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在吸取卵泡时测量卵巢内动脉的搏动指数和阻力指数评价卵子质量的有用性

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 15-16页

作者： takahashi k. Ishida G.M. 张旸 Department of Obstetrics and Gynecology Yamagata University School of Medicine 2-2-2 Iidanishi Yamagata 990- 9585 JapanDr.

Objective: To examine the correlation between the pulsatility and resistance indices (PI and RI) of the intraovarian artery on the day of follicle aspiration and the oocyte quality, intrafollicular oxidative stress, and luteinization. Pulsatility index and RI on the day of hCG administration also were measured. Design: Prospective study. Setting: Obstetrics and gynecology department of a university medical school in Japan. Patient(s): Thirty- five patients in an IVF- ET program. Intervention(s): The PI and RI of the intraovarian artery were measured by transvaginal color ultrasonographic pulsed wave Doppler on the day of hCG administration and the day of follicle aspiration. Follicular fluids and the granulosa cells were collected at follicle aspiration. Main Outcome Measure(s): The PI and RI of the intraovarian artery blood flowon the day of hCG administration and of follicle aspiration, as well as the rate of development of mature oocytes, follicular fluid steroid levels, and the incidence of apoptosis in the granulosa cells. Result(s): The PI and RI on the day of follicle aspiration were correlated positively with the rate of mature oocytes retrieved (PI: r = 0.429; RI: r = 0.348), were correlated negatively with the incidence of apoptotic mural (PI: r =- 0.383; RI: r =- 0.459) and cumulus (PI: r = - 0.378; RI: r =- 0.469) granulosa cells, and were negatively correlated with the concentration of P in the follicular fluid (PI: r =- 0.429; RI: r =- 0.359). The PI and RI on the day of hCG administration were negatively correlated only with the total number of retrieved oocytes (PI: r =- 0.393; RI: r =- 0.374). Conclusion(s): The PI and RI of the intraovarian artery blood flow measured on the day of follicle aspiration may be good indicators of the follicle luteinization and oxidation as well as of oocyte quality.

关键词：阻力指数(RI) 动脉搏动指数卵子质量卵泡内指数评价测量颗粒细胞凋亡人绒膜毛促性腺激素

阻塞性睡眠呼吸暂停患者接受长期经鼻持续气道正压通气治疗后血压下降

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 57-58页

作者： Chin k. Nak.mura T. takahashi k.-I. 孙志军 Department of Physical Therapeutics Kyoto University Hospital of Medicine 54 Shogoin Kawahara-cho Sakyo-Ku 606-8507 Kyoto Japan

目的:有效的经鼻持续气道正压通气(nCPAP)治疗可使阻塞性睡眠呼吸暂停(OSA)患者的血压(BP)下降,但长期nCPAP治疗对OSA患者BP的影响尚不明确,且足以引起血压下降的治疗时限也不明确。作者对长期nCPAP治疗的依从性及其对BP的效应进行了研究。

关键词：睡眠呼吸暂停低通气依从性药物降压观察性研究检查点

卵巢囊肿切除术对残余卵巢组织排卵功能的影响

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 26-27页

作者： takahashi k. Ozak. T. k.nasak. H. Miyazak. k. 张剑萍 Department of Obstetrics and Gynecology Shiga University of Medical Science Ohtsu 520- 2192 Japan

Back.round: Whether the surgery for benign ovarian disease affect ovulatory function on residual ovarian tissue has not yet been established. Methods: We investigated the post-operative function of residual ovaries in 62 patients who underwent laparoscopic ovarian cystectomy or abdominal ovarian cystectomy. Results: The results based on an average of 7.9 monitored ovulatory cycles after surgery showed that 53% of patients did not have natural ovulation from the diseased ovary. The number of developing follicles after ovulation-induction treatments was significantly less in the diseased ovary than in the healthy ovary. However, in 13 of 24 women who became pregnant after surgery, ovulation occurred in the diseased ovary. Although a reduction in maturation of follicles was suggested after cystectomy, some women became pregnant after ovulation from the diseased ovary. Conclusion: Our results suggest that careful attention should be given to preventing post-operative adhesion in the diseased and surgically managed ovary in cases that undergo cystectomy.

关键词：卵巢囊肿切除术排卵功能卵巢组织患侧卵巢诱导排卵卵泡发育成熟卵泡排卵周期腔镜切除卵巢

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肝脏铁超负荷是铜蓝蛋白缺乏症新的临床类型

世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 25-26页

作者： k.no S. Suzuk. H. takahashi k. 张婷 The First Department of Medicine Hamamatsu University School of Medicine Hamamatsu Japan

Back.round &Aims: Aceruloplasminemia is a novel hereditary iron overload disease caused by a mutation in the ceruloplasmin gene and characterized by a complete deficiency of serum ceruloplasmin and iron accumulation in the liver and brain. Methods: We herein studied a novel clinical type of aceruloplasminemia in which a low amount of ceruloplasmin was detected in the serum of a patient. The patient presented with an asymptomatic hepatic iron overload, retinal degeneration, and diabetes mellitus. Magnetic resonance imaging of the liver and basal ganglia showed T2-hypointensity signals associated with parenchy-mal iron accumulation because of an absence of the ferroxidase activity in ceruloplasmin. Results: A gene analysis showed a novel G969S mutation in the ceruloplasmin gene. A biochemical analysis of the patients’serum and a biogenesis study of G969S mutant ceruloplasmin using mammalian cell culture system resulted in the synthesis and secretion of only apoceruloplasmin without any ferroxidase activity. Conclusions: This novel clinical type of aceruloplasminemia should therefore be considered in the differential diagnosis of unexplained hemochromatosis, which is associated with a decrease in the serum ceruloplasmin level.

关键词：铜蓝蛋白缺乏症铁超负荷血红蛋白沉着症过度性视网膜变性氧化酶活性基因突变基因分析无症

首发症状表现为双侧眼眶肿瘤的人类T细胞白血病病毒1相关成人T细胞性白血病

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世界核心医学期刊文摘(眼科学分册) 2006年第3期 14-15页

作者： Yoshik.wa T Ogata N takahashi k. 杨秀梅 Department of Ophthalmology Kansai Medical University Fumizono-cho 10-15 Moriguchi Osaka 570-8 507 Japan Dr.

PURPOSE: To report a case of human T-cell leuk.mia virus type1 (HTLV-1)-associated adult T-cell leuk.mia/lymphoma (ATLL) whose initial sign was exophthalmos. DESIGN: Case report. METHODS: A 64-year-old Japanese man presented with exophthalmos and choroidal folds of the right eye without general symptoms and received ophthalmologic and laboratory examination, magnetic resonance imaging (MRI), and orbital biopsy. METHODS: Antibodies against HTLV-1 were extremely high but atypical lymphocytes were not present in the peripheral blood. MRI showed multiple tumorous lesions in both orbits. Orbital biopsy revealed an orbital mass that consisted of atypical lymphocytes originally from T cells and established the diagnosis of lymphoadenopathy type of ATLL. CONCLUSION: Although ocular involvement by ATLL is extremely rare, ATLL can first present in the orbit, and only the results of a biopsy can provide definitive information for its diagnosis.

关键词：白血病病毒细胞性首发症状人类成人

努南综合征和急性进行性肥厚性心肌病患儿PTPN11基因中一个新的突变

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 19-19页

作者： takahashi k. k.gak. S. k.rotobi S. 贺莉 Department of Developmen tal Medicine (Paediatr-ics) Osaka University Graduate School of Medicine 2-2 Yamada-oka 565-087 1 Suita Osaka Japan

A male infant with clinical features of Noonan syndrome and rapidly progressiv e hypertrophic cardiomyopathy is reported. He manifested severe heart failure an d failure to thrive. Administration of propranolol and cibenzoline improved vent ricular outflow tract obstruction, leading to catch-up growth. Genetic analysis of the patient revealed a novel missense mutation in the PTPN11 gene. Conclusio n:This is the first description of a patient with a Gln510Glu mutation in the pr otein-tyrosine phosphatase, non-receptor type 11 gene. This specific mutation may be associated with a rapidly progressive hypertrophic cardiomyopathy.

关键词：努南综合征 PTPN11 肥厚性心肌病西苯唑啉遗传学分析严重心力衰竭同龄儿童心得安流出道

Precise Synthesis of Organometallic Dendrimers

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复旦学报（自然科学版） 2005年第5期44卷 823-824页

作者： k. Onitsuk. S. takahashi The Institute of Scientific and Industrial Research Osaka University8-1 Mihogaoka Ibaraki Osaka 567-0047 JapanThe Institute of Scientific and Industrial Research Osaka University8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Dendrimers possessing a regularly branched architecture and large spherical dimensions have attracted significant attention because of their unique and tunable properties as well as their potential applications. The incorporation of organometallic species into dendritic molecules has been attracting much attention, because the addition of properties characteristic of organometallic complexes, such as magnetic, electronic, and photo-optical properties, as well as reactivity may lead to the realization of new functionalized dendrimers. Although there are many examples of organometallic dendrimers that contain metallic species at the core or at the periphery, dendrimers composed of organometallic complexes in each generation are still limited. We present here convergent and divergent approaches to novel organometallic dendrimers, of which the sk.letons were built up with platinum-acetylide units.

关键词：有机金属树型化合物乙炔化物合成方法光学性质

正常妊娠脉波速率的变化及其在预测妊娠期高血压疾病中的价值:一项纵向研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 8-8页

作者： Oyama-k.to M. Ohmichi M. takahashi k. 王淑珍 Department of Obstetrics and Gynecology Yamagata University School of MedicineIidanishiYamagataJapan Dr.

Objective:We longitudinally examined the changes of brachial to ank.e distensibility using pulse wave velocity (PWV)-throughout pregnancy and its difference between normal pregnancy and pregnancy-induced hypertension (PIH) groups. Study design:One hundred and eighty-three pregnant women were included in this study. The PWV examinations were performed in a longitudinal way during the first,second,and third trimesters of pregnancy,and immediately and 1 month after delivery. Results:In normal pregnancies,the PWV significantly decreased at the second trimester,increased from the third trimester through immediately after delivery,and decreased again at 1 month after delivery. In PIH patients,it increased in proportion to the progression of gestation. Conclusion:We monitored the longitudinal changes in PWV and constructed a PWV normogram during pregnancy. The predictive value of PWV and blood pressure for PIH was higher than that of blood pressure alone,suggesting the usefulness of measuring PWV to predict PIH.

关键词：正常妊娠纵向研究脉波妊娠中期晚期妊娠妊娠组妊娠早期纵向观察血压监测研究设计

Estimation of water requirement per unit carbon fixed by Eucalyptus camaldulensis in semi-arid land of Western Australia

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Science China Earth Sciences 2002年第z1期45卷 142-147页

作者： T. k.jima Y. Tanak. S. k.toh k. Tahara N. takahashi k. Yamada Department of Applied Chemistry Fac. of Eng. Seikei University Tokyo 180-8633 Japan Japan Science and Technology Corporation Tokyo 110-0015 Japan Deptartment of Fine Materials Engineering Shinshu University Nagano Pre. 386-8567 Japan

Afforestation in arid land is a promising method for carbon fixation, but the effective utili- zation of water is highly important and required. Thus, the evaluation of the amount of water per unit carbon fixed with the tree growth is required to minimize the amount of water supplied to the plants. In this research, a tree is regarded as a carbon fixation reactor with inflows of water and nutrients from roots, and CO_2 as the carbon source from leaves with outflow of water vapor from leaves and accumulation in the tree itself. In the process of photosynthesis and respiration nutri- tional elements are dissolved in water flow in trees. They do not flow out by these reactions, but are accumulated in trees. Thus, we have treated the behaviour of nutrients as a mark.r to evaluate the water/carbon ratio. Assuming that nutrient concentration is constant in sap, and the differences in the ratios of nutrient to carbon in living trees and dead (i.e. litter fall, etc.) are neglected, the ratio of the used water to fixed carbon is given as the ratio of nutrient to carbon in the tree body divided by the ratio of nutrient to water in sap. However, some nutrients are translocated and concentrated within the tree and some may be discarded through litter fall. Thus it is important to examine which nutrient element is the most suitable as the tracer. In this paper, the results of the above method applied to Eucalyptus camaldulensis in semi- arid land of Western Australia are shown. The value of water requirement per unit carbon fixation determined from potassium balance is between 421 k.-H_2O/k.-C for mature trees and 285 k.-H_2O/k.-C for young trees, while the values from calcium balance are much larger than these. The cause of the discrepancy between these values is discussed based on the measured element concentrations in sap and trees and the plant physiology. Finally, the actual average value through the life of a tree is suggested to fall between the two values.

关键词： carbon fixation, unit water requirement, arid land, Western Australia, Eucalyptus camaldulensis,