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Modeling of the role of defects in sintered FeCrAlY foams

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Acta Mechanica Sinica 2007年第5期23卷 511-529页

作者： M.Kepets t.j.lu A.P.Dowling Cambridge University Engineering Department Cambridge CB2 1PZUK MOE Key Laboratory of Strength and Vibration School of AerospaceXi'an Jiaotong UniversityXi'an 710049China

the metal sintering approach offers a costeffective means for the mass-production of open-cell foams from a range of materials, including high-temperature steel alloys, which offer novel mechanical and acoustic properties. In a separate experimental study, the mechanical properties of open-celled steel alloy （FeCrA1Y） foams have been characterized under uniaxial compression and shear loading. Compared to predictions from established models, a significant knockdown in material properties was observed. this knockdown was attributed to the presence of defects throughout the microstructure that result from the unique fabrication process. In the present paper, the microstructure of sintered FeCrA1Y foams was modeled by using a finite element （FE） model. In particular, microstructural variations were introduced to a base lattice, and the effects on the strength and stiffness calculated. A range of defects identified under scanning electronic microscope （SEM） imaging were considered including broken ligaments, thickness variations, and pore blockages, which are the three primary imperfections observed in sintered foams. the corresponding levels of defect present in the material were subsequently input into the FE model, with the resulting predictions correlating well with experimental data.

关键词： Metal foam Mechanical performance Defect Finite element SEM

Biothermomechanical behavior of skin tissue

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Acta Mechanica Sinica 2008年第1期24卷 1-23页

作者： F.Xu t.j.lu K.A.Seffen Engineering Department Cambridge University Cambridge CB2 1PZ UK MOE Key Laboratory of Strength and Vibration School of Aerospace Xi'an Jiaotong University 710049 Xi'an China

Advances in laser, microwave and similar technologies have led to recent developments of thermal treatments involving skin tissue. the effectiveness of these treatments is governed by the coupled thermal, mechanical, biological and neural responses of the affected tissue： a favorable interaction results in a procedure with relatively little pain and no lasting side effects. Currently, even though each behavioral facet is to a certain extent established and understood, none exists to date in the interdisciplinary area. A highly interdisciplinary approach is required for studying the biothermomechanical behavior of skin, involving bioheat transfer, biomechanics and physiology. A comprehensive literature review pertinent to the subject is presented in this paper, covering four subject areas：（a） skin structure, （b） skin bioheat transfer and thermal damage, （c） skin biomechanics, and （d） skin biothermomechanics. the major problems, issues, and topics for further studies are also outlined. this review finds that significant advances in each of these aspects have been achieved in recent years. Although focus is placed upon the biothermomechanical behavior of skin tissue, the fundamental concepts and methodologies reviewed in this paper may also be applicable for studying other soft tissues.

关键词： Review Skin tissue Bioheat transfer Biomechanics Biothermomechanics

the mechanical behavior of nanoscale metallic multilayers:A survey

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Acta Mechanica Sinica 2015年第3期31卷 319-337页

作者： Q.Zhou j.Y.Xie F.Wang P.Huang K.W.Xu t.j.lu State-Key Laboratory for Mechanical Behavior of Material Xi’an Jiaotong University State-Key Laboratory for Mechanical Structure Strength and Vibration Xi’an Jiaotong University

the mechanical behavior of nanoscale metallic multilayers （NMMs） has attracted much attention from both scientific and practical views. Compared with their monolithic counterparts, the large number of interfaces existing in the NMMs dictates the unique behavior of this special class of structural composite materials. While there have been a number of reviews on the mechanical mechanism of micro- laminates, the rapid development of nanotechnology brought a pressing need for an overview focusing exclusively on a property-based definition of the NMMs, especially their size- dependent microstructure and mechanical performance. this article attempts to provide a comprehensive and up-to-date review on the microstructure, mechanical property and plas- tic deformation physics of NMMs. We hope this review could accomplish two purposes：（1） introducing the basic concepts of scaling and dimensional analysis to scientists and engi- neers working on NMM systems, and （2） providing a better understanding of interface behavior and the exceptional qual- ities the interfaces in NMMs display at atomic scale.

关键词： Multilayer Interface Microstructure Mechanical behavior

tRANSMISSION OF SOUND ENERGY tHROUGH ORtHOGONALLY RIB-StIFFENED DOUBLE-LEAF StRUCtURES

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TRANSMISSION OF SOUND ENERGY THROUGH ORTHOGONALLY RIB-STIFFE...

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

the third International Conference on Dynamics, Vibration and Control

作者： F.X.Xin~* and t.j.lu MOE Key Laboratory for Strength and Vibration School of Aerospace Xi’an jiaotong University Xi’an 710049 P.R.China

＜正＞the vibration and sound transmission characteristics of periodically rib-stiffened double-leaf structures is of growing interest due to their wide range applications in civil and transport engineering（e.g.,as the cabin skin of aircrafts,marine ships and express trains）.At low frequencies,a rib-stiffened structure can be approximated as an orthotropic panel when the wavelength of the flexural wave in the panel is much greater than the separation distance of the *** high frequencies,however,when the wavelength is comparable with the stiffener separation,the spatial periodicity of the structure should be carefully taken account of in the theoretical analysis.

关键词： Sound transmission double-leaf partition orthogonal rib-stiffener vibroacoustic performance

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： jie jin Huajing Zhang Qianying lu Linqiang tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu Sijia tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine technology TianjinChina Henan Medical Key Laboratory for Research of trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World journal of Diabetes 2025年第1期16卷 27-33页

作者： Xue Wen lu-Ming Qi Kui Zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

the onset and progression of type 2 diabetes mellitus(t2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World journal of *** article explores the association between t2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in t2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for t2DM.

关键词： type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways treatment Short-chain fatty acids

遮蔽、澄明与“双减”:创新人才涌现的哲学基础与关键

维普期刊数据库评论

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华东师范大学学报（教育科学版） 2025年第1期43卷 1-16页

作者：卢晓东北京大学教育经济研究所北京100871

自然科学基础学科中的拔尖创新人才何以涌现是当下中国的核心论题,其哲学基础和关键能否得以揭示关系到教育观念变革和教育实践定向。此论题同时关涉“双减”这一教育政策概念尚未被把握的本质。在《科学革命的结构》以及库恩一系列论述... 详细信息

自然科学基础学科中的拔尖创新人才何以涌现是当下中国的核心论题,其哲学基础和关键能否得以揭示关系到教育观念变革和教育实践定向。此论题同时关涉“双减”这一教育政策概念尚未被把握的本质。在《科学革命的结构》以及库恩一系列论述中,范式与教-学间的联系是常规科学时期科学教育的本质所涉,不适当的教-学会在学生头脑中形成范式陷阱。范式陷阱作为隐喻与海德格尔的“遮蔽”隐喻虽有不同但高度类似,彼此唤醒。教-学中的教科书以“真”的文字和语言形成了作为掩埋的遮蔽而类似“陷阱”,扭曲/失真的遮蔽使反常现象难以被“看见”和发现,改信的困难凸显范式陷阱作为“陷阱”的特征。在海德格尔处,真理的本质揭示自身为自由,即不被旧范式遮蔽的自由或不陷入范式陷阱的自由。Doublelighten作为英译方使“双减”概念中隐藏不露的微光与澄明得以显露。与遮蔽相对的隐喻是澄明,减少本科学习量和“双减”的哲学本质在澄明。澄明和自由是自然科学领域真理发现和创新人才涌现的本质和关键,全民族始终要将学生在(旧)范式中、在不断增长的知识和技术中所保有的澄明和自由视为珍宝。本文是勾连库恩和海德格尔的一次尝试。

关键词：双减拔尖创新人才科学教育钱学森之问科学革命范式海德格尔

东北作为理解新时代中国文学的方法——广义“新东北文学”论纲

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当代文坛 2025年第1期 126-133页

作者：金钢王璐黑龙江省社会科学院文学研究所

新时代以来,东北文学呈现出繁荣发展的景象,综合考察其内涵与外延,是认识其价值较为客观的途径。如果将“铁西三剑客”等东北青年作家创作定义为狭义的“新东北文学”,那么本文讨论的则是新时代以来反映东北区域社会人生的广义的“新东... 详细信息

新时代以来,东北文学呈现出繁荣发展的景象,综合考察其内涵与外延,是认识其价值较为客观的途径。如果将“铁西三剑客”等东北青年作家创作定义为狭义的“新东北文学”,那么本文讨论的则是新时代以来反映东北区域社会人生的广义的“新东北文学”。新东北文学作为新时代中国文学的一部分,具有其局部性和特殊性,将东北作为方法,可以使新东北文学获得超乎其本来存在范围的意义,承载思想交流的使命,从而理解新时代中国文学的发展脉络。通过对东北老工业基地的衰落与振兴,新世纪以来的城乡互动、地方与世界的关系等问题的分析,能够发现新东北文学超越区域限制的诸多想象,以及认识和解释世界的尝试。

关键词：新时代新东北文学工业

Effect of gamification applications on success of dentistry students

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World journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen Deniz Elif Polat Balkan Burak İncebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** to evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).there was a statistically significant difference in average success scores between students of different groups(P=0.003the average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCluSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education Dentistry