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Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

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Petroleum Science 2024年第1期21卷 567-581页

作者： Chong Lin Qi-Cong Xu Lie-Xiang Han Gao Li Hai He hong-ling Zhou Ji-Ping She CCDC Drilling&Production Technology Research Institute Guanghan618300SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key Lab of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(LCM)is a regular preventive and remedial measure for lost ***,conventional LCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling *** conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid ***,softer,and less frictional LCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** drilling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing

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An Efficient Optimization Design Framework for Low-Resistance Shape of Bionic Amphibious Robot

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China Ocean Engineering 2024年第1期38卷 117-128页

作者： ZHANG Dai-yu ZHANG Man-yu WANG Zhi-dong ZHENG Wen-sheng ling hong-jie HU Jun-ming School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

To realize the low-resistance shape optimization design of amphibious robots,an efficient optimization design framework is proposed to improve the geometric deformation flexibility and optimization *** the proposed framework,the free-form deformation parametric model of the flat slender body is established and an analytical calculation method for the height constraints is *** method is introduced to carry out the high-precision resistance calculation and a constrained Kriging-based optimization method is built to improve the optimization efficiency by circularly infilling the new sample points which satisfying the ***,the shape of an amphibious robot example is optimized to get the low-resistance shape and the results demonstrate that the presented optimization design framework has the advantages of simplicity,flexibility and high efficiency.

关键词： amphibious robot optimization method free-form deformation CFD-based hydrodynamic calculation

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Optimizing theπ-Bridge of Non-fullerene Acceptors to Suppress Dark Current in NIR Organic Photodetectors

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Chemical Research in Chinese Universities 2024年第4期40卷 712-721页

作者： SHAO Lin HUANG Yijun hong ling XU Zishuo YANG Xiye LIU Chunchen HUANG Fei CAO Yong State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640P.R.China Lumidar Technology Co. Ltd.Guangzhou510530P.R.China

Recently,the rapid development of non-fullerene acceptors(NFAs)has laid the foundation for performance improvements in near-infrared(NIR)organic photodetectors(OPDs).However,reducing the bandgap of NFAs to achieve strong absorption in the shorter-wave region usually leads to increased dark current density(J_(d))and decreased responsivity(R),severely limiting the detectivity(D*)of *** date,it remains challenging to manipulate the J_(d) of NIR-OPDs through rational structure engineering of ***,three NIR-NFAs,namely bis(2-decyltetradecyl)4,4′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(6-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(TSIC-4F),bis(2-decyltetradecyl)6,6′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(4-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(STIC-4F),and 2,2′-((2Z,2′Z)-(((2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(2,3-bis(5-(2-butyloctyl)thiophen-2-yl)thieno[3,4-b]pyrazine-7,5-diyl))bis(metha-neylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(TPIC-4F),were designed using the thieno[3,4-b]thiophene(TT)and thieno[3,4-b]pyrazine(TPy)derivatives as theπ-*** to the intramolecular S-S and S-N interactions,STIC-4F and TPIC-4F exhibited smaller backbone distortions than TSIC-4F.A significantly red-shifted absorption with a peak at 1015 nm was observed in TPIC-4F film,larger than that(ca.960 nm)for TSIC-4F and STIC-4F ***,OPDs operating in a photovoltaic mode were successfully fabricated,and TPIC-4F-based OPDs achieved the lowest J_(d) of 3.18×10^(-8) A/cm^(2) at-0.1 ***,although TPIC-4F-based OPDs exhibited the lowest R,higher shot-noise-limited specific detectivity(D_(sh)*)in 1000-1200 nm co

关键词： π-Bridge Near-infrared Non-fullerene acceptor Dark current Organic photodetector

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Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li Jia-Wei Tu Juan Kong ling-ling Yang Jian-hong Jia Chuan Wang Bin Hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

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New material of Coniopteris simplex from the Middle Jurassic of the Ordos Basin,Inner Mongolia,China and implications on its spatio-temporal distribution and paleogeography

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Journal of Palaeogeography 2024年第2期13卷 199-211页

作者： Yun-Feng Li Chang-Lu Zhang Fei Liang Xiao tan Fan-Hao Gong Chun-Lin Sun Tao Li Yu-ling Na Research Center of Paleontology and Stratigraphy Jilin UniversityChangchun 130026Jilin ProvinceChina College of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina College of Paleontology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key Lab of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shenyang Center of Geological Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Coniopteris simplex is a common component in many Jurassic ***,due to morphological variations in sterile fronds and incomplete preservation of reproductive organs,its classification has been controversial for a long ***,we present new material collected from the Middle Jurassic Yan’an Formation in the Ordos Basin,Inner *** new material reveals important morphological characters,including hemi-dimorphic fronds,two forms of sterile pinnae,short-stalked sori and sporangia on fertile fronds,annulus of sporangium composed of about 30 cells,in situ rounded triangular spores with protruded suture,and the lips of trilete laesura encircled by one or two rows of small *** on these observations,we emended the diagnosis of this common *** spatio-temporal distribution of Coniopteris simplex shows that the iconic species was restricted to the paleolatitudes ranging from 19.5°N to 48.9°N in the Northern Hemisphere during the Early—Late Jurassic,mainly distributed in the tropical to paratropical zones,and the paleolongitude ranging from 9.6°E to 129.3°E,which may be limited by the opening of the Viking Corridor and the splitting of the Central Atlantic Ocean.

关键词： Coniopteris simplex Yan'an Formation Middle Jurassic Inner Mongolia Paleogeography

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Tetramethylpyrazine protects lymphocytes from radiationinduced apoptosis through nuclear factor-κB

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Chinese Journal of Natural Medicines 2014年第10期12卷 730-737页

作者： WANG Xiao-Yan MA Zeng-Chun WANG Yu-Guang tan hong-ling XIAO Cheng-Rong LIANG Qian-De tanG Xiang-Lin CHENG Yu GAO Yue Institute of Radiation Medicine Academy of Military Medical Science Chongqing Maternal and Child Health-Care Hospital

AIM: Radiation induces an important apoptosis response in irradiated organs. The objective of this study was to investigate the radioprotective effect of tetramethylpyrazine(TMP) on irradiated lymphocytes and discover the possible mechanism of protection. METHOD: Lymphocytes were pretreated for 12 h with TMP(25-200 μmol·L-1) and then exposed to 4 Gy radiation. Cell apoptosis and the signaling pathway were analyzed. RESULTS: Irradiation increased cell death, DNA fragmentation, activated caspase activation and cytochrome c translocation, downregulated B-cell lymphoma 2(Bcl-2) and up-regulated Bcl-2-associated X protein(Bax). Pretreated with TMP significantly reversed this tendency. Several anti-apoptotic characteristics of TMP, including the ability to increase cell viability, inhibit caspase-9 activation, and upregulate Bcl-2 and down-regulate Bax in 4Gy-irradiated lymphocytes were determined. Signal pathway analysis showed TMP could translate nuclear factor-κB(NF-κB) from cytosol into the nucleus. CONCLUSION: The results suggest that TMP had a radioprotective effect through the NF-κB pathway to inhibit apoptosis, and it may be an effective candidate for treating radiation diseases associated with cell apoptosis.

关键词： Tetramethylpyrazine Radioprotection NF-κB Apoptosis

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Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats

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Food Science and Human Wellness 2024年第4期13卷 1974-1986页

作者： Peipei Dou Xiaoyi Li Xiaoxiao Zou Kai Wang Lei Yao Zhuo Sun Hui hong Yongkang Luo Yuqing tan Key Laboratory of Functional Dairy College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co. Ltd.Shijiazhuang 052160China

Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,Ptaneously hypertensive *** increased Akkermansia,Bacteroides,and Lactobacillus abundance promoted high short chain fatty acid content in feces after WPH *** changes jointly contributed to low blood *** heart weight and cardiomyocyte injuries(hypertrophy and degeneration)were alleviated by *** proteomic results revealed that 19 protein expressions in the heart mainly associated with the wingless/integrated(Wnt)signaling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P<0.01),enhanced total antioxidant capacity(P<0.01)and superoxide dismutase activity(P<0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.

关键词： Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome

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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： ling-Xia Kong Yan-hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

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Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 385-392页

作者： Min-Zhi Chen Ping Xie Xiao-Chang Wu Zhen-Hua tan Hai Qian Zhi-hong Ma Xing Yao Department of Hepatopancreatobiliary Surgery Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China Huzhou Key Laboratory of Molecular Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight. Methods: Bile samples from 20 patients(10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy at our center were subjected to tandem mass tag labeling(TMT) and liquid chromatography-tandem mass spectrometry(LC-MS/MS), followed by further bioinformatic analysis. Results: Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor(PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-Ⅰ and APO A-Ⅱ, were confirmed using enzyme-linked immunosorbent assay. Conclusions: The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.

关键词： Proteome profiling Gallstones Obesity-associated gallstones tandem mass tag labeling PPAR signaling

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Chemoselective and Living/Controlled Polymerization of Alkenyl Methacrylates by the Phosphonium Ylide/Organoaluminum Lewis Pairs

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Chinese Journal of Polymer Science 2024年第2期42卷 159-167,I0005页

作者： Zhi-Kang Chen Wu-Chao Zhao Yi-ling Zhao Cong-Lei Liu Liu-Yin Jiang Yue-Tao Zhang hong-Ping Zhu State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Chemoselective,living/controlled polymerizations of allyl methacrylate(AMA) and vinyl methacrylate(VMA) with/without methyl methacrylate(MMA) by using the phosphonium ylide/organoaluminum based Lewis pairs(LPs) have been *** P-ylide-2/AIMe(BHT)_(2)(Pylide-2=Ph_(3)P=CHMe and BHT=2,6-iBu_(2)-4-MeC_(6)H_(2)O) was demonstrated to be superior by which homopolymers PAMAs(M_(n)=27.6-111.5kg/mol and ■=1.14-1.25) and PVMAs(M_(n)=28.4-78.4 kg/mol and ■=1.12-1.18) and block copolymers PMMA-b-PAMA,PAMA-b-PVMA,PAMA-bPMMA,PMMA-b-PAMA-b-PMMA,PAMA-b-PMMA-b-PAMA,and PAMA-b-PVMA-b-PAMA were *** the polymerizations,all of the monomers were reacted by the conjugated ester vinyl groups leaving intactly the nonconjugated acryloxy *** pendant acryloxy groups attached to the main chain enable further to post-functionalization by the AIBN-induced radical "thiol-ene" reaction using PhCH_(2)*** thiolether side group-containing polymers PAMA-SCH_(2)Ph and PAMA-SCH_(2)Ph-b-PMMA-b-PAMA-SCH_(2)Ph were thus prepared.

关键词： Phosphonium ylide Alkenyl methacrylate Chemoselectivity Living/controlled polymerization Post-functionalization

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