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Protein & Cell 2024年第2期15卷 149-155页

作者： Juan Zhang Dingfeng li Keqiang He Qiang liu Zhongwen Xie School of life Sciences Anhui Agricultural UniversityHefei 230036China State Key Laboratory of Tea Plant Biology and Utilization School of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei230036China Division of life Sciences and Medicine Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of Anesthesiology The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Biomedical Aging Research University of Science and Technology of ChinaHefei 230026China Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The main function of mitochondria is to produce energy in the form of ATP,which is vital to fulfill high energy demand of neurons,mainly for synaptic processes(Lee et al.,2018).Mitochondrial dysfunction acts as a key factor for age-related cognitive decline(Grimm and Eckert,2017).

关键词： function trapping

Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

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Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： Dan li Jinning Jia Haibo Zeng Xiaoyan Zhong Hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. while a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

A single micro-LED manipulation system based on micro-gripper

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Nanotechnology and Precision Engineering 2024年第2期7卷 45-52页

作者： Jie Bai Pingjuan Niu Erdan Gu Jianming li Clarence Augustine TH Tee School of Mechanical Engineering Tiangong University School of Electronic and Information Engineering Tiangong University Institute of Photonics University of Strathclyde Tianjin Key Laboratory of Micro Low Gravity Environment Simulation Technology Tianjin Aerospace Electromechanical Equipment Research Institute Department of Electrical and Information Engineering School of Physics and Electrical Information EngineeringZhejiang Normal University

Micro-LEDs(μLEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μLED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μLED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μLED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. Traditional grippers are too large to manipulate μLEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μLED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μLED arrays.

关键词： Micro-gripper Micro-LED Transfer printing Manipulation

Effects of drive imbalance on the particle emission from a Bose-Einstein condensate in a one-dimensional lattice

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Chinese Physics B 2024年第3期33卷 238-243页

作者：赖龙泉李照 School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730China

Time-periodic driving has been an effective tool in the field of nonequilibrium quantum dynamics,which enables precise control of the particle *** investigate the collective emission of particles from a Bose-Einstein condensate in a one-dimensional lattice with periodic drives that are separate in modulation amplitudes and relative *** addition to the enhancement of particle emission,we find that amplitude imbalances lead to energy shift and band broadening,while typical relative phases may give rise to similar *** results offer insights into the specific manipulations of nonequilibrium quantum systems with tone-varying drives.

关键词： Bose-Einstein condensate particle emission periodic drive

The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier

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Food Science and Human wellness 2024年第2期13卷 999-1010页

作者： Dejiang Xue Shuai Jiang Miao Zhang Kai Shan RenéLametsch Chunbao li Key Laboratory of Meat Processing and Quality Control Ministry of EducationKey Laboratory of Meat ProcessingMinistry of Agriculture and Rural AffairsJiangsu Collaborative Innovation Center of Meat ProductionProcessing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Department of Food Science University of CopenhagenFrederiksberg C DK-1958Denmark

Hemoglobin hydrolysate is derived from the enzymatic degradation of *** work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver *** found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 *** iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative *** the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis *** addition,hemoglobin hydrolysate enhanced the hepatic antioxidant *** together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.

关键词： Hemoglo bin hydrolysate Non-heme iron Absorption liver homeostasis Hepcidin

Trench gate GaN IGBT with controlled hole injection efficiency

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 10-16页

作者： Huang Yi li Yueyue Gao Sheng wang Qi liu Bin Han Genquan School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Electronic Science and Engineering Nanjing UniversityNanjing 210008China School of Microelectronics Xidian UniversityXi’an 710126China

In this paper,a novel trench gate gallium nitride(GaN)insulated gate bipolar transistor(GaN IGBT),in which the collector is divided into multiple regions to control the hole injection efficiency,is designed and theoretically *** incorporation of a P+/P-multi-region alternating structure in the collector region mitigates hole injection within the collector *** the device is in forward conduction,the conductivity modulation effect results in a reduced storage of carriers in the drift *** a result,the number of carriers requiring extraction during device turn-off is minimized,leading to a faster turn-off *** results illustrate that the GaN IGBT with controlled hole injection efficiency(CEH GaN IGBT)exhibits markedly enhanced performance compared to conventional GaN IGBT,showing a remarkable 42.2%reduction in turn-off time and a notable 28.5%decrease in turn-off loss.

关键词： gallium nitride insulated gate bipolar transistor(GaN IGBT) hole injection trench gate turn-off loss

Manufacture the conducting polymer with light

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Science China Chemistry 2024年

作者： Yang li Tianyu li Yan Ji Baoguang liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene)(PEDOT), heralded as the“king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

关键词：

Immune landscape and response to oncolytic virus-based immunotherapy

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Frontiers of Medicine 2024年第3期18卷 411-429页

作者： Chaolong lin wenzhong Teng Yang Tian Shaopeng li Ningshao Xia Chenghao Huang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryDepartment of Laboratory MedicineSchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsXiamen UniversityXiamen361102China

Oncolytic virus(OV)-based immunotherapy has emerged as a promising strategy for cancer treatment,offering a unique potential to selectively target malignant cells while sparing normal ***,the immunosuppressive nature of tumor microenvironment(TME)poses a substantial hurdle to the development of OVs as effective immunotherapeutic agents,as it restricts the activation and recruitment of immune *** review elucidates the potential of OV-based immunotherapy in modulating the immune landscape within the TME to overcome immune resistance and enhance antitumor immune *** examine the role of OVs in targeting specific immune cell populations,including dendritic cells,T cells,natural killer cells,and macrophages,and their ability to alter the TME by inhibiting angiogenesis and reducing tumor ***,we explore strategies to optimize OV-based drug delivery and improve the efficiency of OV-mediated *** conclusion,this review offers a concise and comprehensive synopsis of the current status and future prospects of OV-based immunotherapy,underscoring its remarkable potential as an effective immunotherapeutic agent for cancer treatment.

关键词： oncolytic virus immunotherapy immunotherapeutic agents immune landscape

Physical-Layer Secret Key Generation for Dual-Task Scenarios

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China Communications 2024年第7期21卷 252-266页

作者： Yang lilin li Guyue Guo Tao Xu Hao Hu Aiqun School of Cyber Science and Engineering Southeast UniversityNanjing 210096China Purple Mountain Laboratories Nanjing 210096China Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China

Physical-layer secret key generation(PSKG)provides a lightweight way for group key(GK)sharing between wireless users in large-scale wireless ***,most of the existing works in this field consider only group *** a commonly dual-task scenario,where both GK and pairwise key(PK)are required,traditional methods are less suitable for direct *** the first time,we discover a security issue with traditional methods in dual-task scenarios,which has not previously been *** propose an innovative segment-based key generation method to solve this security *** do not directly use PK exclusively to negotiate the GK as traditional ***,we generate GK and PK separately through segmentation which is the first solution to meet *** also perform security and rate *** is demonstrated that our method is effective in solving this security issue from an information-theoretic *** rate results of simulation are also consistent with the our rate derivation.

关键词： dual-task scenario information-theoretic security physical layer security secret group key generation

Predicting microseismic,acoustic emission and electromagnetic radiation data using neural networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 616-629页

作者： Yangyang Di Enyuan wang Zhonghui li Xiaofei liu Tao Huang Jiajie Yao School of Materials Engineering Changshu Institute of TechnologySuzhou215506China Key Laboratory of Gas and Fire Control for Coal Mines(China University of Mining and Technology) Ministry of EducationXuzhou221116China School of Safety Engineering China University of Mining and TechnologyXuzhou221116China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou221116China

Microseism,acoustic emission and electromagnetic radiation(M-A-E)data are usually used for predicting rockburst ***,it is a great challenge to realize the prediction of M-A-E *** this study,with the aid of a deep learning algorithm,a new method for the prediction of M-A-E data is *** this method,an M-A-E data prediction model is built based on a variety of neural networks after analyzing numerous M-A-E data,and then the M-A-E data can be *** predicted results are highly correlated with the real data collected in the *** field verification,the deep learning-based prediction method of M-A-E data provides quantitative prediction data for rockburst monitoring.

关键词： Microseism Acoustic emission Electromagnetic radiation Neural networks Deep learning Rockburst