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Predictors and clinical significance of the positive cone margin in cervical intraepithelial neoplasia III patients

Chinese Medical Journal 2009年第4期122卷 367-372页

作者： sun xiao-guang ma shui-qing zhang jin-xia wu ming Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background Conization is being widely accepted for diagnosis and treatment of cervical intraepithelial neoplasia （CIN）. There is controversy as to which factors are most predictive of a positive cone margin and the clinical significance of it. We conducted this study to identify the predictive factors and to evaluate the clinical significance of a positive cone margin in CIN III patients.Methods A retrospective review was conducted of 207 patients who had undergone conization due to CIN III from January 2003 to December 2005 at Peking Union Medical College Hospital. Of these, 67 had a subsequent hysterectomy Univariate and multivariate analysis were utilized to define the predictive factors for a positive cone margin, and to compare the pathologic results of conization with subsequent hysterectomy.Results One hundred and fifty-one （72.9%） were margin free of CIN I or worse, 37 （17.9%） had CIN lesions close to the margin and 19 （9.2%） had margin involvement. A total of 56 cases （27.1%） had positive cone margins （defined as the presence of CIN at or close to the edge of a cone specimen）. Univariate analysis showed that the parity, cytological grade multi-quadrants of CIN III by punch biopsy, gland involvement, as well as the depth of conization were significant factors correlated with a positive cone margin （P 〈0.05）. However the age, gravidity, grade of dysplasia in punch biopsy, as well as the cone methods were not significantly correlated （P 〉0.05）. Multivariate analysis revealed that the cytological grade （OR=1.92）, depth of conization （OR=2.03）, parity （OR=3.02） and multi-quadrants of CIN III （OR=4.60） were significant predictors with increased risk for positive margin. The frequency of residual CIN I or worse in hysterectomy specimens was found to be 55.6% （20/36） in patients who were margin free, 71.4% （15/21） in patients with CIN occurring close to margin, and 80.0% （8/10） in patients with margin involvement. The frequency of residual CIN III or worse was

关键词： conization cervical intraepithelial neoplasia factor analysis

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Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-xia ma xian-Bao Cao Hua zhang shui-Hong Zhou Wei-Hong Jiang Yan Jiang jing-wu sun Qin-Tai Yang Xue-Zhong Li Ya-Nan sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen xiao-Shu zhang Hong-Quan Wei Shao-qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-guang Shan guang-Ke Wang jing Ye Shen-Hong Qu Chang-qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu xiao Cai Wei Huang Ru-Xin zhang Yu-Lin Zhao Guo-Dong Yu guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi Hua jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu jing He Yi-Lin mao xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua Han Da-jin Liu Li-Qin Duan ming-Jun Zhao Cui-Ying zhang Hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu jing An Feng-Chun Li Tao Tao jin-Fa Jiang Ying Yang Yao-Rong Dong Lei zhang guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun sun Ying-Qiang Zhao Jie Li Yun xia Jun Liu Fan Liu Wen-jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-qing ma Hui-Jun Chen He-Ping Liu Zong-wu Liu Jian-Xiong Liu xiao-Jia Luo xiao-Hong Bin Ya-Nan Yu Hai-xia Dang Bing Li Fei Teng Wang-Min Qiao xiao-Long Zhu Bing-Wei Chen Qi-guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

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Asian Journal of Urology 2019年第1期6卷 114-121页

作者： Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei ma Yajun xiao Sheng zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo jin Zhichen Guan qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan guang sun qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo jin Jiafu Feng ming Cai Zhaozhao Liang Jie zhang Dingwei Ye Lin Qi Lulin ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie xia Dong Wei Jianbo wu Weiling Fu Zhiping Wang Jianbo Liang Department of Urology Peking University First HospitalBeijingChina Institute of Urology Peking UniversityBeijingChina National Urological Cancer Center BeijingChina Air Force General Hospital PLABeijingChina Department of Urology Peking Union Medical College HospitalBeijingChina Department of Urology Beijing Chao-Yang HospitalBeijingChina Department of Urology Armed-Police General HospitalBeijingChina Department of Urology Shanxi Medical University First HospitalTaiyuanChina Department of Urology Hebei Medical University Second HospitalShijiazhuangChina Department of Urology The General Hospital of the People’s Liberation ArmyBeijingChina Department of Urology First Affiliated Hospital of Jilin UniversityChangchunChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of Urology The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Urology General Hospital of Guangzhou Military Command of PLAGuangzhouChina Department of Urology West China School of MedicineChengduChina Department of Urology Shangdong Province-owned HospitalJinanChina Department of Urology Peking University Shenzhen HospitalShenzhenChina Department of Urology The Central Hospital of Jinan CityJinanChina Department of Urology Shanghai Changzheng HospitalShanghaiChina Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Urology Beijing Anzhen Hospital of Capital Medical UniversityBeijingChina Department of Urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Urology People’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina Department of Urology Guangdong General HospitalGuangzhouChina Department of Urology The First Affil

Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder ***:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December *** operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology ***:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised ***,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(pma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and *** sensitivity using FISH was obtained in high grade and muscle invasive tumors.

关键词： Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage

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East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： Yu-Zhu Cui Kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh wu Jiang Lang Cui mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho guang-Yao Zhao xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-xia sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua zhang guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong jin-qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-sung Lee Kunwoo Yi qing-Hui Liu xiang Liu Ru-Sen Lu masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo sun guang-ming Li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong sun Dong Chen Zhi-shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang Liu Qian Lu Wei Rao jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong jing-Sheng ma Qi-Gen Li Sheng-Dong wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

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2005年中国城市CO2排放数据集

引用

中国人口·资源与环境 2018年第4期28卷 1-7页

作者：蔡博峰刘晓曼陆军王金南刘红光陈洋陈占明丛建辉崔志鹏代春艳董会娟方恺冯彤郭杰李芬孟凡鑫唐伟王庚哲谢运生张建军阿依吐尔逊·沙木西布买日也木·买买提蔡伟光曾胜常盼陈前利陈振国单钰理丁冠乔独威范敏冯相昭干晓宇高壮飞谷雨何凌昊何姚胡鸣明黄丽珍黄桥贾小平菊春燕蓝菁李爽李松李耀光李照令刘合林刘婧文刘庆燕刘竹逯飞马贤磊欧金沛潘栋沈杨税月孙露谭效时唐敏唐袆祺王柯王思亓王香爱王晓培吴家杰吴雪萍肖连香邢文婷徐丽笑叶瑞克袁子坤张飞云张袆张明张琦峰张曦文张宇赵晶赵胜男郑思伟周来友朱天琦曹丽斌冯乐李栋李一静龙瀛孙瑞红环境保护部环境规划院北京100012 中国科学院大气物理研究所北京100029 南京农业大学公共管理学院江苏南京210095 上海财经大学城市与区域科学学院上海200433 中国人民大学经济学院北京100872 山西大学经济与管理学院山西太原030006 E20环境平台咨询部北京100195 重庆工商大学长江上游经济研究中心重庆400067 上海交通大学环境科学与工程学院上海200240 浙江大学公共管理学院浙江杭州310058 天津大学管理与经济学部天津300072 南京农业大学土地管理学院江苏南京210095 深圳市建筑科学研究院股份有限公司北京研创中心广东深圳518049 华南理工大学环境与能源学院广东广州510006 杭州市环境保护科学研究院环境政策研究中心浙江杭州310014 埃因霍芬理工大学建筑学院荷兰埃因霍芬5616SC 江西省科学院能源研究所江西南昌330000 中国地质大学(北京)土地科学技术学院北京100083 新疆农业大学管理学院新疆乌鲁木齐830052 重庆大学建设管理与房地产学院重庆400044 重庆工商大学财政金融学院重庆400067 东安格利亚大学国际发展学院英国诺维奇NR47TJ 环境保护部环境发展中心北京100029 环境保护部环境与经济政策研究中心北京100029 四川大学建筑与环境学院四川成都610065 浙江工业大学政治与公共管理学院浙江杭州310023 美国绿色建筑委员会城市与社区部北京100085 挪威科技大学工程学院挪威约尔维克2815 北京师范大学统计学院北京100875 青岛科技大学环境学院山东青岛266000 北京大学遥感与地理信息系统研究所北京100871 北京师范大学环境学院北京100875 筑波大学日本筑波305-0005 华中科技大学建筑与城市规划学院湖北武汉430074 美国东北大学工学院美国波士顿02115 河北省环境科学研究院规划所河北石家庄050037 中山大学地理科学与规划学院广东广州北京林业大学环境科学与工程学院北京宁波职业技术学院商贸外语学院浙江宁波重庆工商大学土地管理学院重庆日本国立环境研究所社会环境系统研究中心日本筑波中国船舶重工集团公司第七一四研究所北京重庆工商大学管理学院重庆渭南师范学院化学与材料学院陕西渭南福州大学经济与管理学院福建福州扬州大学环境科学与工程学院江苏扬州中国矿业大学管理学院江苏徐州北京大学城市与环境学院北京内蒙古大学公共管理学院内蒙古呼和浩特江苏大学财经学院江苏镇江赤峰学院资源与环境科学学院内蒙古赤峰新余学院经济管理学院江西新余北京市环境保护科学研究院生态与城市环境研究所北京北京清华同衡规划设计研究院有限公司技术创新中心北京100085 北京大学汇丰商学院英国校区华威大学交叉学科研究方法中心英国牛津100871 清华大学建筑学院北京100062 上海工程技术大学管理学院上海021620

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。... 详细信息

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。基于中国高空间分辨率网格数据(CHRED 2.0)、城市层面统计数据以及大量现场调研和走访,建立2005年中国城市CO_2排放数据集,包括工业能源排放、工业过程排放、农业排放、服务业排放、城镇生活排放、农村生活排放、交通排放7个部门的直接排放数据和间接排放数据。该数据集的建立汇总了86名研究人员的工作成果,在企业、城市不同行业与部门、城市工业和城市总化石能源等不同层面进行了大量的交叉验证和数据分析,有效保障了数据的精确性和准确性。结果显示,2005年中国城市碳排放呈现出较大的体量差异和空间格局差异。排放前10的城市几乎比排放后10的城市的排放量高出两个数量级。高排放城市基本都是城市群的核心城市。东部城市直接排放占全国直接排放比例最高,达到44.59%,其次是西部城市21.76%,中部城市22.70%,东北城市10.95%。

关键词：城市 CO 2排放数据集中国高空间分辨率网格

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