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胃癌3D腹腔镜手术的优势与劣势

中华胃肠外科杂志 2016年第2期19卷 148-150页

作者：黄昌明林建贤福建医科大学附属协和医院胃外科福州350001

3D腹腔镜系统是近年来新兴的腹腔镜技术平台。在胃癌根治手术中，其通过构建景深及三维立体结构，还原真实的手术视野，除有利于初学者较快地度过学习曲线外，更重要的是为手术操作提供了较为精准的空间定位，使组织解剖层次更为清晰，... 详细信息

3D腹腔镜系统是近年来新兴的腹腔镜技术平台。在胃癌根治手术中，其通过构建景深及三维立体结构，还原真实的手术视野，除有利于初学者较快地度过学习曲线外，更重要的是为手术操作提供了较为精准的空间定位，使组织解剖层次更为清晰，利于腹腔镜下胃周血管裸化、淋巴结清扫及消化道重建等操作。但是，术者初期对三维视觉不适应以及3D腹腔镜特殊的设备操作和需要特殊设备进行资料展示等方面是3D腹腔镜系统存在的不足。

关键词：胃肿瘤腹腔镜 3D 外科手术

Plasma metabolomic and lipidomic alterations associated with COVID-19

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National Science Review 2020年第7期7卷 1157-1168页

作者： Di Wu ting Shu Xiaobo yang Jian-Xin Song Mingliang Zhang Chengye yao Wen Liu Muhan huang yuan yu Qingyu yang tingju Zhu Jiqian Xu Jingfang Mu yaxin Wang Hong Wang tang tang yujie Ren yongran Wu Shu-Hai Lin yang Qiu Ding-yu Zhang you Shang Xi Zhou Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of Sciences (CAS) State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-Science CAS Center for translational Medicine Jinyintan Hospital Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Jinyintan Hospital Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

the pandemic of the coronavirus disease 2019(COVID-19) has become a global public health crisis. the symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the tCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate(GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with ***, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. this work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.

关键词： SARS-Co V-2 COVID-19 metabolome lipidome

血管紧张素（1—7）对血管紧张素Ⅱ诱导肝星状细胞表达结缔组织生长因子的抑制作用

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中华肝脏病杂志 2012年第6期20卷 458-462页

作者：李旭黄茂梁黄珊张文雍宁佐伟孟莹南方医科大学南方医院急诊科广州510515 南方医科大学南方医院呼吸科广州510515 福建省武警总队医院

目的探讨血管紧张素（Ang）（1-7）对AngⅡ诱导的肝星状细胞（HSC）表达结缔组织生长因子（CtGF）的抑制作用及其机制。方法培养人HSC细胞系（LX2细胞），以AngⅡ刺激24h，分别予以AngⅡ1型受体阻断剂irbesartan、ROCK抑制剂y27632预处... 详细信息

目的探讨血管紧张素（Ang）（1-7）对AngⅡ诱导的肝星状细胞（HSC）表达结缔组织生长因子（CtGF）的抑制作用及其机制。方法培养人HSC细胞系（LX2细胞），以AngⅡ刺激24h，分别予以AngⅡ1型受体阻断剂irbesartan、ROCK抑制剂y27632预处理1h。设立AngⅡ＋Ang（1—7）处理组，观察Ang（1—7）对AngⅡ的抑制作用；Mas受体拮抗剂A779阻断Mas受体，观察对Ang（1—7）抑制效应的阻断作用。利用Western blot、逆转录聚合酶链反应（Rt-PCR）和多基因定量检测系统检测RhoA、ROCK2 mRNA，结缔组织生长因子（CtGF）蛋白和mRNA的表达。结果研究结果显示AngⅡ刺激后，RhoA蛋白（0．87±0．093对比0．337±0．074）、ROCK2mRNA（0．747±0．061对比0．163±0．024）、CtGFmRNA（0．578±0．028对比0．262±0．007）相对表达量与对照组相比显著增高，差异有统计学意义（P值均〈0．01）；irbesartan（RhoA蛋白：0．558±0．030对比0．87±0．093；ROCK2mRNA：0．368±0．023对比0．747±0．061；CtGFmRNA：0．309±0．019对比0．578±0．028）、y27632（RhoA蛋白：0．564±0．067对比0．87±0．093；ROCK2mRNA：0．218±0．046对比0．747±0．061；CtGFmRNA：0．340±0．020对比0．578±0．028）预处理组上述基因或蛋白相对表达量显著减低，差异有统计学意义（P值均〈0．01），Ang（1-7）单独处理组RhoA蛋白（0．449±0．035对比0．337±0．074）及CtGFmRNA（O．256±0．008对比0．262±0．007）与对照组相比无明显改变，差异无统计学意义（P值均〉0．05）；但是Ang（1-7）可抑制AngⅡ诱导的上述基因或蛋白表达的增高（RhoA蛋白：0．615±0．034对比0．87±0．093IROCK2mRNA：0．403±0．040对比0．747±0．061；CtGFmRNA：0．265±0．011对比0．578±0．028），差异有统计学意义护值均〈0．01）；Mas受体拮抗剂A779可以阻断Ang（1-7）对AngⅡ的抑制作用（RhoA蛋白：0．929±0．076对比0．615±0．034；ROCK2mRNA：0．720±0．054对比0．403±0．040fCtGFmRNA：0．568±0．029对比0．265±0．011），差异有统计学意义垆值均〈0.01）。结论AngⅡ通过RhoA-ROCK通路促进人HSC表达CtGFmRNA；Ang（1—7）与其Mas受体结合后对AngⅡ激活的CtGFmRNA的表达具有抑制作用。

关键词：肝硬化血管紧张素Ⅱ 肝星状细胞血管紧张素(1-7) 结缔组织生长因子

加味异功散辅助马来酸曲美布汀治疗腹泻型肠易激综合征疗效及对结肠组织酪酪肽和密封蛋白1表达的影响

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广州中医药大学学报 2022年第3期39卷 508-515页

作者：黄礼韦祎刘英莲海口市第三人民医院中医科海南海口571100 海南医学院中医学院海南海口571199

【目的】研究加味异功散辅助马来酸曲美布汀治疗腹泻型肠易激综合征(IBS-D)的临床疗效及对患者结肠组织中酪酪肽(Pyy)和密封蛋白1(claudin-1)的影响。【方法】将160例脾胃虚弱型IBS-D患者随机分为观察组和对照组,每组各80例。对照组给... 详细信息

【目的】研究加味异功散辅助马来酸曲美布汀治疗腹泻型肠易激综合征(IBS-D)的临床疗效及对患者结肠组织中酪酪肽(Pyy)和密封蛋白1(claudin-1)的影响。【方法】将160例脾胃虚弱型IBS-D患者随机分为观察组和对照组,每组各80例。对照组给予马来酸曲美布汀治疗,观察组在对照组的基础上联合加味异功散治疗,疗程为2周。观察2组患者治疗前后中医症状积分、血清胃肠激素和t淋巴细胞亚群水平,以及结肠黏膜组织Pyy和claudin-1阳性表达率的变化情况,评价2组的中医证候疗效。【结果】(1)治疗2周后,观察组的总有效率为93.75%(75/80),对照组为75.00%(60/80),观察组的中医证候疗效明显优于对照组(Pt),γ-干扰素(INF-γ)、神经肽y(NPy)水平均较治疗前明显降低(Pt、IFN-γ、NPy水平的降低作用均明显优于对照组(PtL)、血管活性肠肽(VIP)水平均较治疗前明显降低(PtL水平的降低作用和对血清SP水平的升高作用均明显优于对照组(Pt淋巴细胞水平均较治疗前升高(Pt淋巴细胞水平均较治疗前降低(Pt淋巴细胞水平的升高作用和对CD8^(+)t淋巴细胞水平的降低作用均明显优于对照组(Pyy的阳性表达率均较治疗前降低(Pyy阳性表达率的降低作用和对claudin-1阳性表达率的升高作用均明显优于对照组(Pyy和claudin-1水平有良好的调节作用。

关键词：加味异功散腹泻型肠易激综合征(IBS-D) 脾胃虚弱型炎症反应胃肠道激素免疫功能酪酪肽(Pyy) 密封蛋白1(claudin-1)

Influence of Caveolin-1 on the Autophagy Induced by glucose/serum Deprivation in PC12 Cells

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Influence of Caveolin-1 on the Autophagy Induced by glucose/...

单纯性肾囊肿与Stanford B型主动脉夹层患者腔内修复术后不良事件的关系

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：张骐麒 huang Liang HAN Chao GUAN Xin LIU yang WANG ya-Jun ZOU Wei Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery College of Life Science Liaoning Normal University Regenerative Medicine Centre First Affiliated Hospital of Dalian Medical University

Autophagy is a natural process of‘self-eating’that occurs within cells and can be either pro-survival or can cause cell *** a pro-survival mechanism,autophagy obtains energy by recycling cellular components such as macromolecules or *** response to glucose/serum Deprivation（GSD）,autophagy is induced and most of these signals converge on the kinase m tOR（mammalian target of rapamycin）.Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling *** studies have implicated that autophagy is associated with stromal Caveolin-1,but the mechanism is not *** the present study,we firstly established an autophagic model of PC12 cells induced by glucose/serum deprivation,the cell viability,DNA damage,[Ca2+]i（intracellular free Ca2+concentration）or MMP（mitochondrialmembrane potential）were determined using Mtt,Confocal Laser Scanning Microscope and Flow Cytometry assays,*** both SH-Sy5y and PC12 cells,GSD condition significantly decreased the cell viability which was accompanied by increased intracellular reactive oxygen species production,lipid peroxidation level,and oxidative DNA *** detected therelationship between autophagy and stromal Caveolin-1,we overexpressed or knocked down Caveolin-1in nerve cells using sh RNA or M-β-CD,and detected the autophagic features of cells after GSD with Western blot,immunofluorescence and q *** results showed that Caveolin-1 promoted GSD-induced *** together,these results establish that caveolin-1 plays a central role in regulation of oxidative stress,metabolic switching,and autophagy in nerve cells,and may represent a critical target in nerve diseases.

关键词： Caveolin-1 Autophagy oxidative stress PC12 glucose/serum Deprivation

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中华心血管病杂志 2022年第8期50卷 774-779页

作者：朱屹罗淞元刘媛黄文晖何鹏程谢年谨薛凌罗建方广东省医学科学院广东省心血管病研究所广东省冠心病防治研究重点实验室广东省人民医院心血管内科血管病诊疗中心广州510080 广东省中医院心内科广州510006

目的探讨合并单纯性肾囊肿(SRC)对Stanford B型主动脉夹层(tBAD)患者施行胸主动脉腔内修复术(tEVAR)后近中期不良事件的影响。方法本研究为回顾性队列研究。连续性入选2010年1月至2015年12月间在广东省人民医院诊断为tBAD并接受tEVAR的... 详细信息

目的探讨合并单纯性肾囊肿(SRC)对Stanford B型主动脉夹层(tBAD)患者施行胸主动脉腔内修复术(tEVAR)后近中期不良事件的影响。方法本研究为回顾性队列研究。连续性入选2010年1月至2015年12月间在广东省人民医院诊断为tBAD并接受tEVAR的患者,根据是否合并SRC,分为SRC组和无SRC组。以性别、年龄±2岁作为匹配因素,按1∶1匹配SRC组和无SRC组。收集并比较两组临床资料的差异,并通过门诊、电话随访及住院复查,记录患者随访期间不良事件。校正影响预后的混杂因素后,采用多因素Cox回归分析主动脉不良事件的危险因素。采用Kaplan-Meier法分析SRC组及无SRC组生存曲线。结果共纳入692例tBAD患者,其中SRC组235例,非SRC组457例。1∶1匹配后,SRC组和无SRC组各229例,SRC组年龄(62.3±10.4)岁,男性209例(91.3%),无SRC组年龄(62.0±10.2)岁,男性209例(91.3%)。多因素Cox回归分析显示,合并SRC(HR=1.991,95%CI:1.090~3.673,P=0.025),急性期介入(HR=13.635,95%CI:5.969~31.147,P=0.001),全麻(HR=2.012,95%CI:1.066~3.799,P=0.031)为tBAD患者施行tEVAR后主动脉不良事件的独立危险因素。Kaplan-Meier生存曲线分析显示,SRC组主动脉相关死亡和主动脉不良事件发生率较无SRC组高(log-rank P=0.031、0.005)。结论合并SRC是tBAD患者接受tEVAR治疗后预后不良的危险因素。

关键词：囊肿主动脉夹层胸主动脉腔内修复术

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2022年第6期117卷 1-272页

作者： Ruvishika S.Jayawardena Kevin D.Hyde Song Wang ya‑Ru Sun Nakarin Suwannarach Phongeun Sysouphanthong Mohamed A.Abdel‑Wahab Faten A.Abdel‑Aziz Pranami D.Abeywickrama Vanessa P.Abreu Alireza Armand AndréAptroot Dan‑Feng Bao Dominik Begerow Jean‑Michel Bellanger Jadson D.P.Bezerra Digvijayini Bundhun Mark S.Calabon ting Cao taimy Cantillo João LVRCarvalho Napalai Chaiwan Che‑Chih Chen Régis Courtecuisse Bao‑Kai Cui Ulrike Damm Cvetomir M.Denchev teodor t.Denchev Chun y.Deng Bandarupalli Devadatha Nimali Ide Silva Lidiane Ados Santos Nawal K.Dubey Sylvain Dumez Himashi SFerdinandez André L.Firmino yusufon Gaforov Achala J.Gajanayake Deecksha Gomdola Sugantha Gunaseelan Shucheng‑He Zin H.Htet Malarvizhi Kaliyaperumal Martin Kemler Kezhocuyi Kezo Nuwan DKularathnage Marco Leonardi Ji‑Peng Li Chunfang Liao Shun Liu Michael Loizides thatsanee Luangharn Jian Ma Hugo Madrid S.Mahadevakumar Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda María P.Martín Niranjan Mekala Pierre‑Arthur Moreau yan‑Hong Mu Pasouvang Pahoua Dhandevi Pem Olinto L.Pereira Wiphawanee Phonrob Chayanard Phukhamsakda Mubashar Raza Guang‑Cong Ren Andrea C.Rinaldi Walter Rossi Binu C.Samarakoon Milan CSamarakoon Vemuri V.Sarma Indunil C.Senanayake Archana Singh Maria F.Souza Cristina M.Souza‑Motta Adriano A.Spielmann Wenxin Su Xia tang XingGuo tian Kasun M.thambugala Naritsada thongklang Danushka S.tennakoon Nopparat Wannathes DingPeng Wei Stéphane Welti Subodini N.Wijesinghe Hongde yang yunhui yang Hai‑Sheng yuan huang Zhang Jingyi Zhang Abhaya Balasuriya Chitrabhanu SBhunjun timur S.Bulgakov Lei Cai Erio Camporesi Putarak Chomnunti y.S.Deepika Mingkwan Doilom Wei‑Jun Duan Shi‑Ling Han Naruemon Huanraluek EBGareth Jones NLakshmidevi yu Li Saisamorn Lumyong Zong‑Long Luo Surapong Khuna Jaturong Kumla Ishara S.Manawasinghe Ausana Mapook Wilawan Punyaboon Saowaluck tibpromma yong‑Zhong Lu Jiye yan yong Wang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouChina Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Biotechnology and Ecology Institute Ministry of Agriculture and ForestryP.O.Box:811Vientiane CapitalLao PDR Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Beijing Key Laboratory of Environment-Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Departamento de Fitopatologia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMato Grosso do Sul CEP 79070-900Brazil College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanChina Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Institute of Plant Science and Microbiology Universität HamburgOrganismic Botany and MycologyOhnhorststr.1822609 HamburgGermany CEFE CNRSUniv.MontpellierEPHEIRDINSERM1919Route de Mende34293 Montpellier Cedex 5France Setor de Micologia Departamento de Biociências e TecnologiaInstituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásRua 235S/NSetor UniversitárioGoiâniaGO CEP:74605-050Brazil Division of Biological Sciences College of Arts and SciencesUniversity of the Philippines Visayas5023 MiagaoIloiloPhilippines CA

this article is the 14th in the Fungal Diversity Notes series,wherein we report 98 taxa distributed in two phyla,seven classes,26 orders and 50 families which are described and *** in this study were collected from Australia,Brazil,Burkina Faso,Chile,China,Cyprus,Egypt,France,French Guiana,India,Indonesia,Italy,Laos,Mexico,Russia,Sri Lanka,thailand,and *** are 59 new taxa,39 new hosts and new geographical distributions with one new *** 59 new species comprise Angustimassarina kunmingense,Asterina lopi,Asterina brigadeirensis,Bartalinia bidenticola,Bartalinia caryotae,Buellia pruinocalcarea,Coltricia insularis,Colletotrichum fexuosum,Colletotrichum thasutense,Coniochaeta caraganae,Coniothyrium yuccicola,Dematipyriforma aquatic,Dematipyriforma globispora,Dematipyriforma nilotica,Distoseptispora bambusicola,Fulvifomes jawadhuvensis,Fulvifomes malaiyanurensis,Fulvifomes thiruvannamalaiensis,Fusarium purpurea,Gerronema atrovirens,Gerronema favum,Gerronema keralense,Gerronema kuruvense,Grammothele taiwanensis,Hongkongmyces changchunensis,Hypoxylon inaequale,Kirschsteiniothelia acutisporum,Kirschsteiniothelia crustaceum,Kirschsteiniothelia extensum,Kirschsteiniothelia septemseptatum,Kirschsteiniothelia spatiosum,Lecanora immersocalcarea,Lepiota subthailandica,Lindgomyces guizhouensis,Marthe asmius pallidoaurantiacus,Marasmius tangerinus,Neovaginatispora mangiferae,Pararamichloridium aquisubtropicum,Pestalotiopsis piraubensis,Phacidium chinaum,Phaeoisaria goiasensis,Phaeoseptum thailandicum,Pleurothecium aquisubtropicum,Pseudocercospora vernoniae,Pyrenophora verruculosa,Rhachomyces cruralis,Rhachomyces hyperommae,Rhachomyces magrinii,Rhachomyces platyprosophi,Rhizomarasmius cunninghamietorum,Skeletocutis cangshanensis,Skeletocutis subchrysella,Sporisorium anadelphiae-leptocomae,tetraploa dashaoensis,tomentella exiguelata,tomentella fuscoaraneosa,tricholomopsis lechatii,Vaginatispora favispora and Wetmoreana *** new combin

关键词： 59 New taxa 39 New records Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Sordariomycetes Ustilaginomycotina

南美蟛蜞菊改变资源分配应对CO_(2)升高对其竞争力的负影响

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草地学报 2022年第2期30卷 356-361页

作者：杨洪宇夏维康杨彬黄致云祁珊珊戴志聪杜道林江苏大学环境与安全工程学院江苏镇江212013 江苏大学农业工程学院江苏镇江212013 苏州科技大学江苏水处理技术与材料协同创新中心江苏苏州215009

大气二氧化碳(Carbon dioxide,CO_(2))浓度正随着人类活动向着前所未有的浓度积累。作为光合作用的重要底物,CO_(2)的增加会对植物生长及竞争能力产生影响,因此,研究未来CO_(2)浓度升高背景下植物竞争力的变化对预测未来全球变化背景下... 详细信息

大气二氧化碳(Carbon dioxide,CO_(2))浓度正随着人类活动向着前所未有的浓度积累。作为光合作用的重要底物,CO_(2)的增加会对植物生长及竞争能力产生影响,因此,研究未来CO_(2)浓度升高背景下植物竞争力的变化对预测未来全球变化背景下植物群落演替及外来植物入侵具有重要意义。本研究以人工气候培养箱控制CO_(2)浓度,探究了入侵克隆植物南美蟛蜞菊(Wedelia trilobata)与本地蟛蜞菊(***)的生长和竞争对CO_(2)浓度增加的响应。结果表明,相比于本地蟛蜞菊而言,升高CO_(2)浓度减少了南美蟛蜞菊的生物量积累,并显著影响了茎的伸长(P=0.042),虽然混合种植中南美蟛蜞菊的茎长未表现明显差异,但竞争消除了CO_(2)浓度升高引起的茎长缩短。综合来看,尽管升高CO_(2)浓度减弱了南美蟛蜞菊对本地蟛蜞菊的竞争力,但南美蟛蜞菊可以通过改变在竞争中资源分配策略,使其将更多的资源用于茎段的伸长,主动向外拓张以占领更多的空间。

关键词：植物入侵二氧化碳资源分配全球变化

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涂覆Ni-Cr-Al-y涂层的镍基高温合金热机械疲劳行为

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金属学报 2009年第7期45卷 820-825页

作者：陈竹兵黄志伟王中光朱世杰中国科学院金属研究所沈阳材料科学国家(联合)实验室沈阳110016 Department of Intelligent Mechanical Engineering Fukuoka Institute of TechnologyFukuokaJapan

分别采取大气等离子(APS)和高速火焰(HVOF)工艺制备Ni-Cr-Al-y涂层.对涂覆Ni-Cr-Al-y涂层的高温合金试样的热机械疲劳(tMF)行为进行了研究.结果表明:在相同应变幅下,2种涂层试样都是反相位热机械疲劳(OP tMF)寿命比同相位热机械疲劳(IP ... 详细信息

分别采取大气等离子(APS)和高速火焰(HVOF)工艺制备Ni-Cr-Al-y涂层.对涂覆Ni-Cr-Al-y涂层的高温合金试样的热机械疲劳(tMF)行为进行了研究.结果表明:在相同应变幅下,2种涂层试样都是反相位热机械疲劳(OP tMF)寿命比同相位热机械疲劳(IP tMF)寿命短;在不同应变幅下,试样的热机械疲劳寿命与涂层的喷涂工艺相关.通过断口和纵向剖面图的观察分析表明,裂纹的萌生对试样的寿命有很大的影响.

关键词：镍基高温合金 Ni—Cr—Al—y 涂层热机械疲劳裂纹萌生与扩展