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Big Data Mining and Analytics 2024年第2期7卷 271-293页

作者： sunil Kumar Institute for Communication Systems University of SurreyGuildfordGU27XHUK

Open Air Interface(OAI)alliance recently introduced a new disaggregated Open Radio Access Networks(O-RAN)framework for next generation telecommunications and *** disaggregated architecture is open,automated,software defined,virtual,and supports the latest advanced technologies like Artificial Intelligence(AI)Machine Learning(AI/ML).This novel intelligent architecture enables programmers to design and customize automated applications according to the business needs and to improve quality of service in fifth generation(5G)and Beyond 5G(B5G).Its disaggregated and multivendor nature gives the opportunity to new startups and small vendors to participate and provide cheap hardware software solutions to keep the market *** paper presents the disaggregated and programmable O-RAN architecture focused on automation,AI/ML services,and applications with Flexible Radio access network Intelligent Controller(FRIC).We schematically demonstrate the reinforcement learning,external applications(xApps),and automation steps to implement this disaggregated O-RAN *** idea of this research paper is to implement an AI/ML enabled automation system for software defined disaggregated O-RAN,which monitors,manages,and performs AI/ML-related services,including the model deployment,optimization,inference,and training.

关键词： Artificial Intelligence(AI) Reinforcement Learning(RL) Open Radio Access Networks(O-RAN) Flexible Radio access network Intelligent Controller(FRIC) external Applications(xApps) Machine Learning(ML),sixth generation(6G)

Energy Demand for 21st Century and Present PV Cost Analysis

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Energy Demand for 21st Century and Present PV Cost Analysis

A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer

第十五届国际光伏科学与工程大会

作者： Dilip C.Ghimire Sudip Adhikari sunil adhikary Hideo Uchida Masayoshi Umeno Department of Electrical and Electronic Engineering Chubu University 1200 Matsumoto-cho Kasugai 487-8501 Japan Department of Electronics and Information Engineering Chubu University 1200 Matsumoto-cho Kasugai 487-8501 Japan

The energy demand of 21 century is significantly high due to the increase of world population and the advancement in science and technology. Most of the energy demand of the world has been fulfilled by fossil fuels and nuclear power. The excessive use of fossil fuels has caused the environmental problems in many countries of the world. The oil crisis of the 1970s coupled with the continual decline of fossil fuels reserves made us aware that alternative sources of renewable energy are necessary in order to ensure the world’s energy needs of the immediate future. Photovoltaic (PV) energy is attractive and reliable among the alternative energy sources, and widespread use of it could fulfill the future energy demand without having environmental problems. As a clean energy technology, PV energy can indeed promote sustainable economic development. Nevertheless, most of the primary energy still depends on fossil fuels and current utilization of renewable energy is negligibly small, except for hydropower. There is a forecast that the world primary energy supply in 2030, will increase to over 1.5 times as much as that in 2000 due to the world economic growth and population increase. In addition, energy demand in developing countries will increase significantly. In addition to the energy crisis problem, the massive consumption of fossils fuels with its resulting CO emissions has caused the problem of global warming. The purpose of our research is to illustrate estimated long-term cost of a PV module and a thermal energy system powered by fossil fuels.

关键词： World energy demand PV energy PV cost

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Chinese Journal of Integrative Medicine 2024年第1期30卷 42-51页

作者： sunil Kumar Asmita Das Department of Biotechnology Delhi Technological UniversityDelhi(110042)India

Objective: To obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas(HNSC). Methods: Gene expression data of HNSC samples and peripheral blood mononuclear cells(PBMCs) of HNSC patients were collected from Gene Expression Omnibus(GEO). Differential gene expression analysis of GEO datasets were achieved by the GEO2R tool. Common differentially expressed gerres(DEGs) were screened by comparing DEGs of HNSC with those of PBMCs. The combination was further analyzed for regulating pathways and biological processes that were affected. Results: Totally 110 DEGs were retrieved and identified to be involved in biological processes related to tumor regulation. Then 102 natural compounds were screened for a combination such that the expressions of all 110 commonly DEGs were altered. A combination of salidroside, ginsenoside Rd, oridonin, britanin, and scutellarein was chosen. A multifaceted, multi-dimensional tumor regression was showed by altering autophagy, apoptosis, inhibiting cell proliferation, angiogenesis, metastasis and inflammatory cytokines production. Conclusions: This study has helped develop a unique combination of natural compounds that will markedly reduce the propensity of development of drug resistance in tumors and immune evasion by tumors. The result is crucial to developing a combinatorial natural therapeutic cocktail with accentuated immunotherapeutic potential.

关键词： natural compounds chemopreventive gene expression head and neck cancer immunomodulator salidroside ginsenoside Rd oridonin britanin scutellarein

Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： sunil KANCHI Rohit SHUKLA Archana SHARMA Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

The Properties of Nitrogenated Amorphous Carbon Films Grown by Microwave Surface-wave Plasma CVD: Effects of Gas Composition Pressure

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The Properties of Nitrogenated Amorphous Carbon Films Grown ...

Bile acid metabolism and signaling in health and disease:molecular mechanisms and therapeutic targets

第十五届国际光伏科学与工程大会

作者： Sudip Adhikari Hare Ram Aryal Ashraf M.M.Omer sunil adhikary Hideo Uchida Masayoshi Umeno Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan Department of Electronics and Information Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan Department of Electronics and Information Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan Department of Electronics and Information Engineering Chubu University1200 Matsumoto-choKasugai 487-8501Japan

＜正＞ Nitrogenated amorphous carbon （a-C:N） thin films were grown on p-type silicon and quartz substrates by microwave surface wave plasma chemical vapor deposition （CVD） with various gas composition pressures （GCP）. The deposited a-C:N films were characterized for their optical, structural and electrical properties through UV/VIS/NIR spectroscopy, X-rays photoelectron spectroscopy, fourier transform infrared spectroscopy and solar simulator measurements. Optical absorption coefficient is decreased with increasing GCP. The roughness of the a-C:N is found to be very smooth （about 0.50 nm）. The film deposited at 90 Pa exhibited relatively good photovoltaic action compared to the films deposited at other GCPs.

关键词： Nitrogenated Amorphous Carbon Films MW SWP-CVD Gas Composition Pressure Films Properties

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： Joshua S.Fleishman sunil Kumar Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile acids,once considered mere dietary surfactants,now emerge as critical modulators of macronutrient(lipid,carbohydrate,protein)metabolism and the systemic pro-inflammatory/anti-inflammatory *** acid metabolism and signaling pathways play a crucial role in protecting against,or if aberrant,inducing cardiometabolic,inflammatory,and neoplastic conditions,strongly influencing health and *** curative treatment exists for any bile acid influenced disease,while the most promising and well-developed bile acid therapeutic was recently rejected by the ***,we provide a bottom-up approach on bile acids,mechanistically explaining their biochemistry,physiology,and pharmacology at canonical and non-canonical *** this mechanistic model of bile acids,we explain how abnormal bile acid physiology drives disease pathogenesis,emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic *** provide an in-depth summary on pre-existing bile acid receptor modulators,explain their shortcomings,and propose solutions for how they may be ***,we rationalize novel targets for further translational drug discovery and provide future *** than dismissing bile acid therapeutics due to recent setbacks,we believe that there is immense clinical potential and a high likelihood for the future success of bile acid therapeutics.

关键词： metabolism rejected shortcomings

MXenes: Versatile 2D materials with tailored surface chemistry and diverse applications

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Journal of Energy Chemistry 2024年第3期90卷 253-293,I0008页

作者： sunil Kumar Nitu Kumari Yongho Seo Department of Nanotechnology and Advanced Materials Engineering and HMC Sejong UniversitySeoul 05006South Korea School of Studies in Chemistry Jiwaji UniversityGwalior 474011India

MXenes,the most recent addition to the 2D material family,have attracted significant attention owing to their distinctive characteristics,including high surface area,conductivity,surface characteristics,mechanical strength,*** review begins by presenting MXenes,providing insights into their structural characteristics,synthesis methods,and surface functional *** review covers a thorough analysis of MXene surface properties,including surface chemistry and termination group *** properties of MXenes are influenced by their synthesis,which can be fluorine-based or ***-based synthesis techniques involve etching with fluorine-based reagents,mainly including HF or LiF/HCl,while fluorine-free methods include electrochemical etching,chemical vapor deposition(CVD),alkaline etching,Lewis acid-based etching,*** techniques result in the emergence of functional groups such as-F,-O,-OH,-Cl,*** the MXenes surface,depending on the synthesis method *** of MXenes,such as electrical conductivity,electronic properties,catalytic activity,magnetic properties,mechanical strength,and chemical and thermal stability,are examined,and the role of functional groups in determining these properties is *** review delves into the diverse applications of MXenes,encompassing supercapacitors,battery materials,hydrogen storage,fuel cells,electromagnetic interference(EMI) shielding,pollutant removal,water purification,flexible electronics,sensors,additive manufacturing,catalysis,biomedical and healthcare fields,***,this article outlines the challenges and opportunities in the current and future development of MXenes research,addressing various aspects such as synthesis scalability,etching challenges,and multifunctionality,and exploring novel *** review concludes with future prospects and conclusions envisioning the impact of MXenes on future technologies and innovation.

关键词： MXenes 2D materials Surface chemistry MXenes structure Synthesis Applications

Maize gets an iron boost:Biofortification breakthrough holds promise to combat iron deficiency

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Journal of Integrative Plant Biology 2024年第4期66卷 635-637页

作者： sunil Kumar Sahu State Key Laboratory of Agricultural Genomics Key Laboratory of GenomicsMinistry of AgricultureBGI ResearchShenzhen 518083China BGI Research Wuhan 430074China

Micronutrient deficiencies affect more than two billion people worldwide,resulting in poor health,developmental issues,and even *** deficiency is one of the most prevalent micronutrient deficiencies worldwide and impa... 详细信息

关键词： population breakthrough holds

Guardians of the fragrance:Uncovering the genetics behind citrus oil glands

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Plant Communications 2024年第5期5卷 97-99页

作者： sunil Kumar Sahu Muhammad Imran State Key Laboratory of Agricultural Genomics Key Laboratory of GenomicsMinistry of AgricultureBGI ResearchShenzhen 518083China BGI Research Wuhan 430074China State Key Laboratory for Conservation and Utilization of Subtropical AgroBioresources College of AgricultureSouth China Agriculture UniversityGuangzhou 510642China Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China

The colorful,nutrient-rich peels of citrus fruits have long been valued for their tangy flavors and aromatic *** oils are produced and stored in special secretory structures called oil glands,which are prevalent across citrus varieties(Knight et al.,2001).Oil glands serve as"reservoirs"for diverse metabolites such as terpenes and flavonoids that give citrus fruits their characteristic aroma(Mahato et al.,2019;Voo et al.,2012;Xian et al.,2022).Many of these compounds also act as chemical defenses against pest and pathogens(Fisher and Phillips,2008).

关键词： citrus Guard reservoirs

‘Prediabetes’ as a practical distinctive window for workable fruitful wonders: Prevention and progression alert as advanced professionalism

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World Journal of Clinical Pediatrics 2024年第1期13卷 1-6页

作者： sunil Jain Department of Paediatrics Indian Armed Forces Medical Servicesc/o 56 APO 900244India

Diabetes is a devastating public health *** is an intermediate stage in the disease processes leading to diabetes,including types 1 and 2 *** the article“Prediabetes in children and adolescents:An updated review,”the authors presented current *** simplify and systematically clearly present the evidence and rationale for a conceptual framework we term the‘3ASs’:(1)Awareness Sensible;(2)Algorithm Simple;and(3)Appealing *** makers and the public need to be *** prevalence of prediabetes should send alarm bells ringing for parents,individuals,clinicians,and policy *** is defined by the following criteria:impaired fasting glucose(100-125 mg/dL);impaired glucose tolerance(2 h postprandial glucose 140-199 mg/dL);or hemoglobin A1c values of 5.7%–6.4%.Any of the above positive test alerts for *** guidelines do not recommend prioritizing one test over the others for *** should be made on the strengths and shortfalls of each *** preferences and test accessibility should be taken into *** algorithm based on age,physiological stage,health status,and risk factors is *** prevention targeting populations aims to eliminate risk factors through public education and encouraging practices through environmental *** to healthy foods is *** prevention is for individuals with a prediabetes diagnosis and involves a structured program to reduce body weight and increase physical activity along with a healthy *** overall methodical move to a healthy lifestyle for lifelong health is urgently *** energetic prediabetes action is necessary.

关键词： Obesity Overweight Awareness Algorithm Lifestyle Physical exercise Screening Primordial prevention Primary prevention Adolescents