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Gaussian Blur Masked ResNet2.0 Architecture for Diabetic Retinopathy Detection

Computers, Materials & Continua 2023年第4期75卷 927-942页

作者： swagata boruah Archit Dehloo Prajul Gupta Manas Ranjan Prusty A.Balasundaram School of Electronics Engineering Vellore Institute of TechnologyChennai600127India School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India Centre for Cyber-Physical Systems Vellore Institute of TechnologyChennai600127India

Diabetic Retinopathy (DR) is a serious hazard that can result inirreversible blindness if not addressed in a timely manner. Hence, numeroustechniques have been proposed for the accurate and timely detection ofthis disease. Out of these, Deep Learning (DL) and Computer Vision (CV)methods for multiclass categorization of color fundus images diagnosed withDiabetic Retinopathy have sparked considerable attention. In this paper,we attempt to develop an extended ResNet152V2 architecture-based DeepLearning model, named ResNet2.0 to aid the timely detection of DR. TheAPTOS-2019 datasetwas used to train the model. This consists of 3662 fundusimages belonging to five different stages of DR: no DR (Class 0), mild DR(Class 1), moderate DR (Class 2), severe DR (Class 3), and proliferativeDR (Class 4). The model was gauged based on ability to detect stage-wiseDR. The images were pre-processed using negative and positive weightedGaussian-based masks as feature engineering to further enhance the qualityof the fundus images by removing the noise and normalizing the images. Upsamplingand data augmentation methods were used to address the skewnessof the original dataset. The proposed model achieved an overall accuracyof 91% and an area under the receiver-operating characteristic curve (AUC)score of 95.1%, outperforming existing Deep Learning models by around 10%.Furthermore, the class-wise F1 score for No DR was 92%, Mild DR was 82%,Moderate DR was 66%, Severe was DR 89% and Proliferative DR was 80%.

关键词： Diabetic retinopathy deep learning transfer learning image processing image classification

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Probabilistic seismic design of pile-supported building structure incorporating inherent variability of subsoil and ground motion uncertainty

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 135-156页

作者： swagata DebRoy Rajib Saha Civil Engineering Department National Institute of Technology AgartalaJirania-799046Tripura(West)India

Seismic failure of structures supported on pile foundation has revealed the importance of seismic soil-foundation-structure interaction(SSFSI)for ensuring safe *** uncertainties in subsoil properties and seismic loading may lead the problem to be more *** this context,the present study attempts to assess the seismic reliability of pile foundation-supported building structure embedded in inhomogeneous clay layer considering inertial *** strength of clay and earthquake loading is considered as spatially variable uncertain parameters.A non-linear soil-pile-structure system was assumed,and Monte Carlo simulation(MCS)was adopted to obtain probabilistic response of the ***-order reliability method(FORM)is used for reliability *** study indicates significant influence of uncertain parameters on the seismic response of building ***,the influence of material and load uncertainty parameters on the probabilistic seismic response of structure designed following older version of code is higher than counterpart structure designed following recent *** based reliability analysis infers thatserviceability criterion may be the governing parameter for pile foundation ***,the study also indicates that the curvature ductility demand of pile may be considered another crucial design parameter to assess the reliability of pile foundation.

关键词： seismic soil-foundation-structure interaction pile foundation soft clay Monte Carlo simulation FORM OPENSees

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A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder

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World Journal of Pediatrics 2022年第12期18卷 825-834页

作者： Mahasweta Chatterjee Sharmistha Saha swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector JEM BypassKolkataWest Bengal700107India

Background The serotonin transporter(SERT),encoded by the solute carrier family 6 number 4(SLC6A4)gene,controls serotonin(5-HT)availability and is essential for the regulation of behavioral *** SLC6A4 genetic variants,5-HTTLPR and STin2,were widely investigated in patients with various neurobehavioral disorders,including attention deficit hyperactivity disorder(ADHD).Methods We analyzed the association of the 5-HTTLPR(L/S)and STin2(10/12)variants,plasma 5-HT,and 5-hydroxyindole acetic acid(5-HIAA),as well as SERT messenger RNA(mRNA)with ADHD in the eastern Indian *** families with ADHD probands(n=274)and ethnically matched controls(n=367)were recruited following the Diagnostic and Statistical Manual of Mental *** traits,executive function,and intelligence quotient(IQ)of the probands were assessed using the Conner's Parent Rating Scale–Revised,Parental Account of Children’s Symptoms(PACS),Barkley Deficit in Executive Functioning—Child and Adolescent Scale,and Wechsler Intelligence Scale for Children-III,*** obtaining informed written consent,peripheral blood was collected to analyze genetic variants,plasma 5-HT,5-HIAA,and SERT mRNA *** ADHD probands showed a higher frequency of the 5-HTTLPR“L”allele and“L/L”genotype(P<0.05),lower 5-HIAA level,and higher SERT mRNA *** for behavioral problems and hyperactivity were higher in the presence of the“S”allele and“S/S”genotype,while executive deficit was higher in the presence of the“L”*** score was lower in the presence of the STin2“12”allele and L-12 *** Data obtained indicate a significant association of the serotoninergic system with ADHD,warranting further in-depth investigation.

关键词： Attention deficit hyperactivity disorder 5-Hydroxyindole acetic acid 5-Serotonin 5-HTT-linked polymorphic region SERT mRNA

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Analysis of neurotransmitters validates the importance of the dopaminergic system in autism spectrum disorder

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世界儿科杂志:英文版 2023年第8期19卷 770-781页

作者： Sharmistha Saha Mahasweta Chatterjee Nilanjana Dutta swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector-JE.M.BypassKolkataWest Bengal700107India

Background The reasons behind the cardinal symptoms of communication deficits and repetitive,stereotyped behaviors that characterize autism spectrum disorder(ASD)remain *** dopamine(DA)system,which regulates motor activity,goal-directed behaviors,and reward function,is believed to play a crucial role in ASD,although the exact mechanism is still *** have shown an association of the dopamine receptor D4(DRD4)with various neurobehavioral *** We analyzed the association between ASD and four DRD4 genetic polymorphisms,5′flanking 120-bp duplication(rs4646984),rs1800955 in the promoter,exon 112 bp duplication(rs4646983),and exon 348 bp *** also examined plasma DA and its metabolite levels,DRD4 mRNA expression,and correlations of the studied polymorphisms with these parameters by case–control comparative *** expression of DA transporter(DAT),which is important in regulating the circulating DA level,was also *** A significantly higher occurrence of rs1800955“T/TT”was observed in the *** traits were affected by rs1800955“T”and the higher repeat alleles of the exon 348 bp repeats,rs4646983 and *** probands exhibited lower DA and norepinephrine levels together with higher homovanillic acid levels than the control *** and DRD4 mRNA expression were down-regulated in the probands,especially in the presence of DAT rs3836790“6R”and rs27072“CC”and DRD4 rs4646984 higher repeat allele and rs1800955“T”.Conclusion This pioneering investigation revealed a positive correlation between genetic variants,hypodopaminergic state,and impairment in socio-emotional and communication reciprocity in Indian subjects with ASD,warranting further in-depth analysis.

关键词： Autism spectrum disorder Dopamine Neurotransmitter

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Recent developments in the asymmetric synthesis and functionalization of symmetrical and unsymmetrical gem-diborylalkanes

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Organic Chemistry Frontiers 2022年第3期9卷 838-852页

作者： swagata Paul Kanak Kanti Das Debasis Aich Samir Manna Santanu Panda Department of Chemistry Indian Institute of TechnologyKharagpur721302India

gem-Diborylalkanes are an important class of organoboron compounds as they function as a key building block in organic *** the last decade,there has been growing interest in the enantioselective synthesis of gem-diborylalkanes to access a sp^(3) chiral center with two functionalizable *** review summarizes the recent development of the enantioselective synthesis of gem-diborylalkanes and their application in asymmetric synthesis.

关键词： synthesis alkanes synthesis

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An innovative technique of chest wall stabilization and reconstruction in traumatic flail chest:The figure-of-eight suture with polypropylene mesh and musculofascial flap

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Chinese Journal of Traumatology 2022年第2期25卷 122-124页

作者： Klein Dantis swagata Brahmachari Aghosh Raju Suprabha Shankari Department of Cardiothoracic and Vascular Surgery All India Institute of Medical SciencesRaipurIndia Department of General Surgery All India Institute of Medical SciencesBhopalIndia

Surgical stabilization of the flail chest is challenging and has no established *** wall integrity and stability are the main factors that ensure the protection of intrathoracic organs and an adequate respiratory ***,we report a novel chest wall reconstruction technique in a 45-year-old man with a traumatic left flail chest and open pneumothorax diagnosed both clinically and *** approximation and chest wall reconstruction was done using intercostal figure-of-eight suture and polypropylene mesh with vascularized musculofascial *** patient improved gradually and was discharged after three weeks of total hospital *** returned to regular working after a month with no evidence of respiratory distress or paradoxical chest ***-up visit at one year revealed no lung hernia or paradoxical chest *** is a novel,feasible and cost-effective modification of chest wall reconstruction that can be adopted for thoracic wall repair in case of open flail chest,which needs emergency surgical interventions even in resource constraint settings.

关键词： Flail chest Open pneumothorax Polypropylene mesh Figure-of-eight suture Chest wall reconstruction

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GaAs-based resonant tunneling diode:Device aspects from design,manufacturing,characterization and applications

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半导体学报:英文版 2023年第10期44卷 26-35页

作者： swagata Samanta Department of Electronics and Communication Engineering SRM University-APAndhra PradeshIndia

This review article discusses the development of gallium arsenide(GaAs)-based resonant tunneling diodes(RTD)since the *** the best of my knowledge,this article is the first review of GaAs RTD technology which covers different epitaxialstructure design,fabrication techniques,and characterizations for various application *** is expected that the details presented here will help the readers to gain a perspective on the previous accomplishments,as well as have an outlook on the current trends and future developments in GaAs RTD research.

关键词： gallium arsenide microfabrication resonant tunneling devices

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Experimental verification of bridge seismic damage states quantified by calibrating analytical models with empirical field data

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Earthquake Engineering and Engineering Vibration 2008年第4期7卷 383-393页

作者： swagata Banerjee Masanobu Shinozuka Department of Civil and Environmental Engineering University of California

Bridges are one of the most vulnerable components of a highway transportation network system subjected to earthquake ground motions. Prediction of resilience and sustainability of bridge performance in a probabilistic manner provides valuable information for pre-event system upgrading and post-event functional recovery of the network. The current study integrates bridge seismic damageability information obtained through empirical, analytical and experimental procedures and quantifies threshold limits of bridge damage states consistent with the physical damage description given in HAZUS. Experimental data from a large-scale shaking table test are utilized for this purpose. This experiment was conducted at the University of Nevada, Reno, where a research team from the University of California, Irvine, participated. Observed experimental damage data are processed to identify and quantify bridge damage states in terms of rotational ductility at bridge column ends. In parallel, a mechanistic model for fragility curves is developed in such a way that the model can be calibrated against empirical fragility curves that have been constructed from damage data obtained during the 1994 Northridge earthquake. This calibration quantifies threshold values of bridge damage states and makes the analytical study consistent with damage data observed in past earthquakes. The mechanistic model is transportable and applicable to most types and sizes of bridges. Finally, calibrated damage state definitions are compared with that obtained using experimental findings. Comparison shows excellent consistency among results from analytical, empirical and experimental observations.

关键词： highway bridges nonlinear time history analysis fragility curves threshold damage limits mechanisticmodel calibration

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Development of a simple two-step lithography fabrication process for resonant tunneling diode using air-bridge technology

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Journal of Semiconductors 2023年第11期44卷 79-82页

作者： swagata Samanta Jue Wang Edward Wasige Department of Electronics and Communication Engineering SRM University-APAndhra PradeshIndia 2School of EngineeringUniversity of GlasgowGlasgow G128LTUK

This article reports on the development of a simple two-step lithography process for double barrier quantum well(DBQW)InGaAs/AlAs resonant tunneling diode(RTD)on a semi-insulating indium phosphide(InP)substrate using an air-bridge *** approach minimizes processing steps,and therefore the processing time as well as the required *** is particularly suited for material qualification of new epitaxial layer designs.A DC performance comparison between the proposed process and the conventional process shows approximately the same *** expect that this novel technique will aid in the recent and continuing rapid advances in RTD technology.

关键词： air-bridge indium phosphide microfabrication resonant tunneling diode

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Recent advances in semimetallic pnictogen (As, Sb, Bi) based anodes for sodium-ion batteries: Structural design, charge storage mechanisms, key challenges and perspectives

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Nano Research 2021年第11期14卷 3690-3723页

作者： Samrat Sarkar swagata Roy Yufeng Zhao Jiujun Zhang Institute for Sustainable Energy & College of Sciences Shanghai University Shanghai China

In the recent times sodium ion batteries(SIBs)have come to the forefront as an economic and resourceful alternative to lithium-ion batteries(LIBs)for powering portable electronic devices and large-scale grid *** the specific capacity,energy density and long cycle life of batteries depend upon the performance of anode materials;their quest is the ultimate need of the *** the anode materials,the semimetallic pnictogens(As,Sb,Bi)and their compounds offer high gravimetric/volumetric capacities,but suffer from undesired volume expansion and inferior electrical ***,this paper reviews the recent progress in semimetallic pnictogens as alloying anodes and their compounds mainly as conversion-alloying *** debatable sodiation mechanisms(intercalation or alloying)have been presented with emphasis on in situ/ex situ advanced characterization methods well supported by theoretical modeling and *** reviewed electrochemical reaction mechanisms,coherent structural designs and engineering provide a vital understanding of the electrochemical processes of Na^(+) ion *** existing challenges and perspectives are also presented,and several research directions are proposed from the aspects of special morphological design,employing conductive substrates,electrolyte additives and reducing particle size for technical and commercial success of SIBs.

关键词： sodium-ion battery anode pnictogen arsenic antimony bismuth

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