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Science China(Life Sciences) 2009年第4期52卷 344-351页

作者： CUN Wei, GUO Lei, ZHANG Ying, LIU LongDing, wang lichun, LI JianFeng, DONG ChengHong, wang JinJin & LI QiHan Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China 1. Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming 650118 China

Herpes Simplex Virus 1 (HSV1) is capable of inducing two forms of infection in individuals, and the establishment of which type of infection occurs is linked to the transcriptional activation of viral α genes. One of the HSV1 α genes, ICP22, is known to have multiple functions during virus replication, but its distinct roles are still unclear. This study showed that ICP22 functions as a general repressor for certain viral and cellular promoters, and this transcriptional repression by ICP22 is independent of the specific upstream promoter element, as shown using the CAT enzyme assay system. Further work also found that VP16 interfered with ICP22 mediated transcriptional repression of the viral α4 gene, through interactions with specific elements upstream of the α4 gene promoter. These findings support the possibility that ICP22 and VP16 control transcription of HSV1α genes in a common pathway for the establishment of either viral lytic or latent infections.

关键词： herpes simplex virus ICP22 transcription VP16 α gene

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随机删失下经验贝叶斯估计的渐近最优性

数学物理学报（A辑） 2006年第6期26卷 938-947页

作者：王立春北京交通大学理学院数学系北京100044

该文运用经验贝叶斯(empirical Bayes(简称EB))方法,在历史样本和当前样本均被另一个具有未知分布的变量随机右删失的条件下,构造了一个指数分布参数的经验贝叶斯估计并获得了它的渐近最优性．文章最后给出了一个例子和模拟结果．

关键词：经验贝叶斯估计乘积限估计渐近最优性

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随机删失下刻度参数的单调经验贝叶斯检验

应用概率统计 2007年第4期23卷 419-427页

作者：王立春北京交通大学理学院数学系北京100044

利用经验贝叶斯方法研究了刻度指数族的两行动问题,提出了一个在历史样本被随机右删失的条件下收敛速度可以任意接近O(n^(-1))的单调经验贝叶斯检验.

关键词：经验贝叶斯随机删失刻度指数族

中医护理预防髋关节置换术后下肢深静脉血栓的Meta分析

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内蒙古医学杂志 2024年第4期56卷 428-434页

作者：张洪丽顾晨丛杨晓敏魏丽丽杨毅捷胡春娜韩刚杨桐王利春河北省沧州中西医结合医院骨科康复院区河北沧州061000 河北中医学院石家庄050091 承德医学院河北承德067000

目的系统评价髋关节置换术后中医护理预防下肢深静脉血栓形成的临床效果。方法计算机检索PubMed、国家知识基础设施数据库(CNKI)、维普资讯中文期刊服务平台(VIP)、万方学术期刊全文数据库(Wanfang)中关于髋关节置换术后中医护理预防下... 详细信息

目的系统评价髋关节置换术后中医护理预防下肢深静脉血栓形成的临床效果。方法计算机检索PubMed、国家知识基础设施数据库(CNKI)、维普资讯中文期刊服务平台(VIP)、万方学术期刊全文数据库(Wanfang)中关于髋关节置换术后中医护理预防下肢深静脉血栓形成的文献,检索时间为2012—2022年11月。采用Cochrane干预措施系统评价手册(5.1.0版)偏倚风险评估工具对纳入的随机对照研究进行质量评价,运用RevMan5.4软件对纳入文献进行Meta分析。结果纳入11项研究,涉及1087例患者,其中研究组597例,对照组508例。Meta分析结果显示:中医护理下肢深静脉血栓发生率低于常规护理[RR=0.18,95%CI(0.09~0.35),Z=5.03,P0.05)。结论研究结果表明,髋关节置换术后,中医护理对预防下肢深静脉血栓形成有一定效果,且能显著降低纤维蛋白原,但在改善凝血酶原时间和活化部分凝血活酶时间方面,其效果与常规护理相比差异无统计学意义,受纳入范围和纳入研究质量的影响,上述结论尚待更多高质量的试验予以证实。

关键词：中医护理髋关节置换术下肢深静脉血栓 Meta分析凝血功能

A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)

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Science China(Life Sciences) 2012年第4期55卷 336-342页

作者： YANG ErXia ZHAO Heng ZHANG Ying LIU JianSheng LIAO Yun wang lichun CUI PingFang YANG LiXian LIU LongDing DONG ChengHong DONG ShaoZhong SHAO CongWen JIANG Li SUN Le LI QiHan Institute of Medical Biology Chinese Academy of Medicine Science Peking Union Medical College Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases Kunming 650118 China jiangsu Convax Biotechnology Co. Ltd. Taizhou 225300 China

Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.

关键词： CA16 strains proliferation kinetics pathogenicity

Recent advances in landfalling tropical cyclone asymmetric rainfall mechanism and forecast verification over China

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Tropical Cyclone Research and Review 2024年第1期13卷 33-40页

作者： Zifeng Yu Peiyan Chen Fumin Ren lichun Tang Weiwei wang Hui Yu Kun Zhao Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Asia-Pacific Typhoon Collaborative Research Center ShanghaiChina Chinese Academy of Meteorological Sciences BeijingChina Nanjing University of Information Science and Technology NanjingChina Nanjing University NanjingChina

Held every four years,the International Workshop on Tropical Cyclone(IWTC)organized by the World Meteorological Organization has been a global leading conference in theﬁeld of tropical *** preparation for the 10th IWTC(IWTC-10)in December 2022,a summary of research advances of landfalling tropical cyclone(LTC)rainfall during past four years of 2019–2022 has been *** of the latest research advances has been summarized in Lamers et al.(2023),which reviewed the latest forecast and disaster prevention methods related to TC *** a supplement,this article mainly focuses on the recent advances in LTC asymmetric rainfall evolution mechanisms and forecast veriﬁcation results over *** newﬁndings have been made in the LTC inner-core size relationship with the asymmetric rainfall *** major advances focused on asymmetric microphysical characteristics in the TC *** simulation and forecast per-formances of LTC precipitation have been analyzed,and different forecast error sources for rainfall during different landfall stages of TC were *** estimate the risk of TC rainfall hazards in China,a parameterized Tropical Cyclone Precipitation Model was reviewed as well in this article.

关键词： Tropical cyclone Landfall Rainfall Precipitation forecast veriﬁcation

基于混合采样和特征选择的改进随机森林算法研究

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南京邮电大学学报（自然科学版） 2022年第1期42卷 81-89页

作者：汪力纯刘水生南京工程学院信息与通信工程学院江苏南京211167 江苏省烟草专卖局信息中心江苏南京210018

随机森林算法是根据Bagging抽样和随机特征子集划分策略,由多棵决策树组成的集成算法。与其他分类算法相比,随机森林算法有更高的分类精度、更低的泛化误差以及训练速度快等特点,因此在数据挖掘领域得到了多方面的应用。然而随机森林算... 详细信息

随机森林算法是根据Bagging抽样和随机特征子集划分策略,由多棵决策树组成的集成算法。与其他分类算法相比,随机森林算法有更高的分类精度、更低的泛化误差以及训练速度快等特点,因此在数据挖掘领域得到了多方面的应用。然而随机森林算法在分类预测特征维度高且不平衡的数据时,分类性能受到了极大限制。为了更好地处理高维不平衡数据,文中提出了一种基于混合采样和特征选择的改进随机森林算法(Hybrid Samping&Feature Selection Random Forest,HF_RF)。该算法首先从数据层面出发,通过SMOTE算法和随机欠采样相结合的方式对高维不平衡数据集进行预处理,同时引入聚类算法对SMOTE算法进行改进,提高对负类样本的处理性能;然后从算法层面出发,通过ReliefF算法对平衡后的高维数据赋予不同的权值,剔除不相关和冗余特征,对高维数据进行维度约简;最后采用加权投票原则进一步提高算法的分类性能。实验结果显示,改进后的算法与原算法相比,在处理高维不平衡数据方面的各评价指标更高,证明HF_RF算法对于高维不平衡数据的分类性能高于传统随机森林算法。

关键词：随机森林混合采样特征选择高维不平衡数据 HF_RF算法

A COVID-19 Patient Discharged According to Strict Discharge Standards:Viral Negativity in Both Nasopharynx and Feces

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Infectious Diseases & Immunity 2022年第3期2卷 210-212页

作者： Enqiang Chen lichun wang Guangming Tang Menglan wang Yachao Tao Ping Feng Hong Tang Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041China

Severe acute respiratory syndrome Coronavirus 2(SARS-CoV-2)currently has spread all over the ***,the dynamic characteristics of SARS-CoV-2 infections have not previously been described in ***,we report a cured patient in West China Hospital,and describe the dynamic detection of SARS-CoV-2-RNA in different specimens and viral specific IgM and IgG antibodies in *** findings suggest that the fecal SARS-CoV-2-RNA negativity may be considered as a new standard for de *** IgM and IgG antibodies detection were helpful for early diagnosis of SARS-CoV-2 infection and judgment of patients in recovery stage,respectively.

关键词： Feces IgG antibody IgM antibody SARS-CoV-2 Viral RNA

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土壤剖面水分传感器探头仿真与试验

农业机械学报 2017年第10期48卷 245-251,244页

作者：闫华邢振薛绪掌王利春北京农业信息技术研究中心北京100097 农业部农业信息技术重点实验室北京100097

为准确掌握土壤墒情信息,针对农田环境下不同作物根区土壤含水率变化难以实时观测的问题,对土壤剖面水分传感器探头进行了仿真,并通过试验验证,给出了传感器探头设计尺寸的优选方案。在建立传感器探头微量化平面电容二维模型的基础上,... 详细信息

为准确掌握土壤墒情信息,针对农田环境下不同作物根区土壤含水率变化难以实时观测的问题,对土壤剖面水分传感器探头进行了仿真,并通过试验验证,给出了传感器探头设计尺寸的优选方案。在建立传感器探头微量化平面电容二维模型的基础上,分析了传感器探头结构变化对探头微量化平面电容周围电场强度和电容变化的影响,确定了探头结构尺寸的最优组合。当探头铜环电极外径40 mm、内径38.4 mm、轴向长度20 mm、轴向间距15 mm时,探头的灵敏性和探测范围最优。试验结果表明,本文研究的土壤剖面水分传感器测量精度为±1.42%,具有很高的稳定性和一致性。所设计的传感器探头可以根据实际测量深度需要任意组合,满足不同作物根区深度的土壤含水率测量需求。

关键词：土壤水分传感器探头剖面仿真试验

膨胀阻燃LLDPE/EVA复合材料的制备及其改性

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现代塑料加工应用 2016年第4期28卷 15-18页

作者：王立春南通普力马弹性体技术有限公司江苏南通226011

将预先配制好的膨胀阻燃剂[IFR,聚磷酸铵(APP)/季戊四醇(PER)/硼酸锌(ZB)]与线性低密度聚乙烯(LLDPE)/乙烯-醋酸乙烯共聚物(EVA)进行混和,采用双螺杆挤出机,制备阻燃LLDPE/EVA复合材料。用氧化钙(CaO)、天然石墨(NG)、膨胀石墨(EG)对阻... 详细信息

将预先配制好的膨胀阻燃剂[IFR,聚磷酸铵(APP)/季戊四醇(PER)/硼酸锌(ZB)]与线性低密度聚乙烯(LLDPE)/乙烯-醋酸乙烯共聚物(EVA)进行混和,采用双螺杆挤出机,制备阻燃LLDPE/EVA复合材料。用氧化钙(CaO)、天然石墨(NG)、膨胀石墨(EG)对阻燃LLDPE/EVA复合材料进行改性。结果表明:APP/PER/ZB具有明显的膨胀阻燃作用,同时,发现CaO,NG,EG与IFR有协同作用,提高了膨胀炭层的热稳定性和阻燃效率。

关键词：膨胀阻燃线性低密度聚乙烯乙烯-醋酸乙烯共聚物协同作用