Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population
作者机构：Department of UrologyPeking University First HospitalBeijingChina Institute of UrologyPeking UniversityBeijingChina National Urological Cancer CenterBeijingChina Air Force General HospitalPLABeijingChina Department of UrologyPeking Union Medical College HospitalBeijingChina Department of UrologyBeijing Chao-Yang HospitalBeijingChina Department of UrologyArmed-Police General HospitalBeijingChina Department of UrologyShanxi Medical University First HospitalTaiyuanChina Department of UrologyHebei Medical University Second HospitalShijiazhuangChina Department of UrologyThe General Hospital of the People’s Liberation ArmyBeijingChina Department of UrologyFirst Affiliated Hospital of Jilin UniversityChangchunChina Department of UrologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of PathologyThe First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of UrologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Department of UrologyGeneral Hospital of Guangzhou Military Command of PLAGuangzhouChina Department of UrologyWest China School of MedicineChengduChina Department of UrologyShangdong Province-owned HospitalJinanChina Department of UrologyPeking University Shenzhen HospitalShenzhenChina Department of UrologyThe Central Hospital of Jinan CityJinanChina Department of UrologyShanghai Changzheng HospitalShanghaiChina Department of UrologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of UrologyBeijing Anzhen Hospital of Capital Medical UniversityBeijingChina Department of UrologyThe Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of UrologyThe Second Hospital of Tianjin Medical UniversityTianjinChina Department of UrologyPeople’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina Department of UrologyGuangdong General HospitalGuangzhouChina Department of UrologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina Department of UrologyThe First Hospital of Zhejiang ProvinceHangzhouChina Department of UrologyThe First Affiliated Hospital of Dalian Medical UniversityDalianChina Department of UrologyDaping HospitalResearch Institute of SurgeryThird Military Medical UniversityChongqingChina Department of UrologyMianyang Central HospitalMianyangChina Department of UrologyGeneral Hospital of PLA General Staff HeadquartersBeijingChina Department of UrologyFirst Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of UrologyRenmin Hospital of Wuhan UniversityWuhanChina Department of UrologyFudan University Shanghai Cancer CenterShanghaiChina Department of UrologyXiangya Hospital of Central South UniversityChangshaChina Department of UrologyPeking University Third HospitalBeijingChina Department of UrologyCancer Hospital of Chinese Academy of Medical SciencesBeijingChina am Department of UrologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of UrologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of UrologySun Yat-sen University Cancer CenterGuangzhouChina Department of UrologyBeijing Friendship Hospital of Capital Medical UniversityBeijingChina Department of UrologyWenzhou Central HospitalWenzhouChina Department of UrologyPeking University People’s HospitalBeijingChina Department of UrologyThe First Hospital of China Medical UniversityShenyangChina Department of UrologyQinghai Province People’s HospitalXiningChina Department of UrologyBeijing Tongren Hospital of Capital Medical UniversityBeijingChina Department of UrologyQilu Hospital of Shandong UniversityJinanChina Department of UrologyNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of UrologyTianjing Medical University General HospitalTianjinChina Department of UrologyShanghai General HospitalShanghaiChina Department of UrologyBeijing HospitalBeijingChina Department of UrologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of UrologySouthwest HospitalChongqingChina Department of UrologyLanzhou University Second HospitalLanzhouChina Department of UrologyThe People’s Hospital of Guangxi Zhuang Autonomous RegionNanningChina
出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)
年 卷 期：2019年第6卷第1期
页 面：114-121页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage
摘 要：Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors.
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