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Scanning transmission ion microscopy on Fudan SPM facility

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Nuclear Science and Techniques 2011年第5期22卷 282-286页

作者： LI Yongqiang SATOH takahiro SHEN Hao ZHENG Yi LI Xinyi LIU Bo Institute of Modern Physics Applied Ion Beam Physics Laboratory Fudan University Shanghai 200433 China Takasaki Advanced Radiation Research Institute Japan Atomic Energy Agency 1233 Watanuki-machi Takasaki Gunma 370-1292 Japan

In this paper,we report a novel measurement system based on the development of Fudan Scanning Proton Microscopy(SPM) *** using Si-PIN diode(Hamamatsu S1223-01) detector,scanning transmission ion microscopy(STIM) measurement system has been set *** can provide density and structural images with high probing efficiency and non-destruction by utilizing the energy loss of high energy(MeV) and focused ions penetrating through a thin *** measurement is able to map the density distribution of organic elements which mostly compose biology materials,such information can not be detected by using conventional Be-windowed Si(Li) X-ray detector in Particle Induced X-ray Emission(PIXE) *** spatial resolution capability of STIM is higher than PIXE technique at same accelerator *** a result of STIM measurement,Paramecium attached on the top of Kapton tube was measured by STIM.

关键词：显微镜 SPM 离子扫描复旦大学设施测量系统传输

Preoperative evaluation of colorectal cancer using CT colonography, MRI, and PET/CT

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World Journal of Gastroenterology 2014年第45期20卷 16964-16975页

作者： Shigeyoshi Kijima takahiro Sasaki Koichi Nagata Kenichi Utano Alan T Lefor Hideharu Sugimoto Department of Radiology Jichi Medical University Department of Surgery Jichi Medical University

Imaging studies are a major component in the evaluation of patients for the screening,staging and surveillance of colorectal *** review presents commonly encountered findings in the diagnosis and staging of patients with colorectal cancer using computed tomography(CT)colonography,magnetic resonance imaging(MRI),and positron emission tomography(PET)/CT *** colonography provides important information for the preoperative assessment of T *** deformities are associated with muscular or subserosal *** node metastases from colorectal cancer often present with *** is superior to detect calcified ***-dimensional CT to image the vascular anatomy facilitates laparoscopic surgery.T staging of rectal cancer by MRI is an established modality because MRI can diagnose rectal wall laminar structure.N staging in patients with colorectal cancer is still challenging using any imaging *** is more accurate than CT for the evaluation of liver ***/CT colonography isvaluable in the evaluation of extra-colonic and hepatic ***/CT colonography is useful for obstructing colorectal cancers that cannot be traversed ***/CT colonography is able to localize synchronous colon cancers proximal to the obstruction ***,there is no definite evidence to support the routine clinical use of PET/CT colonography.

关键词： Colorectal cancer Preoperative evaluation T staging N staging Liver metastasis Magnetic resonance imaging Computed tomography colonography Positron emission tomography

One-, Two-, and Three-Dimensional Supramolecular Assemblies Based on Tubular and Regular Polygonal Structures of Pillar[n]arenes

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CCS Chemistry 2019年第1期1卷 50-63页

作者： Shixin Fa takahiro Kakuta Tada-aki Yamagishi Tomoki Ogoshi WPI Nano Life Science Institute(WPI-NanoLSI) Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan Graduate School of Natural Science&Technology Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan

Pillar[n]arenes,which were first reported by our groupin2008,arepromisingmacrocycliccompounds in supramolecular *** simple,tubular,and highly symmetrical shape of pillar[n]arenes has allowed various supramolecular ass... 详细信息

关键词： macrocyclic compounds supramolecular assembly host-guest interaction

STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1

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World Journal of Gastroenterology 2006年第5期12卷 703-708页

作者： Toufeng Jin Hajime Nakatani takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya Kobayashi Keijiro Araki Department of Tumor Surgery Kochi Medical School Kochi University Nankoku Kochi 783-8505 Japan and Department of General Surgery College of Medical Yanbian University 119 Juzijie Yanji Jilin Province China Department of Tumor Surgery Kochi-Medical School Kochi University Nankoku Kochi 783-8505 Japan Department of Human Health and Medical Science Graduate school of Kuroshio Science Kochi UniversityNankoku Kochi 783-8503 Japan

AIM： To estimate whether S-TI571 inhibits the expression of vascular endothelial growth factor （VEGF） in the gastrointestinal stromal tumor （GIST） cells. METHODS： We used GIST cell line, GIST-T1. It has a heterogenic 57-bp deletion in exon 11 to produce a mutated c-KIT, which results in constitutive activation of c-KIT. Cells were treated with/without STI571 or stem cell factor （SCF）. Transcription and expression of VEGF were determined by RT-PCR and flow cytometry or Western blotting, respectively. Activated c-KIT was estimated by immunoprecipitation analysis. Cell viability was determined by PITT assay. RESULTS： Activation of c-KIT was inhibited by STI571 treatment. VEGF was suppressed at both the transcriptional and translational levels in a temporal and dose-dependent manner by STI571. SCF upregulated the expression of VEGF and it was inhibited by S-13571. STI571 also reduced the cell viability of the GIST-T1 cells, as determined by PTT assay. CONCLUSION： Activation of c-KIT in the GIST-T1 regulated the expression of VEGF and it was inhibited by ST571. STI571 has antitumor effects on the GIST cells with respect to not only the inhibition of cell growth, but also the suppression of VEGF expression.

关键词： c-KIT Vascular endothelial growth factor(VEGF) S-13571 Gastrointestinal stromal tumor GIST-T1

Improvement of a Real Gas-Sensor for the Origin of Methane Selectivity Degradation by l-XAFS Investigation

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Nano-Micro Letters 2015年第3期7卷 255-260页

作者： takahiro Wada Naoyoshi Murata Takuya Suzuki Hiromitsu Uehara Hiroaki Nitani Yasuhiro Niwa Motohiro Uo Kiyotaka Asakura Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Corporate R&D Headquarters Fuji Electric Co. Ltd Catalysis Research Center Hokkaido University Photon Factory Institute of Materials Structure Science

We have directly investigated the chemical state of the Pd species in a real l-gas sensor device by examining the l-fluorescence X-ray absorption fine structure. The l-gas sensor device was heavily damaged by a heating process in which the temperature was ill-controlled, resulting in decrease of methane selectivity. We found that the Pd O in the fresh l-gas sensor was reduced to Pd metal particles as the methane selectivity decreased. Based on the investigation results, we modified the device structure so as to heat up homogeneously. The lifetime of the sensor was then successfully increased by more than 5 years.

关键词： Micro gas sensor Micro-XAFS Pd/Al2O3 Deactivation

HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer

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World Journal of Clinical Cases 2019年第15期7卷 1964-1977页

作者： Akio Kaito Takeshi Kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto takahiro Kinoshita Department of Gastric Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Gastrointestinal Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research&Clinical Trial Center(EPOC) National Cancer Center Hospital EastKashiwa 277-8577Japan Juntendo University Graduate School of Medicine Tokyo 163-8001Japan Department of Radiation Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan

BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based *** To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based *** Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were *** patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were *** A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based ***,HER2 heterogeneity should be considered during the assessment of HER2 expression.

关键词： Human epidermal growth factor receptor 2 Heterogeneity Trastuzumab Gastric cancer Chemotherapy

Inflammatory bowel disease of primary sclerosing cholangitis:A distinct entity?

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World Journal of Gastroenterology 2014年第12期20卷 3245-3254页

作者： takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Hitoshi Sano Katsuyuki Miyabe Shuya Shimizu Takashi Joh Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Department of Gastroenterology Gifu Prefectual Tajimi Hospital

This is a review of the characteristic findings of inflammatory bowel disease(IBD)associated with primary sclerosing cholangitis(PSC)and their usefulness in the diagnosis of sclerosing *** is a chronic inflammatory disease characterized by idiopathic fibrous obstruction and is frequently associated with *** with PSC(PSC-IBD)shows an increased incidence of pancolitis,mild symptoms,and colorectal *** an increased incidence of pancolitis is a characteristic finding,some cases are endoscopically diagnosed as right-sided ulcerative *** studies have revealed that inflammation occurs more frequently in the right colon than the left *** frequency of rectal sparing and backwash ileitis should be investigated in a future study based on the same *** cholangiographic findings of immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)are similar to those of *** rare association between IBD and IgG4-SC and the unique characteristics of PSC-IBD are useful findings for distinguishing PSC from IgG4-SC.

关键词： Primary sclerosing cholangitis Primary sclerosing cholangitis Inflammatory bowel disease Inflammatory bowel disease-associated with primary sclerosing cholangitis Immunoglobulin G4-related sclerosing cholangitis

A high-resolution environmental change record since 19 cal ka BP in Pumoyum Co, southern Tibet

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Chinese Science Bulletin 2011年第27期56卷 2931-2940页

作者： LU XinMiao ZHU LiPing NISHIMURA Mitsugu MORITA Yoshimune WATANABE takahiro NAKAMURA Toshio WANG Yong Key Laboratory of Tibetan Environment Changes and Land Surce Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China School of Marine Scinece and Technology Tokai University Shizuoka 424-8610 Japan Botanical Garden Okayama University of Science Okayama 700-0005 Japan Graduate School of Science Tohoku University Sendai 980-8578 Japan Centre for Chronological Research Nagoya University Nagoya 464-8602 Japan Graduate University of Chinese Academy of Sciences Beijing 100049 China

A 380-cm-long sediment core was acquired from the deep water area of Pumoyum Co, southern Tibet. Twenty-five plant residue samples were selected, and organic carbon stable isotopes were obtained using the AMS 14 C chronological method. The 14 C age and carbon reservoir effect were calibrated with surface sedimentation rate measurements using 210 Pb dating. Results showed that the core sediment deposited over 19 cal ka BP. Based on a multi-proxy analysis of TOC and IC contents, grain size and pollen assemblage data, the palaeoclimatic evolution of Pumoyum Co was reconstructed since the last glacial. Pumoyum Co was a shallow lake prior to 16.2 cal ka BP; although the glacier around the lake began to melt due to increasing temperatures, climate was still cold and dry. In the interval of 16.2-11.8 cal ka BP, the sedimentary environment fluctuated drastically and frequently. Two cold-events occurred at 14.2 and 11.8 cal ka BP, and these may correspond to the Older Dryas and the Younger Dryas events, respectively. After 11.8 cal ka BP, Pumoyun Co developed into the deep lake as it is now. The lake water temperature was relatively lower at that time because of influx of cold water from glacial meltwater entering the lake. As a result, the multi-proxy indicators showed no sign of warm conditions. Comparisons between the sedimentary record of Pumoyum Co with that of other lakes of the same age in southern Tibet indicate a warmer climate following the last deglaciation influenced the southeastern Tibetan Plateau. These results imply that the southwest Asian monsoon gradually became stronger since the deglaciation during its expansion to the inner plateau. The glacial-supplied water of the lake responded sensitively to cold-events. The entire southern Tibet region was dominantly influenced climatically by the southwest Asian monsoon during the Holocene.

关键词：西藏南部环境变化 CAL BP 合作高分辨率青藏高原东南部古气候演变

Linear-superelastic Ti-Nb nanocomposite alloys with ultralow modulus via high-throughput phase-field design and machine learning

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npj Computational Materials 2021年第1期7卷 1897-1906页

作者： Yuquan Zhu Tao Xu Qinghua Wei Jiawei Mai Hongxin Yang Huiran Zhang takahiro Shimada Takayuki Kitamura Tong-Yi Zhang Materials Genome Institute Shanghai UniversityShanghai 200444China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Department of Mechanical Engineering and Science Kyoto UniversityNishikyo-kuKyoto 615-8540Japan

The optimal design of shape memory alloys(SMAs)with specific properties is crucial for the innovative application in advanced ***,inspired by the recently proposed design concept of concentration modulation,we explore martensitic transformation(MT)in and design the mechanical properties of Ti-Nb nanocomposites by combining high-throughput phase-field simulations and machine learning(ML)*** phase-field simulations generate data of the mechanical properties for various nanocomposites constructed by four macroscopic degrees of *** ML-assisted strategy is adopted to perform multiobjective optimization of the mechanical properties,through which promising nanocomposite configurations are prescreened for the next set of phase-field *** ML-guided simulations discover an optimized nanocomposite,composed of Nb-rich matrix and Nb-lean nanofillers,that exhibits a combination of mechanical properties,including ultralow modulus,linear superelasticity,and near-hysteresis-free in a loading-unloading *** exceptional mechanical properties in the nanocomposite originate from optimized continuous MT rather than a sharp first-order transition,which is common in typical *** work demonstrates the great potential of ML-guided phase-field simulations in the design of advanced materials with extraordinary properties.

关键词： alloys modulus phase