在吸取卵泡时测量卵巢内动脉的搏动指数和阻力指数评价卵子质量的有用性

作     者：Takahashi K. Ishida G.M. 张旸 

作者机构：Department of Obstetrics and GynecologyYamagata University School of Medicine 2-2-2 Iidanishi Yamagata 990- 9585 JapanDr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第6期

页      面：15-16页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：阻力指数(RI) 动脉搏动指数 卵子质量 卵泡内 指数评价 测量 颗粒细胞凋亡 人绒膜毛促性腺激素 

摘      要：Objective: To examine the correlation between the pulsatility and resistance indices (PI and RI) of the intraovarian artery on the day of follicle aspiration and the oocyte quality, intrafollicular oxidative stress, and luteinization. Pulsatility index and RI on the day of hCG administration also were measured. Design: Prospective study. Setting: Obstetrics and gynecology department of a university medical school in Japan. Patient(s): Thirty- five patients in an IVF- ET program. Intervention(s): The PI and RI of the intraovarian artery were measured by transvaginal color ultrasonographic pulsed wave Doppler on the day of hCG administration and the day of follicle aspiration. Follicular fluids and the granulosa cells were collected at follicle aspiration. Main Outcome Measure(s): The PI and RI of the intraovarian artery blood flowon the day of hCG administration and of follicle aspiration, as well as the rate of development of mature oocytes, follicular fluid steroid levels, and the incidence of apoptosis in the granulosa cells. Result(s): The PI and RI on the day of follicle aspiration were correlated positively with the rate of mature oocytes retrieved (PI: r = 0.429; RI: r = 0.348), were correlated negatively with the incidence of apoptotic mural (PI: r =- 0.383; RI: r =- 0.459) and cumulus (PI: r = - 0.378; RI: r =- 0.469) granulosa cells, and were negatively correlated with the concentration of P in the follicular fluid (PI: r =- 0.429; RI: r =- 0.359). The PI and RI on the day of hCG administration were negatively correlated only with the total number of retrieved oocytes (PI: r =- 0.393; RI: r =- 0.374). Conclusion(s): The PI and RI of the intraovarian artery blood flow measured on the day of follicle aspiration may be good indicators of the follicle luteinization and oxidation as well as of oocyte quality.