Therapeutic implications of cancer stem cells in prostate cancer

作     者：Pinaki Banerjee Prachi Kapse Shehnaz Siddique Moumita Kundu Jasoda Choudhari Varshasnata Mohanty Diksha Malhotra Suresh W.Gosavi Rajesh N.Gacche Gopal C.Kundu Pinaki Banerjee;Prachi Kapse;Shehnaz Siddique;Moumita Kundu;Jasoda Choudhari;Varshasnata Mohanty;Diksha Malhotra;Suresh W.Gosavi;Rajesh N.Gacche;Gopal C.Kundu

作者机构：National Centre for Cell ScienceSavitribai Phule Pune University CampusPune 411007India School of Basic Medical ScienceSavitribai Phule Pune UniversityPune 411007India School of BiotechnologyKIIT Deemed to be UniversityBhubaneswar 751024India Department of BiotechnologySavitribai Phule Pune UniversityPune 411007IndiaSchool of BiotechnologyKIIT Deemed to be UniversityBhubaneswar 751024India Kalinga Institute of Medical Sciences(KIMS)KIIT Deemed to be UniversityBhubaneswar 751024India 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2023年第20卷第6期

页      面：401-420页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Department of Biotechnology(DBT),Govt of India supported by the Council of Scientific and Industrial Research(CSIR),Govt.of India supported by the University Grants Commission(UGC),Govt.of India partly supported by BT/INF/22/SP42155/2021 from the Department of Biotechnology,Ministry of Science and Technology,Govt.of India 

主　　题：Epithelial-mesenchymal transition metastasis prostate cancer cancer stem cells tumor growth tumor microenvironment signaling 

摘      要：Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells(PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs;methods for isolation and enrichment of PCSCs;and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.