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Tumor biomarkers for diagnosis,prognosis and targeted therapy

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2391-2476页

作者： Yue Zhou lei tao Jiahao Qiu Jing Xu Xinyu Yang Yu Zhang Xinyu Tian Xinqi Guan Xiaobo Cen Yinglan Zhao Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Medicine Tibet UniversityLhasa 850000China National Chengdu Center for Safety Evaluation of Drugs State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Tumor biomarkers,the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression,have been demonstrated to possess critical and encouraging value in screening and early diagnosis,prognosis prediction,recurrence detection,and therapeutic efficacy monitoring of *** the past decades,continuous progress has been made in exploring and discovering novel,sensitive,specific,and accurate tumor biomarkers,which has significantly promoted personalized medicine and improved the outcomes of cancer patients,especially advances in molecular biology technologies developed for the detection of tumor ***,we summarize the discovery and development of tumor biomarkers,including the history of tumor biomarkers,the conventional and innovative technologies used for biomarker discovery and detection,the classification of tumor biomarkers based on tissue origins,and the application of tumor biomarkers in clinical cancer *** particular,we highlight the recent advancements in biomarker-based anticancer-targeted therapies which are emerging as breakthroughs and promising cancer therapeutic *** also discuss limitations and challenges that need to be addressed and provide insights and perspectives to turn challenges into opportunities in this ***,the discovery and application of multiple tumor biomarkers emphasized in this review may provide guidance on improved precision medicine,broaden horizons in future research directions,and expedite the clinical classification of cancer patients according to their molecular biomarkers rather than organs of origin.

关键词： diagnosis breakthrough biomarkers

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： tao lei DOU Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Comparison of inebilizumab or rituximab in addition to glucocorticoid therapy for neuromyelitis optica spectrum disorders

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1073-1078页

作者： Chu-Yuan Lou Yong Wang Jia-Yuan Xing Teng Ma lei tao Xiao-Tang Wang Run-Sheng Wang Neuroophthalmic Center Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004Shaanxi ProvinceChina

AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were *** groups underwent hormone shock therapy during the acute ***,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after ***,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment ***:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab ***:The combination of inebilizumab and high-dose glucocorticoids proves to be *** comparison to rituximab injections,inebilizumab displays better tolerance and ***,it demonstrates a partial effect in preventing optic nerve ***,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.

关键词： neuromyelitis optica spectrum disorders inebilizumab rituximab glucocorticoids

混合动力汽车发动机启停工况扭振自适应模糊控制

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重庆大学学报 2024年第1期47卷 104-114页

作者：陈龙陶磊太原理工大学机械与运载工程学院太原030024 吉林大学汽车仿真与控制国家重点实验室长春130025

混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发... 详细信息

混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发动机启停工况动力学仿真模型和发动机启停控制逻辑,提出发动机启停扭振自适应模糊控制策略,开展2种运行状态下发动机启停工况仿真,对比分析无控制和自适应模糊控制下传动系扭转振动响应曲线。结果表明,自适应模糊控制相比无控制状态:定置停车时发动机启动和停机工况扭振平均衰减率分别为23.8%和30.1%,车辆行进间发动机启动和停机工况扭振平均衰减率分别为12.1%和23.6%。该方法可有效衰减发动机启停工况传动系扭转振动,提升混合动力汽车发动机启停工况NVH(noise,vibration,and harshness)性能。

关键词：行星混联传动系启停工况扭转振动主动控制自适应模糊控制

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中国幼儿(学龄前)动画品牌商业模式研究

电影评介 2024年第8期 66-71页

作者：雷涛浙江传媒学院动画与数字艺术学院

得益于变现能力的极大增强和IP(Intellectual Property,知识产权)经济的崛起,国产动画近年来发展迅速,竞争也变得异常激烈。其中,由于起步晚,艺术表达和商业模式独特,2-6岁的幼儿动画(又称学龄前动画)垂直细分领域在国内却鲜被挖掘。近... 详细信息

得益于变现能力的极大增强和IP(Intellectual Property,知识产权)经济的崛起,国产动画近年来发展迅速,竞争也变得异常激烈。其中,由于起步晚,艺术表达和商业模式独特,2-6岁的幼儿动画(又称学龄前动画)垂直细分领域在国内却鲜被挖掘。近年来,《小猪佩奇》《汪汪队立大功》《海底小纵队》等海外经典幼儿动画快速占领国内市场,这使得研究探索中国幼儿动画品牌的开发和市场运营显得尤为迫切。本文从行业传承、市场现状、海外特点等角度对中国幼儿动画的商业模式进行梳理和研究,以期探索具有中国特色的幼儿动画产业可持续发展路径。

关键词：幼儿动画 IP经济授权模式

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数字驱动的教育强国建设:机遇、挑战和进路

中国电化教育 2024年第3期 12-19页

作者：陶蕾杨欣重庆师范大学教育科学学院重庆401331 西南大学基础教育研究中心重庆400715

探究数字驱动的教育强国建设,既是创造性地阐释由数字化转型与教育强国所构成的中国式教育现代化,也是积极应答“如何兑现数字化潜力”这一全球性教育命题。归根究底,数字化的技术跃迁、基建条件和政策导向固然能为教育强国建设提供高... 详细信息

探究数字驱动的教育强国建设,既是创造性地阐释由数字化转型与教育强国所构成的中国式教育现代化,也是积极应答“如何兑现数字化潜力”这一全球性教育命题。归根究底,数字化的技术跃迁、基建条件和政策导向固然能为教育强国建设提供高质量的外部机遇,但教育强国建设在数字化映照的实践瓶颈、理论盲区和治理风险也意味着不容回避的内在挑战。为此,数字驱动的教育强国建设有必要推进主动超前布局的数字制度建设、有力应对变局的数字人才培养和奋力开拓新局的数字范式构建。如此一来,数字驱动的教育强国建设既能充分汲取数字化的外在供给,也能恰当回应教育强国建设的内生需求,进而开辟出一条质量更高、贡献更多、影响更大的中国式教育现代化道路。

关键词：教育强国数字化转型数字驱动高质量中国式教育现代化

Dangling Ligand Enables an Iron Hexa-Coordinated Molecular Catalyst for Water Oxidation by Photocatalysis

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CCS Chemistry 2024年第3期6卷 623-630页

作者： Bing Yang Qi Liu Xiang-Zhu Wei tao lei Qing-Qing Yang Xu-Zhe Wang Jing-Xin Jian Xin Jiang Chen-Ho Tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials New Cornerstone Science LaboratoryTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal *** this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic ***,we describe a unique hexa-coordinated catalyst 1[Fe^(II)(Py_(3)tacn)Cl_(2)]and its reference 2[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,*** anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst *** our delight,the“open form”of catalyst 1 provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and *** turnover number and turnover frequency values of 2332 and 60 s^(−1)are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.

关键词： water oxidation photocatalysis homogeneous catalysis iron complexes dangling ligand intermediates characterization

非化学计量比的Hf(Zr)_(1+x)O_(2)稳定性和铁电性的起源

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Science China Materials 2024年第4期67卷 1282-1287页

作者：陶蕾张艳芳杜世萱 School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

铪基氧化物(Hf(Zr)O_(2))因其优异的铁电性质而成为计算机存储等应用中备受青睐的材料.然而,化学计量比的铪基氧化物基态是非铁电的单斜相.在密度泛函理论计算中,我们发现插入铪或锆原子将随着插入浓度的增加,将Hf(Zr)O_(2)的基态从单... 详细信息

铪基氧化物(Hf(Zr)O_(2))因其优异的铁电性质而成为计算机存储等应用中备受青睐的材料.然而,化学计量比的铪基氧化物基态是非铁电的单斜相.在密度泛函理论计算中,我们发现插入铪或锆原子将随着插入浓度的增加,将Hf(Zr)O_(2)的基态从单斜相转变为三方相.声子色散和态密度投影揭示了插入的Hf(Zr)原子消除了已有的非等效Hf(Zr)原子之间的竞争,从而稳定了r相.此外,Hf/Zr插层原子的有序分布进一步降低了形成能和铁电转换势垒,导致高耐久性和超低的矫顽场.能带结构显示,Hf/Zr插层原子引起的局域平带对漏电流的贡献最小.最后,我们证明了ZrO_(2)对于形成非化学计量比的Hf(Zr)_(1+x)O_(2)至关重要.

关键词：非化学计量比计算机存储密度泛函理论计算高耐久性铁电性质有序分布

微波无压烧结制备(TiB+TiC)/Ti复合材料的组织及力学性能

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材料热处理学报 2024年第2期45卷 53-62页

作者：宋光远雷鹰李雨陶磊安徽工业大学冶金工程学院安徽马鞍山243032 铜陵学院机械工程学院安徽铜陵244002 攀钢集团攀枝花钢铁研究院有限公司钒钛资源综合利用国家重点实验室四川攀枝花617000

采用微波无压烧结技术制备了(TiB+TiC)/Ti复合材料。选用石墨粉和TiB_(2)作为增强相的C源和B源,通过球磨将其附着到Ti基体表面,烧结时与Ti基体发生反应,原位生成TiC和TiB增强相。为了避免红外测温精确度较低的弊端,使用微波功率和烧结... 详细信息

采用微波无压烧结技术制备了(TiB+TiC)/Ti复合材料。选用石墨粉和TiB_(2)作为增强相的C源和B源,通过球磨将其附着到Ti基体表面,烧结时与Ti基体发生反应,原位生成TiC和TiB增强相。为了避免红外测温精确度较低的弊端,使用微波功率和烧结时间作为变量,探索制备(TiB+TiC)/Ti复合材料的最佳条件,研究微波烧结工艺对复合材料微观结构和力学性能的影响。结果表明:1 kW功率下烧结27.5 min制备的复合材料力学性能最佳,极限抗压强度为1633 MPa,应变为34.88%,显微硬度为367 HV0.2;随着微波功率的增加,增强相发生粗化,复合材料的力学性能降低。复合材料的断口表面呈现出韧窝和解理面的混合断裂特征。

关键词：微波无压烧结微波功率烧结时间微观结构力学性能