Bile acid signaling and bariatric surgery
作者机构：National Clinical Research Center for Endocrine and Metabolic DiseasesShanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrinology and MetabolismRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Diabetes Complications and MetabolismBeckman Research Institute of City of HopeDuarteCAUSA Eugene Robert Summer ProgramCity of HopeDuarteCAUSA Shanghai Key Laboratory of Compound Chinese Medicines and the Ministry of Education(MOE)Key Laboratory of Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2017年第1卷第4期
页 面：208-213页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This workwas supported by the National Cancer Institute 2R01CA139158,John Hench Foundation,George Schaeffer Foundation,Chinese National Natural Science Foundation(81270935) Transform Medicine Innovation Foundation of Shanghai Jiao Tong University School of Medicine(15ZH2001) Research Project Funded by the Shanghai Municipal Health Bureau(20114301) the Fund of the Key Laboratory of Stem Cell Biology of Chinese Academy of Sciences(201601)
主 题：Bile acid(BA) Bariatric surgery Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 5 (TGR5) Microbiota
摘 要：The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic *** surgical procedures,such as Roux-en-Y gastric bypass(RYGB)and vertical sleeve gastrectomy(VSG),currently provide the most effective treatment for obesity and type 2 diabetes(T2D),as well as for non-alcoholic steatohepatitis(NASH).However,the underlying mechanisms of the beneficial effects of bariatric surgery remain *** studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric *** review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor(FXR)and G protein-coupled bile acid receptor 5(TGR5)in bariatric *** also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications.
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