TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells
作者机构：Department of ImmunologyThe University of Texas MD Anderson Cancer Center7455 Fannin StreetBox 902HoustonTX77030USA Jiangsu Key Laboratory of Immunity and MetabolismDepartment of Pathogenic Biology and ImmunologyXuzhou Medical University209 Tongshan RoadXuzhou221004JiangsuChina College of PharmacyYeungnam UniversityGyeongsan712-749Republic of Korea MD Anderson Cancer Center UT Health Graduate School of Biomedical SciencesHoustonTX77030USA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2021年第18卷第9期
页 面：2262-2274页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：This study was supported by grants from the National Institutes of Health(AI64639 and GM84459) the core facilities of MD Anderson Cancer Center are supported by the NIH/NCI Cancer Center Support Grant(CCSG)P30CA016672
主 题：T cell survival Effector and memory CD8 T cells Protective immunity Bacterial infection TRAF2 NIK Tpl2
摘 要：Generation and maintenance of antigen-specific effector and memory T cells are central events in immune responses against *** show that TNF receptor-associated factor 2(TRAF2)maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against *** signaling axis involves activation of Tpl2 and its downstream kinase ERK by NF-κB-inducing kinase(NIK)and degradation of the proapoptotic factor *** mediates Tpl2 activation by stimulating the phosphorylation and degradation of the Tpl2 inhibitor ***,while NIK is required for Tpl2-ERK signaling under normal conditions,uncontrolled NIK activation due to loss of its negative regulator,TRAF2,causes constitutive degradation of p105 and Tpl2,leading to severe defects in ERK activation and effector/memory CD8 T cell ***,TRAF2 controls a previously unappreciated signaling axis mediating effector/memory CD8 T cell survival and protective immunity.
维普期刊数据库