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Endoscopic diagnosis of gastrointestinal graft-versus-host disease

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World journal of Gastroenterology 2008年第14期14卷 2262-2267页

作者： Chun-Fang Xu Lan-Xiang Zhu Xiao-Ming Xu Wei-Chang Chen de-Pei Wu department of Gastroenterology The First Affiliated Hospital of SooChow University 188 Shizi Street Suzhou 215006 Jiangsu Province China

AIM:To evaluate the diagnostic value of endoscopy in patients with gastrointestinal graft-versus-host disease (GI GVHD). METHODS:We identified 8 patients with GI GVHD following allogeneic hematopoietic stem cell trans-plantation (HSCT). GVHD was defined histologically as the presence of gland apoptosis, not explained by other inflammatory or infectious etiologies. RESULTS:The symptoms of GI GVHD included anorexia, nausea, vomiting, watery diarrhea, abdominal pain, GI bleeding, etc. Upper endoscopic appearance varied from subtle mucosal edema, hyperemia, erythema to obvious erosion. Colonoscopic examination showed diffuse edema, hyperemia, patchy erosion, scattered ulcer, sloughing and active bleeding. Histological changes in GI GVHD included apoptosis of crypt epithelial cells, dropout of crypts, and lymphocytic infiltration in epithelium and lamina propria. The involvement of stomach and rectocolon varied from diffuse to focal. CONCLUSION:Endoscopy may play a significant role in early diagnosis of GI GVHD patients following allogeneic HSCT, and histologic examination of gastrointestinal biopsies is needed to confirm the final diagnosis.

关键词： Gastrointestinal graft-versus-host disease Endoscopy Diagnosis Allogeneic hematopoietic stem cell transplantation

Catalysts for Hydration of Cyclohexene to Cyclohexanol

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Chemical Research in Chinese Universities 2013年第4期29卷 743-746页

作者： FANG de-ren LU Jin-yan ZHANG Hui-min LI Jie WANG Yan-yan Shandong Provincial Key Lab of Chemical Engineering Institute of Applied Catalysis Yantai University Yantai 264005 P. R. China

The hydration of cyclohexene was determined in a stirred tank of 100 mL in a batch mode in the presence of modified or unmodified resin as catalyst. The ion-exchange sulfonate resin was modified with alkyl secondary amine. At an optimum amination rate of 15%, the conversion of cyclohexene reached to 22% and the selectivity of cyclohexanol was 95.6%. In a temperature range of 90--150℃, the activity and selectivity of the modified resin ca- talyst were much higher than those of the unmodified resin catalyst, which was attributed to the inclusion formed between cyclohexene and alkyl chain and also the quasi-lipophilic phase formed around the outer surface of resin beads. The formed quasi-lipophilic phase formed enhanced the conversion of cyclohexene and depressed the forma- tion of by-products.

关键词： Hydration Cyclohexene Ion-exchange resin Modification Aminate rate

Carcass image segmentation using CNN-based methods

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Information Processing in Agriculture 2021年第4期8卷 560-572页

作者： Diogo Nunes Goncalves Vanessa Aparecida de Moares Weber Julia Gindri Bragato Pistori Rodrigo da Costa Gomes Anderson Vicoso de araujo Marcelo Fontes Pereira Wesley Nunes Goncalves Hemerson Pistori Federal University of Mato Grosso do Sul Av.Costa e Silvas/nBairro UniversitarioCampo GrandeMS 79070-900Brazil INOVISAO Dom Bosco Catholic UniversityAvenida Tamandare6000CP 100Jardim SeminarioCampo GrandeMS 79117-900Brazil EMBRAPA Gado de Corte Av.Radio Maia830Vila PopularCampo GrandeMS 79106-550Brazil State University of Mato Grosso do Sul Av.Dom Antonio Barbosa4155Vila Santo AmaroCampo GrandeMS 79115-898Brazil

Carcass grading can be used as an important metric to determine meat ***,carcass grading is usually performed by a specialist,making it a subjective and errorprone *** increase the accuracy of such task,image-based systems have been proposed in the *** of the most important parts of an image-based system is the image segmentation,which aims to identify the regions of the carcass in the *** this paper,we propose the use of two recent image segmentation methods called Superpixel+CNN(Convolutional Neural Network)and *** evaluate both methods,we have also built a dataset of carcass images and their *** of approximately 96%of pixel accuracy show the robustness of the methods in carcass image *** novelty of this work is the proposal and comparison of recent deep learning methods that use CNN and superpixels in carcass *** this way,the methods can be used in carcass grading systems to increase the accuracy of the grading task.

关键词： Carcass grading Image segmentation Convolutional neural networks Superpixels

Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss

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journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 203-208页

作者： Yao-wen WANG Ji-hao REN Yong-de LU Tuan-fang YIN Ding-hua XIE Otolaryngology-Head and Neck Surgery department Ningbo First Hospital Ningbo 315000 China Otolaryngology-Head and Neck Surgery department the Second Xiangya Hospital Central South University Changsha 410001 China

Objective: To observe and compare the efficacy of intratympanic application of dexamethasone (DXM) for the treatment of refractory sudden sensorineural hearing loss (SSNHL), the DXM was given in three different ways: by tympanic membrane injection, by drip through a ventilation tube, and by perfusion through a round window catheter. Methods: We conducted a nonrandomized retrospective clinical trial involving 55 patients with refractory SSNHL. For 21 patients (the perfusion group), DXM (2.5 mg/0.5 ml) was perfused transtympanically through a round window catheter using an infusion pump for 1 h twice a day for 7 d giving a total amount of 35.0 mg. For 23 patients (the injection group), DXM (2.5 mg/time) was injected by tympanic membrane puncture at intervals of 2 d on a total of four occasions giving a total amount of 10.0 mg. For 11 patients (the drip group), DXM (2.5 mg/0.5 ml) was dripped via a ventilation tube placed by myringotomy, once on the first day and twice a day for the remaining 6 d giving a total amount of 32.5 mg. Thirty-two patients with refractory SSNHL who refused to undertake further treatments were defined as the control group. Hearing recovery and complications were compared among the groups. Hearing results were evaluated based on a four-frequency (0.5, 1.0, 2.0, 4.0 kHz) pure tone average (PTA). Results: Post-treatment audiograms were obtained one month after treatments were completed. The improvements in average PTA for the perfusion, injection, and drip groups were 9.0, 8.6, and 1.7 dB, respectively. Hearing improvement was significantly greater in the perfusion and injection groups than in the control group (1.4 dB) (P<0.05). In the perfusion group, 8 out of 21 patients (38.1%) had a PTA improvement of 15?56 dB (mean 29.8 dB); in the injection group, 8 out of 23 patients (34.8%) had a PTA improvement of 16?54 dB (mean 24.9 dB); in the drip group, 1 of 11 patients (9.1%) had a PTA improvement of 26.0 dB; in the control group, 3 out of 32 patie

关键词： Sudden sensorineural hearing loss dexamethasone Intratympanic Round window

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用神经网络法确定含水层参数

国外地质与勘测 1993年第4期 51-53,62页

作者： Aziz,ara 熊道锟

Distribution and quantitative zonation of unloading cracks at a proposed large hydropower station dam Site

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journal of Mountain Science 2017年第10期14卷 2106-2121页

作者： ZHAO Wei-hua FROST J.D. HUANG Run-qiu YAN Ming JIN Long-de State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu School of Civil and Environmental Engineering Georgia Institute of Technology

Rock mass unloading is an important rock engineering problem because unloading may impact the stability of a rock mass slope. Based on hydroelectric engineering principles, this study focuses on the classification of unloading zones to reflect the rock mass structure characteristics. Geological background and slope structure of the study region were considered to investigate the distribution and deformation of the unloading process. Quantitative indices were classified according to the formation mechanisms and the geological exhibition of unloading zones. The P-wave velocity(V_P), the ratio of the wave velocity(V_p) the ratio of the test P-wave velocity along the adit depth to the P-wave velocity of intact rock, the sum of joint openings every 2 meters(S_t), and the density of open joints(D_t) were calculated as quantitative indices for the rock mass unloading zone. The characteristics of the unloading zone of rock mass slopes at the dam site were successfully determined. The method of combining qualitative data with quantitative indices was found to be effective for the classification of slope unloading zones.

关键词： Slope Structure Unloading Phenomena Classify Unloading Zones Quantitative Indexes

design of a rapid-cycling synchrotron for flash proton therapy

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Nuclear Science and Techniques 2023年第10期34卷 1-11页

作者： Ying Shi Man-Zhou Zhang Lian-Hua Ou-Yang Zhi-Ling Chen Xiu-Fang Li de-Ming Li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The purpose of this study was to design a rapid-cycling synchrotron, making it capable of proton beam ultrahigh dose rate irradiation, inspired by laser accelerators. The design had to be cheap and simple. We consider our design from six aspects: the lattice, injection, extraction, space charge effects, eddy current effects and energy switching. Efficiency and particle quantity must be addressed when injected. The space charge effects at the injection could affect particles' number. The eddy current effects in the vacuum chambers would affect the magnetic field itself and generate heat, all of which need to be taken into account. Fast extraction can obtain 10^(10) protons/pulse, equal to instantaneous dose rate up to 10~7 Gy/s in a very short time, while changing various extraction energies rapidly and easily to various deposition depths. In the further research, we expect to combine a delivery system with this accelerator to realize the FLASH irradiation.

关键词： FLASH Rapid-cycling synchrotron Proton therapy

Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy

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World journal of Gastroenterology 2006年第24期12卷 3936-3937页

作者： Giovanni D de Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone Giovanni Persico Centro per l'Innovazione Tecnologica in Chirurgia-Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate Universita degli Studi di Napoli Federico Ⅱ Facoltà di Medicina e ChirurgiaNapoliItaly

Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.

关键词： Dieulafoy's lesion GI hemorrhage Smallbowel Capsule endoscopy Push enteroscopy

Active Oxygen Radical Scavenging Ability of Water-Soluble β-Alanine C_(60) Adducts

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Chinese Chemical Letters 2001年第11期12卷 997-1000页

作者： Tao SUN Zhi Shen JIA Wei Xiang CHEN Ya Xu JIN Zhu de XU department of Chemistry Zhejiang UniversityHangzhou 310027

Water-soluble b-alanine C60 adducts were synthesized, and the scavenging ability to superoxygen anion radical O2- and hydroxyl *** were studied by autoxidation of pyrogallol and chemiluminescence, respectively. It was found thatβ-alanine C60 adducts showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50% inhibition concentration (IC50) for superoxygen anion radical and hydroxyl radical were 0.15 mg/mL and 0.048 mg/mL, respectively. The difference should be mainly attributed to the different scavenging mechanisms.

关键词： b-alanine C_(60) adducts superoxygen anion radical O_(2)^(.-) hydroxyl radical autoxidation of pyrogallol chemiluminescence.