A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)
A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)作者机构：Institute of Medical Biology Chinese Academy of Medicine Science Peking Union Medical College Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases Kunming 650118 China jiangsu Convax Biotechnology Co. Ltd. Taizhou 225300 China
出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)
年 卷 期：2012年第55卷第4期
页 面：336-342页
核心收录：
学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 07[理学] 08[工学] 09[农学] 0906[农学-兽医学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：supported by the National Basic Research Program of China (Grant No. 2011CB504903) the National Natural Science Foundation of China (Grant No. 81171573) the Important National Science & Technology Specific Projects (Grant No. 2009ZX10004-308) the General Program of Applied Basic Research Programs Commission, Foundation of Yunnan Province (Grant No. 2011FB116)
主 题：CA16 strains proliferation kinetics pathogenicity
摘 要：Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.
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