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电弧炉异常炉况电极调节应激干预技术的研究

工业加热 2024年第10期53卷 1-8页

作者：蔡安江乔宁李琨张永武吴超周文栋权鑫西安建筑科技大学机电工程学院陕西西安710055 西安电炉研究所有限公司陕西西安710061 陕西省“四主体一联合”电炉工程技术研究中心陕西西安710061

三相交流电弧炉在冶炼过程中常遭遇短路和断弧异常炉况,这不仅延长了通电和出钢时间,增加了能耗,还威胁到生产的安全性和稳定性。提出了一种创新的基于电弧声信号分析的电极调节应激干预技术,以优化EAF冶炼过程。首先基于75 t普碳钢EAF... 详细信息

三相交流电弧炉在冶炼过程中常遭遇短路和断弧异常炉况,这不仅延长了通电和出钢时间,增加了能耗,还威胁到生产的安全性和稳定性。提出了一种创新的基于电弧声信号分析的电极调节应激干预技术,以优化EAF冶炼过程。首先基于75 t普碳钢EAF生产现场的电弧声信号探究了短路、断弧与稳态运行时三类电弧声时频特征;利用平滑伪维格纳分布算法来评估电弧声的能量密度水平,确定了异常炉况与稳态运行时的特征频率,实现了异常炉况判别。此外,通过分析稳态运行、短路与断弧前期及发生期的电弧声特征频率,揭示了异常炉况的预测规律。在此基础上,在现有的电极调节控制系统中集成了应激干预机制,并通过程序化实现了自动化控制。工程验证结果表明,该技术能够有效地在3~4秒前预测并干预异常炉况,显著减少了短路和断弧事件,同时降低了7.5%的单吨冶炼能耗,证实了其在提升EAF冶炼效率和降低成本方面的潜力。

关键词：电弧声信号异常炉况判别预测平滑伪维格纳分布电极调节应激干预机制

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20%螺虫乙酯·呋虫胺悬浮剂配方开发

世界农药 2024年第3期46卷 39-42页

作者：王飞菲吕文东解维星刘志航张艳海利尔药业集团股份有限公司山东青岛266000 潍坊市高密市农业农村局山东高密261500

为研究开发20%螺虫乙酯·呋虫胺悬浮剂最优配方。运用湿法砂磨方法,对润湿分散剂、稳定剂、增稠剂、防冻剂、消泡剂等表面活性剂进行筛选。最终获得最优配方:螺虫乙酯10%(折百),呋虫胺10%(折百),1%G5000,2%4913,3%t-45,10%S6,0.5%消泡剂... 详细信息

为研究开发20%螺虫乙酯·呋虫胺悬浮剂最优配方。运用湿法砂磨方法,对润湿分散剂、稳定剂、增稠剂、防冻剂、消泡剂等表面活性剂进行筛选。最终获得最优配方:螺虫乙酯10%(折百),呋虫胺10%(折百),1%G5000,2%4913,3%t-45,10%S6,0.5%消泡剂630,5%甘油,0.5%硅酸镁铝,0.2%黄原胶,水补足至100%。经测定各项指标均符合悬浮剂的质量技术标准。田间药效试验表明该制剂对介壳虫防效突出。

关键词：螺虫乙酯呋虫胺悬浮剂药效

Bile acid signaling and bariatric surgery

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Liver Research 2017年第4期1卷 208-213页

作者： Jingyan t.an Silvia Huang Siming Sun Lili Ding Eryun Zhang Yanjun Liu wendong Huang National Clinical Research Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrinology and MetabolismRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCAUSA Eugene Robert Summer Program City of HopeDuarteCAUSA Shanghai Key Laboratory of Compound Chinese Medicines and the Ministry of Education(MOE)Key Laboratory of Standardization of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina

the rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic *** surgical procedures,such as Roux-en-Y gastric bypass(RYGB)and vertical sleeve gastrectomy(VSG),currently provide the most effective treatment for obesity and type 2 diabetes(t2D),as well as for non-alcoholic steatohepatitis(NASH).However,the underlying mechanisms of the beneficial effects of bariatric surgery remain *** studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric *** review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor(FXR)and G protein-coupled bile acid receptor 5(tGR5)in bariatric *** also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications.

关键词： Bile acid(BA) Bariatric surgery Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 5 (tGR5) Microbiota

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白虎加人参汤对2型糖尿病大鼠脂代谢的影响

世界中医药 2024年第7期19卷 962-968页

作者：吕树泉张辉张淑芳潘保朝姚彬苏秀海王元松李文东李函舟田甜苗静河北中医学院附属沧州中西医结合医院沧州061001 河北中医学院研究生院石家庄050091 承德医学院研究生院承德067000 天津市第二人民医院天津300192

目的:研究白虎加人参汤对2型糖尿病(t2DM)模型大鼠腺苷一磷酸活化蛋白激酶(AMPK)/固醇反应元件结合蛋白-1(SREBP1)信号通路的影响。方法:通过高脂饲料联合链脲佐菌素(StZ)注射建立t2DM模型大鼠,并用不同剂量的白虎加人参汤灌胃。通过检... 详细信息

目的:研究白虎加人参汤对2型糖尿病(t2DM)模型大鼠腺苷一磷酸活化蛋白激酶(AMPK)/固醇反应元件结合蛋白-1(SREBP1)信号通路的影响。方法:通过高脂饲料联合链脲佐菌素(StZ)注射建立t2DM模型大鼠,并用不同剂量的白虎加人参汤灌胃。通过检测各组大鼠造模给药后血清中相关生化指标和肝组织病理学变化,评估白虎加人参汤对t2DM模型大鼠的治疗作用;然后,运用定量聚合酶链反应(qPCR)和蛋白质免疫分析法检测白虎加人参汤干预后,各组大鼠肝组织中AMPK/SREBP1信号通路关键因子腺苷一磷酸活化蛋白激酶(AMPK)、乙酰辅酶A羧化酶1(ACC1)、脂肪酸合成酶(FASN)、AtP柠檬酸裂解酶(ACLY)基因及蛋白水平,初步探究白虎加人参汤治疗t2DM模型大鼠的作用机制。结果:白虎加人参汤可明显降低t2DM模型大鼠血清中空腹血糖(FBG)、口服葡萄糖耐量试验(OGtt)、谷丙转氨酶(GPt)、谷草转氨酶(GOt)、总胆固醇(tC)、三酰甘油(tG)以及低密度脂蛋白胆固醇(LDL-C)水平,升高高密度脂蛋白胆固醇(HDL-C)水平,同时改善t2DM模型大鼠肝组织病理学变化。qPCR及蛋白质免疫分析结果显示,白虎加人参汤可显著降低t2DM模型大鼠肝组织中AMPK基因与蛋白水平,上调SREBP1、ACC1、ACLY、FASN基因与蛋白水平。结论:白虎加人参汤对t2DM模型大鼠具有治疗作用,其作用机制可能与调节肝组织中AMPK/SREBP1信号通路,改善脂代谢有关。

关键词：白虎加人参汤 2型糖尿病血糖脂代谢腺苷一磷酸活化蛋白激酶/固醇反应元件结合蛋白-1(AMPK/SREBP1)信号通路中医药作用机制实验研究

Notoginsenoside Ft1 acts as a tGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1541-1554页

作者： Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang tong t.an Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang wendong Huang Li Yang Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Diabetes Complications and Metabolism Diabetes and Metabolism Research InstituteBeckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Pharmacy Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China Graduate School of Biological Science City of Hope National Medical CenterDuarteCA 91010USA Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001China

Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor tGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic *** have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of tGR5 in ***,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still *** we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not tgr5^(-/-) obese *** addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr t.anscriptional activities in the ileum to activate tgr5 in the adipose *** metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA *** results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice.

关键词： Notoginsenoside Ft1 Obesity Insulin resistance Bile acids tGR5 FXR GLP-1 Metabolic disorders

Desmoglein 2(DSG2) Is A Receptor of Human Adenovirus type 55 Causing Adult Severe Community-Acquired Pneumonia

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Virologica Sinica 2021年第6期36卷 1400-1410页

作者： Jing Zhang Kui Ma Xiangyu Wang Yinbo Jiang Shan Zhao Junxian Ou wendong Lan Wenyi Guan Xiaowei Wu Heping Zheng Bin Yang Chengsong Wan Wei Zhao Jianguo Wu Qiwei Zhang Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou510632China Guangdong Provincial Key Laboratory of tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou510515China Guangdong Provincial Dermatology Hospital Southern Medical UniversityGuangzhou510091China

Human adenovirus type 55(HAdV-B55) is a re-emergent acute respiratory disease pathogen that causes adult communityacquired pneumonia(CAP). Previous studies have shown that the receptor of HAdV-B14, which genome is highly similar with HAdV-B55, is human Desmoglein 2(DSG2). However, whether the receptor of HAdV-B55 is DSG2 is undetermined because there are three amino acid mutations in the fiber gene between HAdV-B14 and HAdV-B55. Here, firstly we found the 3t3 cells, a mouse embryo fibroblast rodent cell line which does not express human DSG2, were able to be infected by HAdV-B55 after t.ansfected with pcDNA3.1-DSG2, while normal 3t3 cells were still unsusceptible to HAdV-B55 infection. Next, A549 cells with h DSG2 knock-down by siRNA were hard to be infected by HAdV-B3/-B14/-B55, while the control siRNA group was still able to be infected by all these types of HAdVs. Finally, immunofluorescence confocal microscopy indicated visually that Cy3-conjugated HAdV-B55 viruses entered A549 cells by binding to DSG2 ***, DSG2 is a major receptor of HAdV-B55 causing adult CAP. Our finding is important for better understanding of interactions between adenoviruses and host cells and may shed light on the development of new drugs that can interfere with these processes as well as for the development of potent prophylactic vaccines.

关键词： Human adenovirus type 55(HAdV-B55) Severe community-acquired pneumonia Adenovirus receptor Desmoglein 2(DSG2)

toward batch synthesis of high-quality graphene by cold-wall chemical vapor deposition approach

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Nano Research 2022年第11期15卷 9683-9688页

作者： Kaicheng Jia Ziteng Ma wendong Wang Yongliang Wen Huanxin Li Yeshu Zhu Jiawei Yang Yuqing Song Jiaxin Shao Xiaoting Liu Qi Lu Yixuan Zhao Jianbo Yin Luzhao Sun Hailin Peng Jincan Zhang Li Lin Zhongfan Liu Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China School of Physics and Astronomy University of ManchesterManchester M139PLUK State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Engineering University of CambridgeCambridge CB30FAUK Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Key Laboratory of Opto-Electronics technology Ministry of EducationCollege of Electronic Science and TechnologyFaculty of Information TechnologyBeijing University of TechnologyBeijing 100024China State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China

Chemical vapor deposition(CVD)has emerged as a promising approach for the controlled growth of graphene films with appealing scalability,controllability,and ***,the synthesis of high-quality graphene films still suffers from low production capacity and high energy consumption in the conventional hot-wall CVD *** contrast,owing to the different heating mode,cold-wall CVD(CW-CVD)system exhibits promising potential for the industrial-scale production,but the quality of as-received graphene remains inferior with limited domain size and high defect ***,we demonstrated an efficient method for the batch synthesis of high-quality graphene films with millimeter-sized domains based on CW-CVD *** reduced defect density and improved properties,the as-received graphene was proven to be promising candidate material for electronics and anti-corrosion *** study provides a new insight into the quality improvement of graphene derived from CW-CVD system,and paves a new avenue for the industrial production of high-quality graphene films for potential commercial applications.

关键词： graphene cold-wall chemical vapor deposition(CVD) defects electrical performance

科技金融政策能否提升科技人才集聚水平——基于多期DID的经验证据

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科技进步与对策 2022年第20期39卷 131-140页

作者：谢文栋上海财经大学公共经济与管理学院上海200433

科技人才是实现我国科技自立自强的核心要素,而科技金融政策是推动我国科技产业发展的重要举措,也是促进地区科技人才集聚的积极探索。以科技金融政策作为一项准自然实验,利用2004-2019年全国281个城市面板数据构建多期双重差分模型,实... 详细信息

科技人才是实现我国科技自立自强的核心要素,而科技金融政策是推动我国科技产业发展的重要举措,也是促进地区科技人才集聚的积极探索。以科技金融政策作为一项准自然实验,利用2004-2019年全国281个城市面板数据构建多期双重差分模型,实证分析科技金融政策对城市科技人才集聚水平的影响和作用机制。研究发现:科技金融政策显著提升城市科技人才集聚水平;科技金融政策主要通过政府干预效应、结构升级效应和创新驱动效应提升城市科技人才集聚水平;科技金融政策对科技人才集聚水平的影响随着城市行政级别的提升呈现“边际效应递增”规律。据此,提出对策建议,包括推进科技金融政策有序扩散、强化试点政策的科技人才集聚效应并扩展作用路径、设计科技金融政策梯度发展战略、促进地区间均衡协调发展。

关键词：科技金融政策科技人才集聚双重差分法政府干预效应

Evaluating the prognostic value of microRNA-203 in solid tumors based on a meta-analysis and the Cancer Genome Atlas(tCGA) datasets

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Evaluating the prognostic value of microRNA-203 in solid tum...