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Gut.microbiome:A revolut.on in t.peⅡdiabet.s mellit.s

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World Journal of Diabet.s 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman t.jaswin Mariappan Naveen Jeyaraman Sat.ish Mut.u swaminathan Ramasubramanian Gabriel Silva Sant.s Lucas Furt.do da Fonseca JoséFábio Lana Depart.ent.of Ort.opaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Depart.ent.of Ort.opaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Depart.ent.of Ort.opaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Depart.ent.of Communit. Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Depart.ent.of Ort.opaedics Government Medical CollegeKarur 639004Tamil NaduIndia Depart.ent.of Biot.chnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Depart.ent.of Ort.opaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

t.peⅡdiabet.s mellit.s(t.DM)has experienced a dramat.c increase globally across count.ies of various income levels over t.e past.t.ree *** persist.nt.prevalence of t.DM is at.ribut.d t. a complex int.rplay of genet.c and environment.l *** numerous pharmaceut.cal t.erapies have been developed,t.ere remains an urgent.need for innovat.ve t.eat.ent.approaches t.at.offer effect.veness wit.out.significant.adverse *** t.is cont.xt.t.e explorat.on of t.e gut.microbiome present. a promising *** has increasingly shown t.at.t.e gut.microbiome of individuals wit. t.DM exhibit. dist.nct.differences compared t. healt.y individuals,suggest.ng it. pot.nt.al role in t.e disease’s pat.ogenesis and *** emerging field offers diverse applicat.ons,part.cularly in modifying t.e gut.environment.t.rough t.e administ.at.on of prebiot.cs,probiot.cs,and fecal microbiome *** int.rvent.ons aim t. rest.re a healt.y microbiome balance,which could pot.nt.ally alleviat. or even reverse t.e met.bolic dysfunct.ons associat.d wit. *** current.result. from clinical t.ials have not.yet.shown dramat.c effect. on diabet.s management.t.e groundwork has been laid for deeper *** and fut.re clinical t.ials are crit.cal t. advancing our underst.nding of t.e microbiome’s impact.on *** furt.er elucidat.ng t.e mechanisms t.rough which microbiome alt.rat.ons influence insulin resist.nce and glucose met.bolism,researchers can develop more t.rget.d *** pot.nt.al t. harness t.e gut.microbiome in developing new t.erapeut.c st.at.gies offers a compelling prospect.t. t.ansform t.e t.eat.ent.landscape of t.DM,pot.nt.ally reducing t.e disease’s burden significant.y wit. approaches t.at.are less reliant.on t.adit.onal pharmaceut.cals and more focused on holist.c,syst.mic healt. improvement..

关键词： t.peⅡdiabet.s Gut.microbiome Probiot.cs Prebiot.cs Fecal microbiot. t.ansplant.t.on

Biodegradat.on of met.anol vapor in a biofilt.r

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Journal of Environment.l Sciences 2003年第5期15卷 691-696页

作者： Durai Arulneyam t.swaminathan Biot.chnologyResearchCent.e BiotechnologyResearchCentre DepartmentofChemicalEngineeringIndianInstituteofTechnologyMadrasChennai600036IndiaDepartmentofChemicalEngineeringIndianInstituteofTechnologyMadrasChennai600036India

Volat.le organic compounds (VOCs) are a new class of air pollut.nt. posing t.reat.t. t.e environment. Newer t.chnologies are being developed for t.eir cont.ol among which biofilt.at.on seem t. be most.at.ract.ve. Biofilt.at.on of met.anol vapor from air st.eam was evaluat.d in t.is st.dy. Experiment.l invest.gat.ons were conduct.d on a laborat.ry scale biofilt.r, cont.ining mixt.re of compost.and polyst.rene inert.part.cles as t.e filt.r mat.rials. Mixed consort.um of act.vat.d sludge was used as an inoculum. t.e cont.nuous performance of biofilt.r for met.anol removal was monit.red for different.concent.at.ons and flow rat.s. t.e removal efficiencies decreased at.higher concent.at.ons and higher gas flow rat.s. A maximum eliminat.on capacit. of 85 g/(m 3·h) was achieved. t.e response of biofilt.r t. upset.loading operat.on showed t.at.t.e biofilm in t.e biofilt.rs was quit. st.ble and quickly adapt.d t. adverse operat.onal condit.ons.

关键词： biofilt.r met.anol removal efficiency eliminat.on capacit. degradat.on

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Phot.elect.ochemical behaviour of Cdln2S4 films deposit.d by pulse elect.odeposit.on using non-aqueous elect.olyt.

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Front.ers of Mat.rials Science 2013年第4期7卷 379-386页

作者： Chockalingam JAYANt.I swaminathan DHANAPANDIAN Kollegal Ramakrishna MURALI Depart.ent.of Physics Government Arts College Dharmapud 636705 Tamilnadu India Depart.ent.of Physics Annamalai University Annamalainagar 608002 Tamilnadu India Elect.ochemical Mat.rials Science Division. Cent.al Elect.ochemical Research Inst.t.t.. Karaikudi 630006 Tamilnadu. India

Cdln2S4 films were deposit.d by t.e pulse elect.odeposit.on t.chnique on t.n oxide-coat.d glass subst.at.s, at.different.dut. cycles in t.e range of 6%-50%. t.e deposit.on pot.nt.al was -0.7 V vs, sat.rat.d calomel elect.ode （SCE） using non-aqueous di（et.ylene glycol） elect.olyt., XRD analysis of t.e films indicat.d polycryst.lline nat.re. Grain size, st.ain and dislocat.on densit. were evaluat.d from t.e XRD dat., EDX analysis of t.e surface composit.on confirms t.e format.on of st.ichiomet.ic Cdln2S4 films, Opt.cal st.dies show a direct.band-gap values in t.e range of 2.14-2.23 eV for t.e films deposit.d at.different.dut. cycles. Room t.mperat.re resist.vit. of t.e films was in t.e range of 40-21 *** wit. t.e increase of dut. cycle. Phot.elect.ochemical （PEC） solar cells const.uct.d wit. t.e films deposit.d at.50% dut. cycle and post.heat.t.eat.d at.500~C indicat.d open circuit.volt.ge （Voc） of 0.595 V, short.circuit.current.densit. （Jsc） of 6.20 ***-2, fill fact.r （if） of 0.61, efficiency （t.） of 3.75%, series resist.nce （Rs） of 4Q and shunt.resist.nce （Rsh） of 2.50kQ. Making use of t.e advant.ges of pulse elect.odeposit.on it.can be used t. deposit.nanocryst.lline films which can be employed in opt.elect.onic and phot.volt.ic devices.

关键词： t.in film semiconduct.r Cdln2S4 phot.elect.ochemical (PEC) cell

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Damage mechanism ident.ficat.on in composit.s via machine learning and acoust.c emission

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npj Comput.t.onal Mat.rials 2021年第1期7卷 852-866页

作者： C.Muir B.swaminathan A.S.Almansour K.Sevener C.Smit. M.Presby J.D.Kiser t.M.Pollock S.Daly Mat.rials Depart.ent University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Cent.r ClevelandOHUSA Mat.rials Scienceand Engineering Depart.ent University of Michigan-Ann ArborAnn ArborMIUSA Mechanical Engineering Depart.ent University of California-Santa BarbaraSanta BarbaraCAUSA

Damage mechanism ident.ficat.on has scient.fic and pract.cal ramificat.ons for t.e st.uct.ral healt. monit.ring,design,and applicat.on of composit. *** advances in machine learning uncover pat.ways t. ident.fy t.e waveform-damage mechanism relat.onship in higher-dimensional spaces for a comprehensive underst.nding of damage *** review evaluat.s t.e st.t. of t.e field,beginning wit. a physics-based underst.nding of acoust.c emission waveform feat.re ext.act.on,followed by a det.iled overview of waveform clust.ring,labeling,and error analysis *** requirement. for damage mechanism ident.ficat.on in any machine learning framework,including t.ose current.y in use,under development.and yet.t. be explored,are discussed.

关键词： composit.s composit. mechanism

A machine learning framework for damage mechanism ident.ficat.on from acoust.c emissions in unidirect.onal SiC/SiC composit.s

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npj Comput.t.onal Mat.rials 2021年第1期7卷 1326-1335页

作者： C.Muir B.swaminathan K.Fields A.S.Almansour K.Sevener C.Smit. M.Presby J.D.Kiser t.M.Pollock S.Daly Mat.rials University of California-Santa BarbaraSanta BarbaraCAUSA Mechanical Engineering University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Cent.r ClevelandOHUSA Mat.rials Science and Engineering University of Michigan-Ann ArborAnn ArborMIUSA

In t.is work,we demonst.at. t.at.damage mechanism ident.ficat.on from acoust.c emission(AE)signals generat.d in minicomposit.s wit. elast.cally similar const.t.ent. is *** waveforms were generat.d by SiC/SiC ceramic mat.ix minicomposit.s(CMCs)loaded under uniaxial t.nsion and recorded by four sensors(t.o models wit. each model placed at.t.o ends).Signals were encoded wit. a modified part.al power scheme and subsequent.y part.t.oned t.rough spect.al *** cracking and fiber failure were ident.fied based on t.e frequency informat.on cont.ined in t.e AE event.t.ey produced,despit. t.e similar const.t.ent.elast.c propert.es of t.e mat.ix and ***,t.e result.nt.ident.ficat.on of AE event. closely followed CMC damage chronology,wherein early mat.ix cracking is lat.r followed by fiber breaks,even t.ough t.e approach is fully domain-knowledge ***,t.e part.t.ons were highly precise across bot. t.e model and locat.on of t.e sensors,and t.e part.t.oning was *** present.d approach is promising for CMCs and ot.er composit. syst.ms wit. elast.cally similar const.t.ent..

关键词： composit.s damage mechanism

帕里骨化醇单用以及联合成纤维细胞生长因子23受体抑制剂在慢性肾功能衰竭中的心脏保护作用:试验与临床研究

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中华高血压杂志(中英文) 2019年第11期 1098-1098页

作者： Czaya B Seeherunvong W Singh S Yanucil C Ruiz P Qui-roz Y Grabner A Kat.oufis C swaminathan S Abit.ol C Rodriguez-It.rbe B Faul C Freundlich M

在尿毒症动物的研究中发现,维生素D受体(vit.min D recept.r,VDR)激动剂如帕里骨化醇(paricalcit.l,Pc)可减轻心肌肥大,但目前在慢性肾脏病患者中尚未观察到该作用是否存在。成纤维细胞生长因子23(fibroblast.growt. fact.r 23,FGF23)... 详细信息

在尿毒症动物的研究中发现,维生素D受体(vit.min D recept.r,VDR)激动剂如帕里骨化醇(paricalcit.l,Pc)可减轻心肌肥大,但目前在慢性肾脏病患者中尚未观察到该作用是否存在。成纤维细胞生长因子23(fibroblast.growt. fact.r 23,FGF23)水平升高可激活心肌钙调神经磷酸酶/活化t.胞核因子(nuclear fact.r of act.vat.d t.cell,NFAt.信号通路,引起心肌肥厚,可能对抗VDR激动剂治疗的心肌保护

关键词：成纤维细胞生长因子骨化醇心脏保护作用慢性肾功能衰竭临床研究受体抑制剂