Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats
作者机构：Key Laboratory of Functional DairyCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co.Ltd.Shijiazhuang 052160China
出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)
年 卷 期：2024年第13卷第4期
页 面：1974-1986页
核心收录：
学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083203[工学-农产品加工及贮藏工程]
基 金：supported by the Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)
主 题：Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome
摘 要：Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,P0.01),and reduced renin concentration(P0.05),thereby reducing systolic blood pressure(SBP)(12.63%,P0.05)in spontaneously hypertensive *** increased Akkermansia,Bacteroides,and Lactobacillus abundance promoted high short chain fatty acid content in feces after WPH *** changes jointly contributed to low blood *** heart weight and cardiomyocyte injuries(hypertrophy and degeneration)were alleviated by *** proteomic results revealed that 19 protein expressions in the heart mainly associated with the wingless/integrated(Wnt)signaling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P0.01),enhanced total antioxidant capacity(P0.01)and superoxide dismutase activity(P0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.
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