Cellular journey of nanomaterials:Theories,trafficking,and kinetics Cellular journey of nanomaterials:Theories,trafficking,andkinetics
作者机构：School of Energy and Environment and State Key Laboratory of Marine PollutionCity University of Hong KongHong KongChina Research Centre for the Oceans and Human HealthCity University of Hong Kong Shenzhen Research InstituteShenzhenChina
出 版 物：《Aggregate》 (聚集体（英文）)
年 卷 期：2023年第4卷第6期
页 面：11-26页
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：Hong Kong Research Grants Council,Grant/Award Numbers:11102321,C6014-20 W Shenzhen Municipal Science and Technology Innovation Commission,Grant/Award Number:JCYJ20210324134000001
主 题：cellular journey exocytosis intracellulartrafficking kineticmodel
摘 要：Engineered nanomaterials(NMs)are increasingly fabricated in various fields involv-ing consumer goods,waste management,and biomedical applications such as drug delivery,diagnosis,and treatment of pathological *** these NMs are intentionally or unexpectedly in contact with the human body,there are growing concerns about their intracellular journey,especially considering the therapeu-tic or deleterious effects after they cross the cell *** this review,the cellular journey of NMs including internalization,intracellular trafficking,and depo-sition/exocytosis is systematically *** work highlights the accumulation of NMs in cells not only depends on the moment of NMs crossing the cell membrane but also at the following trafficking and exocytosis process.A deeper understanding of the cellular journey of NMs implies that an alternative strategy to fabricate spe-cific targeting NMs is to bypass a few pathways of intracellular trafficking to achieve potent therapeutic effects with minimal *** comprehensively reviewing the cellular journey of NMs,current progress and application scenarios of kinetic models are ***,this review focuses on the bottleneck problems and the corresponding solution technologies for studying the cellular journey of *** progresses on the cellular journey of NMs provide new insights into the fab-rication of biomedical NMs and facilitate technology development for probing the nano-cell interaction with high temporal-spatial resolution.
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