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Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick Chi-wai Lui Oswens siu-Hung Lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

Cancer stem-like cells in Epstein-Barr virus-associated nasopharyngeal carcinoma

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Chinese Journal of Cancer 2014年第11期33卷 529-538页

作者： Samantha Wei-Man Lun siu-Tim Cheung Kwok-wai Lo Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaPrince of Wales Hospital Department of Surgery The University of Hong Kong Li Ka Shing Institute of Health Science The Chinese University of Hong Kong

Although the Epstein-Barr virus(EBV) has spread to all populations in the world, EBV-associated nasopharyngeal carcinoma(NPC) is prevalent only in South China and Southeast Asia. The role of EBV in the malignant transformation of nasopharyngeal epithelium is the main focus of current researches. Radiotherapy and chemoradiotherapy have been successful in treating early stage NPC, but the recurrence rates remain high. Unfortunately, local relapse and metastasis are commonly unresponsive to conventional treatments. These recurrent and metastatic lesions are believed to arise from residual or surviving cells that have the properties of cancer stem cells. These cancer stem-like cells(CSCs) have the ability to selfrenew, differentiate, and sustain propagation. They are also chemo-resistant and can form spheres in anchorage-independent environments. This review summarizes recent researches on the CSCs in EBVassociated NPC, including the findings regarding cell surface markers, stem cell-related transcription factors, and various signaling pathways. In particular, the review focuses on the roles of EBV latent genes [latent membrane protein 1(LMP1) and latent membrane protein 2A(LMP2A)], cellular microRNAs, and adenosine triphosphate(ATP)-binding cassette chemodrug transporters in contributing to the properties of CSCs, including the epithelial-mesenchymal transition, stem-like transition, and chemo-resistance. Novel therapeutics that enhance the efficacy of radiotherapy and chemoradiotherapy and inhibitors that suppress the properties of CSCs are also discussed.

关键词：肿瘤干细胞 EB病毒鼻咽癌潜伏膜蛋白1 上皮细胞东南亚地区三磷酸腺苷 EBV

香港地区中学文凭考试诊断反馈系统的开发及改进

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中国考试 2024年第2期 40-46页

作者：禤美瑶萧伟乐周钜宽杨汉基席小明香港考试及评核局中国香港999077

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与... 详细信息

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与学生提供诊断性反馈报告,突出学生在不同能力或范畴的不足与强项。来自14所学校的约2200名学生及教师试用了该系统,通过问卷调查和访谈法,收集意见建议,以改进系统设计。系统改良版在“数据主导评核提升计划”中正式推出,辅之以学科教师培训,以帮助学校提升评核质量。

关键词：香港地区中学文凭考试诊断反馈评核促进学习个性化学习

Clinicopathological survey of 23 patients with lacrimal fossa lesions in Hong Kong

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 311-313页

作者： Danny siu-Chun Ng Edwin Chan Kin Yau Clement wai-Nang Chan Department of Ophthalmology Tung Wah Eastern Hospital

AIM: To survey the clinicopathological correlations of lacrimal fossa lesions in the Hong Kong population. METHODS: A total of 23 patients with lacrimal fossa lesions were identified radiologically. The mean age at the time of diagnosis was 52 year-old. The medical records of patients diagnosed with lacrimal fossa lesions and subsequently underwent radiological investigations were collected and reviewed retrospectively throughout a six years period from 2000 to 2006 from three regional hospitals (Tung Wah Eastern Hospital, Pamela Youde Nethersole Eastern Hospital and Queen Mary Hospital) belonging to the Hong Kong Mega Cluster. Patient demographics, presenting signs and symptoms, imaging modalities, pathological reports and subsequent management were recorded. RESULTS: The most common initial presenting symptom was upper lid swelling (83%) followed by proptosis (13%). 19 patients (83%) had benign lacrimal fossa lesion and 4 patients (17%) had malignancy. Three of the malignancies were lymphomas and one was adenoid cystic carcinoma. CONCLUSION: Age is an important factor in considering the differential diagnosis of lacrimal fossa lesion. Lymphoproliferative diseases have the highest incidence in patients over 60 years of age while inflammatory lesions are more common in younger patients in Hong Kong.

关键词： lacrimal gland tumor lymphoma

Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy

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Engineered Regeneration 2021年第1期2卷 70-81页

作者： wai Ki Wong Bohan Yin Anel Rakhmatullina Jingying Zhou siu Hong Dexter Wong Department of Bioengineering Imperial College LondonLondon SW72AZUnited Kingdom Department of Biomedical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Biomedical Sciences The Chinese University of Hong KongShatinHong KongChina

Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the *** outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor ***,such interaction is often not optimal in vivo and results in low therapeutic *** reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell *** this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.

关键词： T-cell mechanobiology Dynamic nanobiomaterials Adoptive T-cell immunotherapy T-Ligand presentation

An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina Yat Wa Liu Lin Yang Man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu Freddy Man-Hin Lam Daihai He Lei Yang Yan Li Gilman Kit-Hang siu Stefanos Tyrovolas Yao Jie Xie David Man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence

High Potential Columnar Nanocrystalline AlN Films Deposited by RF Reactive Magnetron Sputtering

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Nano-Micro Letters 2012年第1期4卷 40-44页

作者： Chengzhang Han Da Chen Yaozhong Zhang Dong Xu Yijian Liu Eric siu-wai Kong Yafei Zhang Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University Department of Applied Physics College of Science Shandong University of Science and Technology

Columnar nanocrystalline aluminum nitride(cnc-AlN) thin films with(002) orientation and uniform texture have been deposited successfully on large silicon wafers by RF reactive magnetron *** the optimum sputtering parameters, the deposited cnc-AlN thin films show a c-axis preferred orientation with a crystallite size of about 28 nm and surface roughness(RMS) of about 1.29 nm. The cnc-AlN thin films were well transparent with an optical band gap about 4.8 e V, and the residual compressive stress and the defect density in the film have been revealed by Ramon spectroscopy. Moreover, piezoelectric performances of the cnc-AlN thin films executed effectively in a film bulk acoustic resonator structure.

关键词： Columnar film Aluminum nitride Piezoelectric effect RF sputtering Optical property

A Facile Route for the Large Scale Fabrication of Graphene Oxide Papers and Their Mechanical Enhancement by Cross-linking with Glutaraldehyde

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Nano-Micro Letters 2011年第4期3卷 215-222页

作者： Nantao Hu Lei Meng Rungang Gao Yanyan Wang Jing Chai Zhi Yang Eric siu-wai Kong Yafei Zhang Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science & TechnologyShanghai Jiao Tong University

A facile route for the large scale production of graphene oxide(GO) papers and their mechanical enhancement has been presented in this work. The novel paper-like GO made from individual GO sheets in aqueous suspension can be achieved in large scale by a simple drop casting method on hydrophobic *** enhancement in mechanical stiffness(341%) and fracture strength(234%) of GO paper have been achieved upon modification with a small amount(less than 10 wt%) of glutaraldehyde(GA). The cross-linking reaction takes place between hydroxyl groups on the surface of GO and aldehyde groups of GA, through forming hemiacetal structure, which can result in distinct mechanical enhancement of the GO papers.

关键词： Graphene oxide paper Glutaraldehyde Cross-linking Mechanical enhancement

Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong

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Journal of Geriatric Cardiology 2016年第5期13卷 415-419页

作者： Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong siu wai Tang The Nethersole School of Nursing: Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Cardiac Rehabilitation Centre Tung Wah Eastern Hospital Hong Kong China

Background Heart failure （HF） is a physically and socially debilitating disease that carries the burden of hospital re-admission and mortality. As an aging society, Hong Kong urgently needs to find ways to reduce the hospital readmission of HF patients. This study evaluates the effects of a nurse-led HF clinic on the hospital readmission and mortality rates among older HF patients in Hong Kong. Methods This study is a retrospective data analysis that compares HF patient in a nurse-led HF clinic in Hong Kong compared with HF patients who did not attend the clinic. The nurses of this clinic provide education on lifestyle modification and symptom monitoring, as well as titrate the medications and measure biochemical markers by following established protocols. This analysis used the socio-demographic and clinical data of HF patients who were aged 〉 65 years old and stayed in the clinic over a six-month period. Results The data of a total of 78 HF patients were included in this data analysis. The mean age of the patients was 77.38 ± 6.80 years. Approximately half of the HF patients were male （51.3%）, almost half were smokers （46.2%）, and the majority received 〈 six years of formal education. Most of the HF patients （87.2%） belonged to classes II and III of the New York Heart Association Functional Classification, with a mean ejection fraction of 47.15± 20.31 mL. The HF patients who attended the clinic （n = 38, 75.13 ± 5.89 years） were significantly younger than those who did not attend the clinic （n = 40, 79.53 ± 6.96 years）（P = 0.04）, and had lower recorded blood pressure. No other statistically significant difference existed between the socio-demographic and clinical characteristics of the two groups. The HF patients who did not attend the nurse-led HF clinic demonstrated a significantly higher risk of hospital readmission [odd ratio （OR）： 7.40; P 〈 0.01] than those who attended after adjusting for the effect of age and blood pressure. In addition, HF patients who att

关键词： Heart failure Hospital readmission Mortality Nurse-led clinic