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Strategy for marker-assisted breeding,status of genetic linkage maps,and QTL for aquaculture species

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Strategy for marker-assisted breeding,status of genetic link...

Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis

2005水产科技论坛

作者： Nobuaki OKAMOTO Kanako FUJI Eriko OHARA takuya HARA Cecilia Castano SANCHEZ Takashi SAKAMOTO Akiyuki OZAKI M.R.M.COIMBRA Sok Kean KHOO Osamu HASEGAWA Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan Faculty of Marine Science Tokyo University of Marine Science and TechnologyTokyoJapan National Research Institute of Aquaculture Fisheries Research AgencyMieJapan Universidade Federal Rural de Pernambuco Recife-PEBrazil Laboratory of Cancer Genetics Van Andel Institute Michigan USA Kanagawa Prefectural Fisheries Research Institute KanagawaJapan

＜正＞Recent advanced techniques in molecular biology have facilitated the dissection of many genetic traits in animals. One of the most important tools of these techniques is genetic linkage maps based on DNA markers such as microsatellite markers. The genetic markers mapped on a linkage map can be used to analyze the quantitative trait loci （QTL） responsible for economically important traits such as disease resistance, growth, and fecundity. In addition, genetic linkage maps also facilitate the positional cloning of functional genes contributing to the quantitative traits. Mapping and identifying the genetic markers linked to economically important traits is critical for marker-assisted breeding. Marker-assisted breeding such as marker-assisted selection （MAS） and marker-assisted gene introgression （MAI） are highly expected to improve the selective breeding programs of aquaculture species. In this paper, we introduce a comprehensive strategy for selective breeding by integrating molecular markers, genetic linkage maps, and QTL data that have been reported in aquaculture species.

关键词： DNA marker genetic linkage map QTL marker-assisted breeding MAS MAI

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World Journal of Gastroenterology 2015年第6期21卷 1880-1886页

作者： Ken Kawakami takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi Second Department of Internal Medicine Osaka Medical College Division of Lower Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Gastroenterology Osaka City University Graduate School of Medicine

AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)***:This was a prospective,multicenter,observational *** May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively *** patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per *** dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 *** of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at *** the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment *** 2wk,73.1%of patients experienced clinical *** tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,*** was well ***:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment *** induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC.

关键词： Ulcerative colitis Tacrolimus Rapid induction ther

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香甜味沙拉酱脂肪酸差异与品质相关性研究

食品与发酵工业 2021年第14期47卷 70-75页

作者：尹明雨柳泽琢也松冈亮辅奚印慈王锡昌上海海洋大学食品学院上海201306 上海海洋大学食品科学技术研究室上海201306

该文以6种香甜味沙拉酱(BL、HS、HM、QB、KF、WM)为研究对象,对沙拉酱脂肪含量以及其脂肪酸组成进行鉴定与分析,并构建评价品质模型。结果显示,不同沙拉酱脂肪含量存在显著差异。QB和HS组沙拉酱脂肪含量显著高于BL、HM、KF、WM组(P<0.0... 详细信息

该文以6种香甜味沙拉酱(BL、HS、HM、QB、KF、WM)为研究对象,对沙拉酱脂肪含量以及其脂肪酸组成进行鉴定与分析,并构建评价品质模型。结果显示,不同沙拉酱脂肪含量存在显著差异。QB和HS组沙拉酱脂肪含量显著高于BL、HM、KF、WM组(P<0.05);沙拉酱中不饱和脂肪酸含量较高,主要以油酸(C18∶1 N9C)和亚油酸甲酯(C18∶2 N6C)为主,通过心血管健康指数表明,沙拉酱能够软化血管、抑制血栓形成;主成分分析法共提取5个主成分,其累计贡献率为71.41%,层次聚类分析的结果表明5个主成分可以对沙拉酱进行有效品质评价。6种沙拉酱中QB品质最佳,BL的品质最差。主成分分析结合层次聚类分析综合评价方法可为不同沙拉酱的脂质品质评价提供参考,并为沙拉酱的新品开发与工业生产提供理论依据。

关键词：沙拉酱脂质脂肪酸主成分层次聚类

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He对仅含位错的纯Fe力学性能的影响研究

材料导报 2016年第10期30卷 1-4页

作者：潘小强徐虬杉浦悠作横谷拓哉义家敏正中国核动力研究设计院反应堆燃料与材料国家重点实验室成都610041 日本京都大学原子炉实验所

在反应堆运行过程中,核材料中的He通过核反应产生,并对材料性能的影响较大。通常认为,He会造成材料强度的上升,韧塑性的下降。制备了不同变形量的仅含位错的纯铁样品,开展了He原子对于样品力学性能影响研究,并对影响机理进行了初步分析... 详细信息

在反应堆运行过程中,核材料中的He通过核反应产生,并对材料性能的影响较大。通常认为,He会造成材料强度的上升,韧塑性的下降。制备了不同变形量的仅含位错的纯铁样品,开展了He原子对于样品力学性能影响研究,并对影响机理进行了初步分析。结果表明,不同的变形量下,He的注入使得样品的拉伸强度或有所提升,或变化不大,但所有样品的延伸率均得到了不同程度的提高。该结果与通常认为的"氦脆"现象不相一致,由此可见,He并不总是降低金属材料的力学性能。

关键词：纯铁 He离子注入位错力学性能

Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication

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World Journal of Gastroenterology 2016年第33期22卷 7569-7578页

作者： Ayato Murata takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Department of Hepatology Shonan-East General Hospital Department of Pathology Juntendo University Shizuoka Hospital Department of Gastroenterology Juntendo University School of Medicine

AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus *** In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank *** Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 *** Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR.

关键词： Human AKR1B10 protein Hepatocellular carcinoma Chronic hepatitis C Immunohistochemistry Risk factor Sustained virological response

高温高压下钛铁矿FeTiO3和（Fe,Mg）SiO3电导率

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高温高压下钛铁矿FeTiO3和（Fe,Mg）SiO3电导率

Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

中国地球物理学会第22届年会

作者：吴小平张宝华 Tomoo Katsura Anton Shatskiy takuya Matsuzaki 中国科学技术大学地球与空间科学学院中国科学技术大学地球与空间科学学院日本冈山大学地球内部研究所 Misasa Tottori-ken 682-0193 日本日本冈山大学地球内部研究所 Misasa Tottori-ken 682-0193 日本日本冈山大学地球内部研究所 Misasa Tottori-ken 682-0193 日本

＜正＞钛铁矿FeTiO3通常存在于金伯利岩包体中,在常温常压下FeTiO3表现为稳定的钛铁矿结构,压力超过16GPa时,钛铁矿结构转变为钙钛矿结构。由于钛铁矿结构也是地幔硅酸盐矿物（Fe,Mg）SiO3 在过渡地幔（410-660 km）温压条件下的主要矿...

＜正＞钛铁矿FeTiO3通常存在于金伯利岩包体中,在常温常压下FeTiO3表现为稳定的钛铁矿结构,压力超过16GPa时,钛铁矿结构转变为钙钛矿结构。由于钛铁矿结构也是地幔硅酸盐矿物（Fe,Mg）SiO3 在过渡地幔（410-660 km）温压条件下的主要矿物结构之一,因此钛铁矿FeTiO3的高温高压电导率测量将有助于理解结构类似的硅酸盐矿物（Fe,Mg）SiO3的电导率,进而帮助认识过渡地幔的电导率结构。

关键词：

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Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi Masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru Ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri Noritomo Shimada Hiroshi Shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro Nouso Akemi Tsutsui takuya Nagano Norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro Nakamura Kojiro Michitaka Yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib

Effects of Beam Startup Characteristics on Dose Delivery Accuracy at Low Monitor Units in Step-and-Shoot Intensity Modulated Radiation Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2013年第1期2卷 1-5页

作者： Kazunori Fujimoto Kunihiko Tateoka Yuji Yaegashi Katsumi Shima Junji Suzuki Yuichi Saito Akihiro Nakata takuya Nakazawa Tadanori Abe Masaki Yano Masanori Someya Kensei Nakata Masakazu Hori Masato Hareyama Koichi Sakata Department of Medical Physics Graduate School of Medicine Sapporo Medical University Sapporo Japan Department of Radiology Sapporo Medical University Sapporo Japan Radiation Therapy Research Institute Social Medical Corporation Teishinkai Sapporo Japan

Intensity modulated radiation therapy (IMRT) is a highly accurate technique that is usually implemented in either dynamic or step-and-shoot fashion with many segments each having low monitor units (MUs). The present study evaluated the effects of beam startup characteristics on the dose delivery accuracy for each segment at low MUs for step-and-shoot IMRT with an Elekta Precise accelerator at the highest dose rates. We used a two-dimensional semi-conductor detector for the dose measurements. The field size of each segment was assumed to be 20 ×20 cm2 and each segment was set to deliver 1 - 10 MUs. Our results show a variation in dose delivery accuracy between segments for the same IMRT beam, which can be attributed to the beam startup characteristics. This variability is attributed to the changes in the transient changes in the temperatures of the electron gun filament and the magnetron. That is, the transient increase in the temperature of the filament leads to increasing doses with time and that of the magnetron leads to decreasing doses with time during the first few MUs.

关键词： Startup Performance Step-and-Shoot IMRT Low Monitor Units

小学科学教师的教学思想及方法的中日比较研究

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外国中小学教育 2013年第9期 30-35页

作者：孟令红 (日)松浦拓也 (日)角屋重树北京教育学院教师教育数理学院实验中心北京100044 日本广岛大学大学院教育学研究科日本东广岛市739-8524 原日本国立教育政策研究所教育课程研究中心基础研究部日本东京市100-8951

本研究以中国为主体、日本为客体,从教学现状和教学环境方面对中日小学科学教师进行了问卷调查,通过调查对中日两国的小学科学教学情况进行了比较研究。目的是通过比较研究更加深入地理解中国小学科学教师的教学思想及方法的特点,同时,... 详细信息

本研究以中国为主体、日本为客体,从教学现状和教学环境方面对中日小学科学教师进行了问卷调查,通过调查对中日两国的小学科学教学情况进行了比较研究。目的是通过比较研究更加深入地理解中国小学科学教师的教学思想及方法的特点,同时,为我国小学科学教育教学改革提供具有可操作性的参考、借鉴。

关键词：小学科学教师教学方法中日比较