Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain

作     者：Juan Zhang Dingfeng Li Keqiang He Qiang Liu Zhongwen Xie Juan Zhang;Dingfeng Li;Keqiang He;Qiang Liu;Zhongwen Xie

作者机构：School of Life SciencesAnhui Agricultural UniversityHefei 230036China State Key Laboratory of Tea Plant Biology and UtilizationSchool of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei230036China Division of Life Sciences and MedicineHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of AnesthesiologyThe First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Biomedical Aging ResearchUniversity of Science and Technology of ChinaHefei 230026China Center for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2024年第15卷第2期

页      面：149-155页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.82125009,U19A2034,31871082,91849101,32121002,82071185,32100794 and 92149303) the National Key R&D Program of China (2020YFA0509300,2021YFA0804900) the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000) CAS Project for Young Scientists in Basic Research (YSBR-013) Collaborative Innovation Program of Hefei Science Center,CAS (2022HSC-CIP003) the Fundamental Research Funds for the Central Universities (YD2070002011,WK2070000168) Institute of Health and Medicine,Hefei Comprehensive National Science Center (QYZD20220003) 

主　　题：function trapping 

摘      要：DearEditor,Brain aging is associated with a decrease in cognitive function,which is often accompanied by defective changes in mitochondrial morphology and reduction in mitochondrial function(Faitg et al.,2021).The main function of mitochondria is to produce energy in the form of ATP,which is vital to fulfill high energy demand of neurons,mainly for synaptic processes(Lee et al.,2018).Mitochondrial dysfunction acts as a key factor for age-related cognitive decline(Grimm and Eckert,2017).