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Tr.als for.Gather.ng Infor.ation on an Unknown Peak in the GC-MS Spectr. of Hor.e and Pony Hair.Extr.cts

Advances in Entomology 2021年第2期9卷 100-111页

作者： Maia Tsikolia Till Opatz ulrich Kauhl Nur.ayat Tabanca Betul Demir.i Saundr. H. TenBr.eck Kenneth J. Linthicum ulrich r. bernier US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice (USDA-Ar.) Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville FL USA Nichbisi Scientific r.sear.h Center.(NSr.) Mtskheta Georgia Institute of Or.anic Chemistr. University of Mainz Mainz Germany US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice (USDA-Ar.) Subtropical Horticulture Research Station (SHRS) Miami FL USA Depar.ment of Phar.acognosy Faculty of Pharmacy Anadolu University Eskisehir Turkey Univer.ity of Flor.da’s Institute of Food and Agr.cultur.l Sciences (UF/IFAS) Hor.e Teaching Unit Gainesville FL USA

The volatile compounds fr.m hor.e and pony hair. and skin wer. analyzed to deter.ine bioactive molecules that ar. kair.mones used for.host location by blood-feeding dipter.. In this study, hor.e and pony hair.samples wer. extr.cted with or.anic solvents (pentane or.hexane) and analyzed by gas chr.matogr.phy-mass spectr.metr. analysis (GC-MS) with closed electr.n ionization (CEI). Using the GC-MS analysis, we obser.ed a compound peak, which could not be identified by compar.son to mass spectr. in the mass spectr.l libr.r.. This unknown compound was often the lar.est peak in the chr.matogr.m and had a r.tention index and mass spectr.l fr.gmentation similar.to nonanal. However. ther. wer. sever.l differ.nces in the fr.gmentation patter.. When compar.d to a nonanal r.fer.nce standar., it was evident that this was a differ.nt compound. Hydr.distillation of pony hair.was another.extr.ction method to obtain the unknown component in higher.concentr.tions. Analysis of this extr.ct with GC-flame ionization detector.(FID) with GC-MS confir.ed the same unknown peak. Fur.her.exper.ments and analysis with the var.ous mass spectr.scopy tools gave the possible molecular.ion with mass-to-char.e r.tio (m/z) 142, cor.esponding to the unknown component.

关键词： Nonanal Skin Emanation Insect Pests Equus caballus Equus fer.s caballus Mass Spectr.scopy Str.ctur. Elucidation

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Diver.ity and Biological Activities of Endophytic Fungi Associated with Micr.pr.pagated Medicinal Plant <i>Echinacea pur.ur.a</i>(L.) Moench

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Amer.can Jour.al of Plant Sciences 2012年第8期3卷 1105-1114页

作者： Luiz H. r.sa Nur.ayat Tabanca Natascha Techen David E. Wedge Zhiqiang Pan ulrich r. bernier James J. Becnel Natasha M. Agr.monte Lar.y A. Walker.r.ta M. Mor.es Center.for.Water.and Wetland r.sour.es The University of Mississippi Field Station Abbeville USA Depar.amento de Micr.biologia Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Minas Gerais Brazil National Center.for.Natur.l Pr.ducts r.sear.h Research Institute of Pharmaceutical Sciences School of Pharmacy University of Mississippi Oxford USA USDA-Ar. Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville USA USDA-Ar. Natural Products Utilization Research Unit (NPURU) University of Mississippi Oxford USA

Echinacea is one of the top ten selling medicinal her.s in Eur.pe and United States. Commer.ially available for.ulations may contain differ.nt plant par.s of thr.e species (Echinacea pur.ur.a, E. pallida, and E. angustifolia). Our.study evaluates the diver.ity of micr.bial community associated with healthy E. pur.ur.a clones and their.ability to pr.duce defense compounds. We r.cover.d and identified thir.y-nine fungal endophytes thr.ugh the molecular.methods in 15 distinct phylotypes, which wer. closely r.lated to species of the following gener. Cer.tobasidium, Cladospor.um Colletotr.chum, Fusar.um, Glomer.lla, and Mycoleptodiscus. These taxa wer. pr.viously r.por.ed as decomposer.and phytopathogenic fungi. The fungal community associated with two E. pur.ur.a clones showed high r.chness and dominance indices with differ.nt distr.bution among plant or.ans. Cr.de extr.cts of fungal isolates wer. tested for.antifungal and insecticidal biological activities. A total of 16 extr.cts (41%) showed antifungal pr.per.ies;while just the extr.ct of M. indicus exhibited lar.icidal activity against A. aegypti. These r.sults suggest that the symbiosis between the endophytic fungal community and micr.pr.pagated clones of E. pur.ur.a was r.-established after.acclimatization to soil and the endophytic fungi pr.duced compounds against phytopathogenic fungi.

关键词： Endophytes Biological Activity Medicinal Plant Symbiosis Botanical Dr.g Micr.or.anisms

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家以外的家萨格奈实验学校

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室内设计与装修 2024年第7期 82-85页

作者：无 Maxime Br.uillet(摄影) Étienne bernier(摄影) 西溪(编译) Agence Spatiale Appar.il Ar.hitectur. BGLA ar.hitectur. 不详

由Agence Spatiale公司、Appar.il建筑公司和BGLA建筑公司联合设计的实验学校坐落在Joachim公园的中心地带,这是一个牢牢扎根于当地环境的建筑典范。设计旨在解构学校这一传统的建筑类型,力图打造一个友好、无障碍并亲近儿童的环境。

关键词：实验学校无障碍中心地带

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Optical wavelength meter.with machine lear.ing enhanced pr.cision

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Photonics r.sear.h 2023年第3期11卷 420-430页

作者： GAZI MAHAMUD HASAN MEHEDI HASAN PENG LIU MOHAMMAD r.D Er.C bernier Tr.VOr.JAMES HALL Photonic Technology Labor.tor. Advanced Research ComplexUniversity of OttawaK1N 6N5 OntarioCanada Huawei Technologies Canada KanataK2K 3J1 OntarioCanada

A photonic implementation of a wavelength meter.typically applies an inter.er.meter.to measur. the fr.quencydependent phase shift pr.vided by an optical delay *** wor. shows that the infor.ation to be r.tr.eved is encoded by a vector.r.str.cted to a cir.ular.cone within a 3D Car.esian object *** measur.d data belong to the image of the object space under.a linear.or.hogonal *** impair.ents r.sult in br.ken or.hogonal symmetr.,but the mapping r.mains *** cir.ular.cone is r.tained as the object space,which suggests that the conventional conic section fitting for.the wavelength meter.application is a pr.matur. r.duction of the object space fr.m r.(3)to r.(2).The inver.e map,constr.cted by a lear.ing algor.thm,compensates impair.ents such as sour.e intensity fluctuation and er.or. in delay time,coupler.tr.nsmission,and photor.ceiver.sensitivity while being r.bust to *** simple algor.thm does not r.quir. initial estimates for.all par.meter. except for.a br.ad br.cket of the delay;fur.her.weak nonlinear.ty intr.duced by uncer.ain delay can be cor.ected by a r.bust golden sear.h *** phase-r.tr.eval pr.cess is invar.ant to sour.e power.and its *** demonstr.te that,to the extent that the ten par.meter. of the inter.er.meter.model captur. all significant impair.ents,a pr.cision limited only by the level of r.ndom noise is *** to measur.d data collected fr.m a fabr.cated Si_(3)N_(4)wavelength meter.gr.ater.than an or.er.of magnitude impr.vement in pr.cision compar.d with the conventional method is achieved.

关键词： delay cir.ular invar.ant

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Autor.gr.ssive neur.l networ.s with exogenous var.ables for.indoor.temper.tur. pr.diction in buildings

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Building Simulation 2021年第1期14卷 165-178页

作者： Benoit Delcr.ix Jér.me Le Ny Michel bernier Muhammad Azam Bingr.i Qu Jean-Simon Venne Depar.ment of Mechanical Engineer.ng Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Depar.ment of Electr.cal Engineer.ng and GEr.D Polytechnique Montréal2500 Chemin de PolytechniqueMontréalQCH3T 1J4Canada Smar. Building Lab BrainBox AIMontréalQCCanada

Ther.al models of buildings ar. helpful to for.cast their.ener.y use and to enhance the contr.l of their.mechanical ***,these models ar. building-specific and r.quir. a tedious,er.or.pr.ne and time-consuming development effor. r.lying on skilled building ener.y *** to white-box and gr.y-box models,data-dr.ven(black-box)models r.quir. less development time and a minimal amount of infor.ation about the building *** this paper.autor.gr.ssive neur.l networ. models ar. compar.d to gr.y-box and black-box linear.models to simulate indoor.*** models ar. tr.ined,validated and compar.d to actual exper.mental data obtained for.an existing commer.ial building in Montr.al(QC,Canada)equipped with r.of top units for.air.*** show that neur.l networ.s mimic mor. accur.tely the ther.al behavior.of the building when limited infor.ation is available,compar.d to gr.y-box and black-box linear.*** gr.y-box model does not per.or. adequately due to its under.par.meter.zed natur.,while the linear.models cannot captur. non-linear.phenomena such as r.diative heat tr.nsfer.and ***,the neur.l networ. models outper.or. the alter.ative models in the pr.sented application,r.aching a coefficient of deter.ination r. up to 0.824 and a r.ot mean squar. er.or.down to 1.11℃,including the er.or.pr.pagation over.time for.a 1-week per.od with a 5-minute *** consider.ng a 50-hour.time hor.zon,the best neur.l networ.s r.ach a much lower.r.ot mean squar. er.or.of ar.und 0.6℃,which is suitable for.applications such as model pr.dictive contr.l.

关键词： ther.al model building simulation exper.mental validation multi-layer.per.eptr.n linear.vs.non-linear black-box vs.gr.y-box

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Alzheimer.s disease:a tale of two diseases?

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Neur.l r.gener.tion r.sear.h 2021年第10期16卷 1958-1964页

作者： Eleonor. Nar.ini r.an Hogan Anthony Flamier.Gilber. bernier Whitehead Institute for.Biomedical r.sear.h CambridgeMAUSA Stem Cell and Developmental Biology Labor.tor. Hôpital Maisonneuve-RosemontMontrealQCCanada Depar.ment of Neur.sciences University of MontrealMontrealQCCanada

Spor.dic late-onset Alzheimer.s disease(SLOAD)and familial ear.y-onset Alzheimer.s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,ar. thought to r.pr.sent a spectr.m of the same disor.er.based on near.identical behavior.l and histopathological ***,FEOAD tr.nsgenic mouse models have been used in past decades as a sur.ogate to study SLOAD pathogenic mechanisms and as the gold standar. to validate dr.gs used in clinical ***,such r.sear.h has yielded little output in ter.s of ther.peutics tar.eting the disease’s development and *** this shor. r.view,we inter.ogate the widely accepted view of one,dimor.hic disease thr.ugh the pr.sm of the Bmi1+/–mouse model and the distinct chr.matin signatur.s obser.ed between SLOAD and FEOAD br.ins.

关键词： aging Alzheimer.s disease BMI1 epigenetics familial late-onset spor.dic

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Implications of safety r.quir.ments for.the tr.atment of THMC pr.cesses in geological disposal systems for.r.dioactive waste

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Jour.al of r.ck Mechanics and Geotechnical Engineer.ng 2017年第3期9卷 46-52页

作者： Fr.dér.c bernier Fr.nk Lemy Pier.e De Cannièr. Valér. Detilleux Feder.l Agency for.Nuclear.Contr.l (FANC) Brussels 1000 Belgium Bel V Brussels 1070 Belgium

The mission of nuclear.safety author.ties in national r.dioactive waste disposal pr.gr.mmes is to ensur. that people and the envir.nment ar. pr.tected against the hazar.s of ionising r.diations emitted by the *** implies the establishment of safety r.quir.ments and the over.ight of the activities of the waste management or.anisation in char.e of implementing the *** Belgium,the safety r.quir.ments for.geological disposal r.st on the following pr.nciples:defence-in-depth,demonstr.bility and the r.diation pr.tection pr.nciples elabor.ted by the Inter.ational Commission on r.diological Pr.tection(ICr.).Applying these pr.nciples r.quir.s notably an appr.pr.ate identification and char.cter.sation of the pr.cesses upon which the safety functions fulfilled by the disposal system r.ly and of the pr.cesses that may affect the system ***,r.sear.h and development(r.D)on safety-r.levant ther.o-hydr.-mechanical-chemical(THMC)issues is impor.ant to build confidence in the safety *** paper.points out the key THMC pr.cesses that might influence r.dionuclide tr.nspor. in a disposal system and its sur.ounding envir.nment,consider.ng the dynamic natur. of these *** natur. and significance ar. expected to change accor.ing to pr.vailing inter.al and exter.al conditions,which evolve fr.m the r.positor. constr.ction phase to the whole heatingecooling cycle of decaying waste after.*** these pr.cesses have a potential impact on safety,it is essential to identify and to under.tand them pr.per.y when developing a disposal concept to ensur. compliance with r.levant safety *** par.icular.the investigation of THMC pr.cesses is needed to manage *** includes the identification and char.cter.sation of uncer.ainties as well as for.the under.tanding of their.safety-r.levance.r.D may also be necessar. to r.duce uncer.ainties of which the magnitude does not allow demonstr.ting the safety of the disposal system.

关键词： r.dioactive waste Geological disposal Per.or.ance assessment Safety assessment Safety functions Safety r.quir.ments

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Watt-level and spectr.lly flat mid-infr.r.d super.ontinuum in fluor.indate fiber.

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Photonics r.sear.h 2018年第6期6卷 609-613页

作者： Fr.NCIS THEBEr.E NANCY BEr.BE SAMUEL POULAIN SOLENN COXIC LOUIS-r.FAEL r.BICHAUD MAr.IN bernier r.AL VALLEE Defence r.D Canada Valcartier Centre Quebec G3J1X5 Canada Le Ver.e Fluor. Campus KerLann F-35170 Bruz Brittany France Center.for.Optics Photonics and Lasers (COPL) Universite Laval Quebec G1V0A6 Canada

We r.por. on infr.r.d super.ontinuum(SC) gener.tion in step-index fluor.indate-based fiber.by using an all-fiber.laser.sour.e. In compar.son to widely used ZBLAN fiber. for.high-power.mid-infr.r.d(MIr. SC gener.tion, fluor.indate fiber. have multiphoton absor.tion edges at significantly longer.wavelengths and can sustain similar.intensities. r.cent developments highlighted in the pr.sent study allowed the pr.duction of fluor.indate fiber. with MIr.backgr.und loss of 2 dB/km, which is similar.to or.even better.than ZBLAN *** using an all-fiber.picosecond laser.sour.e based on an er.ium amplifier.followed by a thulium power.amplifier.we demonstr.te the gener.tion of 1.0 W infr.r.d SC spanning over.2.25 octaves fr.m 1 μm to 5 μm. The gener.ted MIr.SC also exhibits high spectr.l flatness with a 6 dB spectr.l bandwidth fr.m 1.91 μm to 4.77 μm and an aver.ge power.two or.er. of magnitude gr.ater.than in pr.vious demonstr.tions with a similar.spectr.l distr.bution.

关键词： SC In MIr MFD Watt-level and spectr.lly flat mid-infr.r.d super.ontinuum in fluor.indate fiber.

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比利时高放废物处置库设计及与基岩和工程屏障体系的热–水–力性状的相关研究(英文)

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岩石力学与工程学报 2006年第4期25卷 681-692页

作者：李香绫 bernier Fr.dér.c Bel Johan Eur.dice SCK.CEN国家核能研究中心 ONDr.F/NIr.S国家放射性废弃物和多裂隙材料管理局

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩... 详细信息

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩在地下 223 m 处的力学性质,并调查和论证处置的可行性,为处置库屏障(天然和人工)提供可靠数据。在 HADES 的众多现场试验中,很多试验用来对基岩和工程屏障体系(包括封口和回填的可行性)的热–水–力性状进行研究,包括 CACTUS,ATLAS,BACCHUS 和 r.SEAL 等项目。自 1995 年以来,研究开发计划向大型和示范性试验方向发展。最主要成果是运用工业技术建立地下研究设施(竖井和井巷)可行性得到了验证,且这种工业技术给研究提供一个较好机会,便于进一步认识基岩泥岩(CLIPEX 方案)的水–力性状及了解隧道开挖工程(SELFr.C 课题)对挖掘破坏区的影响。另一个重大成果是成功地实现对一种称为“OPHELE”的预制膨润土(人工屏障材料)加热和水化地面大型试验。下一步工作内容包括实现大尺寸现场加热器试验(Pr.CLAY 试验),此试验预计于 2006 年开始,并可持续 10 a 之久。据此,首先简要描述比利时高放废物处置库设计,然后回顾 Boom 泥岩和工程屏障体系的热–水–力性状相关试验,最后介绍下一步大规模 Pr.CLAY 试验。

关键词：高放废弃物贮存设计地下研究设施工程屏障体系热-水-力耦合性态开挖破坏区模型试验大尺寸现场试验

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Major.bleeding events in octagenar.ans associated with dr.g inter.ctions between dabigatr.n and P-gp inhibitor.

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Jour.al of Ger.atr.c Car.iology 2019年第11期16卷 806-811页

作者： Mar.or.e bernier Sar.h-Line Lancr.r.t Fanny r.cher.Elise K Van-Obber.hen Pier.e Olivier.Thibaud Lavr.t Nadège Par.ssol-Gir.r. Milou-Daniel Dr.ci Depar.ment of Phar.acology and Toxicology PharmacoVigilance CenterUniversity of Nice Côte d'Azur Medical CenterHôpital de Cimiez4 Avenue Reine VictoriaBP 117906003NiceFrance Emer.ency Depar.ment Shor. Stay Unit University of Nice Côte d'Azur Medical CenterHôpital Pasteur 230Voie Romaine 06001NiceFrance

Backgr.und The dir.ct or.l anticoagulant dabigatr.n does not r.quir. any r.utine ther.peutic dr.g ***,concer.s about possible dr.g inter.ctions susceptible to incr.ase its inher.nt bleeding r.sk,especially in ver. elder.y patients,have been r.ised *** aim of our.study was to evaluate to what extent the co-pr.scr.ption of P-gp inhibitor. with dabigatr.n may incr.ase its plasma levels and lead to bleeding complications,in usual conditions of car. of the ver. *** Fifty-eight patients over.85 year. old with non valvular.atr.al fibr.llation r.ceiving dabigatr.n wer. included in a pr.spective *** wer. scr.ened for.the pr.sence of P-gp inhibitor.(Gr.up A)or.not(Gr.up B).r.sults Patients fr.m Gr.up A had incr.ased dabigatr.n mean plasma concentr.tions as compar.d with patients fr.m Gr.up B(A vs.B:182.2±147.3 vs.93.7±64.9 ng/m L).One thir. of the patients fr.m Gr.up A had dabigatr.n concentr.tions that wer. deemed"out of r.nge"ver.us none in Gr.up B(P=0.05).This was associated with mor. fr.quent bleeding complications in Gr.up A(A:30.4%,B:8.6%,P=0.04).Conclusion In our.cohor. of ver. elder.y patients,at least,the co-pr.scr.ption of dabigatr.n with P-gp inhibitor. in usual conditions of car. r.sulted in higher.dabigatr.n plasma concentr.tions and mor. fr.quent bleeding occur.ences.

关键词： Dabigatr.n Dr.g inter.ction Hemor.hage P-gp inhibitor.,The elder.y

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