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Upgrading and upstaging of low-risk prostate cancer among Korean patients： a multicenter study

Asian Journal of Andrology 2015年第5期17卷 811-814,I0009页

作者： Insang Hwang Donghoon Lim Young Beom Jeong Seung Chol Park Jun Hwa Noh Dong Deuk Kwon taek won kang Department of Urology Chonnam National University Medical School Gwangju Korea Department of Urology Chosun University Medical School Gwangju Korea Department of Urology Chonbuk National University Medical School Jeonju Korea Department of Urology Wonkwang University School of Medicine Iksan Korea Department of Urology Kwangju Christian Hospital Gwangju Korea

Only 54% of prostate cancer cases in Korea are localized compared with 82% of cases in the US. Furthermore, half of Korean patients are upgraded after radical prostatectomy （41.6%-50.6%）. We investigated the risk factors for upgrading and/or upstaging of low-risk prostate cancer after radical prostatectomy. We retrospectively reviewed the medical records of 1159 patients who underwent radical prostatectomy at five hospitals in Honam Province. Preoperative data on standard clinicopathological parameters were collected. The radical prostatectomy specimens were graded and staged and we defined a ＂worsening prognosis＂ as a Gleason score ≥ 7 or upstaging to ≥ pT3. Multivariate logistic regression models were used to assess factors associated with postoperative pathological upstaging. Among the 1159 patients, 324 were classified into the clinically low-risk group, and 154 （47.5%） patients were either upgraded or upstaged. The multivariable analysis revealed that the preoperative serum prostate-specific antigen level （odds ratio [OR], 1.131; 95% confidence interval [CI], 1.007-1.271; P = 0.037）, percent positive biopsy core （OR： 1.018; 95% CI： 1.002-1.035; P = 0.032）, and small prostate volume （≤30 ml）（OR： 2.280; 95% CI： 1.351-3.848; P = 0.002） were predictive of a worsening prognosis. Overall, 47.5% of patients with low-risk disease were upstaged postoperatively. The current risk stratification criteria may be too relaxed for our study cohort.

关键词： prostate cancer prostatectomy risk factors

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Novel Perovskite Oxide Hybrid Nanofibers Embedded with Nanocatalysts for Highly Efficient and Durable Electrodes in Direct CO_(2) Electrolysis

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Nano-Micro Letters 2024年第5期16卷 214-230页

作者： Akromjon Akhmadjonov Kyung taek Bae kang taek Lee Department of Mechanical Engineering KAISTDaejeon 34141Republic of Korea KAIST Graduate School of Green Growth and Sustainability Daejeon 34141Republic of Korea

The unique characteristics of nanofibers in rational electrode design enable effec-tive utilization and maximizing material properties for achieving highly efficient and sustainable CO_(2) reduction reactions( CO_(2)RRs)in solid oxide elec-trolysis cells(SOECs).However,practical appli-cation of nanofiber-based electrodes faces chal-lenges in establishing sufficient interfacial contact and adhesion with the dense *** tackle this challenge,a novel hybrid nanofiber electrode,La_(0.6)Sr_(0.4)Co_(0.15)Fe_(0.8)Pd_(0.05)O_(3-δ)(H-LSCFP),is developed by strategically incorporating low aspect ratio crushed LSCFP nanofibers into the excess porous interspace of a high aspect ratio LSCFP nanofiber framework synthesized via electrospinning *** consecutive treatment in 100% H_(2) and CO_(2) at 700°C,LSCFP nanofibers form a perovskite phase with in situ exsolved Co metal nanocatalysts and a high concentration of oxygen species on the surface,enhancing CO_(2) *** SOEC with the H-LSCFP electrode yielded an outstanding current density of 2.2 A cm^(-2) in CO_(2) at 800°C and 1.5 V,setting a new benchmark among reported nanofiber-based *** twinning of the H-LSCFP reveals improved contact adhesion and increased reaction sites for CO_(2)*** present work demonstrates a highly catalytically active and robust nanofiber-based fuel electrode with a hybrid structure,paving the way for further advancements and nanofiber applications in CO_(2)-SOECs.

关键词： Nanofibers Fuel electrodes Digital twinning CO_(2)reduction reaction Solid oxide electrolysis cells

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Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy

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Asian Journal of Andrology 2016年第1期18卷 54-59页

作者： Eu Chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung taek won kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung Department of Urology Chonnam National University Medical School Gwangju Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju Republic of Korea Department of Radiology Chonnam National University Medical School Gwangju Republic of Korea Department of Hemato-oncology Chonnam National University Medical School Gwangju Republic of Korea Department of Neurosurgery Chonnam National University Medical Schoo Gwangju Republic of Korea

Several studies have revealed that the preoperative serum testosterone and percent tumor volume （PTV） predict extra-prostatic extension （EPE） and biochemical recurrence （BCR） after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy （LRP）. We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen （PSA）〉0.2 ng ml^-1. The threshold for serum total testosterone was 3.0 ng ml^-1, Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone （〈3.0 ng ml^-1） was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone （〈3.0 ng ml^-1, adjusted OR, 8.52; 95% CI, 5.04-14.4, P = 0.001） predicted EPE and PTV （adjusted OR, 1.02; 95% CI, 1.01-1.05, P = 0.046） predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.

关键词： biochemical recurrence extra-prostatic extension prostate neoplasms prostatectomy testosterone tumor burden

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Apalutamide for metastatic castration-sensitive prostate cancer:final analysis of the Asian subpopulation in the TITAN trial

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Asian Journal of Andrology 2023年第6期25卷 653-661页

作者： Byung Ha Chung Jian Huang Hiroji Uemura Young Deuk Choi Zhang-Qun Ye Hiroyoshi Suzuki taek won kang Da-Lin He Jae Young Joung Sabine D Brookman-May Sharon McCarthy Amitabha Bhaumik Anildeep Singh Suneel Mundle Simon Chowdhury Neeraj Agarwal Ding-Wei Ye Kim N Chi Hirotsugu Uemura Gangnam Severance Hospital Yonsei University College of MedicineSeoul 06273South Korea Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhou 510123China Yokohama City University Medical Center Minami-kuYokohamaKanagwa 232-0024Japan Severance Hospital Yonsei University College of MedicineSeoul 03722South Korea Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Toho University Sakura Medical Center Chiba 285-0841Japan Chonnam National University Hospital and Medical School Gwangju 61469South Korea Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Prostate Cancer Center National Cancer CenterGoyang 10408South Korea Janssen Research and Development Spring HousePA 19002USA Ludwig Maximilians University Munich 80539Germany Janssen Research and Development RaritanNJ 08869USA Janssen Medical Affairs Asia PacificSingapore 118222Singapore Guy’s and St Thomas’NHS Foundation Trust London SE14YBUK University of Utah Huntsman Cancer Institute Salt Lake CityUT 84112USA Fudan University Shanghai Cancer Center Shanghai 200032China Vancouver Prostate Centre University of British ColumbiaVancouverBritish Columbia V6H 3Z6Canada Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial showed improvement in overall survival(OS)and other efficacy endpoints with apalutamide plus androgen deprivation therapy(ADT)versus ADT alone in patients with metastatic castration-sensitive prostate cancer(mCSPC).As ethnicity and regional differences may affect treatment outcomes in advanced prostate cancer,a post hoc final analysis was conducted to assess the efficacy and safety of apalutamide in the Asian ***-driven endpoints were OS,and time from randomization to initiation of castration resistance,prostate-specific antigen(PSA)progression,and second progression-free survival(PFS2)on first subsequent therapy or *** endpoints were assessed using the Kaplan–Meier method and Cox proportional-hazards models without formal statistical testing and adjustment for *** Asian patients received once-daily apalutamide 240 mg(n=111)or placebo(n=110)plus *** a median follow-up of 42.5 months and despite crossover of 47 placebo recipients to open-label apalutamide,apalutamide reduced the risk of death by 32%(hazard ratio[HR]:0.68;95%confidence interval[CI]:0.42–1.13),risk of castration resistance by 69%(HR:0.31;95%CI:0.21–0.46),PSA progression by 79%(HR:0.21;95%CI:0.13–0.35)and PFS2 by 24%(HR:0.76;95%CI:0.44–1.29)relative to *** outcomes were comparable between subgroups with low-and high-volume disease at *** new safety issues were *** provides valuable clinical benefits to Asian patients with mCSPC,with an efficacy and safety profile consistent with that in the overall patient population.

关键词： apalutamide Asia event-driven analysis metastatic castration-sensitive prostate cancer overall survival

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Primary signet ring cell carcinoma of the appendix:A rare case report and our 18-year experience

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World Journal of Gastroenterology 2008年第37期14卷 5763-5768页

作者： Yoon Ho Ko Chan-Kwon Jung Soon Nam Oh Tae Hee Kim Hye Sung won Jin Hyoung kang,Hyung Jin Kim, won Kyung kang, Seong taek Oh, Young Seon Hong Jin Hyoung kang Hyung Jin Kim won Kyung kang Seong taek Oh Young Seon Hong Departmentof Internal Medicine Kangnam St. Mary's hospital CatholicUniversity Seoul 137-701 South Korea Department of Hospital Pathology Kangnam St. Mary's hospital Catholic University Seoul137-70 l South Korea Department of Radiology Kangnam St. Mary'shospital Catholic University Seoul 137-701 South Korea Department of General Surgery Kangnam St. Mary's hospitalCatholic University Seoul 137-701 South Korea

Primary adenocarcinoma of the appendix is a rare malignancy that constitutes 〈 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carc noma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appen- dectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent ap- pendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin （FOIFOX-4）. The patient currently is well without progression of disease 12 mo after beginning chemotherapy.

关键词： Appendiceal neoplasms Carcinoma Signet ring cell Chemotherapy

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Superelastic metastable Ti-Mo-Sn alloys with high elastic admissible strain for potential bio-implant applications

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Journal of Materials Science & Technology 2023年第32期163卷 45-58页

作者： Shuanglei Li Jae H.Kim Seung won kang Jae Ho Kim Tae-Hyun Nam Jong-taek Yeom Titanium Alloys Department Metal Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Materials Engineering and Convergence Technology&Research Institute for Green Energy Convergence Technology(RIGET) Gyeongsang National University900 GazwadongJinjuGyeongnam 52828Republic of Korea

The demand for titanium alloys simultaneously having high elastic admissible strain and large recovery strain for bio-implant applications is ***-free Ti-based shape memory alloys are promising candidates for obtaining the required multifunctional *** this study,a wide content range of(0-15)wt%of low-cost,toxicity-free,and high-biocompatible Sn element was added to the Ti-8Mo(wt%)alloy to study its effect on the superelastic recovery and mechanical properties of biomedical Ti-Mo-Sn *** tailoring Sn content,desired multifunctional properties of high elastic admissible strain and room temperature superelasticity were achieved in the studied Ti-Mo-Sn *** was found that the increase in Sn content stabilized theβphase and a singleβphase was obtained at room temperature in Ti-8Mo-(13,15)Sn *** addition of Sn modified the lattice parameters of theα″martensite andβphase and affected the lattice deformation stain ofβ→α″.The lattice deformation strain along the[011]βdirection was found to be decreased by-0.26%/wt%*** room temperature superelasticity with a recovery strain of 3.1%and an elastic admissible strain of 1%was obtained in the Ti-8Mo-13Sn *** Sn content increased to 15 wt%,a high elastic admissible strain of 1.56%and a recovery strain of 2.0%were *** Ti-Mo-Sn alloys with excellent multifunctional properties are promising candidates for bio-implant applications.

关键词： Ti-Mo-Sn alloy Shape memory alloy Elastic admissible strain Elastic modulus Superelasticity

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Detection of Graphene Cracks By Electromagnetic Induction,Insensitive to Doping Level

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 351-361页

作者： Taeshik Yoon Sumin kang Tae Yeob kang taek-Soo Kim Department of Mechanical Engineering KAISTDaejeon 34141Korea Graphene Research Center KAISTDaejeon 34141Korea

Detection of cracks is a great concern in production and operation processes of graphene based devices to ensure uniform ***,we show a detection method for graphene cracks by electromagnetic *** time varying magnetic field leads to induced voltage signals on graphene,and the signals are detected by a *** measured level of induced voltage is correlated with the number of cracks in graphene *** correlation is attributed to the increasing inductive characteristic of defective graphene,and it is verified by electromagnetic simulation and radio frequency ***,we demonstrate that the induced voltage signal is insensitive to the doping level of *** work can potentially lead to the development of a high-throughput and reliable crack inspection technique for mass production of graphene applications.

关键词： Graphene,crack detection inductance electromagnetic induction insensitive to doping

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Three-dimensional free view reconstruction in axially distributed image sensing

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Chinese Optics Letters 2017年第8期15卷 40-43页

作者： chang-taek seo shin-won kang myungjin cho 3d display components support center gumi electronics and information technology research instituteGumi-siGyeongsangbuk-do 730-853Korea school of electronics engineering college of it engineeringkyungpook national universityDaegu 702-701Korea department of electrical electronicand control engineeringiitchankyong national university327 Chungang-roAnseong-siGyonggi-do 456-749Korea

Three-dimensional （3D） acquisition has been the most important technique for augmented reality or virtual reality industries. Stereo vision can obtain 3D infor- mation of objects using disparity between two images captured by a stereo camera. However, due to lack of per- spectives for 3D objects in this technique, accurate 3D information may not be generated and the number of viewing points is limited. By contrast, multi-view or super multi-view imaging techniques can obtain more accurate 3D information because they use multiple cameras for pickup of 3D objects so that more perspec- tives and viewing points of 3D objects can be recorded.

关键词： view free Three-dimensional free view reconstruction in axially distributed image sensing

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Exercise therapy for sarcopenia and diabetes

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World Journal of Diabetes 2023年第5期14卷 565-572页

作者： Seung-taek Lim Sunghwun kang Institute of Sports and Arts Convergence(ISAC) Inha UniversityIncheon 22212South Korea Waseda Institute for Sport Sciences Waseda UniversitySaitama 341-0018Japan Laboratory of Exercise Physiology College of ArtCulture and EngineeringKangwon National UniversityChuncheon-si 24341South Korea Interdisciplinary Program in Biohealth-machinery convergence engineering Kangwon National UniversityChuncheon-si 24341South Korea

Aging is characterized by the gradual deterioration of function at the molecular,cellular,tissue,and organism levels in *** typical diseases caused by changes in body composition,as well as functional decline in the human body’s organs due to aging include sarcopenia and metabolic *** accumulation of dysfunctional agingβcells with age can cause decreased glucose tolerance and *** decline has a multifactorial origin,involving lifestyle habits,disease triggers,and age-dependent biological *** reduced function ofβcells in elderly people lowers insulin sensitivity,which affects protein synthesis and interferes with muscle *** functional decrease and aggravation of disease in elderly people with less regular exercise or physical activity causes imbalances in food intake and a continuous,vicious *** contrast,resistance exercise increases the function ofβcells and protein synthesis in elderly *** this review,we discuss regular physical activities or exercises to prevent and improve health,which is sarcopenia as decreased muscle mass and metabolic disorders as diabetes in the elderly.

关键词： Elderly Diabetes Sarcopenia Resistance exercise Aging Muscle

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Influence of different nitrogen application on flour properties,gluten properties by HPLC and end-use quality of Korean wheat

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Journal of Integrative Agriculture 2018年第5期17卷 982-993页

作者： Seong-Woo Cho Chon-Sik kang taek-Gyu kang Kwang-Min Cho Chul Soo Park Department of Crop Science and Biotechnology Chonbuk National University National Institute of Crop Science Rural Development Administration Research Center of Bioactive Materials Chonbuk National University

This study was performed to identify how the different levels of nitrogen application affected the variances of gluten properties and end-use qualities and the differences of variances among Korean wheat cultivars. Protein and dry gluten content, SDS sedimentation volume and water absorption of Mixolab increased as nitrogen application increased. This ratio of the increase was higher in Korean wheat cultivars for bread than in Korean wheat cultivars for noodles and cookies. The proportion of（α＋β）-gliadin measured by reversed-phase high-performance liquid chromatography（RP-HPLC） increased, but the proportion of ω-and γ-gliadin decreased as the protein content increased. The Korean wheat cultivars for bread showed a high proportion of（α＋β）-gliadin increase, the Korean cultivars for noodles had a high proportion of γ-gliadin decrease and the Korean wheat cultivars for cookies had a high proportion of ω-gliadin decrease. However, there was no variation of the component in the proportion of glutenin component measured by RP-HPLC, even though the protein content was increased, but all of the protein fractions measured by size exclusion（SE）-HPLC were increased. The soluble monomeric protein showed a high proportion of Korean wheat cultivars for bread by the increase of protein content. Bread loaf volume increased by the increase of protein content but there were no variances in the ratio of increase among Korean wheat cultivars. The cookie diameter decreased with the increase of protein content, and this ratio of decrease was the highest in Korean wheat cultivars for cookies. The hardness of cooked noodles also increased by the increase of protein content but there were no variations in springiness and cohesiveness. The decrease proportion of ω-gliadin affected the increase of bread loaf volume, the hardness of cooked noodles, and the decrease of cookie diameter.

关键词： wheat gluten end-use quality cultivar nitrogen application

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