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Nonalcoholic Fatty Liver Disease in Lean/Nonobese and Obese Individuals:A Comprehensive Review on Prevalence,Pathogenesis,Clinical Outcomes,and Treatment

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 502-515页

作者： Ankoor H.Patel Dhiraj Peddu Sahil Amin Mohamed I.Elsaid Carlos D.Minacapelli Toni-Marie Chandler Carolyn Catalano vinod k.rustgi Department of Medicine Division of Gastroenterology and HepatologyRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Center for Liver Diseases and Masses Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Department of Biomedical Informatics College of MedicineThe Ohio State UniversityColumbusOHUSA Secondary Data Core Center for BiostatisticsCollege of MedicineThe Ohio State UniversityColumbusOHUSA

Nonalcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,with an estimated prevalence of 25% *** is closely associated with metabolic syndrome,which are both becoming increasingly more common with increasing rates of insulin resistance,dyslipidemia,and *** NAFLD is strongly associated with obesity,lean or nonobese NAFLD is a relatively new phenotype and occurs in patients without increased waist circumference and with or without visceral ***,there is limited literature comparing and illustrating the differences between lean/nonobese and obese NAFLD patients with regard to risk factors,pathophysiology,and clinical *** this review,we aim to define and further delineate different phenotypes of NAFLD and present a comprehensive review on the prevalence,incidence,risk factors,genetic predisposition,and ***,we discuss and compare the clinical outcomes,such as insulin resistance,dyslipidemia,hypertension,coronary artery disease,mortality,and progression to nonalcoholic steatohepatitis,among lean/nonobese and obese NAFLD ***,we summarize the most up to date current management of NAFLD,including lifestyle interventions,pharmacologic therapies,and surgical options.

关键词： NAFLD Lean or nonobese nonalcoholic fatty liver disease Obese nonalcoholic fatty liver disease Clinical outcomes Treatment Incidence Prevalence Risk factors

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Plant-available water capacity of soils at a regional scale:Analysis of fixed and dynamic field capacities

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Pedosphere 2024年第3期34卷 590-605页

作者： vinod PHOGAT Paul RPETRIE Casandra COLLINS Marcos BONADA South Australian Research and Development Institute GPO Box 397Adelaide SA 5001(Australia) School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideWaite CampusPMB1Glen Osmond SA 5064(Australia) College of Science and Engineering Flinders UniversityBedford Park SA 5042(Australia) The University of New South Wales Sydney NSW 2052(Australia) ARC Training Centre for Innovative Wine Production University of AdelaidePMB1Glen Osmond SA 5064(Australia)

Estimation of the plant-available water capacity(PAWC)of soils at a regional scale helps in adopting better land use planning,developing suitable irrigation schedules for crops,and optimizing the use of scarce water *** the current study,72 soil profiles were sampled from the Barossa region of South Australia to estimate pedo-transfer functions deduced from easily estimated soil *** functions were then used to estimate the fixed(10 and 33 kPa)and dynamic pressure head(h_(fc))water contents at field capacity(FC)for minimum drainage flux(0.01 and 0.001 cm d^(-1)),which serves as the upper boundary for plant-available water in *** estimated residual water content was corrected for subsoil constraints,especially the exchangeable sodium percentage(ESP).The results showed that the mean values of h_(fc)in sand-dominated light and medium textured soils(i.e.,sand,loamy sand,sandy loam,and loam)varied in a narrow range(15.8-18.2 kPa),whereas those in the clay-dominated heavy textured soils(i.e.,clay loam)showed a wide range(11.3-49.3 kPa).There were large differences in PAWC for dynamic FC(PAWC_(fc))and fixed FC at 10 kPa(PAWC10),33 kPa(PAWC33),and a mix of 10and 33 kPa(PAWC_(10,33))pressure heads depending on soil ***,the difference between PAWC at 10 kPa and h_(fc)(ΔPAWC_(10))was positive,whereas that between 33 kPa and h_(fc)(ΔPAWC_(33))was negative across all ***,the estimation of PAWC assuming a fixed FC at 10 and 33 kPa pressures(i.e.,PAWC_(10,33))for sandy,clay,and silty soils reduced the difference between fixed and dynamic pressure PAWCs to<10% across the *** estimation of PAWC was improved by incorporating the impact of subsoil constraints,such as high ESP,which was more pronounced for clay and silty *** findings demonstrate the inherent inconsistencies between static pressure and flux-based dynamic FC estimations in *** heterogeneity,intra-texture variability,subsoil constraints,and swell

关键词： crop lower limit drained upper limit pedo-transfer function soil hydraulic parameter soil texture

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Fine-tuning electronic structure of N-doped graphitic carbon-supported Co-and Fe-incorporated Mo_(2)C to achieve ultrahigh electrochemical water oxidation activity

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Carbon Energy 2024年第7期6卷 134-149页

作者： Md.Selim Arif Sher Shah Hyeonjung Jung vinod k.Paidi kug-Seung Lee Jeong Woo Han Jong Hyeok Park Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea Department of Chemistry University of North BengalRaja RammohunpurDarjeelingWest BengalIndia Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Pohang Accelerator Laboratory Beamline DivisionPohangRepublic of Korea European Synchrotron Radiation Facility France

Mo_(2)C is an excellent electrocatalyst for hydrogen evolution reaction(HER).However,Mo_(2)C is a poor electrocatalyst for oxygen evolution reaction(OER).Herein,two different elements,namely Co and Fe,are incorporated in Mo_(2)C that,therefore,has a finely tuned electronic structure,which is not achievable by incorporation of any one of the ***,the resulting electrocatalyst Co_(0.8)Fe_(0.2)-Mo_(2)C-80 displayed excellent OER catalytic performance,which is evidenced by a low overpotential of 214.0(and 246.5)mV to attain a current density of 10(and 50)mA cm^(-2),an ultralow Tafel slope of 38.4 mV dec^(-1),and longterm stability in alkaline *** data demonstrates that Co_(0.8)Fe_(0.2)-Mo_(2)C-80 requires the lowest overpotential(1.00 V)for OER and Co centers to be the active *** ultrahigh catalytic performance of the electrocatalyst is attributed to the excellent intrinsic catalytic activity due to high Brunauer-Emmett-Teller specific surface area,large electrochemically active surface area,small Tafel slope,and low chargetransfer resistance.

关键词： fine-tuning electronic structures heteronanostructures Mo_(2)C multimetal(Co/Fe) oxygen evolution reaction

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Application of Response Surface Methodology for Analysing and Optimizing the Finned Solar Air Heater

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Journal of Thermal Science 2024年第3期33卷 985-1009页

作者： Vineet SINGH vinod Singh YADAV Vaibhav TRIVEDI Manoj kUMAR Niraj kUMAR Department of Mechanical Engineering School of Engineering&TechnologyIFTM UniversityMoradabadUttar PradeshIndia Department of Mechanical Engineering NITUttarakhandPauriUttarakhandIndia Department of Electronics and Communication Engineering Jaypee Institute of Information TechnologyNoidaUttar Pradesh201309India

In this research paper,a solar air heater with triangular fins has been experimentally analysed and ***,an experimental set-up of a solar air heater having triangular fins has been developed at the location of 28.10°N,78.23°*** heat transfer rate through fins and fins efficiency has been determined by the Finite Difference Method model *** experimental data and modeled data of response parameters have been optimized in MINITAB-17 software by the Response Surface Methodology *** creating the response surface design,three input parameters have been selected namely solar intensity,Reynolds number,and fin base-to-height *** range of solar intensity,Reynolds number,and fin base-to-height ratio is 600 to 1000W/m^(2),4000 to 6000,and 0.4 to 0.8 *** response surface design has been analyzed by calculating the outlet temperature,friction factor,Nusselt number,fin efficiency,thermal performance factor,and exergy *** optimum settings of input parameters:solar intensity is 1000 W/m^(2);Reynolds number is 4969.7,and the fin base to height ratio is 0.6060,on which these response:namely outlet temperature of 92.531℃,friction factor of 0.2350,Nusselt number of 127.761,thermal efficiency of 50.836%,thermal performance factor of 1.4947,and exergy efficiency of 8.762%.

关键词： solar air heater optimization fins exergy response surface methodology air

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Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu vinod kumar kajal kamboj Ashok kumar Pannu Ashok kumar Yadav Mandip Bhatia Atul Saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of Experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue Cytokine Doxycycline Serum ferritin C reactive protein

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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra kashyap Nidhi Varshney Tarun Prakash Verma Ajay kumar Jain Debi Chatterji vinod kumar Amit Mishra Awanish kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

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Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443,I0009页

作者： Lucas Hanssens Maarten Houlleberghs C.vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.M.Denayer Christine E.A.kirschhock Johan A.Martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team(COk-kAT) 3001 LeuvenBelgium NMR/X-Ray Platform for Convergence Research(NMRCoRe) 3001 LeuvenBelgium Centre for Ordered Materials Organometallics and Catalysis(COMOC)Department of ChemistryGhent University9000 GhentBelgium Department of Chemical Engineering Vrije Universiteit Brussel1050 BrusselBelgium

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH_(4)/CO_(2) exchange Direct gas exchange

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Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

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Cancer Pathogenesis and Therapy 2024年第2期2卷 65-73页

作者： Rachitha Singhabahu Sujani M[]kodagoda Gamage vinod Gopalan Cancer Molecular Pathology School of MedicineGrifth UniversityGold Coast Queensland 422Australia Faculty of Health Sciences and Medicine Bond UniversityRobina 4226Australia

The significance of the heme-metabolizing enzyme heme oxygenase-1(HMOx1)in the pathogenesis of colorectal cancer(CRC)has not been fully ***1 cytoprotection is imperative to limit oxidative ***,its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly *** study re-views various mechanisms associated with the paradoxical role of HMOx1,which is advantageous for tumor growth,refractoriness,and survival of cancer cells amid oxidative stress in heme-induced *** alternate role of HMOx1 promotes cell proliferation and metastasis through immune modulation and *** HMOx1 has been found to reverse tumor ***,HMOx1 acts as a conditional tumor promoter in CRC pathogenesis.

关键词： Heme Carcinogenesis Colorectal cancer HMOX1 Promoter

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Database Search Behaviors: Insight from a Survey of Information Retrieval Practices

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Intelligent Information Management 2024年第5期16卷 195-218页

作者： Babita Trivedi Brijender Dahiya Anjali Maan Rajesh Giri vinod Prasad Department of Physics Swami Shraddhanand College University of Delhi Delhi India Department of Physics Pt.N.R.S.G.C. Rohtak Maharshi Dayanand University Rohtak India Department of Physics Rajdhani College University of Delhi Delhi India

This study examines the database search behaviors of individuals, focusing on gender differences and the impact of planning habits on information retrieval. Data were collected from a survey of 198 respondents, categorized by their discipline, schooling background, internet usage, and information retrieval preferences. key findings indicate that females are more likely to plan their searches in advance and prefer structured methods of information retrieval, such as using library portals and leading university websites. Males, however, tend to use web search engines and self-archiving methods more frequently. This analysis provides valuable insights for educational institutions and libraries to optimize their resources and services based on user behavior patterns.

关键词： Information Retrieval Database Search User Behavior Patterns

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COVID-19 status quo:Emphasis on gastrointestinal and liver manifestations

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World Journal of Gastroenterology 2021年第46期27卷 7969-7981页

作者： Abhishek Bhurwal Carlos D Minacapelli Evan Orosz kapil Gupta Christopher Tait Ishita Dalal Clark Zhang Eric Zhao vinod k.rustgi Department of Medicine Division of Gastroenterology and HepatologyRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Center for Liver Diseases and Masses Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

The coronavirus disease 2019(COVID-19)has caused one of the worst public health crises in modern *** though severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory tract,gastrointestinal manifestations are well described in *** review will discuss the epidemiology,virology,manifestations,immunosuppressant states,and lessons learned from ***:At the time of writing,COVID-19 had infected more than 111 million people and caused over 2.5 million deaths *** medical comorbidities including obesity,pre-existing liver condition and the use of proton pump inhibitor have been described as risk factor for severe ***-19 most frequently causes diarrhea(12.4%),nausea/vomiting(9%)and elevation in liver enzymes(15%-20%).The current data does not suggest that patients on immunomodulators have a significantly increased risk of mortality from *** current guidelines from American Gastroenterological Association and American Association for the Study of Liver Diseases do not recommend pre-emptive changes in patients on immunosuppression if the patients have not been infected with *** and relevance:The COVID-19 pandemic has prompted a change in structure and shape of gastroenterology departmental *** should be performed only when necessary and with strict protective *** consultations in the form of telehealth services and home drug deliveries have revolutionized the field.

关键词： COVID-19 Status quo Epidemiology Virology Gastrointestinal manifestations Liver manifestations Immunosuppressed states

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