Gut microbiome:A revolution in typeⅡdiabetes mellitus

作     者：Madhan Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana 

作者机构：Department of OrthopaedicsACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of OrthopaedicsBrazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of OrthopaedicsOrthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community MedicineGovernment Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of OrthopaedicsGovernment Medical CollegeKarur 639004Tamil NaduIndia Department of BiotechnologyFaculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of OrthopaedicsGovernment Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2024年第15卷第9期

页      面：1874-1888页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：TypeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation 

摘      要：TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.