Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis
Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis作者机构：Cancer Molecular PathologySchool of MedicineGrifth UniversityGold Coast Queensland 422Australia Faculty of Health Sciences and MedicineBond UniversityRobina 4226Australia
出 版 物：《Cancer Pathogenesis and Therapy》 (癌症发生与治疗（英文）)
年 卷 期：2024年第2卷第2期
页 面：65-73页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Heme Carcinogenesis Colorectal cancer HMOX1 Promoter
摘 要：The significance of the heme-metabolizing enzyme heme oxygenase-1(HMOx1)in the pathogenesis of colorectal cancer(CRC)has not been fully ***1 cytoprotection is imperative to limit oxidative ***,its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly *** study re-views various mechanisms associated with the paradoxical role of HMOx1,which is advantageous for tumor growth,refractoriness,and survival of cancer cells amid oxidative stress in heme-induced *** alternate role of HMOx1 promotes cell proliferation and metastasis through immune modulation and *** HMOx1 has been found to reverse tumor ***,HMOx1 acts as a conditional tumor promoter in CRC pathogenesis.
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