ETT)内测定的气道峰压(ptrac)与麻醉机测定的气道峰压(pprox)的差异。结果 FOPT插入前后pprox的差异无统计学意义(P>0.05)。FOPT分别放置于ETT顶端、顶端下方1 cm和顶端上方1 cm时,FOPT测得的ptrac的差异无统计学意义(P>0.05)。气腹前测定的ptrac值显著低于pprox值(P0.05),但体位改变后的ptrac值显著低于pprox值(P60 min时的pprox显著高于气腹时间40且≤50 min、>50且≤60 min、>60 min时的ptrac均显著高于气腹时间0.05);在气腹时间>60 min的患者中,术后10 min的ptrac和pprox均较气腹前显著升高(P值均<0.05)。结论 FOPT可以放置在气道内直接测定气道压力,并且不影响气道内的压力,压力测定对放置的位置要求不高。在术中,各种因素对气道压力产生影响时,FOPT测定的气道压力较传统麻醉机压力测定更为灵敏、准确。

关键词：光纤压力传感器腹腔镜气道压力直接测压

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共享富农:农业农村现代化中的民生福祉增进

农村经济 2021年第10期 9-17页

作者：钟真封启帆王翔瑞中国人民大学农业与农村发展学院北京市100086

共享发展是新时代民生福祉增进的重要途径。"十三五"期间,国家在产业精准脱贫、特殊农村区域发展、推动城乡基础设施和基本公共服务均等化三个方面深入推进共享富农,取得了巨大成就,在个体维度、区域维度和城乡维度上分别形成了多主体... 详细信息

共享发展是新时代民生福祉增进的重要途径。"十三五"期间,国家在产业精准脱贫、特殊农村区域发展、推动城乡基础设施和基本公共服务均等化三个方面深入推进共享富农,取得了巨大成就,在个体维度、区域维度和城乡维度上分别形成了多主体参与、多模式引领、多线条推进的重要经验,但也存在着政策效率低、匹配性差和结构性问题突出等不足。面向"十四五",共享富农仍然面临着贫困治理重点将发生重大转变、特殊农村区域发展约束将进一步增强、城乡基础设施与基本公共服务均等化任重道远等挑战。为此,需要深刻理解新发展理念,在加快完善新时代制度化减贫体系、积极构建特殊农村区域农牧业绿色化发展体系、着力打造公平互补的城乡基础设施与基本公共服务体系等方面继续推进共享富农。

关键词：共享富农产业精准脱贫特殊农村区域发展城乡均等化民生福祉

经皮椎间孔镜技术治疗腰椎间盘突出症30例的近期疗效

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上海医学 2012年第6期35卷 473-475页

作者：郑拥军叶乐王祥瑞上海交通大学医学院附属仁济医院麻醉科 200127

目的观察经皮椎间孔镜技术(PTED)治疗经保守治疗无效的腰椎间盘突出症患者的近期疗效。方法选择单节段椎间盘突出症患者30例,行侧后路经皮THESSYS椎间孔镜下椎间盘髓核摘除手术,应用疼痛视觉模拟评分(VAS评分)、Oswestry功能障碍(ODI)... 详细信息

目的观察经皮椎间孔镜技术(PTED)治疗经保守治疗无效的腰椎间盘突出症患者的近期疗效。方法选择单节段椎间盘突出症患者30例,行侧后路经皮THESSYS椎间孔镜下椎间盘髓核摘除手术,应用疼痛视觉模拟评分(VAS评分)、Oswestry功能障碍(ODI)指数及改良Macnab标准评价其临床疗效。结果术后1周及术后1、3个月的VAS评分分别为(3.0±0.8)、(2.3±0.6)、(2.0±0.5)分,均显著低于术前的(8.0±1.4)分(P值均<0.01)。术后1周及术后1、3个月的ODI指数分别为(30.2±9.2)%、(14.3±4.4)%及(13.8±7.3)%,均显著低于术前的(78.2±16.6)%(P值均<0.01)。根据改良Macnab标准评价疗效:优22例,良5例,可2例,差1例。仅1例患者于术后当天出现一过性神经麻痹,未行特殊处理,3d后症状消失。结论应用PTED行髓核摘除术治疗腰椎间盘突出症的近期疗效可靠。

关键词：椎间孔镜腰椎间盘突出症射频消融