检索结果-南通市图书馆

Early and Sensitive Detection of Pathogens for Public Health and Biosafety:An Example of Surveillance and Genotyping of SARS-CoV-2 in Sewage Water by Cas12a-Facilitated Portable Plasmonic Biosensor

引用

Research 2024年第2期2023卷 259-272页

作者： Tianzhong Li Yuzhi Chen Zhi Chen Yuan Hao Minyi Liang Yingxia Liu Guanyong Ou Huanian Zhang Yuxuan Tang Yabing Hao swelm wageh Omar AAl-Hartomy Abul Kalam Bin Zhang Xin Shi Xuejin Li Han Zhang College of Physics and Optoelectronic Engineering Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Sensor Technology Shenzhen 518060China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuan 511518China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China School of Medicine Southern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255049China Department of Physics Faculty of ScienceKing Abdulaziz University Jeddah 21589Saudi Arabia Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityP.0.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.0.Box9004Abha 61413 Saudi Arabia Health Sciences Institute China Medical UniversityShenyang 110000China The Chinese University of Hong Kong Shenzhen 518060China

Infectious diseases severely threaten public health and global *** addition to transmission through the air,pathogenic microorganisms have also been detected in environmental liquid samples,such as sewage *** biochemical detection methodologies are time-consuming and cost-ineffective,and their detection limits hinder early *** the present study,ultrafine plasmonic fiber probes with a diameter of 125μm are fabricated for clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas)-12a-mediated sensing of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Single-stranded DNA exposed on the fiber surface is trans-cleaved by the Cas12a enzyme to release gold nanoparticles that are immobilized onto the fiber surface,causing a sharp reduction in the surface plasmon resonance(SPR)*** proposed fiber probe is virus-specific with the limit of detection of~2,300 copies/ml,and genomic copy numbers can be reflected as shifts in wavelengths.A total of 21 sewage water samples have been examined,and the data obtained are consistent with those of quantitative polymerase chain reaction(qPCR).In addition,the Omicron variant and its mutation sites have been fast detected using S gene-specific *** study provides an accurate and convenient approach for the real-time surveillance of microbial contamination in sewage water.

关键词： fiber consuming hinder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ionized cocatalyst to promote CO_(2) photoreduction activity over core-triple-shell ZnO hollow spheres

引用

Rare Metals 2022年第4期41卷 1077-1079页

作者： swelm wageh Omar A.Al-Hartomy Maged F.Alotaibi Li-Jun Liu Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia College of Chemistry and Chemical Engineering Wuhan Textile UniversityWuhan430200China

Solar-driven CO_(2) conversion into value-added chemicals is a sustainable solution to achieve carbon ***’s group have recently reported Mn,C-codoped ZnO coretriple-shell hollow spheres(CTSHSs)for efficient CO_(2) **... 详细信息

关键词： reduction spheres catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TiO_(2) nanosheets with exposed {001} facets for photocatalytic applications

引用

Nano Research 2016年第1期9卷 3-27页

作者： Chimmikuttanda Ponnappa Sajan swelm wageh Ahmed.A.Al-Ghamdi Jiaguo Yu Shaowen Cao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Physics and Engineering Mathematics Department Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

TiO_(2) nanosheets with highly reactive{001}facets({001}-TiO_(2))have attracted great attention in the fields of science and technology because of their unique *** recent years,many efforts have been made to synthesize{001}-TiO_(2) and to explore their applications in *** this review,we summarize the recent progress in preparing{001}-TiO_(2) using different techniques such as hydrothermal,solvothermal,alcohothermal,chemical vapor deposition(CVD),and sol gel-based ***,the enhanced efficiency of{001}-TiO_(2) by modification of carbon materials,surface deposition of transition metals,and non-metal doping is ***,the applications of{001}-TiOR-based photocatalysts in the degradation of organic dyes,hydrogen evolution,carbon dioxide(CO_(2))reduction,bacterial disinfection,and dye-sensitized solar cells are *** believe this entire review on TiO_(2) nanosheets with{001}facets can further inspire researchers in associated fields.

关键词： TiO_(2) nanosheets {001}facets photocatalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced Photocatalytic H_(2)-production Activity of CdS Nanoflower using Single Atom Pt and Graphene Quantum Dot as Dual Cocatalysts

引用

Chinese Journal of Structural Chemistry 2022年第6期41卷 6-14页

作者： Yi Yang Jinsong Wu Bei Cheng Liuyang Zhang Ahmed Abdullah Al-Ghamdi swelm wageh Youji Li State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Nanostructure Research Centre(NRC)Wuhan University of TechnologyWuhan 430070China Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia College of Chemistry and Chemical engineering Jishou UniversityJishouHunan 416000China

Single-atom catalysts have high catalytic activity due to their unique quantum size effects and optimal atom ***,visi-ble-light-responsive photocatalysts were designed by coupling CdS with graphene quantum dots(GQDs)and platinum single atoms(PtSAs).GQDs and PtSAs were successively loaded on ultrathin CdS nanosheets through freeze-drying and in-situ photocatalytic *** synergistic effect between PtSAs and GQDs results in superior photocatalytic activity with a hydrogen production rate of 13488μmol h^(-1)g^(-1)as well as the maximum apparent quantum efficiency(AQE)of 35.5%in lactic acid aqueous solution,which is 62 times higher than that of pristine CdS(213μmol g^(-1)h^(-1)).The energy conversion efficiency is ca.13.05%.As a photosensitizer and an electron reservoir,GQDs can not only extend the light response of CdS to the visible-light region(400-800 nm),but also promotes the separation of photoinduced electron-hole ***,PtSAs,with unique electronic and geometric features,can provide more efficient proton reduction *** finding provides an effective strategy to remarkably improve the photocatalytic H_(2) production performance.

关键词： hierarchical nanostructure single-atom catalysts graphene quantum dots CdS nanosheets hydrogen production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

S型异质结CO_(2)还原光催化剂

引用

物理化学学报 2021年第6期37卷 3-4页

作者： swelm wageh Ahmed AAl-Ghamdi 刘丽君 Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia 武汉纺织大学化学与化工学院武汉430200

Photocatalytic CO_(2) reduction to solar fuels attracts great interest due to the growing fossil fuel shortage and global warming. Developing high-efficiency photocatalyst is the key for the solar fuel production ~(1,2). TiO_(2), as an inert, nontoxic and earth-abundant semiconductor, has been widely used for photocatalytic CO_(2) reduction.

关键词： reduction. abundant (2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Growth and Characterization of Novel System of Nanoparticles Embedded in Phosphate Glass Matrix

引用

World Journal of Condensed Matter Physics 2011年第2期1卷 24-32页

作者： wageh swelm Anwar Higazy Mohammed Algradee 不详

We present a study of growth of a novel system of CdTe nanoparticles embedded in sodium/lithium-mixed phosphate glass matrix in a strong quantum confinement regime. The prepared systems are characterized by differential thermal analysis, X-ray diffraction, TEM, optical absorption, infrared and Raman Spectroscopy. We have investigated the effect of glass matrix composition and annealing time on the growing of the CdTe semiconductor nanoparticles. We found that the decrease in Na2O content and addition of ZnO to the glass composition is strongly affecting the nanoparticles formation and capping surface of the nanoparticls. On the other hand, we have calculated the size of nanoparticles by effective mass approximation (EMA) and empirical method based on tight binding approximation and found that the calculation based on tight binding approximation are very plausible than that one calculated by EMA.

关键词： Semiconductor Nanoparticles CdTe Infrared and optical Spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一种乳酸菌-金属有机框架复合物用于强化肿瘤乏氧光动力和免疫治疗

引用

Science China Materials 2023年第1期66卷 363-374页

作者：李田忠王金勇陈桐楷 swelm wageh Ahmed AAl-Ghamdi 于江天谢中建张晗 Interdisciplinary Center of High Magnetic Field Physics of Shenzhen University College of Physics and Optoelectronic EngineeringDepartment of OtolaryngologyShenzhen Institute of Translational MedicineShenzhen Second People’s Hospitalthe First Affiliated HospitalShenzhen UniversityShenzhen 518060China Shenzhen International Institute for Biomedical Research Shenzhen 518000China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038China

开发长期有效的癌症治疗技术仍然是科研工作者和临床医生面临的重要任务.厌氧型乳酸菌(LAB)具有天然的乏氧倾向性,可自发富集在缺氧的肿瘤微环境中.金属有机框架(MOF)是一类独特的纳米材料,其中的ZIF-67可以自发分解过氧化氢产氧,且析... 详细信息

开发长期有效的癌症治疗技术仍然是科研工作者和临床医生面临的重要任务.厌氧型乳酸菌(LAB)具有天然的乏氧倾向性,可自发富集在缺氧的肿瘤微环境中.金属有机框架(MOF)是一类独特的纳米材料,其中的ZIF-67可以自发分解过氧化氢产氧,且析氧能力可被光照增强.然而,LAB或MOF单独应用于肿瘤治疗的效果并不令人满意.在本文中,我们制备了一种MOF修饰的乳酸菌制剂,用以在缺氧性肿瘤中局部产生活性氧(ROS)助力光动力治疗,同时精准诱导宿主肿瘤免疫.这些细菌表面被ZIF-67纳米材料修饰(LAB@ZIF-67),经体内循环后富集在肿瘤微环境中.细菌表面的ZIF-67可以被CT-26细胞吸收,并且在光照后检测到细胞内快速生成ROS.体内实验表明,该细菌复合物可通过光动力疗法消灭肿瘤,同时诱导肿瘤特异的炎性反应,招募巨噬细胞和T细胞实现肿瘤的免疫治疗.此类材料-细菌复合物为今后研发肿瘤主动靶向药物和癌症免疫疗法提供了新思路.

关键词：肿瘤微环境金属有机框架光动力免疫治疗肿瘤免疫缺氧性巨噬细胞厌氧型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fully depleted vdW heterojunction based high performance photovoltaic photodetector

引用

Journal of Materiomics 2023年第6期9卷 1039-1047页

作者： Yonghong Zeng Fanxu Meng Sidi Fan Pengfei Wang Cuiyun Kou Mingyi Sun Haiguo Hu Rui Cao swelm wageh Omar A.Al-Hartomy Abul Kalam Bowen Du Wenchao Ding Songrui Wei Zhinan Guo Qiuliang Wang Han Zhang College of Physics and Optoelectronic Engineering Institute of Microscale OptoelectronicsInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and TechnologyInterdisciplinary Center of High Magnetic Field Physics of Shenzhen UniversityShenzhen UniversityShenzhen518060China Guangzhou Key Laboratory of Sensing Materials and Devices Center for Advanced Analytical ScienceSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou510006China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Research Center for Advanced Materials Science(RCAMS) Department of ChemistryCollege of ScienceKing Khalid UniversityP.O.Box 9004Abha61413Saudi Arabia Foshan Electrical and Lighting Co. LTD64 North Fenjiang RoadFoshanChina Institute of Electrical Engineering Chinese Academy of SciencesBeijing100190China Center of Characterization and Analysis Jilin Institute of Chemical TechnologyJilin132022China

Van der Waals(vdW)heterojunctions,with their unique electronic and optoelectronic properties,have become promising candidates for photodetector *** the contribution of the depletion region in vdW heterojunction,which would enhance both of the collection efficiency and speed of the photogenerated carriers,presents an effective strategy for achieving high performance vdW heterojunction ***,a fully depleted vdW heterojunction photodetector is built on two-dimensional(2D)semiconductor materials(GaTe and InSe)layered on a pattered bottom electrode in vertical structure,in which the generation and motion of carriers are exclusively achieved in the depletion *** to the intrinsic built-in electric field,the elimination of series resistance and the depletion region confinement of carriers,the as-fabricated photodetector exhibits prominent photovoltaic properties with a high open-circuit voltage of 0.465 V,as well as photoresponse characteristics with outstanding responsivity,detectivity and photoresponse speed of 63.7 A/W,3.88×10^(13)Jones,and 32.7 ms *** overall performance of this fully depleted GaTe/InSe vdW heterojunctions photodetectors are ranking high among the top level of 2D materials based *** indicates the device architecture can provide new opportunities for the fabrication of high-performance photodetectors.

关键词： Two-dimensional material van der waals heterojunction Fully depleted photodetector Photovoltaic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

引用

Research 2023年第3期2022卷 281-294页

作者： Jianye Fu Wenwei Han Xue Zhang Yutong Sun Rajendra Bhadane Bo Wei Li Li Liangmin Yu Jinbo Yang Jessica MRosenholm Outi MHSalo-Ahen Taojian Fan Bin Zhang wageh swelm Ahmed AAl-Ghamdi Lin Xia Han Zhang Meng Qiu Hongbo Zhang Xin Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China College of Chemistry and Chemical Engineering China University of PetroleumQingdao 266555China. Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Structural Bioinformatics Laboratory BiochemistryÅbo Akademi University20520 TurkuFinland. Center for Innovation Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Marine Biomedical Research Institute of Qingdao Qingdao 266100China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Hangzhou No.14 High School Hangzhou 310000China Turku Bioscience Centre University of Turku andÅbo Akademi University20520 TurkuFinland

Oligonucleotide-based therapy has experienced remarkable development in the past 2 decades,but its broad applications are severely hampered by delivery *** used viral vectors and lipid nanovectors are suffering from immune clearance after repeating usage or requiring refrigerated transportation and storage,*** this work,amino-modified virus-mimetic spike silica nanoparticles(NH_(2)-SSNs)were fabricated using a 1-pot surfactant-free approach with controlled spike lengths,which were demonstrated with excellent delivery performance and biosafety in nearly all cell types and *** indicated that NH2-SSNs entered cells by spike-dependent cell membrane docking and dynamin-dependent *** positively charged spikes with proper length on the surface can facilitate the efficient encapsulation of RNAs,protect the loaded RNAs from degradation,and trigger an early endosome escape during intracellular trafficking,similarly to the cellular internalization mechanism of *** the fantastic properties of NH_(2)-SSNs in nucleic acid delivery,it revealed that nanoparticles with solid spikes on the surface would be excellent vehicles for gene therapy,presenting self-evident advantages in storage,transportation,modification,and quality control in large-scale production compared to lipid nanovectors.

关键词： surfactant loaded transportation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

引用

National Science Review 2022年第8期9卷 100-109页

作者： Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar A.Al-Hartomy swelm wageh Abdullah G.Al-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education 3. Shenzhen Institute of Translational Medicine 4. Department of Otolaryngology Shenzhen Second People’s Hospital 5. the First Affiliated Hospital 6. Institute of Microscale Optoelectronics Shenzhen University 7. Shenzhen International Institute for Biomedical Research 8. Shenzhen Han’s Tech Limited Company 9. Shenzhen Metasensing Tech Limited Company Department of Physics Faculty of Science King Abdulaziz University Research Center for Advanced Materials Science (RCAMS) King Khalid University Department of Chemistry College of Science King Khalid University Zhongmin (Shenzhen) Intelligent Ecology Co.Ltd Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Department of Laboratory Medicine Shenzhen Children’s Hospital Optoelectronics Research Center School of Science Minzu University of China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Research Unit of Adaptive Evolution and Control of Emerging Viruses Chinese Academy of Medical Sciences Institute of Pathogenic Organism Shenzhen Center for Disease Control and Prevention Respiratory Department Shenzhen Children’s Hospital Institute of Pediatrics Shenzhen Children’s Hospital

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-Co V-2 variants,including Omicron, are required to be identified as soon as the samples are identified as ‘positive’.Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance(SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat(CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification,within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-Co V-2, and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron) and BA.1(a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in China, identified by the Centers for Disease Control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.

关键词： surface plasmon resonance CRISPR SARS-CoV-2 Omicron variant

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：