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TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells

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Cellular & Molecular Immunology 2021年第9期18卷 2262-2274页

作者： Xiaoping Xie Lele Zhu Zuliang Jie Yanchuan Li Meidi Gu Xiaofei Zhou Hui Wang Jae-Hoon Chang Chun-Jung Ko Xuhong Cheng Shao-cong sun Department of Immunology The University of Texas MD Anderson Cancer Center7455 Fannin StreetBox 902HoustonTX77030USA Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyXuzhou Medical University209 Tongshan RoadXuzhou221004JiangsuChina College of Pharmacy Yeungnam UniversityGyeongsan712-749Republic of Korea MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences HoustonTX77030USA

Generation and maintenance of antigen-specific effector and memory T cells are central events in immune responses against *** show that TNF receptor-associated factor 2(TRAF2)maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against *** signaling axis involves activation of Tpl2 and its downstream kinase ERK by NF-κB-inducing kinase(NIK)and degradation of the proapoptotic factor *** mediates Tpl2 activation by stimulating the phosphorylation and degradation of the Tpl2 inhibitor ***,while NIK is required for Tpl2-ERK signaling under normal conditions,uncontrolled NIK activation due to loss of its negative regulator,TRAF2,causes constitutive degradation of p105 and Tpl2,leading to severe defects in ERK activation and effector/memory CD8 T cell ***,TRAF2 controls a previously unappreciated signaling axis mediating effector/memory CD8 T cell survival and protective immunity.

关键词： T cell survival Effector and memory CD8 T cells Protective immunity Bacterial infection TRAF2 NIK Tpl2

Predicition of Domain and three-dimensional structure of Homo sapiens PPARγ transcript variant 1 Protein

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Predicition of Domain and three-dimensional structure of Hom...

Recycling and depolymerization of waste polyethylene terephthalate bottles by alcohol alkali hydrolysis

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： cong sun yechao Han Wenfeng zhang Department of Biochemistry and Molecular Biology School of Basical Medical Sciences Jilin Institute for Veterinary Drug and Feed Control

To predict the three-dimensional structure and binding site of ligand based on amino acidsequence of peroxisome proliferator-activated receptor gamma(PPARγ),transcript variant1 *** secondary structure and surface properties of PPARγtranscript variant 1 Proteinsuch as hydrophilicity,physical and chemical properties,surface probability,flexibleregions,trans–membrane domain,signal peptide and secondary structure were analyzedto predict its binding site of ligand by bioinformatics methods and *** threedimensionalstructure was obtained by submitting amino acid sequence to the *** potential bingding site of ligand were ***:The secondarystructure and bingding site of ligand of PPARγtranscript variant 1 Protein were predictedsuccessfully by *** study provided a foundation for identificationof its advantage binding site of ligand and understanding its biological functions on thebasis of protein structure.

关键词： PPARγ transcript variant 1 protein binding site

来源： cnki会议评论

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Journal of Central South University 2018年第3期25卷 543-549页

作者： sun cong-hao CHEN Xiang-ping ZHUO Qiang ZHOU Tao Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources(School of Chemistry and Chemical Engineering) Central South University

In this work,a novel alcohol alkali hydrolysis method was explored for the preparation of terephthalic acid(TPA)from waste polyethylene terephthalate(PET).First,a series of single factor experiments on the depolymerization rate of waste PET bottles and the yield of TPA were conducted to determine the optimized experimental conditions,in terms of reaction time,reaction temperature,dosage of ethylene glycol and sodium bicarbonate,amount of distilled water and stirring *** IR spectra and elemental analysis were carried out for the characterization of obtained *** optimal experimental conditions,over 98%PET can be depolymerized into the target product(TPA)and the purity and yield of TPA are over 97%and 94%,*** the experimental and analytical results support a feasible process for the preparation of TPA from waste *** is expected that this alcohol alkali hydrolysis method can promise an effective way for the sustainable recycling of waste PET.

关键词： waste polyethylene terephthalate terephthalic acid alcohol alkali hydrolysis ethylene glycol

文化研究“失语症”问题——当阿多诺文化工业理论遭遇中国经验

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上海大学学报（社会科学版） 2016年第2期33卷 84-92页

作者：孙士聪首都师范大学文学院北京100089

文化研究"失语"论正在走出草创期的本土文化研究自我回顾与反思的表征,但这一诊断的合法性有待琢磨。证之以阿多诺文化工业理论在本土文化经验中的历史性遭际,可知文化理论在经验现实中的不同呈现形式,总是与文化批评和文化研究争讼,以... 详细信息

文化研究"失语"论正在走出草创期的本土文化研究自我回顾与反思的表征,但这一诊断的合法性有待琢磨。证之以阿多诺文化工业理论在本土文化经验中的历史性遭际,可知文化理论在经验现实中的不同呈现形式,总是与文化批评和文化研究争讼,以及与大众文化深刻嬗变的历史性相纠缠。文化研究"失语症"问题之提出,则根植于理论认识、认知背景以及本土化观念所建构的"问题式"中,"美国文化研究本土化"的失败个案可以在镜鉴意义上证伪"失语"判断。

关键词：文化研究失语阿多诺文化工业理论中国经验

Properties of Cementitious Rendering Mortar Prepared with Recycled Fine Aggregates

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 1053-1056页

作者：潘智生 Department of Civil and Structural Engineering The Hong Kong Polytechnic University

The results of an experimental study on investigating the properties of cementitious rendering mortars prepared with a recycled fine aggregate（RA） were *** RA was obtained from a recycling plant in which mixed demolition wastes were processed by mechanical crushing,sieving and sorting *** series of rendering mortar mixes were prepared with a constant water/cement and a constant aggregate/cement ratios of 0.55 and 3 *** sand and natural crushed rock fine were originally used in the two series separately,and they were consistently replaced by 25%,50%,75% and 100% by the recycled *** experimental results showed that mechanical properties,such as compressive strength,flexural strength and modulus of elasticity of the mortars prepared with the RA were lower than the mortars made with the natural ***,the bond strength at the interface between the mortar and masonry bricks determined by the Triplet test was found to be higher for the mortars prepared with the RA.

关键词： rendering mortar recycled fine aggregate triplet test mechanical properties

In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating Qin Zhongming Huang Yifan Wu Long sun cong Wang Wei Wang Gang Feng Yiying Qi Department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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细胞因子在骨髓增殖性肿瘤中的研究进展

中国实验血液学杂志 2015年第3期23卷 878-882页

作者：孙聪聪李英山东大学附属省立医院血液科山东济南250021

骨髓增殖性肿瘤(myeloproliferative neoplasms,MPN)是一组以一系或多系成熟的粒细胞、红细胞、巨核细胞或单核细胞扩增为特征的克隆性疾病,起源于造血干细胞水平,经典的BCR-ABL1(-)MPN包括真性红细胞增多症(polycythemia vera,PV)、原... 详细信息

骨髓增殖性肿瘤(myeloproliferative neoplasms,MPN)是一组以一系或多系成熟的粒细胞、红细胞、巨核细胞或单核细胞扩增为特征的克隆性疾病,起源于造血干细胞水平,经典的BCR-ABL1(-)MPN包括真性红细胞增多症(polycythemia vera,PV)、原发性血小板增多症(ET)和骨髓纤维化(MF)。近年来发现细胞因子的异常表达及其活动与MPN是相关的,基因表达谱显示许多与免疫和促炎细胞因子相关的基因在MPN中异常表达。细胞因子在MPN的发病机制中有重要的作用且与临床症状相联系,这或许是MPN病理生理机制探索中的重大发现。本文将对细胞因子在MPN发病机制中的作用,细胞因子与MPN的临床相关性,当前治疗方法与针对细胞因子的新的治疗方法的组合等方面作一综述。

关键词：骨髓增殖性肿瘤细胞因子慢性炎症治疗方法

Highly adaptive and broadband triboelectric energy harvester with stretching silicone rubber strip for variable harmonic frequency vibration

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Nano Research 2024年第5期17卷 4089-4099页

作者： Taili Du Dianlong Shen Ziyue Xi Hongyong Yu Fangyang Dong cong Zhao Meixian Zhu Yongjiu Zou Peiting sun Minyi Xu Dalian Key Laboratory of Marine Micro/Nano Energy and Self-powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian 116026China Collaborative Innovation Research Institute of Autonomous Ship Dalian Maritime UniversityDalian 116026China

An enormous number of wireless sensing nodes(WSNs)are of great significance for the Internet of Things(IoT).It is tremendously prospective to realize the in-situ power supply of WSNs by harvesting unutilized mechanical vibration energy.A harmonic silicone rubber triboelectric nanogenerator(HSR-TENG)is developed focusing on ubiquitous constant working frequency *** unique design of the strip serving as a flexible resonator realizes both soft contact and high and broadband *** significant factors influencing the 1^(st)-order vibration mode of the strip are developed for realizing the harmonic frequency adaptation to external *** surface treatment of the strip improves the output performance of HSR-TENG by 49.1%as well as eliminates the adhesion *** HSR-TENG is able to achieve a voltage output bandwidth of 19 Hz under a vibration strength of 3.0,showing its broadband *** peak power density of 153.9 W/m^(3)is achieved and 12×0.5 W light-emitting diodes(LEDs)are successfully illuminated by the *** can continuously power a temperature sensor by harvesting the actual compressor vibration *** brief,the HSR-TENG provides a promising way for constant frequency vibration energy harvesting,so as to achieve in-situ power supply for the WSNs in the vicinity.

关键词： vibration energy harvesting triboelectric nanogenerator flexible silicone rubber strip harmonic vibration broadband

Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation

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World Journal of Psychiatry 2024年第8期14卷 1216-1223页

作者： Xin Jin Chun-Yun Xu Jin-Feng Fei Yu Fang cong-Hao sun Department of Psychiatry Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the *** several treatment methods exist,their efficacy is *** recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric *** To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with *** This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third Municipal Hospital,affiliated with Huzhou University,between January 2020 and December *** received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment *** observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to ***,the observa-tion group showed a more pronounced decrease than the control *** T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 ***,the increase was particularly more substantial in the observation group than in the control *** patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the ***,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to th

关键词： Alzheimer's disease Non-persistentθshort array fast pulse mode Depression Clinical efficacy Dementia Repetitive transcranial magnetic stimulation