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LR members in inflammation-associated arcinogenesis

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Cellular & Molecular Immunology 2017年第5期14卷 403-405页

作者： ha Zhu Xuetao Cao Institute of Immunology Zhejiang University School of Medicine Hangzhou 310058 China National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Med- ical University Shanghai 200433 China Department of Immunology & Center for Immu- notherapy Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China

Chronic inflammation is regarded as an impor- tant factor in cancer progression. In addition to the immune surveillance function in the early stage of tumorigenesis, inflammation is also known as one of the hallmarks of cancer and can supply the tumor microenvironment with bioactive mole- cules and favor the development of other hallmarks of cancer, such as genetic instability and angiogen- esis, Moreover,

关键词： NLR members inflammation-associated carcinogenesis

不同土壤改良技术对设施番茄生长及果实品质的影响

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北方园艺 2024年第17期 43-50页

作者：哈蓉陈永伟靳韦徐灿张敏王昊宁夏农垦农林牧技术推广服务中心宁夏银川750004

以大果番茄“普罗旺斯”为试材,采用测定多项生理指标并进行主成分分析的方法,研究了不同土壤改良技术对设施番茄营养生长和果实品质的影响,以期为提高设施番茄生长发育、改善果实品质提供参考依据。结果表明:土壤中阳离子交换量、碱解... 详细信息

以大果番茄“普罗旺斯”为试材,采用测定多项生理指标并进行主成分分析的方法,研究了不同土壤改良技术对设施番茄营养生长和果实品质的影响,以期为提高设施番茄生长发育、改善果实品质提供参考依据。结果表明:土壤中阳离子交换量、碱解氮、速效钾、钙等微量元素和有机质含量显著增加,SH效果较好。番茄株高、茎粗、叶片面积的生长发育速率均高于对照;根系长度、粗度在SH处理下最好,根系鲜质量、干质量在SB处理下最高。各试验处理均增加了果实纵横径和产量,EB效果最为明显,产量增加40.98%;果实中糖分和营养物质含量均高于对照,氨基酸总量以SH处理最高为10.35 g·kg^(-1),营养价值最高。结合主成分综合分析,在SH处理下番茄生长和品质最佳。综上,设施内应用土壤改良技术,可改善土壤理化性质,缓解土壤障碍,对番茄根系和植株有一定促生作用,以太阳热处理效果最佳。

关键词：土壤改良设施番茄生长发育营养品质氨基酸

Endoscopic resection of gastric and esophageal cancer

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Gastroenterology Report 2015年第4期3卷 330-338,I0002页

作者： Bryan Balmadrid Joo ha Hwang Division of Gastroenterology University of WashingtonSeattleWAUSA

Endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)techniques have reduced the need for surgery in early esophageal and gastric cancers and thus has lessened morbidity and mortality in these *** is a relatively new technique in western countries and requires rigorous training to reproduce the proficiency of Asian countries,such as Korea and Japan,which have very high complete(en bloc)resection rates and low complication *** plays a valuable role in early esophageal *** has shown better en bloc resection rates but it is easier to master and maintain proficiency in EMR;it also requires less procedural *** early esophageal adenocarcinoma arising from Barrett’s,ESD and EMR techniques are usually combined with other ablative modalities,the most common being radiofrequency ablation because it has the largest dataset to prove its *** EMR techniques have been used with some success in early gastric cancers but ESD is currently preferred for most of these *** has the added advantage of resecting into the submucosa and thus allowing for endoscopic resection of more aggressive(deeper)early gastric cancer.

关键词： endoscopic submucosal dissection endoscopic mucosal resection endoscopic ablation early gastric cancer early esophageal cancer

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融合特征优化的跨数据集高光谱图像分类

中国图象图形学报 2024年第8期29卷 2175-2187页

作者：马晓瑞哈林谌敦斌梅亮王洪玉大连理工大学信息与通信工程学院大连116024 大连理工大学光电工程与仪器科学学院大连116024

目的高光谱图像分类可实现对地物目标的逐像素识别,是对地观测中的关键技术。由于采集环境变迁与成像设备差异等因素的影响,不同高光谱图像特征分布偏移,影响现有模型的跨数据集分类精度。针对此,提出了一种融合特征优化的无监督跨数据... 详细信息

目的高光谱图像分类可实现对地物目标的逐像素识别,是对地观测中的关键技术。由于采集环境变迁与成像设备差异等因素的影响,不同高光谱图像特征分布偏移,影响现有模型的跨数据集分类精度。针对此,提出了一种融合特征优化的无监督跨数据集高光谱图像分类方法。方法提出了基于奇异值抑制的特征均衡策略实现数据内独立优化,通过限制奇异值正则项兼顾特征的可迁移性与可鉴别性;提出了基于隐式增广的特征匹配策略实现数据间特征协同优化,引导源域特征逼近目标域提高模型的泛化性;设计了基于隐式鉴别器的对抗学习框架实现数据间特征类别级优化,提高了预测多样性,实现跨数据集分类。结果实验在Pavia数据集组和HyRANK数据集组上进行,与多种最新的跨数据高光谱图像分类方法进行了对比,在Pavia数据集组中,相比于性能第2的模型,总体精度、平均精度和к系数分别提高了1.75%、3.55%和2.17%;在HyRANK数据集组中,相比于性能第2的模型,总体精度、平均精度和к系数分别提高了6.58%、13.10%和7.96%。同时进行了消融实验,研究了各个模块对高光谱图像分类效果的影响。实验结果表明,每一模块在提高高光谱图像分类效果方面都是有效的。结论本文提出的融合特征优化的跨数据集高光谱图像分类方法可以在无监督的条件下显著提高跨数据集高光谱图像分类精度,提高分类预测的多样性,得到更好的分类效果。

关键词：高光谱图像分类跨数据集分类特征优化领域自适应无监督分类域对抗网络

An Automatically Filtering Blacklist Model of Social Network Based on Semantic Web

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Journal of harbin Institute of Technology(New Series) 2014年第6期21卷 67-73页

作者： Le ha Guo-Zi Sun College of Computer Nanjing University of Posts & Telecommunications Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks

According to the features of the semantic web technology,it is very suitable to solve the security issue of the current social network ***,in this paper,it extends the existing ontology model of the social network with some relevant classes,and introduces a brand new ontology which is used to represent the malicious *** introducing these models,a method of identifying the malicious message is ***,the experiments and simulations analyze the feasibility of the whole *** results validate that the malicious users can be automatically filtered,and some worthy digital evidence can be effectively provided to forensic investigators.

关键词： social network semantic web ontology OWL digital evidence

益生菌及其代谢产物调控胰高血糖素样肽-1缓解2型糖尿病的研究进展

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食品科学 2024年第12期45卷 292-303页

作者：程之梁张钰龙杨涵哈惠王潆笛陈菲菲刘飞焦月华东北农业大学食品学院乳品科学教育部重点实验室黑龙江哈尔滨150030 黑龙江中医药大学药物安全性评价中心黑龙江哈尔滨150040

2型糖尿病(type 2 diabetes mellitus,T2DM)是一种由碳水化合物摄入与代谢不平衡导致的慢性代谢性疾病,是当前全球最难治疗的代谢性疾病之一。患者主要表现出高血糖、胰岛素分泌不足、胰岛素抵抗、多食多饮多尿等症状。T2DM常伴随着很... 详细信息

2型糖尿病(type 2 diabetes mellitus,T2DM)是一种由碳水化合物摄入与代谢不平衡导致的慢性代谢性疾病,是当前全球最难治疗的代谢性疾病之一。患者主要表现出高血糖、胰岛素分泌不足、胰岛素抵抗、多食多饮多尿等症状。T2DM常伴随着很多并发症如动脉粥样硬化、肾功能损伤、非酒精性脂肪性肝病等。胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种由31个氨基酸组成的多肽,主要用于维持体内葡萄糖稳态和缓解T2DM,但是其半衰期较短,在体内很容易被降解。本文先介绍了益生菌及其对宿主体内GLP-1有调控作用的代谢产物,并介绍了GLP-1对T2DM的缓解作用,包括GLP-1与T2DM的联系、二甲双胍与GLP-1激动剂的临床应用、GLP-1对T2DM缓解作用的不足以及相关益生元对GLP-1含量的调控;最后介绍了益生菌及其代谢产物对GLP-1的调控机制,其中包括短链脂肪酸、胆汁酸、色氨酸及其衍生物和胞外多糖,以期为益生菌及其代谢产物调控宿主GLP-1的产生与释放,并对T2DM的缓解作用方面的研究提供一定的参考。

关键词： 2型糖尿病益生菌胰高血糖素样肽-1 代谢产物

Optimal Spatial Allocation of Initial Attack Resources for Firefighting in the Republic of Korea Using a Scenario Optimization Model

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Journal of Mountain Science 2014年第2期11卷 323-335页

作者： Yohan LEE Byungdoo LEE Kyung ha KIM Korea Rural Economic Institute 117-3 Hoegi-ro Dongdeamun-guSeoul 130-710 South Korea Korea Forest Research Institute Hoegiro 57 Dongdaemun-guSeoul 130-712 South Korea

【Title】 This study explores the optimal spatial allocation of initial attack resources for firefighting in the Republic of Korea. To improve the effectiveness of Korean initial attack resources with a range of policy goals, we create a scenario optimization model that minimizes the expected number of fires not receiving a predefined response. In this study, the predefined response indicates the number of firefighting resources that must arrive at a fire before the fire escapes and becomes a large fire. We use spatially explicit GIS-based information on the ecology, fire behavior, and economic characterizations important in Korea. The data include historical fire events in the Republic of Korea from 1991 to 2007, suppression costs, and spatial information on forest fire extent. Interviews with forest managers inform the range of we address in the decision model. Based on the geographic data, we conduct a sensitivity analysis by varying the parameters systematically. Information on the relative importance of the components of the settings helps us to identify “rules of thumb” for initial attack resource allocations in particular ecological and policy settings.

关键词： Spatial allocation Initial attack Firefighting The Republic of Korea Senario optimization

Detection of Chlamydophila psittaci from feral pigeons in environmental samples:problems with currently available techniques

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Integrative Zoology 2010年第1期5卷 63-69页

作者： Ila GEIGENFEIND Daniel ha AG-WACK ERNAGEL Department of Biomedicine Institute of AnatomyUniversity of BaselBaselSw itzerland

Chlamydophila psittaci(Lillie,1930)Everett et al.,1999,the pathogenic agent of human ornithosis,is widespreadin feral pigeon populations and many cases of transmission from feral pigeons to humans have been *** of the present study was to detect *** in environmental samples to find out more about possibletransmission routes and,therefore,to assess the zoonotic risk for *** samples were collected from nestboxes in a feral pigeon ***,samples were taken from the feather dust film covering the water surface ofpublic fountains where pigeons regularly *** samples were tested for the presence of chlamydial antigenusing an antigen enzyme-linked immunosorbent assay to prove shedding of *** by feral *** testdetects a genus specific lipopolysaccharide in the outer membrane of the chlamydial *** were testedusing the IDEIA PCE Chlamydia Test kit(DakoCytomation)and positive results were verified with IDEIA ChlamydiaBlocking Reagents(DakoCytomation).The IDEIA PCE Chlamydia Test yields a high proportion of positive ***,when IDEIA Chlamydia Blocking was performed,most of the positive results turned out to be negative orcould not be *** conclude that antigen-enzyme-linked immunosorbent assay tests are not suitable fordetecting *** in environmental *** publications where no blocking test was used should bereconsidered critically.

关键词： antigen-enzyme-linked immunosorbent assay Chlamydophila psittaci Columba livia environmen-tal samples zoonosis

Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development

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Bone Research 2013年第2期1卷 146-161页

作者： ha-Young Kim Subburaman Mohan Musculoskeletal Disease Center Loma Linda VA HealthCare System Departments of Medicine Loma Linda University Division of Endocrinology Department of Internal MedicineWonkwang University Sanbon Hospital

The importance of the thyroid hormone axis in the regulation of skeletal growth and maintenance has been well established from clinical studies involving patients with mutations in proteins that regulate synthesis and/or actions of thyroid hormone. Data from genetic mouse models involving disruption and overexpression of components of the thyroid hormone axis also provide direct support for a key role for thyroid hormone in the regulation of bone metabolism. Thyroid hormone regulates proliferation and/or differentiated actions of multiple cell types in bone including chondrocytes, osteoblasts and osteoclasts. Thyroid hormone effects on the target cells are mediated via ligand-inducible nuclear receptors/transcription factors, thyroid hormone receptor （TR） a and ~, of which TRa seems to be critically important in regulating bone cell functions. In terms of mechanisms for thyroid hormone action, studies suggest that thyroid hormone regulates a number of key growth factor signaling pathways including insulin-like growth factor-I, parathyroid hormone related protein, fibroblast growth factor, Indian hedgehog and Wnt to influence skeletal growth. In this review we describe findings from various genetic mouse models and clinical mutations of thyroid hormone signaling related mutations in humans that pertain to the role and mechanism of action of thyroid hormone in the regulation of skeletal growth and maintenance.

关键词： thyroid hormone bone cartilage growth factors bone cells