Effect of oophorectomy and exogenous estrogen replacement on liver injury in experimental obstructive jaundice
Effect of oophorectomy and exogenous estrogen replacement on liver injury in experimental obstructive jaundice作者机构：Department of General Surgery Karaelmas University Medical School Zonguldak 67100 Turkey Department of General Surgery Gaziantep State Hospital Gaziantep Department of General Surgery Gazi University Medical School Ankara 06500 Turkey Department of Immunology Gazi UniversityMedical School Ankara 06500 Turkey
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2008年第14卷第18期
页 面：2818-2824页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Estrogen Liver injury Oophorectomy Obstructive jaundice
摘 要：AIM: To investigate the role of estrogen on liver injury in an experimental obstructive jaundice ***: Three groups of female rats were constituted; group 1 was oophorectomized and given E2 (n = 14), group 2 was oophorectomized and given placebo (n = 14), and group 3 was sham operated (n = 14). Fourteen days following constitution of bile duct ligation, all groups were compared in terms of serum tests, histopathologic parameters, and tissue levels of IFN-γ and ***: The parameters representing both the injury and/or the reactive response and healing were more pronounced in groups 1 and 2 (χ2 = 17.2, χ2 = 10.20; χ2 = 12.4, P 0.05). In the sham operated or E2 administered groups significantly lower tissue levels of IFN-γ and higher IL-6 levels were found. In contrast, high IFN-γ and low IL-6 tissue levels were found in the oophorectomized and placebo group (P 0.001). Kupffer cell alterations were observed to be more pronounced in the groups 1 and 3 (χ2 = 6.13, P 0.05).CONCLUSION: Our study indicates that E2 impaired liver functions, accelerated both the liver damage and healing. In the conditions of bile duct obstruction, estrogen significantly changed the cytokine milieu in the liver.
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