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Adipokines and ghrelin in gastric cancer cachexia

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World Journal of Gastroenterology 2008年第23期14卷 3633-3641页

作者： Mustafa Kerem Zafer Ferahkose utku Tonguc yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin Department of General Surgery Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey Department of Biochemistry Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey

AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor.

关键词： Gastric cancer Cachexia Resistin Ghrelin Leptin Adiponectin Insuline

Impact of sorafenib on epidural fibrosis: An immunohistochemical study

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World Journal of Clinical Cases 2018年第9期6卷 249-258页

作者： Osman Tanriverdi Uzay Erdogan Canan Tanik Ilhan yilmaz Omur Gunaldi Huseyin utku Adilay Ayca Arslanhan Metehan Eseoglu Department of Neurosurgery and Psychiatry University of Health Sciences Bak?rky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology Department of Pathology University of Health Sciences ?i?li Hamidiye Etfal Training and Research Hospital Department of Neurosurgery University of Health Sciences ?i?li Hamidiye Etfal Training and Research Hospital Department of Neurosurgery Medical Faculty Bal?kesir University Institute of Neurological Science Marmara University Department of Neurosurgery Medical Faculty Medipol University

AIM To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis(EF). METHODS The study used CD105 and osteopontin antibodiesin an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats(n = 16) were divided into two groups: control(L1-2 level laminectomy only) and sorafenib treatment(L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared. RESULTS The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib. CONCLUSION Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor.

关键词： Vascular endothelial growth factor CD105 Osteopontin Sorafenib Spinal epidural fibrosis

ELECTRORHEOLOGICAL PROPERTIES OF TALC POWDER/SILICONE OIL SUSPENSIONS UNDER DC FIELDS

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Chinese Journal of Polymer Science 2007年第3期25卷 245-252页

作者： Hasim yilmaz Ummihan yilmaz Chemistry Department Sciences FacultyHarran University63190 OsmanbeySanliurfaTurkey Chemistry Department Sciences FacultyGazi University06500 TeknikokullarAnkaraTurkey

In this study, the electrorheological （ER） behavior of suspensions prepared from d50 = 2.4 lam talc powder, dispersed in insulating silicone oil （SO） medium was investigated. Sedimentation stabilities of suspensions （c = 5 wt%） prepared using these talc powder powders were determined to be 78 days. The ER activity of all the suspensions was observed to increase with increasing electric field strength, concentration and decreasing shear rate. The shear stress of talc powder suspensions increased linearly with increasing concentrations of the particles and with the applied electric field strength. Electric field viscosity of all the suspensions decreased sharply with increasing shear rate and showed a typical shear thinning non-Newtonian visco-elastic behavior. Effects of frequency on the ER activity of talc powder/SO system were also investigated.

关键词： Electrorheological fluids Talc powder/silicone oil suspensions Shear stress

Mechanistic Transformations Involving Radical and Cationic Polymerizations

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Chinese Journal of Polymer Science 2020年第3期38卷 205-212,I0004页

作者： Gorkem yilmaz Yusuf Yagci Istanbul Technical University Department of ChemistryMaslak34469 IstanbulTurkey Center of Excellence for Advanced Materials Research(CEAMR)and Department of Chemistry Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

Mechanistic transformation approach has been widely applied in polymer synthesis due to its unique feature combining structurally different polymers prepared by different polymerization *** methods for the formation of block and graft copolymers through mechanistic transformation involve almost all polymerizations ***,certain polymerization processes require extensive purification processes,which can be time-consuming and *** developments on controlled/living polymerizations involving radical and cationic mechanisms with the ability to control molecular weight and functionality led to new pathways for mechanistic *** this mini-review,we systematically discussed relevant advances in the field through three main titles namely(i)from radical to cationic mechanism,(ii)from cationic to radical mechanism,and(iii)application of specific catalyst systems for both radical and cationic polymerizations.

关键词： Transformation Radical polymerization Cationic polymerization Controlled/living polymerization Photopolymerization

ELECTRORHEOLOGICAL PROPERTIES OF DIATOMITE/SILICONE OIL SUSPENSIONS UNDER DC FIELDS

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Chinese Journal of Polymer Science 2006年第5期24卷 463-471页

作者： Hasim yilmaz Chemistry Department Sciences FacultyHarran University63190 OsmanbeySanliurfaTurkey

In this study, electrorheological （ER） behavior of suspensions prepared from 3.0 and 9.0 μm diatomite particulate, dispersed in insulating silicone oil （SO） medium was investigated. Sedimentation stabilities of suspensions （c = 5 wt%） prepared using these diatomite powders were determined to be 32 days （d = 3 μm） and 24 days （d = 9 μm）, respectively. ER activity of all the suspensions was observed to increase with increasing electric field strength, concentration and decreasing shear rate. Shear stress of diatomite suspensions increased linearly with increasing concentrations of the particles and with the applied electric field strength. Electric field viscosity of all the suspensions decreased sharply with increasing shear rate and particle size, showing a typical shear thinning non-Newtonian visco-elastic behavior. Effects of high temperature and polar promoter onto ER activity ofdiatomite/SO system were also investigated.

关键词： Electrorheological fluids Diatomite/silicone oil suspensions Shear stress.

The geometric resistivity correction factor for several geometrical samples

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Journal of Semiconductors 2015年第8期36卷 1-8页

作者： Serdar yilmaz Mersin University Science and Arts Faculty Physics Department Mersin University Advanced Technology Education Research and Application Center

This paper reviews the geometric resistivity correction factor of the 4-point probe DC electrical conduc- tivity measurement method using several geometrical samples. During the review of the literature, only the articles that include the effect of geometry on resistivity calculation were considered. Combinations of equations used for various geometries were also given. Mathematical equations were given in the text without details. Expressions for the most commonly used geometries were presented in a table for easy reference.

关键词： semiconductor four point probe conductivity measurement resistivity correction factor

Comparisons of the suture zones along a geotraverse from the Scythian Platform to the Arabian Platform

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Geoscience Frontiers 2014年第6期5卷 855-875页

作者： Ali yilmaz Shota Adamia Hüseyin yilmaz Cumhuriyet University Engineering FacultyDepartment of Environmental EngineeringKayseri StreetCU.CampusTR-58140 SivasTurkey Nodia Institute of Geophysics 1M.Alexidze Str.0195TbilisiGeorgia Cumhuriyet University Engineering FacultyDepartment of Geophysical EngineeringTR-58140 SivasTurkey

The area from the Greater Caucasus to the southeast Turkey is characteri：;.ed and shaped by several major continental blocks. These are Scythian Platform, Pontian-Transcaucasu.,; Continent-Arc System （PTCAS）, the Anatolian-lranian and the Arabian Platforms. The aim of this paper is to define these continental blocks and describe and also compare their boundary relationships along the suture zones. The Scythian Platform displays the evidence of the Hercynian and Alpine orogens. This platform is separated from the PTCAS by the Greater Caucasus Suture Zone. The incipient collision began along this suture zone before middle-late Carboniferous whereas the final collision occurred before Oligocene. The PTCAS can be divided into four structural units：（1） the Georgian Block - northern part of the Pontian-Transcaucasian island-arc, （2） the southern and eastern Black Sea Coast-Adjara-Trialeti Unit, （3） the Artvin-Bolnisi Unit, comprising the northern part of the southern Transcaucasus, and （4） the Imbricated Bayburt-Garabagh Unit. The PTCAS could be separated from the Anatolian Iranian Platform by the North Anatolian-Lesser Caucasus Suture （NALCS） zone. The initial collision was developed in this suture zone during Senonian-early Eocene and final collision before middle Eocene or Oligocene-Miocene. The Anatolian-lranian Platform （AIP） is made up of the Tauride Platform and its metamorphic equivalents together with Iranian Platform. It could be separated from the Arabian Platform by the Southeastern Anatolian Suture （SEAS） zone. The collision ended before late Miocene along this suture zone. The southernmost continental block of the geotraverse is the Arabian Platform, which constitutes the northern part of the Arabian-African Plate. This platform includes a sequence from the Precambrian felsic volcanic and clastic rocks to the Campanian-early Maastrichtian fiyschoidal clastics. All the suture zones include MORB and SSZ-types ophiolites in different ages. However, the ages of

关键词： Scythian Plattorm Arabian Platform Suture zones Ceotraverse

Supergravity-induced interactions on thick branes

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Chinese Physics B 2014年第4期23卷 135-146页

作者： Nejat T.yilmaz Department of Electrical and Electronics Engineering Yassar UniversitySelsuk Yassar Kampüsü niversite CaddesiNo:35-37 AgaliYol35100 Bornova zmir Turkey

The gravity coupling of the symmetric space sigma model is studied in the solvable Lie algebra parametrization. The corresponding Einstein equations are derived and the energy-momentum tensor is calculated. The results are used to derive the dynamical equations of the warped five-dimensional （5D） geometry for localized bulk scalar interactions in the framework of thick brane world models. The Einstein and scalar field equations are derived for flat brane geometry in the context of minimal and non-minimal gravity-bulk scalar couplings.

关键词： supergravity branes 5D warped geometry symmetric spaces

Seasonal Variation of Cumulative CO_2 Emission from a Vertisol Under Apricot Orchard in Semi-Arid Southeast Turkey

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Pedosphere 2012年第3期22卷 322-332页

作者： G.yilmaz Department of Environmental Engineering Harran UniversityS anliurfa 63100 (Turkey)

Understanding the factors affecting the CO 2 emission from agricultural practices is crucial for global warming.A study was performed in an apricot orchard field in the experimental farm of the Harran University,Southeast Turkey,to i) quantify weekly and seasonal variations of the CO 2 emissions from a Vertisol under apricot orchard;ii) evaluate the difference in CO 2 emission between the area under trees and rows;and iii) assess the relationships between the amounts of CO 2 emissions and environmental parameters for better use and management of the soils from the view point of carbon balance and flux in a semi-arid environment under drip *** CO 2 emission measurements were performed during May 2008 and May 2010,from both under tree crowns (CO 2-UC) and between tree rows (CO 2-BR),on a weekly basis in southeast Turkey with a semi-arid *** 2 emissions were statistically correlated with weather and soil parameters such as air temperature,relative humidity,rainfall,soil water content,and soil temperature at various depths from 5 to 100 *** weekly emissions ranged from 82 to 1 110 kg CO 2 ha 1 week 1 and from 96 to 782 kg CO 2 ha 1 week 1 in CO 2-UC and CO 2-BR,*** in CO 2 emission in the second year was due to increases in mean air and soil *** weekly and monthly cumulative CO 2 emissions were positively correlated with the air and soil *** linear regression analysis explained 35% and 83% variations in average weekly and monthly CO 2 emissions,by using meteorological *** the interaction effects of meteorological parameters in regression equations nearly doubled the variance explained by the regression *** to stepwise regression analysis,soil and air temperatures were found to have the most significant impact on the temporal variability of the soil CO 2 emission.

关键词： global warming meteorological data plowing soil temperature stepwise regression