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Isolation of aromatic yeasts(non-Saccharomycescerevisiae) from Korean traditional nuruksand identification of fermentation characteristics

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Agricultural Sciences 2013年第5期4卷 136-140页

作者： Choi Ji Ho Soo Hwan Yeo Ji-Hye Park Han Seok Choi Ji-Eun Gang Soo In Kim Seok Tae Jeong So ra Kim Fermentation & Food Processing Division Department of Agro-food Resource NAAS RDA Suwon Korea

Ethyl caproate and isoamyl alcohol are important for the quality of Yakju, one of the Korean traditional alcoholic bev.rages. From Korean traditional fermentation agent, Nuruk, we have isolated 8 yeasts which produced rich aromatic compounds using YEPD agar plates (1% yeast extract, 2% peptone, 2% dextrose, 2% agar) containing 50 uL cerulenin at 30℃. The isolated aromatic yeasts are identified as Pichia anomala (4 strains), Pichia fabianii (2 strains), Pichia farinose (1 strains), Geotrichum candidum (1 strains). We conducted alcohol fermentation with each of the aromatic yeasts and the compounds (ethyl caproate and isoamyl alcohol) producing range were 59.5 - 193.2 ppm and 10.8 - 91.6 ppm respectively. As a control, Fermivin®, famous aromatic wine yeast, was 89.4 ppm and 16.2 ppm respectively. We also find that the isolated Pichia anomala could produce higher level ethanol (4.2% - 5.0%, v/v) than other species (0.4% - 2.2%, v/v). Using the aromatic yeasts in fermentation industries, we expect to improve the quality of traditional alcoholic bev.rages.

关键词： Aromatic Yeast Pichia sp. Yakju Korean Traditional Alcoholic Bev.rage Ethyl Caproate

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环孢素A治疗类风湿关节炎(摘要)

循证医学 2001年第1期1卷 30-31页

作者： Wells G Haguenauer D Shea B Suarez-Almazor M E Welch v A Tugwell P 戴冽

1 背景类风湿关节炎(ra)是以T淋巴细胞激活及白介素产生增多为特点的一种自身免疫性疾病。环孢素是一种具有免疫抑制作用的真菌多肽,能抑制T淋巴细胞和细胞因子的产生,已被应用于器官移植预防排异反应。环孢素作为一种改变病情抗风湿药... 详细信息

1 背景类风湿关节炎(ra)是以T淋巴细胞激活及白介素产生增多为特点的一种自身免疫性疾病。环孢素是一种具有免疫抑制作用的真菌多肽,能抑制T淋巴细胞和细胞因子的产生,已被应用于器官移植预防排异反应。环孢素作为一种改变病情抗风湿药(DMARD)对ra也有效,尤其是其它治疗如注射金制剂、青霉胺或抗疟药无效时。

关键词：环孢素A 药物治疗类风湿关节炎副作用安慰剂

volatile organic compound emission and biochemical properties of degraded Ultisols ameliorated by no tillage and liming

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Pedosphere 2020年第5期30卷 597-606页

作者： Laura GIAGNONI Cosimo TAITI Paloma LEON Corrado COSTA Paolo MENESATTI rafael ESPEJO Clara GOMEZ-PACCARD Chiquinquira HONTORIA Eduardo vAZQUEZ Marta BENITO Stefano MANCUSO Giancarlo RENELLA Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceP.le delle Cascine 18Florence 50144(Italy) Departamento de Production Agraria E.T.S.I.AgrondmicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridAvda.Complutense s/nMadrid 28040(Spain) Consiglio per la Ricerca in Agricoltura e I'Analisi dell'Economia Agraria(CREA)-Unita di Ricerca per ilngegneria Agraria via della Pascolare 16Monterotondo ScaloRM 00015(Italy) Department of Soil Biogeochemistry and Soil Ecology University of BayreuthDr.Hans-Frisch-Strafie 1-3Bayreuth 95448(Germany) University of Padua Department of AgronomyFoodNatural ResourcesAnimals and Environment(DAFNAE)Viale dell'Universita 16Legnaro 35020(Italy)

TTie Ultisols in the rana de Canamero area in Southwest Spain showed aluminum(Al)phytotoxicity,and the clearance of natural vegetation and decades of intensive conventional agriculture caused the deplation of soil organic matter(SOM).Therefore,we studied the long-term effects of no tillage and liming using sugar beet foam(SF)and red gypsum(RG),alone or in combination,on the restoration of Ultisols affected by acidification,Al phytotoxicity,and SOM *** measured the main soil chemical properties,soil microbial biomass,soil enzyme activities involved in carbon,nitrogen,phosphorus,and sulfur mineralization,and the emission of volatile organic compounds(vOCs).The results indicated that liming effectively neutralized the soil acidity in the long term and,in combination with no tillage,significantly increased soil microbial biomass and enzyme ***-three vOCs were detected using the proton transfer reaction-time of flight(PTR-ToF)technique,and both liming and tillage changed the vOC emission *** greatest difference in vOC emission pattern was observed between no-tilled un-amended soils and tilled lime-amended soils,suggesting the activation of different metabolic pathways within the microbial communities of soils under different *** in vOC emission patterns could be attributed to the decomposition of carbohydrates,which were also sustained by the higher enzyme activities in the lime-amended soils.

关键词： carbohydrate decomposition degraded soils long-term field trial soil acidity soil enzyme activities soil microbial biomass soil restoration

Gammasphere上裂变丰中子核核结构若干前沿领域的新进展(Ⅱ:第三和第四部分)(英文)

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原子核物理评论 2010年第3期27卷 363-389页

作者：罗亦孝 J.H.Hamilton J.O.rasmussen A.v.ramayya C.Goodin A.v.Daniel N.J.Stone 朱胜江 J.K.Hwang 刘少华 C.J.Beyer 李科 H.L.Crowell D.Al mehed S.Frauendorf A.Covello v.Di mitrov 张敬业车兴来姜卓 D.Fong A.Gelberg I.Stefanescu A.Gargano E.F.Jones P.M.Gore I.Y.Lee G.M.Ter-Akopian Yu.Ts.Oganessian M.A.Stoyer R.Donangelo 马文超 J.D.Cole J.Kormicki 张学谦 S.C.Wu J.Gilat T.N.Ginter S.J.Asztalos Physics Department Vanderbilt University Nashville TN 37235 USA Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Flerov Laboratory for Nuclear Reactions JINR Dubna Russia Joint Institute for Heavy Ion Research Oak Ridge TN 37831 USA Department of Physics Oxford University Oxford OX1 3PU United Kingdom Department of Physics and Astronomy University of Tennessee Knoxville Tennessee 37996 USA Physics Department Tsinghua University Beijing 100084 China Department of Physics University of Notre Dame Notre Dame IN 46556 USA Institut far Strahlenphysik FZD-Rossendorf Postfach 510119 D-01314 Dresden Germany Dipartimento di Scienze Fisiche Universita di Napoli Federico II and Istituto Nazionale di Fisica Nuclear Complesso Universitario di Monte S. Angelo Via Cintia 80126 Napoli Italy Idaho Accelerator Center Idaho State University Pocatello ID-83209-8263 USA Institut fur Kernphysik Universitat zu Koln 50937 Kdln Germany Department of Chemistry and Biochemistry University of Maryland MD 20742 USA Lawrence Livermore National Laboratory Livermore CA 94550 USA Instituto de Fisica Facultad de Ingenieria C. C. 30 11300 Montevideo Uruguay Mississippi State University Drawer 5167 Mississippi State MS 39762 USA Idaho National Laboratory Bldg. IRCPL MS2114 Idaho Falls ID 83415 USA Department of Physics National Tsing Hua University Hsinchu Taiwan 30013 China National Superconducting Cyclotron Laboratory Michigan State University East Lansing Michigan 48824 USA Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大... 详细信息

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大四极形变到Z=43(Tc),44(Ru)和45(Rh)同位素中具有中等四极形变之大三轴形变的过渡。Nb(Z=41)同位素具有过渡核的特征。根据邻近同位素和同中素带交叉信息的系统性及推转壳模型(CSM)计算,Tc和Rh偶-N同位素中观察到的带交叉产生于一对h11/2中子的转动顺排。首次观察到100Nb(Z=41,N=59)的高自旋能级纲图和形变态,从而证实了100Nb中的形状共存,并确认,在Nb同位素链上,基态形状突变发生于N=58(球形)到N=59(大形变);而在Sr(Z=38),Y(Z=39)和Zr(Z=40)各同位素链上,基态形状突变均发生于N=59(球形)到N=60(大形变)。100Nb具有大形变基态,同现有理论预言相矛盾,其大形变的基态及转动带所具有的很大的和不规则的转动惯量具有重要的理论意义。对奇-质子Cs(Z=55)和La(Z=57)丰中子同位素八极激发的详细研究,发现了141,143,144Cs同位素链上电二极矩D0随中子数增加而减小的急剧变化,此前在145,147La中观察到的电二极矩D0的较缓和的减小似乎亦很陡地下延至148La。在Cs和La同位素中观察到的电二极矩D0的急剧下降很可能同偶-质子核146Ba和224ra中观察到的电二极矩D0的急剧下降相类似,后者已获反射非对称平均场壳修正理论的成功解释。实验证明,141Cs具有很大电二极矩D0。141Cs和142Xe中观测到的很大的电二极矩D0和仅在141Cs中观察到的电二极矩D0的simplex量子数相关性需要进一步的理论研究。根据转动频率比值ω-(I)/ω+(I)的检定,同Xe同位素一样,认定Cs同位素中包括号143Cs的八极激发为八极振动,而在La同位素中存在八极形变。

关键词：形状过渡轴对称形状三轴形变形状突变带交叉奇-质子八极激发 B(E1)/B(E2)比值电二极矩D0 二极矩的下降八极振动 Cs,La同位素

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绿芦笋的预冷和自发气调贮藏

中国果品研究 1993年第1期13卷 6-9页

作者： Y.GARIEPY G.S.v.raGHAvAN F.GASTAIGNE J.ARUL C.WILLEMOT 周志才加拿大麦克纳学院农业工程系加拿大拉法尔大学食品科技系

首先研究评估三种预冷技术对当地生长的绿芦笋在1.5℃普通大气(ra)下贮藏21天的效果。其次研究评估两种不同相对湿度(ra)和三种不同气体组成,在1.5℃自发气调贮藏(MA)21天的绿芦笋品质。在实验容器上装有硅窗以保持 MA 条件。贮藏前预... 详细信息

首先研究评估三种预冷技术对当地生长的绿芦笋在1.5℃普通大气(ra)下贮藏21天的效果。其次研究评估两种不同相对湿度(ra)和三种不同气体组成,在1.5℃自发气调贮藏(MA)21天的绿芦笋品质。在实验容器上装有硅窗以保持 MA 条件。贮藏前预冷芦笋,可减少损耗20%以上。然而,这三种预冷技术之间差异并不显著。28天后,MA 贮藏的芦笋与相对湿度为80%的 ra 贮藏(质量损耗60%)和相对湿度为95%的 ra 贮藏(质量损耗41%) 相比,色泽较好,外观新鲜、质地较硬,质量损耗较低(<12%)。尽管硅窗能适当控制CO_2浓度,但为了防止缺氧呼吸,必须定期注入氧气。

关键词：绿芦笋自发气调贮藏气体组成缺氧呼吸贮藏条件空气预冷装置呼吸率多年生植物天后塑膜袋

铈基模型催化剂的纳米结构:有序CeO_(2)(111)薄膜上的Pt-Co纳米颗粒

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Chinese Journal of Catalysis 2020年第6期41卷 985-997页

作者： Yaroslava Lykhach TomasSkala Armin Neitzel Nataliya Tsud Klara Beranova Kevin CPrince vladimir Matolin Jorg Libuda 弗里德里希-亚历山大埃尔朗根-纽伦堡大学埃尔朗根催化资源中心界面研究与催化91058埃尔朗根德国查尔斯大学数学与物理学院表面与等离子体科学系 18000布拉格捷克共和国 Elettra-Sincrotrone Trieste SCpA StradaStatale 14km 163.534149巴索维扎-的里雅斯特意大利

制备并表征了原子分散的模型体系:氧化铈负载的Pt-Co核壳催化剂.采用超高真空物理气相沉积法制备了有序CeO2(111)膜上的Pt@Co和Co@Pt核壳纳米结构,并用同步辐射光电子能谱和共振光发射光谱对其进行了研究.在低Co覆盖率(0.5 ML)下Co在CeO... 详细信息

制备并表征了原子分散的模型体系:氧化铈负载的Pt-Co核壳催化剂.采用超高真空物理气相沉积法制备了有序CeO2(111)膜上的Pt@Co和Co@Pt核壳纳米结构,并用同步辐射光电子能谱和共振光发射光谱对其进行了研究.在低Co覆盖率(0.5 ML)下Co在CeO2(111)上沉积生成Co-CeO2(111)固溶体,然后在更高Co覆盖率下生长为金属Co纳米粒子.Pt@Co和Co@Pt两种模型结构在300-500 K温度范围内都能稳定地抗烧结.在500 K退火后, Pt@Co纳米结构含有接近纯的钴壳,而Co@Pt中的铂壳部分被金属钴覆盖.在550 K以上,在Pt@Co和Co@Pt纳米结构中近表面区域的重新排序中产生了次表层的Pt Co合金和富铂外壳.对于Co@Pt纳米粒子,近表面区域的化学有序性取决于沉积铂壳的初始厚度.无论初始铂壳的厚度如何,在有氧存在下对Co@Pt纳米结构进行退火,都会导致Pt-Co合金的分解以及Co的氧化.Co的逐步氧化与吸附质诱导的Co偏析共同导致在负载的Co@Pt纳米结构表面形成厚的Co O层.这一过程伴随着CeO2(111)薄膜的裂解,以及在550K以上氧气中退火后CeO2包裹氧化的Co@Pt纳米结构.很明显,于不同温度下在氧气和氢气的氧化-还原循环过程中,无论铂的初始厚度是多少,负载的Co@Pt纳米颗粒的结构和化学成分的变化主要是由氧化所致,而还原处理的影响则很小.

关键词：核壳纳米粒子模型催化剂 Pt-Co 氧化铈化学有序性同步辐射光电子能谱

Paxillin serine 178 phosphorylation in control of cell migration and metastasis formation through regulation of EGFR expression in breast cancer

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Journal of Cancer Metastasis and Treatment 2019年第6期4卷 71-86页

作者： Saertje verkoeijen Ya-Feng Ma Wies van Roosmalen Reshma Lalai Martine H.A.M.van Miltenburg Marjo de Graauw Bob van de Water Sylvia E.Le Dévédec Institute for Life Sciences&Chemistry Hogeschool Utrecht HUUtrecht 3501 AAthe Netherlands Division of Drug Discovery and Safety Leiden Academic Centre for Drug ResearchLeiden UniversityLeiden 2300 RAthe Netherlands

Aim:Paxillin is a well-known multidomain scaffold protein that is involved in the regulation of cell-matrix adhesion dynamics,a process required for the tumor cell migration and *** of the serine residue 178 requires c-Jun NH2-terminal kinase(JNK)activation,which occurs downstream of epidermal growth factor receptor(EGFR)-mediated signaling and drives cell *** this study,we investigated the significance of paxillin Ser178 phosphorylation in breast cancer ***:We employed the rat mammary carcinoma MTLn3 cell line with which we established stabile variants of both wild type and mutant GFP-paxillin *** those,we next performed sev.ral in vitro assays including cell proliferation,migration and focal adhesion ***,we monitored the metastatic spread of both cell line variants in an othrotopic mouse model for breast ***:Here we show that expression of the phospho-defective mutant paxillinS178A in the metastatic mammary adenocarcinoma MTLn3 cell-line significantly decreased EGF-induced cell migration,which was correlated with impaired focal adhesion ***,paxillinS178A attenuated lung metastasis formation in an orthotopic in vivo mammary gland tumor/metastasis model,demonstrating the importance of JNK-mediated paxillin phosphorylation in breast cancer *** of paxillinS178A caused a decrease in EGFR expression, ;while re-expression of EGFR in MTLn3-paxillinS178A cells fully restored EGF-driven cell motility and focal adhesion ***,re-expression of EGFR in MTLn3-paxillinS178A rescued spontaneous metastasis from breast to ***:Ov.rall our data show an important role for JNK-mediated paxillin Ser178 phosphorylation in the regulation of EGFR expression and thereby,in EGF-driven cell migration and metastasis formation.

关键词： Paxillin c-Jun NH2-terminal kinase focal adhesion epidermal growth factor receptor cell migration metastasis breast cancer

影响海德堡眼底照相机和海德堡眼底照相机Ⅱ测试-再测试结果变异性的因素

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 34-35页

作者： Strouthidis N.G. White E.T. Owen v.M.F. D.F. Garway-Heath 宋虎平 Dr. Glaucoma Research Unit Moorfields Eye Hospital 162 City Road London EC1V 2PD United Kingdom

Aims: To evaluate the test-retest variability of stereometric parameter measurements made with the Heidelberg retina tomograph (HRT) and Heidelberg retina tomograph -II (HRT-II), and to establish which parameter(s) provided the most repeatable and reliable measurements with both devices. An investigation into the factors affecting the repeatability of the measurements of this parameter(s) was conducted. Methods: 43 ocular hypertensive and 31 glaucoma subjects were recruited to a test-retest study. One eye from each subject underwent HRT and HRT-II imaging by two observers on each of two occasions within 6 weeks of each other. Lens grading was carried out by LOCS III grading and Scheimpflug camera generated densitogram analysis. Results: Rim area (ra) and mean cup depth measurements were found to be least variable. Both inter-test reference height difference and image quality had a strong relation (R2 > 0.5, p ra difference and, together, are responsible for 70%of ra measurement variability. Image quality was influenced by lens opacity, cylindrical error, and age. Inter-test ra measurement differences were unrelated to the observer or visit interval. Conclusions: ra represents an appropriate measure for monitoring glaucomatous progression. Reference height difference and image quality were the factors thatmost influenced ra measurement variability. Image analysis strategies that address these factors may reduce test-retest variability.

关键词：眼底照相机变异性海德堡

使用冷藏精液进行大熊猫(Ailuropoda melanoleuca)人工授精

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应用与环境生物学报 2001年第6期7卷 558-562页

作者：黄炎李德生张和民杜军张贵权魏荣平 LAU ra Mc Geehan JOGAYLE Howard 汤纯香王鹏彦中国保护大熊猫研究中心四川汶川623006 圣地亚哥动物园协会美国斯密史苏尼安国家公园保护研究中心

使用在 4℃冷藏 2 4h和 48h的精液对 5岁的雌性大熊猫妃妃进行了人工授精 ,以保持圈养大熊猫的遗传多样性 .供精者乐乐是一只患皮肤癌的雄性大熊猫 ,睾丸体积为 (386 .1± 2 14)cm3 ,在 2 0 0 0 0 2 2 3～ 0 5 11期间 ,4次人工采精 ... 详细信息

使用在 4℃冷藏 2 4h和 48h的精液对 5岁的雌性大熊猫妃妃进行了人工授精 ,以保持圈养大熊猫的遗传多样性 .供精者乐乐是一只患皮肤癌的雄性大熊猫 ,睾丸体积为 (386 .1± 2 14)cm3 ,在 2 0 0 0 0 2 2 3～ 0 5 11期间 ,4次人工采精 :刺激电压 5～ 8v ,射精电压 5～ 8v ,每次采精量 (3.2± 1.2 )mL ,精子密度为 (12 0 8.5± 5 6 4.9)× 10 6/mL-1,每次精子总量 (390 8.3± 2 5 46 .6 )× 10 6,精液平均活力为 84.8%± 4.1% ,活率为 87.8%± 5 .2 % ,运动状态为 2 .9± 0 .2 5 ,畸形率为 2 8.3%± 11.1% ,平均顶体正常率为 96 %± 1% ,pH值为 7.9± 0 .3.乐乐的精液用TEST稀释后 ,在 4℃冷藏 2 4h、48h和 72h后 ,精子活力分别是 6 5 % ,5 8%和 47% ,精子的活率分别为 73% ,73%和 6 8% .用酶免法对雌兽妃妃尿液中雌激素的检测 ,发现妃妃的雌激素在发情前期开始增加 ,在发情前期的最后一天达到最大峰值 ,在发情期(4月 3日～ 5日 )迅速下降到正常值 ,进行人工授精的最佳时间是在雌兽尿液中的雌激素达到最大峰值后的 48～ 72h之间 .妃妃在 2 0 0 0 0 8 10顺利地产下一仔 ,雌性 ,妊娠期 12 7d ,初生幼仔 179.3g.图 1表 3参

关键词：大熊猫人工授精电刺激采精低温冷藏雌激素遗传多样性精液