Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy

作     者：Wai Ki Wong Bohan Yin Anel Rakhmatullina Jingying Zhou Siu Hong Dexter Wong 

作者机构：Department of BioengineeringImperial College LondonLondon SW72AZUnited Kingdom Department of Biomedical EngineeringThe Hong Kong Polytechnic UniversityKowloonHong KongChina School of Biomedical SciencesThe Chinese University of Hong KongShatinHong KongChina 

出 版 物：《Engineered Regeneration》 (再生工程(英文))

年 卷 期：2021年第2卷第1期

页      面：70-81页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the start-up funding(A0033912)from the Department of Biomedical Engineering Start-up Fund for RAPs under the Strategic Hiring Scheme(0035876) the Hong Kong Polytechnic University(University Grant Council),for supporting this work 

主　　题：T-cell mechanobiology Dynamic nanobiomaterials Adoptive T-cell immunotherapy T-Ligand presentation 

摘      要：Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the *** outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor ***,such interaction is often not optimal in vivo and results in low therapeutic *** reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell *** this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.