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Mulberry Biomass-Derived Nanomedicines Mitigate colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu cheng Xu Wei Sun Erhu Zhao Min Wang Rui L.Reis subhas c.kundu Xiaoxiao Shi Bo Xiao State Key Laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China chongqing Key Laboratory of Soft-Matter Material chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal IcVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(Uc)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean carr Xiaoxiao Shi Rui LReis subhas ckundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China college of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(Uc)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic caO_(2) nanospheres with cu_(2)O *** resulting caO_(2)–cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of caO_(2)–cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven caO_(2)–cu_(2)O offers a promising therapeutic platform for robust treatment of Uc via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

基于忆阻器的感-存-算一体化人工触觉感知系统（英文）

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Science china Materials 2024年第11期 3675-3683页

作者：谢玉龙 subhas c.kundu 范苏娜张耀鹏 State Key Laboratory for Modification of chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University 3Bs Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of Minho

构筑人工智能交互系统依然存在挑战,其原因在于缺少高性能的感知-计算集成系统.本研究基于丝素蛋白复合忆阻器与压阻式传感器设计了集感-存-算功能于一体的人工触觉感知系统.传感器由聚二甲基硅氧烷/银纳米线构成,可快速响应外界压力刺...

构筑人工智能交互系统依然存在挑战,其原因在于缺少高性能的感知-计算集成系统.本研究基于丝素蛋白复合忆阻器与压阻式传感器设计了集感-存-算功能于一体的人工触觉感知系统.传感器由聚二甲基硅氧烷/银纳米线构成,可快速响应外界压力刺激.丝素蛋白复合忆阻器具有优异的循环稳定性及突触可塑性模拟功能,可作为人工突触处理触觉信息.本文集成的触觉感知系统可实现对压力信号的感知、存储及加工,证实了其模拟生物体触觉神经系统的可能,有望在自动驾驶、可穿戴柔性电子、仿生机器人等人工智能领域广泛应用.

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Therapeutic implications of cancer stem cells in prostate cancer

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cancer Biology & Medicine 2023年第6期20卷 401-420页

作者： Pinaki Banerjee Prachi Kapse Shehnaz Siddique Moumita kundu Jasoda choudhari Varshasnata Mohanty Diksha Malhotra Suresh W.Gosavi Rajesh N.Gacche Gopal c.kundu National centre for cell Science Savitribai Phule Pune University CampusPune 411007India School of Basic Medical Science Savitribai Phule Pune UniversityPune 411007India School of Biotechnology KIIT Deemed to be UniversityBhubaneswar 751024India Department of Biotechnology Savitribai Phule Pune UniversityPune 411007IndiaSchool of BiotechnologyKIIT Deemed to be UniversityBhubaneswar 751024India Kalinga Institute of Medical Sciences(KIMS) KIIT Deemed to be UniversityBhubaneswar 751024India

Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells(PcScs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PcScs;methods for isolation and enrichment of PcScs;and various cellular and metabolic signaling pathways involved in PcSc induction and maintenance, as well as therapeutic targeting.

关键词： Epithelial-mesenchymal transition metastasis prostate cancer cancer stem cells tumor growth tumor microenvironment signaling

Electroosmotic oscillatory flow of micropolar fluid in microchannels:application to dynamics of blood flow in microfluidic devices

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 749-766页

作者： J.c.MISRA S.cHANDRA G.c.SHIT P.K.kundu Department of Mathematics Institute of Technical Education and ResearchSiksha O Anusandhan University Department of Mathematics Jadavpur University

The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss＇s law of charge distribution are solved within the framework of the Debye-Hückel approximation. The fluid velocity and microrotation are assumed to depend linearly on the Reynolds number. The study shows that the amplitude of microrotation is highly sensitive to the changes in the magnitude of the suction velocity and the width of the microchannel. An increase in the micropolar parameter gives rise to a decrease in the amplitude of microrotation. Numerical estimates reveal that the microrotation of the suspended microelements in blood also plays an important role in controlling the electro-osmotically actuated flow dynamics in microbio-fluidic devices.

关键词： blood flow electrohydrodynamic effect microfluidics channel flow

An analytical study on the Rayleigh wave generation in a stratified structure

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1039-1054页

作者： A.MANDI S.kundu P.PATI P.c.PAL Department of Mathematics and computing Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India

In this paper,an analytical method is used to investigate the Rayleigh wave generation in a stratified structure and the wave generation in a dry sandy layer constrained between the couple stress and inhomogeneous orthotropic *** study is devoted to analyzing the impact of various effective parameters associated with the media on the phase velocities of the *** displacement components for each medium are derived by implementing the separable variable *** frequency equa-tion is secured by using the displacement components in the boundary conditions,imposed at the interfaces between the layer and ***,the secured equation is the relation between the phase velocity and the wave *** computations are performed,and graphical representations are demonstrated between the phase velocity and the wave number for both phase velocities with different values of the *** comparison between the phase velocities is observed for the same value of each pa-rameter.

关键词： Rayleigh wave dry sandy layer couple stress orthotropic phase velocity wave number

Fuel properties and emission characteristics of biodiesel produced from unused algae grown in India

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Petroleum Science 2018年第2期15卷 385-395页

作者： Rachan Karmakar Krishnendu kundu Anita Rajor School of Energy and Environment Thapar University Department of Biofuel CSIR CMERI CoEFM

The high price of different biodiesels and the need for many of their raw ingredients as food materials are the main constraints to be overcome when seeking the best potential alternative fuels to petro-diesel. Apart from that, some properties like high density, viscosity and acid value along with low cloud and pour points preclude their use in com- pression ignition （cI） engines as these properties can cause serious damage to the parts of the engine and reduce engine life. In this experiment, biodiesel was produced from the oil of unused algae by a two-step ＇acid esterification followed by transesterification＇ procedure. Taguchi＇s method was applied to design the experiment, and a L25 orthogonal array was prepared to optimize the biodiesel production procedure. The optimized conditions for transesterification were： methanol to oil molar ratio of 6：1, catalyst （KOH） concentration of 2.5 wt%, reaction time of 90 min and reaction temperature of 50 ~c, achieving a biodiesel production of 89.7% with free fatty acid content of 0.25%. It was found that the cI engine emitted less cO, cO2 and hydrocarbon and higher NOx using algal biodiesel than that using petro-diesel. All properties of the algal biodiesel were within the limit of ASTM standards.

关键词： Algae Biodiesel Fuel characterization Emission

Quantitative analysis of the interaction of heterologous viruses with Plum pox virus in c5 HoneySweet transgenic plums

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Journal of Integrative Agriculture 2019年第10期18卷 2302-2310页

作者： Khushwant Singh Tereza Neubauerová Jiban Kumar kundu Plant Virus and Vector Interactions Group Division of Crop Protection and Plant Health Crop Research Institute

Stone fruits are an important crop in most parts of the world and are heavily challenged by several viruses including Plum pox virus (PPV), Prune dwarf virus (PDV), Prunus necrotic ringspot virus (PNRSV), and Apple chlorotic leaf spot virus (AcLSV). We validated the PPV resistance in c5 plum plants (commercially known as HoneySweet) grown in the czech Republic for more than 16 years in a field trial experiment under natural environmental conditions. We quantified single (PPV-Rec) and mixed viruses (PPV-Rec+AcLSV, PPV-Rec+PDV and PPV-Rec+AcLSV+PDV) in c5 transgenic plums inoculated for the period 2016 to 2018. The accumulation of PPV-Rec was high (~5.43E+05 copies) compared with that of AcLSV (~8.70E+04 copies) in the inoculated graft of c5 transgenic plants. Leaves close to the inoculum sources showed a differential level of virus titre in single and mixed infections (~10 to ~5×10^2 copies). c5 plants with permanent virus pressure showed 103- to 105-fold fewer copies of viruses than those of the inoculated graft. We observed high accumulation of conserved miRNAs such as miR167, miR69 and miR396 in c5 plants co-infected with PPV, AcLSV and PDV that are associated with its resistance against viruses. Overall, i) c5 transgenic plums showed high resistance to PPV infection, and a low level (~32 copies) of PPV only accumulated in some grafted plants, ii) high accumulation of PPV was found in inoculated grafts in single PPV infection and mixed infections, iii) heterologous virus infection sustained by AcLSV or PDV did not suppress PPV resistance, and iv) high and low conserved microRNAs accumulated in c5 plants.

关键词： PPV PDV AcLSV c5 HoneySweet resistance

Device and circuit analysis of a sub 20 nm double gate MOSFET with gate stack using a look-up-table-based approach

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Journal of Semiconductors 2017年第12期38卷 37-41页

作者： S chakraborty A Dasgupta R Das M Kar A kundu c K Sarkar Department of Electronics and communications Engineering Heritage Institute of Technology Kolkata 700107India Nano Device Simulation Laboratory Department of Electronics and Telecommunication EngineeringJadavpur UniversityKolkata 700032India

In this paper, we explore the possibility of mapping devices designed in TcAD environment to its modeled version developed in cadence virtuoso environment using a look-up table （LUT） approach. circuit simu- lation of newly designed devices in TcAD environment is a very slow and tedious process involving complex scripting. Hence, the LUT based modeling approach has been proposed as a faster and easier alternative in ca- dence environment. The LUTs are prepared by extracting data from the device characteristics obtained from device simulation in TcAD. A comparative study is shown between the TcAD simulation and the LUT-based alternative to showcase the accuracy of modeled devices. Finally the look-up table approach is used to evaluate the perform- ance of circuits implemented using 14 nm nMOSFET.

关键词： 14 nm double gate MOSFET look-up table VerilogA