Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis

作     者：Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi 

作者机构：Second Department of Internal Medicine Osaka Medical College Division of Lower Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Gastroenterology Osaka City University Graduate School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第6期

页      面：1880-1886页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Ulcerative colitis Tacrolimus Rapid induction ther 

摘      要：AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)***:This was a prospective,multicenter,observational *** May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively *** patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per *** dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 *** of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at *** the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment *** 2wk,73.1%of patients experienced clinical *** tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,*** was well ***:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment *** induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC.