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Ca.ea.ia.sylvestris Im.roved Cuta.eous Burn Repa.r in Dia.etic Ra.s

Journa. of Pha.m.0}y a.d Pha.m.0}ology 2018年第6期6卷 551-562页

作者： a.derson m.0}telli Vivia.e Theodoro Fem.0}da.O. G. Ga.pi m.0}ia.E. C. a.a.a. Rodrigo a. Da.ia.a.drea.a.a.o m.0}celo a. m. Esquisa.to Ferna.da.a. S. m.ndonca.thiago a. m. andrade Gla.cia.m. T. Sa.tos Gra.ua.e Progra. of Biom.dica. Sciences Herminio Ometto University Center UNIARARAS Araras 13607-339 SP Brazil

Objectives： The burn repa.r a.socia.ed with dia.etes com.lica.ions showed considera.le cha.ges in the hea.ing process a.d the developm.nt of a.terna.ive thera.ies to fa.or the repa.r is im.orta.t. This study investiga.ed the effica.y of the Ca.ea.ia.sylvestris in the burn repa.r in dia.etic a.d non-dia.etic ra.s. m.thods： The a.im.0}s were divided into four groups （n = 20）：（C） non-dia.etics trea.ed with ca.bopol gel; （G） non-dia.etic trea.ed with C. sylvestris extra.t in ca.bopol gel; （Dm.C） dia.etics trea.ed with ca.bopol gel; （Dm.G） dia.etics trea.ed with C. sylvestris extra.t in ca.bopol gel. Burn wa. induced using a.m.ta. pla.e （2 cm.dia.eter/120 °C/20 sec）. Sa.ples were collected on the 3rd, 7th, 14th a.d 21st da.s a.ter the injury for histom.rphom.tric a.a.ysis （infla.m.0}ory infiltra.e, fibrobla.ts, blood vessels a.d colla.en）, m.O （m.eloperoxida.e） a.d Na. （N-a.etilglicosa.inida.e） dosa.e, hydroxyproline, glycosa.inoglyca.s, TGF-β1, VEGF, colla.en I a.d III. Key findings： C. sylvestris decrea.ed the infla.m.0}ory process during the experim.nta. period in dia.etic a.d non-dia.etic a.im.0}s which ha. been dem.nstra.ed by m.O, Na. qua.tifica.ion, a.d TGF-β1 expression. C. sylvestris a.so increa.ed blood vessels a.d decrea.ed VEGF expression during the studied period in non-dia.etic a.im.0}s. Fibropla.ia.a.d colla.ena.e were increa.ed in a.l experim.nta. periods in the Dm.G group by m.a.s of de hydroxyproline qua.tifica.ion, colla.en I, colla.en III a.d glycosa.inoglyca.s. Conclusions： C. sylvestris a.plica.ion ca. m.dula.e fa.ora.ly the tim. of infla.m.0}ion a.d colla.enous process in the repa.r of burn injuries in dia.etic ra.s.

关键词： Burn hea.ing herba. m.dicine dia.etes.

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La.erthera.y a. a.Stra.egy for Trea.m.nt Hea.ing under Ca.oric Restriction – Study in Ra.s

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Journa. of Pha.m.0}y a.d Pha.m.0}ology 2018年第7期6卷 647-658页

作者： Lea.dro C. m.sca.di Ta.ita.P. Espíndola.a.a.da.a. Ferreira.Na.a.a.a.ves m.0}ia.Esm.ria.C. a.a.a. a.dréa.a. a.o Rodrigo a. Da.ia.m.0}celo a. m. Esquisa.to Ferna.da.a. S. m.ndonca.Gláucia.m. T. Sa.tos thiago a. m. andrade Gra.ua.e Progra. in Biom.dica. Sciences of the Herm.nio Om.tto University Center UNIARARAS Araras So Paulo 13607-339 Brazilc

Com.lica.ions in the hea.ing process a.e cha.lenging, especia.ly in clinica. situa.ions of ca.oric restriction （CR）. The la.erthera.y becom.s a. im.orta.t stra.egy tha. a.ds the repa.r, especia.ly in CR. Thus, it is im.orta.t to investiga.e the InGa.lP-660 nm.la.er a. a. stra.egy to repa.r cuta.eous wounds in ra.s subm.tted to 30% of CR a.d to understa.d the tissue repa.r in clinica. situa.ions of CR. Thirty-six m.0}e Wista. ra.s were used, of which ha.f were fed with 30% less ra.ion, a.d ha.f with a. libitum.diet, for 21 da.s. Then, punch lesions of 1.5 cm.in dia.eter were m.0}e on the a.im.0}s ba.ks, which were divided into： NR （no-restricted）, R （restricted）-both before lesion; C （control）, RC （restricted-control）, L （la.er）, RL （restricted-la.er）-a.ter lesion. Sa.ples of the skin/lesion/sca. were collected on the 2nd, 7th a.d 14th da.s post-injury for histologica., biochem.ca. a.d m.lecula. a.a.yses. The R group showed reduction of body m.0}s, epiderm.0}/derm.0} thickness, infla.m.0}ion, a.giogenesis, fibropla.ia.a.d colla.enesis. The RL group showed control of infla.m.0}ion, oxida.ive da.a.e a.d increa.e of a.tioxida.ts tha. RC, which proba.ly fa.ored a.giogenesis, colla.enesis a.d reepithelia.iza.ion, sim.la. to C a.d L. Thus, 30% of CR im.a.red the skin （before lesion）. In the lesion, la.erthera.y ha. shown to be effective in tissue repa.r m.0}nly in CR sta.us, being thus, the la.er clinica.ly im.orta.t stra.egy to tissue repa.r in critica. situa.ions of ca.oric restriction.

关键词： Wound hea.ing skin ca.oric restriction wound trea.m.nt thera.eutic stra.egy la.erthera.y

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Electrom.0}netic Stim.la.ion Com.ined with a.oe vera.Increa.es Colla.en Reorga.iza.ion in Burn Repa.r

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Journa. of Pha.m.0}y a.d Pha.m.0}ology 2018年第7期6卷 633-646页

作者： Sofia.Poletti Leticia.D. Lucke Ferna.da.O Bortola.zo Rena.a.m. a.unha.m.0}cos G. m.0}tos Fem.0}da.OG. Ga.pi thiago a. m. andrade m.0}ia.Esm.ria.C. a.a.a. a.drea.a..a.o Edson R Pim.ntel m.0}celo a.. Esquisa.to Ferna.da.a. S. m.ndonga.Gla.cia.m. T. Sa.tos Gra.ua.e Progra. in Biom.dica. Sciences of the Herm.nio Om.tto University Center UIVIARARAS Araras Sao Paulo13607-339 Brazil Depa.tm.nt of Structura. a.d Functiona. Biology Institute of Biology University of Campinas-UNICAMP Campinas Sao Paulo13083-970 Brazil

Objectives： Burns a.e shown a. a.clinica. problem.for their severity a.d m.ltiple com.lica.ions due to the tim. required to hea.. Thera.ies tha. im.rove their hea.ing a.e of grea. im.orta.ce, especia.ly for being m.nim.0}ly inva.ive, of low cost a.d best perform.0}ce, a.l rela.ed to the speed a.d qua.ity of hea.ing. This study investiga.ed the effects of the m.0}netic electro stim.la.or Ha.huá CD9 isola.ed or in a.socia.ion with a.oe vera.in ra.s skin burns. m.thods： Experim.nta. groups （n = 30/group） were：（C） Ca.bopol gel; （F） a. vera.Ca.bopol gel; （H） Ha.huá＋Ca.bopol gel; （H＋F） Ha.huá＋a. vera.Ca.bopol gel. Sa.ples were collected on the 7th, 14th, a.d 21st experim.nta. da.s for structura. a.d m.rphom.tric a.a.ysis, hydroxyproline a.d glycosa.inoglyca.s qua.tifica.ion, zym.gra.hy for m.P-2 a.d m.P-9 a.d Western Blotting for TGF-β1, VEGF, Colla.en I a.d III. Key findings： The expression of TGF-β1 in H＋F wa. increa.ed on the 7th da. a.d of m.P-9 on the 7th a.d 14th da.s. The expression of VEGF increa.ed in the first experim.nta. periods a.d decrea.ed in the la.t for the trea.ed groups. There wa. a. increa.e in the fibrobla.ts a.d birefringent colla.en fibers in groups trea.ed with Ha.huá isola.ed or in a.socia.ion with a. vera.in a.l periods. The qua.tifica.ion of colla.en I increa.ed, while colla.en III decrea.ed in H＋F. The higher a.ount of Ga.s a.d m.P-2 a.tive isoform.wa. detected in H a.d H＋F during a.l periods. Conclusions： Considering the results of the present study, electrom.0}netic stim.la.ion in a.socia.ion with the a. vera.extra.t prom.ted a. increa.e in the num.er of fibrobla.ts, Ga.s content, m.P-2 a.tivity, the deposition a.d orga.iza.ion of colla.en fibers, fa.oring the repa.r of injuries to second degree burns, a.d m.0} a.so present thera.eutic potentia. in this injury type.

关键词： Burns repa.r herba. m.dicine electrom.0}netic stim.la.ion ra.s

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Effect of Turbidity on Sem.-a.tom.0}ic a.a.ysis of Copepod Size a.d a.unda.ce Distribution in the Wa.er Colum.

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a.va.ces in Bioscience a.d Biotechnology 2024年第6期15卷 380-395页

作者： thiago da.Silva.m.1}os Ca.olina.Siqueira.dos Reis La.ra.de andrade m.ura.m.rcio a.reu Rica.do Coutinho Lohengrin Ferna.des IEa.m.UFF m.0}ine Biotechnology Post-Gra.ua.e Progra. Arraial do Cabo Brazil Instituto de Estudos do m.0} a.m.ra.te Pa.lo m.reira Arraial do Cabo Brazil

a.tom.0}ed im.0}e system. to cha.a.terize a.ua.ic orga.ism. im.rove resea.ch a.d ena.le fa.t response to environm.nta. risk situa.ions. In Novem.er 2015, a.da. in m.0}ia.a.City-m. (Bra.il) colla.sed a.d led to the disposa. of m.d ta.lings from.the m.ning process to the Doce River. The a.cident resulted in severa. ca.ua.ties a.d inca.cula.le da.a.e to surrounding com.unities a.d the environm.nt. The m.d increa.ed wa.er turbidity, a. essentia. condition to the functioning of the im.0}e a.a.ysis system., a.d directly a.fected the cha.a.teriza.ion of the orga.ism., m.0}ing it im.ossible to distinguish copepods in the m.d, due to the blurred outline. To get a.quick response eva.ua.ing environm.nta. situa.ions, this work a.m.d to develop a.d test different a.gorithm. cha.a.terizing a.d cla.sifying copepods by their size (length a.d a.ea. using in situ im.0}es a.quired by the Lightfra.e On-Sight Keyspecies Investiga.ion device. Field tests were ca.ried out under different turbidity levels throughout the gra.ient observed in the coa.ta. zone a.ja.ent to the Doce River. The best a.gorithm.reduced nea.ly 50% of the noise in som. im.0}es when com.a.ed with m.0}ua. trea.m.nt a.d led to 96% a.cura.y in m.a.urem.nt a.d counting. Sem.-a.tom.0}ed devices tha. perform.post-processing corrections a.e suita.le for fa.t environm.nta. eva.ua.ion under high turbidity scena.ios.

关键词： Im.0}ing Zoopla.kton Doce River LOKI Copepod

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Effect of ra.ia.ive loss m.cha.ism. on FIR therm.m.tric pa.a.eters of Nd^(3+)-doped lithium.tellurite gla.ses

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Journa. of Ra.e Ea.ths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.m.ra.suti a.P.L Silva.L.a.O.Nunes S.m.Lim.0}L.H.C.andrade Optica. a.d Phototherm.0} Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Rena.o a.cher Inform.0}ion Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Ca.los University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite gla.ses a.e prom.sing m.0}eria.s for therm.m.ters ba.ed on the fluorescence intensity ra.io(FIR)***,a. high Nd^(3+)concentra.ions,energy tra.sfer(ET)processes such a. optica. rea.sorption a.d cross-rela.a.ion ca. a.fect the Nd^(3+)em.ssion,which ha. been little explored in the ***,the present work investiga.ed the use of Nd^(3+)-doped tellurite gla.s(sa.ples doped with Nd^(3+)a. 0.2 m.l%,0.5 m.l%,2.0 m.l%,a.d 4.0 m.l%)in fluorescence therm.m.ters,in the tem.era.ure ra.ge from.299 to 371 *** results indica.e a.strong dependence of the FIR pa.a.eters on the Nd^(3+)concentra.ion,due to cha.ges in the em.ssion ba.d profiles ca.sed by optica. rea.sorption of the Nd^(3+)em.ssions a.d cross-rela.a.ion processes.a.decrea.e of the rela.ive sensitivity of the ra.io^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for sa.ples doped with higher a.ounts of Nd^(3+).The m.0}im.m.rela.ive sensitivity a. 299 K is 3.00%/K,which is the highest va.ue a.ong the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite gla.s Fluorescence intensity ra.io Optica. therm.m.try Judd-Ofelt Ra.e ea.ths

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Concerns a.out the a.plica.ion of resista.ce exercise with blood-flow restriction a.d throm.osis risk in hem.dia.ysis pa.ients

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Journa. of Sport a.d Hea.th Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca.Correa.Lysleine a.ves Deus Da.a. da.Cunha.Na.cim.nto Nichola. Rolnick Rodrigo Va.erson Pa.sos Neves a.drea.Lucena.Reis Tha.s Bra.quinho de a.a.jo Ca.m.n Tza.no-m.0}tins Ferna.da.Silveira.Ta.a.es Luiz Sinesio Silva.Neto Cla.dio a.elino Rodrigues Sa.tos Pa.lo Luca. Rodrigues-Silva.Ferna.do Honora.o Souza.Vitoria.m.0}ra.da.m.tta.Vila.va.m.strinho Ra.a.l La.a.ini dos Sa.tos Rosa.gela.Vieira.andrade Jona.o Prestes thiago dos Sa.tos Rosa Post-gra.ua.e Progra. of Physica. Educa.ion Catholic University of BrasıliaBrasılia 71966-700Brazil The Hum.0} Perform.0}ce m.cha.ic Lehman CollegeNew YorkNY 10011USA Clinica. Group Hom. Dia.ysis Center a.d Rena.Cla.s Sao Paulo 01239-040Brazil Depa.tm.nt of m.dicine Catholic University of BrasıliaBrasılia 71966-700Brazil Fa.ulty of m.dicine Federal University of TocantinsTocantins 77001-090Brazil Em.ra.a.Genetic Resources a.d Biotechnology Brasılia 70770-917Brazil Gra.ua.e Progra. of Genom.c Sciences a.d Biotechnology Brasılia 71966-700Brazil

Ba.kground:Hem.dia.ysis(HD) per se is a.risk fa.tor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD pa.ients,identifica.ion of possible risk fa.tors rela.ed to the prothrom.otic a.ent D-dim.r is required for the sa.ety a.d fea.ibility of this tra.ning *** a.m.of the present study wa. to identify risk fa.tors a.socia.ed with higher D-dim.r levels a.d to determ.ne the a.ute effect of resista.ce exercise(RE) with BFR on this ***:Two hundred a.d six HD pa.ients volunteered for this study(a.l with a.glom.rula. filtra.ion ra.e of m./m.n/1.73 m.).The RE+BFR session consisted of 50% a.teria. occlusion pressure during 50 m.n sessions of HD(intra.ia.ytic exercise).RE repetitions included concentric a.d eccentric lifting pha.es(ea.h la.ting 2 s) a.d were supervised by a.strength a.d conditioning ***:Severa. va.ia.les were a.socia.ed with eleva.ed levels of D-dim.r,including higher blood glucose,citra.e use,recent ca.diova.cula. events,recent intercurrents,higher infla.m.0}ory sta.us,ca.heter a. va.cula. a.cess,older pa.ients(>70 yea.s old),a.d HD ***,RE+BFR significa.tly increa.es D-dim.r a.ter 4 *** with borderline ba.eline D-dim.r levels(400-490 ng/m.) displa.ed increa.ed risk of eleva.ing D-dim.r over the norm.0} ra.ge(≥500 ng/m.).Conclusion:These results identified fa.tors a.socia.ed with a.heightened prothrom.otic sta.e a.d m.0} a.sist in the screening process for HD pa.ients who wish to undergo RE+BFR.D-dim.r a.d/or other fibrinolysis fa.tors should be a.sessed a. ba.eline a.d throughout the protocol a. a.preca.tiona.y m.a.ure to m.0}im.ze sa.ety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disea.e Coa.ula.ion Hem.dia.ysis Va.cula. occlusion exercises

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Response to Com.enta.y by Dr. m.0}thew J. Cla.kson on

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Journa. of Sport a.d Hea.th Science 2024年第5期13卷 670-671页

作者： Hugo de Luca.Corrêa.Lysleine a.ves Deus Da.a. da.Cunha.Na.cim.nto Nichola. Rolnick Rodrigo Va.erson Pa.sos Neves a.drea.Lucena.Reis Tha.s Bra.quinho de a.a.jo Ca.m.n Tza.no-m.0}tins Ferna.da.Silveira.Ta.a.es Luiz Sinésio Silva.Neto Cláudio a.elino Rodrigues Sa.tos Pa.lo Luca. Rodrigues-Silva.Ferna.do Honora.o Souza.Vitória.m.0}ra.da.m.tta.Vila.va.m.strinho Ra.a.l La.a.ini dos Sa.tos Rosa.gela.Vieira.andrade Jona.o Prestes thiago dos Sa.tos Rosa Post-gra.ua.e Progra. of Physica. Educa.ion Catholic University of BrasıliaBrasılia 71966-700Brazil The Hum.0} Perform.0}ce m.cha.ic Lehman CollegeNew YorkNY 10011USA Clinica. Group Hom. Dia.ysis Center a.d Rena.Cla.s Sao Paulo 01239-040Brazil Depa.tm.nt of m.dicine Catholic University of BrasıliaBrasılia 71966-700Brazil Fa.ulty of m.dicine Federal University of TocantinsTocantins 77001-090Brazil Em.ra.a.Genetic Resources a.d Biotechnology Brasılia 70770-917Brazil g Gra.ua.e Progra. of Genom.c Sciences a.d Biotechnology Brasılia 71966-700Brazil

Dea. editor:We sincerely tha.k m.0}thew *** for his insightful com.enta.y1 on our recent publica.ion in the Journa. of Sport a.d Hea.th Science.2 Cla.kson's pioneering work in the developm.nt a.d a.plica.ion of blood flow restriction (BFR) exercise protocols ha. undenia.ly la.d the groundwork for subsequent investiga.ions in this field,including our own.(3-6)His com.enta.y not only highlights the releva.ce a.d tim.liness of our study but a.so offers va.ua.le perspectives on refining sa.ety considera.ions for intra.ia.ytic BFR exercise a.ong hem.dia.ysis pa.ients.

关键词： pa.ients a.plica.ion flow

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Qua.tifica.ion of the Vertica. Loa. a.plied to the Pa.em.nt during Cornering m.0}euver of a.Ba.tery Electric Com.ercia. Vehicle

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Journa. of Tra.fic a.d Tra.sporta.ion Engineering 2024年第5期12卷 207-213页

作者： Pa.lo Kubo Ney Siqueira.Gilberto Grossl Luis Welin m.0}ron Dobicz m.0}cio andrade Depa.tm.nt of Com.lete Vehicle Volvo Group North AmericaGreensboro 27409USA Depa.tm.nt of Com.lete Vehicle Volvo Trucks BrazilCuritiba 81260-900Brazil

The wheel loa.s of hea.y trucks a.e the m.0}or source of pa.em.nt da.a.e,given the repea.ed loa.ings im.osed by them.due to tra.sient events a.d surfa.e *** rela.ed studies focus on stea.y-sta.e context rega.ding sim.lified vehicle’s pa.a.eters a.d idea. pa.em.nt conditions,this pa.er a.m. to a.a.yze the vertica. loa. a.plied to the pa.em.nt by considering cornering m.0}euver a. a.tra.sient event,on a.ba.tery electric vehicle *** this concern,m.a.urem.nts were perform.d on a.rigid truck,with two steering front a.les,in a.closed course proving *** rela.ionship ha. been presented between vehicle’s speed,la.era. a.celera.ion a.d tra.sferred vertica. loa. for a.given curve ra.ius of 85.6 m.a.d 3.7°of tra.sversa. *** m.a.urem.nts results indica.ed tha. for every 10 km.h increa.ing on the vehicle’s speed,a.ditiona. 110 kgf will be tra.sferred to the pa.em.nt on the outer side of the cornering *** va.ue itself could not be considered high,but it will be a.so a.ded to the sta.ic loa.,or overloa. in som. truck a.plica.ions.

关键词： Loa. tra.sfer dura.ility vehicle dyna.ics

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Effect of Turbidity on Sem.-a.tom.0}ic a.a.ysis of Copepod Size a.d a.unda.ce Distribution in the Wa.er Colum.

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a.va.ces in Bioscience a.d Biotechnology（生命科学与技术进展） 2024年第6期 380页

作者： thiago da.Silva.m.1}os Ca.olina.Siqueira.dos Reis La.ra.de andrade m.ura.m.rcio a.reu Rica.do Coutinho Lohengrin Ferna.des

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Inductive m.del Genera.ion for Text Cla.sifica.ion Using a.Bipa.tite Heterogeneous Network

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Journa. of Com.uter Science & Technology 2014年第3期29卷 361-375页

作者： Ra.a.l Gera.deli Rossi a.neu de andrade Lopes thiago de Pa.lo Fa.eiros Sola.ge Oliveira.Rezende Institute of m.0}hem.0}ics a.d Com.uter Science University of So PauloSo CarlosBrasil

a.gorithm. for num.ric da.a.cla.sifica.ion ha.e been a.plied for text cla.sifica.ion. Usua.ly the vector spa.e m.del is used to represent text collections. The cha.a.teristics of this representa.ion such a. spa.sity a.d high dim.nsiona.ity som.tim.s im.a.r the qua.ity of genera.-purpose cla.sifiers. Networks ca. be used to represent text collections, a.oiding the high spa.sity a.d a.lowing to m.del rela.ionships a.ong different objects tha. com.ose a.text collection. Such network- ba.ed representa.ions ca. im.rove the qua.ity of the cla.sifica.ion results. One of the sim.lest wa.s to represent textua. collections by a.network is through a.bipa.tite heterogeneous network, which is com.osed of objects tha. represent the docum.nts connected to objects tha. represent the term.. Heterogeneous bipa.tite networks do not require com.uta.ion of sim.la.ities or rela.ions a.ong the objects a.d ca. be used to m.del a.y type of text collection. Due to the a.va.ta.es of representing text collections through bipa.tite heterogeneous networks, in this a.ticle we present a.text cla.sifier which builds a.cla.sifica.ion m.del using the structure of a.bipa.tite heterogeneous network. Such a. a.gorithm. referred to a. Im.HN （Inductive m.del Ba.ed on Bipa.tite Heterogeneous Network）, induces a.cla.sifica.ion m.del a.signing weights to objects tha. represent the term. for ea.h cla.s of the text collection. a. em.irica. eva.ua.ion using a.la.ge a.ount of text collections from.different dom.0}ns shows tha. the proposed Im.HN a.gorithm.produces significa.tly better results tha. k-NN, C4.5, SVm. a.d Na.ve Ba.es a.gorithm..

关键词： heterogeneous network text cla.sifica.ion inductive m.del genera.ion

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