Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats
作者机构:Key Laboratory of Functional DairyCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co.Ltd.Shijiazhuang 052160China
出 版 物:《Food Science and Human Wellness》 (食品科学与人类健康(英文))
年 卷 期:2024年第13卷第4期
页 面:1974-1986页
核心收录:
学科分类:0832[工学-食品科学与工程(可授工学、农学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083203[工学-农产品加工及贮藏工程]
基 金:supported by the Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)
主 题:Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome
摘 要:Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,P0.01),and reduced renin concentration(P0.05),thereby reducing systolic blood pressure(SBP)(12.63%,P0.05)in spontaneously hypertensive *** increased Akkermansia,Bacteroides,and Lactobacillus abundance promoted high short chain fatty acid content in feces after WPH *** changes jointly contributed to low blood *** heart weight and cardiomyocyte injuries(hypertrophy and degeneration)were alleviated by *** proteomic results revealed that 19 protein expressions in the heart mainly associated with the wingless/integrated(Wnt)signaling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P0.01),enhanced total antioxidant capacity(P0.01)and superoxide dismutase activity(P0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.